JP2004267216A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004267216A5 JP2004267216A5 JP2004132989A JP2004132989A JP2004267216A5 JP 2004267216 A5 JP2004267216 A5 JP 2004267216A5 JP 2004132989 A JP2004132989 A JP 2004132989A JP 2004132989 A JP2004132989 A JP 2004132989A JP 2004267216 A5 JP2004267216 A5 JP 2004267216A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- coupled receptor
- polypeptide
- amino acid
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920001184 polypeptide Polymers 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 16
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 16
- 239000002157 polynucleotide Substances 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 15
- 108091033319 polynucleotide Proteins 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 238000000034 method Methods 0.000 claims 9
- 239000013598 vector Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108091006027 G proteins Proteins 0.000 claims 2
- 102000030782 GTP binding Human genes 0.000 claims 2
- 108091000058 GTP-Binding Proteins 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229940125425 inverse agonist Drugs 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 239000004031 partial agonist Substances 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10921398P | 1998-11-20 | 1998-11-20 | |
| US12041699P | 1999-02-16 | 1999-02-16 | |
| US12185299P | 1999-02-26 | 1999-02-26 | |
| US12394699P | 1999-03-12 | 1999-03-12 | |
| US12394999P | 1999-03-12 | 1999-03-12 | |
| US13643699P | 1999-05-28 | 1999-05-28 | |
| US13643999P | 1999-05-28 | 1999-05-28 | |
| US13712799P | 1999-05-28 | 1999-05-28 | |
| US13713199P | 1999-05-28 | 1999-05-28 | |
| US13656799P | 1999-05-28 | 1999-05-28 | |
| US13643799P | 1999-05-28 | 1999-05-28 | |
| US14144899P | 1999-06-29 | 1999-06-29 | |
| US15663399P | 1999-09-29 | 1999-09-29 | |
| US15665399P | 1999-09-29 | 1999-09-29 | |
| US15663499P | 1999-09-29 | 1999-09-29 | |
| US15655599P | 1999-09-29 | 1999-09-29 | |
| US15728299P | 1999-10-01 | 1999-10-01 | |
| US15728199P | 1999-10-01 | 1999-10-01 | |
| US15728099P | 1999-10-01 | 1999-10-01 | |
| US15729499P | 1999-10-01 | 1999-10-01 | |
| US15729399P | 1999-10-01 | 1999-10-01 | |
| US41676099A | 1999-10-12 | 1999-10-12 | |
| US41704499A | 1999-10-12 | 1999-10-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584067A Division JP2003534767A (ja) | 1998-11-20 | 1999-10-13 | ヒトオーファンｇタンパク質共役型受容体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007129923A Division JP2007209352A (ja) | 1998-11-20 | 2007-05-15 | ヒトオーファンｇタンパク質共役型受容体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004267216A JP2004267216A (ja) | 2004-09-30 |
| JP2004267216A5 true JP2004267216A5 (cg-RX-API-DMAC7.html) | 2007-02-01 |
Family
ID=27586698
