JP2005505579A5 - - Google Patents
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- Publication number
- JP2005505579A5 JP2005505579A5 JP2003530818A JP2003530818A JP2005505579A5 JP 2005505579 A5 JP2005505579 A5 JP 2005505579A5 JP 2003530818 A JP2003530818 A JP 2003530818A JP 2003530818 A JP2003530818 A JP 2003530818A JP 2005505579 A5 JP2005505579 A5 JP 2005505579A5
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- formula
- igf receptor
- receptor antagonist
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 12
- 239000002464 receptor antagonist Substances 0.000 claims 8
- 229940044551 receptor antagonist Drugs 0.000 claims 8
- 150000001413 amino acids Chemical group 0.000 claims 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 5
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 4
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 3
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 239000005557 antagonist Substances 0.000 claims 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- FSXRLASFHBWESK-HOTGVXAUSA-N Phe-Tyr Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)C1=CC=CC=C1 FSXRLASFHBWESK-HOTGVXAUSA-N 0.000 claims 1
- 108010017622 Somatomedin Receptors Proteins 0.000 claims 1
- 102000004584 Somatomedin Receptors Human genes 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- FSXRLASFHBWESK-UHFFFAOYSA-N dipeptide phenylalanyl-tyrosine Natural products C=1C=C(O)C=CC=1CC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FSXRLASFHBWESK-UHFFFAOYSA-N 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/962,756 US6875741B2 (en) | 1998-09-02 | 2001-09-24 | Insulin and IGF-1 receptor agonists and antagonists |
| PCT/US2002/030412 WO2003027246A2 (en) | 2001-09-24 | 2002-09-24 | Antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005505579A JP2005505579A (ja) | 2005-02-24 |
| JP2005505579A5 true JP2005505579A5 (cg-RX-API-DMAC7.html) | 2006-01-05 |
Family
ID=25506313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569654A Pending JP2005517741A (ja) | 2001-09-24 | 2002-09-24 | インシュリン及びｉｇｆ−１レセプターのアゴニスト及びアンタゴニスト |
| JP2003530818A Pending JP2005505579A (ja) | 2001-09-24 | 2002-09-24 | アンタゴニスト |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569654A Pending JP2005517741A (ja) | 2001-09-24 | 2002-09-24 | インシュリン及びｉｇｆ−１レセプターのアゴニスト及びアンタゴニスト |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6875741B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP1432433A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2005517741A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2002366384A1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2459999A1 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2003027246A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7625859B1 (en) | 2000-02-16 | 2009-12-01 | Oregon Health & Science University | HER-2 binding antagonists |
| US6521738B2 (en) * | 1999-12-29 | 2003-02-18 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogs |
| WO2003020201A2 (en) | 2001-08-28 | 2003-03-13 | Eli Lilly And Company | Pre-mixes of glp-1 and basal insulin |
| AU2003205830A1 (en) | 2002-01-23 | 2003-09-02 | Mohamed Raafat El-Gewely | Molecular libraries |
| US7261876B2 (en) * | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
| US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
| US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| EP2385132B1 (en) * | 2002-04-22 | 2014-03-05 | Oncolix, Inc. | Multimeric ligands with enhanced stability |
| NZ571508A (en) * | 2002-05-24 | 2010-05-28 | Schering Corp | Neutralizing human anti-IGFR antibody |
| US8034904B2 (en) * | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US7538195B2 (en) * | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| CA2493532C (fr) * | 2002-07-31 | 2014-05-27 | Yves Saint-Laurent Parfums | Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules |
| US20040176291A1 (en) * | 2002-09-24 | 2004-09-09 | Elly Nedivi | Methods and compositions for soluble CPG15 |
| US7638605B2 (en) * | 2003-05-01 | 2009-12-29 | ImClone, LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
| US20050187175A1 (en) * | 2003-09-30 | 2005-08-25 | Elly Nedivi | Methods and compositions for CPG15-2 |
| US7605120B2 (en) * | 2003-10-22 | 2009-10-20 | Amgen Inc. | Antagonists of the brandykinin B1 receptor |
| CN1938428A (zh) | 2003-11-12 | 2007-03-28 | 先灵公司 | 多基因表达的质粒系统 |
| AR046639A1 (es) * | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