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584067A Withdrawn JP2003534767A (ja) | 1998-11-20 | 1999-10-13 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2004132989A Withdrawn JP2004267216A (ja) | 1998-11-20 | 2004-04-28 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2007129923A Pending JP2007209352A (ja) | 1998-11-20 | 2007-05-15 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2008033839A Pending JP2008133300A (ja) | 1998-11-20 | 2008-02-14 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2009159339A Withdrawn JP2009298791A (ja) | 1998-11-20 | 2009-07-03 | ヒトオーファンｇタンパク質共役型受容体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584067A Withdrawn JP2003534767A (ja) | 1998-11-20 | 1999-10-13 | ヒトオーファンｇタンパク質共役型受容体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007129923A Pending JP2007209352A (ja) | 1998-11-20 | 2007-05-15 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2008033839A Pending JP2008133300A (ja) | 1998-11-20 | 2008-02-14 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2009159339A Withdrawn JP2009298791A (ja) | 1998-11-20 | 2009-07-03 | ヒトオーファンｇタンパク質共役型受容体 |
Country Status (12)
| Country | Link |
|---|---|
| EP (8) | EP1849866B1 (cg-RX-API-DMAC7.html) |
| JP (5) | JP2003534767A (cg-RX-API-DMAC7.html) |
| KR (5) | KR100765039B1 (cg-RX-API-DMAC7.html) |
| AT (3) | ATE301673T1 (cg-RX-API-DMAC7.html) |
| AU (2) | AU770056B2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2348377C (cg-RX-API-DMAC7.html) |
| DK (3) | DK1133559T3 (cg-RX-API-DMAC7.html) |
| ES (3) | ES2289610T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL142538A0 (cg-RX-API-DMAC7.html) |
| NZ (3) | NZ527622A (cg-RX-API-DMAC7.html) |
| PT (3) | PT1584683E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2000031258A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69938015T2 (de) * | 1998-03-12 | 2009-01-15 | Astellas Pharma Inc. | Neue G Protein-gekoppelte Rezeptorproteine |
| US6071722A (en) * | 1998-04-24 | 2000-06-06 | Smithkline Beecham Corporation | Nucleic acids encoding a G-protein coupled 7TM receptor (AXOR-1) |
| JP2002512780A (ja) * | 1998-04-24 | 2002-05-08 | スミスクライン ビーチャム コーポレーション | 新規７ｔｍ受容体ａｘｏｒ−２のクローニング |
| EP1155031A4 (en) * | 1998-11-03 | 2002-11-27 | Smithkline Beecham Corp | G PROTEIN TORQUE RECEPTOR, SAID AXOR-14 |
| USRE42190E1 (en) | 1998-11-20 | 2011-03-01 | Arena Pharmaceuticals, Inc. | Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors |
| US20030017528A1 (en) | 1998-11-20 | 2003-01-23 | Ruoping Chen | Human orphan G protein-coupled receptors |
| US7816492B2 (en) | 1998-11-20 | 2010-10-19 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors |
| US6221660B1 (en) | 1999-02-22 | 2001-04-24 | Synaptic Pharmaceutical Corporation | DNA encoding SNORF25 receptor |
| WO2000050458A1 (en) * | 1999-02-26 | 2000-08-31 | Smithkline Beecham Corporation | Cloning of a p2y-like 7tm receptor (axor17) |
| US6620615B1 (en) | 1999-04-23 | 2003-09-16 | Curagen Corporation | G-protein coupled receptor—encoding nucleic acids |
| EP1189944A4 (en) * | 1999-06-21 | 2002-09-11 | Smithkline Beecham Corp | AXOR16, R CEPTEUR COUPL UNE PROT INE G |
| CA2378786A1 (en) * | 1999-07-13 | 2001-01-18 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | G-protein coupled receptor and dna sequences thereof |
| EP1198569A1 (en) * | 1999-07-30 | 2002-04-24 | MERCK PATENT GmbH | G-protein coupled receptor and dna sequences thereof |
| CA2382889A1 (en) * | 1999-08-27 | 2001-03-08 | Takuya Watanabe | Novel g protein-coupled receptor protein and dna thereof |
| US6998255B1 (en) | 1999-09-24 | 2006-02-14 | Solvay Pharmaceuticals B.V. | Human G-protein coupled receptor |