| WO2005082415A2 (en) * | 2004-02-25 | 2005-09-09 | Dana Farber Cancer Institute, Inc. | Inhibitors of insulin-like growth factor receptor-1 for inhibiting tumor cell growth |
| EP1755660B1 (en) * | 2004-05-07 | 2010-03-24 | The University of North Carolina at Chapel Hill | Method for enhancing or inhibiting insulin-like growth factor-i |
| US8187595B2 (en) | 2004-05-07 | 2012-05-29 | The University Of North Carolina At Chapel Hill | Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I |
| JP2008510692A (ja) * | 2004-08-20 | 2008-04-10 | ノボ ノルディスク アクティーゼルスカブ | 薬学的に活性なインスリン受容体調節分子 |
| US20090197800A1 (en) * | 2004-10-27 | 2009-08-06 | Novo Nordisk A/S | Insulin Receptor Binding Peptides with Non-Insulin Gene Activation Profiles and Uses Thereof |
| AU2005305157B2 (en) * | 2004-10-27 | 2011-09-01 | Oklahoma Medical Research Foundation | Adrenocorticotropic hormone analogs and related methods |
| EP2281841A3 (en) * | 2004-12-03 | 2013-10-23 | Merck Sharp & Dohme Corp. | Biomarkers for pre-selection of patients for anti-IGF1R therapy |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| ES2732623T3 (es) | 2005-01-06 | 2019-11-25 | Innate Pharma Sa | Tratamientos y métodos de combinación anti-KIR |
| NZ586780A (en) | 2005-03-23 | 2012-02-24 | Genmab As | Antibodies against CD38 for treatment of multiple myeloma |
| US20060233810A1 (en) * | 2005-04-15 | 2006-10-19 | Yaolin Wang | Methods and compositions for treating or preventing cancer |
| NZ564098A (en) | 2005-06-15 | 2010-04-30 | Schering Corp | Anti-IGF1R antibody formulations |
| RU2502523C2 (ru) | 2005-06-17 | 2013-12-27 | Имклоун Элэлси | АНТИТЕЛА ПРОТИВ PDGFRα ДЛЯ ЛЕЧЕНИЯ ВТОРИЧНОЙ ОПУХОЛИ КОСТИ |
| WO2007011610A2 (en) * | 2005-07-18 | 2007-01-25 | Acologix, Inc. | Protein formulation for promoting hard tissue formation |
| CN101321780A (zh) * | 2005-10-05 | 2008-12-10 | 诺沃-诺迪斯克有限公司 | 胰岛素受体拮抗剂及相关组合物、用途和方法 |
| EA017265B1 (ru) * | 2006-02-03 | 2012-11-30 | Имклоун Элэлси | Применение антитела imc-a12, которое является ингибитором igf-ir, для лечения рака предстательной железы |
| WO2007095113A2 (en) * | 2006-02-10 | 2007-08-23 | Massachusetts Institute Of Technology | Cpg15 and cpg15-2 compounds and inhibitors as insulin receptor and insulin-like growth factor receptor agonists and antagonists |
| EP2468767B1 (en) | 2006-06-22 | 2015-10-28 | Walter and Eliza Hall Institute of Medical Research | Structure of the insulin receptor ectodomain |
| US20080064039A1 (en) * | 2006-07-06 | 2008-03-13 | Pienkos Philip T | Dominant negative ligand drug discovery system |
| CN101802001A (zh) | 2007-04-24 | 2010-08-11 | 安提拉公司 | Igf-1r结合性蛋白和拮抗剂 |
| US8574577B2 (en) * | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| US8557243B2 (en) * | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US20110189206A1 (en) | 2008-01-03 | 2011-08-04 | Barbas Iii Carlos F | Antibody Targeting Through a Modular Recognition Domain |
| US8557242B2 (en) * | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| CA2713348C (en) | 2008-01-30 | 2018-10-09 | Indiana University Research And Technology Corporation | Ester-based peptide prodrugs |
| WO2010080609A1 (en) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| EP2376099A4 (en) * | 2008-12-19 | 2012-04-25 | Univ Indiana Res & Tech Corp | INSULIN AGAIN YL-BASED GROWTH FACTORS WITH HIGH ACTIVITY AT THE INSULIN RECEPTOR |
| CA2747490C (en) | 2008-12-19 | 2017-02-14 | Indiana University Research And Technology Corporation | Insulin analogs |
| US9155801B2 (en) | 2009-05-28 | 2015-10-13 | The United States Government As Represented By The Department Of Veterans Affairs | Amino acid sequences which enhance peptide conjugate solubility |
| EP2470201A4 (en) * | 2009-08-28 | 2013-01-30 | Bayer Healthcare Llc | COFACTORS ENABLING THE THROMBINIC ACTIVATION OF FACTOR VII AND THEIR USES |
| AU2011268327B2 (en) | 2010-06-16 | 2016-02-25 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| CA2803164C (en) | 2010-06-24 | 2018-08-21 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| CA2825894C (en) | 2011-02-02 | 2021-11-30 | Amgen Inc. | Prognosis of cancer using a circulating biomarker |
| EP2712423A4 (en) * | 2011-02-25 | 2015-06-10 | Wellstat Diagnostics Llc | Assays for detecting enzymatic activity |
| DK2714738T3 (en) | 2011-05-24 | 2019-01-28 | Zyngenia Inc | MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS |
| AU2012267492A1 (en) * | 2011-06-10 | 2014-01-09 | President And Fellows Of Harvard College | Modulation of pancreatic beta cell proliferation |