| GB9923177D0 (en) * | 1999-09-30 | 1999-12-01 | Pfizer Ltd | Novel polypeptide |
| US6204017B1 (en) | 1999-10-07 | 2001-03-20 | Schering Corporation | Polynucleotide encoding a histamine receptor |
| GB9923890D0 (en) * | 1999-10-08 | 1999-12-08 | Pfizer Ltd | Novel polypeptide |
| GB9923893D0 (en) * | 1999-10-08 | 1999-12-08 | Pfizer Ltd | Novel polypeptide |
| GB9924960D0 (en) * | 1999-10-21 | 1999-12-22 | Pfizer Ltd | Novel polypeptide |
| GB9924956D0 (en) * | 1999-10-21 | 1999-12-22 | Pfizer Ltd | Novel polypeptide |
| EP1230361A2 (en) * | 1999-10-27 | 2002-08-14 | PHARMACIA & UPJOHN COMPANY | G protein-coupled receptors expressed in human brain |
| ATE375390T1 (de) * | 1999-10-29 | 2007-10-15 | Pfizer | G-protein-gekoppelter rezeptor-ähnliche proteine |
| WO2001032864A2 (en) * | 1999-11-03 | 2001-05-10 | Merck Patent Gmbh | Gpcr-kd5 polypeptides and dna sequences thereof |
| US6461836B1 (en) | 1999-11-05 | 2002-10-08 | Smithkline Beecham Corporation | Molecular cloning of a 7TM receptor (AxOR34) and screening methods thereof |
| EP1237909A2 (en) * | 1999-11-16 | 2002-09-11 | PHARMACIA & UPJOHN COMPANY | Human g protein-coupled receptors |
| US7029857B1 (en) | 1999-12-17 | 2006-04-18 | H. Lundbeck A/S | Processes for obtaining compounds employing SNORF72 receptors |
| WO2001046414A1 (fr) * | 1999-12-20 | 2001-06-28 | Banyu Pharmaceutical Co., Ltd. | Nouvelle proteine receptrice couplee a la proteine de fixation de guanosine triphosphate, bg26 |
| WO2001046454A1 (en) | 1999-12-23 | 2001-06-28 | Cor Therapeutics, Inc. | P2y12 receptor |
| AU2230401A (en) * | 1999-12-28 | 2001-07-09 | Helix Research Institute | Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same |
| GB0001700D0 (en) * | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Novel protein |
| US7138249B2 (en) | 2000-02-04 | 2006-11-21 | Takeda Pharmaceutical Company Limited | Screening method |
| EP1266005B1 (en) * | 2000-03-14 | 2007-03-07 | Bayer HealthCare AG | Regulation of human lipoxin a4 receptor-like protein |
| AU3930201A (en) * | 2000-03-17 | 2001-09-24 | Bayer Aktiengesellschaft | Regulation of human leukotriene B4-like G protein-coupled receptor |
| AU2001241156A1 (en) * | 2000-03-21 | 2001-10-03 | Yamanouchi Pharmaceutical Co..Ltd. | Novel leukotriene b4 receptor |
| US20030087287A1 (en) * | 2000-03-28 | 2003-05-08 | Masanori Miwa | Novel g-protein-coupled receptor protein and dna thereof |
| AU4467301A (en) * | 2000-03-31 | 2001-10-08 | Helix Research Institute | Novel guanosine triphosphate-binding protein-coupled receptor gprv53, gene thereof and production and use of the same |
| AU2001248755A1 (en) * | 2000-04-12 | 2001-10-23 | Takeda Chemical Industries Ltd. | Novel g protein-coupled receptor protein and dna thereof |
| EP1178110A1 (en) * | 2000-08-01 | 2002-02-06 | Aventis Pharma Deutschland GmbH | EDG8 receptor for sphingosine 1-phosphate , its preparation and use |
| AU6744501A (en) * | 2000-05-18 | 2001-11-26 | Bayer Aktiengesellschaft | Regulation of human dopamine-like g protein-coupled receptor |
| WO2002000719A2 (en) * | 2000-06-23 | 2002-01-03 | Tularik Inc. | Human and mouse g-protein couipled receptors |
| AU2001281862A1 (en) * | 2000-06-26 | 2002-01-08 | Akzo Nobel N.V. | G-protein coupled receptor org10 |
| AU2001281933A1 (en) * | 2000-06-30 | 2002-01-14 | Ingenium Pharmaceuticals Ag | Human g protein-coupled receptor igpcr17, and uses therof |
| WO2002004518A2 (en) * | 2000-07-06 | 2002-01-17 | Bayer Corporation | Human neuropeptide y-like g protein-coupled receptor |
| EP1311546A2 (en) * | 2000-08-09 | 2003-05-21 | Millenium Pharmaceuticals, Inc. | Methods for using 14266, a human g protein-coupled receptor |
| US6790608B2 (en) * | 2000-09-20 | 2004-09-14 | The Regents Of The University Of California | Methods of identifying and ADP-glucose receptor ligand, agonist or antagonist |
| ES2282304T3 (es) | 2000-11-01 | 2007-10-16 | Astellas Pharma Inc. | Procedimiento para seleccionar antiplaquetas. |
| CA2426037A1 (en) * | 2000-11-07 | 2002-05-16 | Paradigm Therapeutics Limited | A "bach" g protein coupled receptor polypeptide and polynucleotide encoding this receptor |
| AU2002219890B2 (en) * | 2000-11-27 | 2007-06-14 | Arena Pharmaceuticals, Inc. | Endogenous and non-endogenous versions of human G protein-coupled receptors |
| EP1338651B9 (en) | 2000-12-01 | 2007-05-09 | Astellas Pharma Inc. | Method of screening remedy for diabetes |
| US20020155473A1 (en) * | 2000-12-22 | 2002-10-24 | Zaoyuan Peng | Methods for identifying G-protein coupled receptors associated with diseases |
| US7220580B2 (en) | 2000-12-22 | 2007-05-22 | University Of South Florida | Sphingosine 1-phosphate receptor gene, sppr |
| GB0100782D0 (en) * | 2001-01-11 | 2001-02-21 | Glaxo Group Ltd | Assay |
| JPWO2002088355A1 (ja) * | 2001-04-25 | 2004-08-19 | 藤沢薬品工業株式会社 | 新規なグアノシン三リン酸結合タンパク質共役型の受容体ｐｌａｃｅ６００２３１２およびその遺伝子、並びにそれらの製造および用途 |
| US7419658B2 (en) | 2001-07-09 | 2008-09-02 | Euroscreen S.A. | Isolated ligand of ChemerinR |
| US7858755B2 (en) | 2001-07-09 | 2010-12-28 | Euroscreen S.A. | Monoclonal antibodies that bind Chemerin polypeptide |
| US20030096299A1 (en) | 2001-07-09 | 2003-05-22 | Valerie Wittamer | Natural ligand of G protein coupled receptor ChemR23 and uses thereof |
| US6946244B2 (en) | 2001-08-07 | 2005-09-20 | Euroscreen, S.A. | Methods of identifying a ligand, an agonist, and an antagonist of G protein coupled receptor GPR86 (P2Y13) |
| US7338772B2 (en) | 2002-04-12 | 2008-03-04 | Schering Corporation | G-protein coupled receptor ligands and methods |
| WO2004022086A1 (ja) * | 2002-09-02 | 2004-03-18 | Takeda Pharmaceutical Company Limited | 副腎皮質ホルモン分泌調節剤 |
| AU2003271149A1 (en) * | 2002-10-11 | 2004-05-04 | Yamanouchi Pharmaceutical Co., Ltd. | Method of screening remedy for renal failure |
| US7056685B1 (en) | 2002-11-05 | 2006-06-06 | Amgen Inc. | Receptor ligands and methods of modulating receptors |
| CA2509218C (en) | 2002-12-20 | 2010-09-07 | Merck & Co., Inc. | 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as edg receptor agonists |
| CN102558155A (zh) | 2003-01-14 | 2012-07-11 | 阿伦纳药品公司 | 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗 |
| US7083933B1 (en) | 2003-05-09 | 2006-08-01 | Prosidion Limited | Methods for identification of modulators of OSGPR116 activity |
| JP2007526747A (ja) * | 2003-06-27 | 2007-09-20 | タノックス インコーポレーテッド | ヒトマスト細胞発現膜タンパク質 |