| EP2776042B1 (en) | 2011-11-11 | 2019-03-20 | Duke University | Combination drug therapy for the treatment of solid tumors |
| US9573987B2 (en) | 2011-12-20 | 2017-02-21 | Indiana University Research And Technology Corporation | CTP-based insulin analogs for treatment of diabetes |
| US8980259B2 (en) | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
| US9073996B2 (en) | 2012-08-31 | 2015-07-07 | The University Of North Carolina At Chapel Hill | Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor 1 (IGF-1) |
| CA2886228A1 (en) | 2012-09-26 | 2014-04-03 | Indiana University Research And Technology Corporation | Insulin analog dimers |
| WO2014158900A1 (en) | 2013-03-14 | 2014-10-02 | Indiana University Research And Technology Corporation | Insulin-incretin conjugates |
| EA201890895A1 (ru) | 2013-03-15 | 2019-02-28 | Зинджения, Инк. | Мультивалентные и моновалентные мультиспецифические комплексы и их применение |
| MX388301B (es) | 2014-09-03 | 2025-03-19 | Boehringer Ingelheim Int | Il-23a y tnf-alfa orientados y compuesto y sus usos. |
| ES2947409T3 (es) | 2014-09-24 | 2023-08-08 | Univ Indiana Res & Tech Corp | Profármacos de insulina a base de amida lipídica |
| EP3206710B1 (en) | 2014-09-24 | 2020-05-06 | Indiana University Research & Technology Corporation | Incretin-insulin conjugates |
| US11634470B2 (en) * | 2015-10-23 | 2023-04-25 | Jai Prakash | Integrin binding peptides and uses thereof |
| WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
| WO2021146657A1 (en) * | 2020-01-16 | 2021-07-22 | The Translational Genomics Research Institute | Methods of identifying synthetic molecular binding agents |
| WO2022020246A1 (en) * | 2020-07-23 | 2022-01-27 | The Scripps Research Institute | Insulin receptor-mediated enhancement of gene transfer |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876242A (en) | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| EP0378671B1 (en) * | 1988-06-30 | 1997-03-12 | City Of Hope | Insulinomimetic and insulin receptor binding site peptides |
| US5652214A (en) * | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
| US6310040B1 (en) | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
| JPH07508025A (ja) | 1992-05-08 | 1995-09-07 | トーマス・ジェファーソン・ユニバーシティ | インスリン様増殖因子（ｉｇｆ−１）類似体 |
| DE4432943A1 (de) | 1994-09-15 | 1996-03-21 | Radulescu Razvan T Dr Med M D | Numerical Mirror Image Strategy (NUMIS) |
| RU2078769C1 (ru) | 1995-08-18 | 1997-05-10 | Научно-исследовательский институт биомедицинской химии РАМН | Пептидный фрагмент, обладающий биологической активностью инсулина |
| US5912160A (en) | 1995-08-22 | 1999-06-15 | Thomas Jefferson University | Gab1, Grb2 binding protein, and compositions for making and methods of using the same |
| US6028053A (en) * | 1995-10-27 | 2000-02-22 | Mount Sinai Hospital Corporation | Peptide inhibitors of a phosphotyrosine-binding domain containing protein |
| JP2000515726A (ja) | 1996-06-07 | 2000-11-28 | ジェネティックス・インスチチュート・インコーポレーテッド | 分泌蛋白をコードする成人ｐｂｍｃ由来のポリヌクレオチド |
| ATE296446T1 (de) * | 1997-01-15 | 2005-06-15 | Telik Inc | Modulatoren von insulinrezeptor-aktivität |
| EP1034188B1 (en) | 1997-11-27 | 2006-06-07 | Commonwealth Scientific And Industrial Research Organisation | Method of designing agonists and antagonists to igf receptor (1-462) |
| WO2000040613A1 (en) * | 1999-01-06 | 2000-07-13 | Genentech, Inc. | Insulin-like growth factor (igf) i mutant variants |
| EP2368902A3 (en) * | 2000-03-29 | 2011-12-21 | DGI Bio Technologies LLC | Insulin and IGF-1 receptor agonists and antagonists |
-
2001
- 2001-09-24 US US09/962,756 patent/US6875741B2/en not_active Expired - Fee Related
-
2002
- 2002-09-24 JP JP2003569654A patent/JP2005517741A/ja active Pending
- 2002-09-24 CA CA002459999A patent/CA2459999A1/en not_active Abandoned
- 2002-09-24 AU AU2002366384A patent/AU2002366384A1/en not_active Abandoned
- 2002-09-24 CA CA002460055A patent/CA2460055A1/en not_active Abandoned
- 2002-09-24 EP EP02775987A patent/EP1432433A4/en not_active Withdrawn
- 2002-09-24 WO PCT/US2002/030412 patent/WO2003027246A2/en not_active Ceased
- 2002-09-24 JP JP2003530818A patent/JP2005505579A/ja active Pending
- 2002-09-24 EP EP02806867A patent/EP1496935A4/en not_active Withdrawn
- 2002-09-24 AU AU2002341834A patent/AU2002341834A1/en not_active Abandoned
- 2002-09-24 WO PCT/US2002/030312 patent/WO2003070747A2/en not_active Ceased
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