| US7524638B1 (en) | 2003-06-27 | 2009-04-28 | Osi Pharmaceuticals, Inc. | Methods for identification of modulators of OSGPR114 or OSGPR78 activity, and their use in the treatment of disease |
| DOP2006000008A (es) * | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| GB0508990D0 (en) * | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
| CN103323606A (zh) | 2006-04-11 | 2013-09-25 | 艾尼纳制药公司 | 使用gpr119受体鉴定可用于增加个体骨质量的化合物的方法 |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| KR20100033419A (ko) | 2007-07-19 | 2010-03-29 | 메타볼렉스, 인코포레이티드 | 당뇨병 및 대사 장애의 치료를 위한 ｒｕｐ3 또는 ｇｐｒ119 수용체의 작용제로서 ｎ-아자시클릭 치환된 피롤, 피라졸, 이미다졸, 트리아졸 및 테트라졸 유도체 |
| CA2697551C (en) | 2007-09-20 | 2013-03-12 | Irm Llc | Piperidine derivatives as modulators of gpr119 activity |
| EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
| AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
| CN102666553B (zh) | 2009-10-01 | 2015-05-06 | 赛马拜制药公司 | 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐 |
| US8791100B2 (en) | 2010-02-02 | 2014-07-29 | Novartis Ag | Aryl benzylamine compounds |
| US20130023494A1 (en) | 2010-04-06 | 2013-01-24 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| ES2676209T3 (es) | 2010-06-23 | 2018-07-17 | Metabolex Inc. | Composiciones de 5-etil-2-{4-[4-(4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina |
| BR112013008100A2 (pt) | 2010-09-22 | 2016-08-09 | Arena Pharm Inc | "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles." |
| US20140018371A1 (en) | 2011-04-01 | 2014-01-16 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012145361A1 (en) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US20140038889A1 (en) | 2011-04-22 | 2014-02-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| US20140051714A1 (en) | 2011-04-22 | 2014-02-20 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
| EP3242666B9 (en) | 2015-01-06 | 2024-12-25 | Arena Pharmaceuticals, Inc. | Compound for use in treating conditions related to the s1p1 receptor |
| IL285890B (en) | 2015-06-22 | 2022-07-01 | Arena Pharm Inc | Slate-free crystal of the arginine salt of (Ar)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-4,3,2,1-tetrahydro-cyclopent[b]indole-3-yl ) acetic acid |
| CN109862896A (zh) | 2016-08-03 | 2019-06-07 | 西玛贝医药公司 | 用于治疗炎症性胃肠疾病或胃肠病症的氧亚甲基芳基化合物 |
| MA49456A (fr) | 2017-06-19 | 2020-04-29 | Arena Pharm Inc | Composés et procédés pour le traitement de nafld et de nash |
| KR102859841B1 (ko) | 2018-06-06 | 2025-09-12 | 아레나 파마슈티칼스, 인크. | S1p1 수용체와 관련된 병태의 치료 방법 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0868510A2 (en) * | 1995-11-15 | 1998-10-07 | Cor Therapeutics, Inc. | P2u2 PURINERGIC RECEPTOR |
| JP2000505644A (ja) * | 1996-01-11 | 2000-05-16 | ヒューマン ジノーム サイエンシーズ，インコーポレイテッド | ヒトｇタンパク質結合レセプター |
| WO1998031810A2 (en) * | 1997-01-21 | 1998-07-23 | Schering Corporation | Mammalian chemokines; receptors; reagents; uses |
| US6221627B1 (en) * | 1997-02-24 | 2001-04-24 | Smithkline Beecham Corporation | cDNA clone HDPB130 that encodes a novel human 7-transmembrane receptor |
| US5955303A (en) * | 1997-03-06 | 1999-09-21 | Incyte Pharmaceuticals, Inc. | Human chemokine receptor-like protein |
| US6555339B1 (en) * | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| US6060272A (en) * | 1997-05-07 | 2000-05-09 | Human Genome Sciences, Inc. | Human G-protein coupled receptors |
| EP0899332A3 (en) * | 1997-08-15 | 2000-07-05 | Smithkline Beecham Corporation | The G-protein coupled receptor HFIAO41 |
| CA2239255A1 (en) * | 1997-10-23 | 1999-04-23 | Smithkline Beecham Corporation | Cdna clone hneaa81 that encodes a human 7-transmembrane receptor |
| US5932445A (en) * | 1997-11-07 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Signal peptide-containing proteins |
| US6252056B1 (en) * | 1997-11-11 | 2001-06-26 | Ono Pharmaceutical Co., Ltd. | Human lysophosphatidic acid receptor and use thereof |
| US6207412B1 (en) * | 1997-11-13 | 2001-03-27 | The Regents Of The University Of California | Identification of a G protein-coupled receptor transcriptionally regulated by protein tyrosine kinase signaling in hematopoietic cells |
| EP1054903A4 (en) * | 1998-02-20 | 2002-10-09 | Smithkline Beecham Corp | FISHBOY, A G PROTEIN COUPLED RECEPTOR |
| DE69938015T2 (de) * | 1998-03-12 | 2009-01-15 | Astellas Pharma Inc. | Neue G Protein-gekoppelte Rezeptorproteine |
| AU3749499A (en) * | 1998-04-16 | 1999-11-01 | Millenium Pharmaceuticals, Inc. | Novel molecules of the bgckr-related protein family and uses thereof |
| SE9801455D0 (sv) * | 1998-04-24 | 1998-04-24 | Astra Pharma Inc | New receptor |
| JP2002512780A (ja) * | 1998-04-24 | 2002-05-08 | スミスクライン ビーチャム コーポレーション | 新規７ｔｍ受容体ａｘｏｒ−２のクローニング |
| US6071722A (en) * | 1998-04-24 | 2000-06-06 | Smithkline Beecham Corporation | Nucleic acids encoding a G-protein coupled 7TM receptor (AXOR-1) |
| JP2002531057A (ja) * | 1998-08-19 | 2002-09-24 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | Ｅｄｇ受容体ファミリーに関連したｇタンパク質結合受容体である１４２７４受容体 |
| JP2003532369A (ja) * | 1998-08-20 | 2003-11-05 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | Ｇタンパク質結合受容体である１４４００受容体 |
| CA2340616A1 (en) * | 1998-08-24 | 2000-03-02 | Alphagene, Inc. | Secreted proteins and polynucleotides encoding them |
| AU5801099A (en) * | 1998-09-02 | 2000-03-21 | Millennium Pharmaceuticals, Inc. | 14926 receptor, a novel g-protein coupled receptor |
| WO2000022131A2 (en) * | 1998-10-13 | 2000-04-20 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human g protein-coupled receptors |
| CA2344605A1 (en) * | 1998-10-16 | 2000-04-27 | Millennium Pharmaceuticals, Inc. | G-protein coupled receptors |
| EP1127128A1 (en) * | 1998-11-04 | 2001-08-29 | Chiron Corporation | Isolated vshk-1 receptor polypeptides and methods of use thereof |
| DE69933688T2 (de) * | 1998-11-06 | 2007-08-23 | Bayer Healthcare Ag | G-protein-gekoppelter rezeptoren, die holomog zu ebv-induzierter gpcr (ebi-2) sind, verfahren zur identifizierung von ihren entsprechenden liganden |
| US6221660B1 (en) * | 1999-02-22 | 2001-04-24 | Synaptic Pharmaceutical Corporation | DNA encoding SNORF25 receptor |
| US6689866B1 (en) * | 1999-03-09 | 2004-02-10 | Curagen Corporation | Polynucleotides and proteins encoded thereby |
| US6590938B1 (en) * | 1999-09-30 | 2003-07-08 | Conexant Systems, Inc. | DCT domain conversion of a higher definition signal to lower definition signal |
| GB9923177D0 (en) * | 1999-09-30 | 1999-12-01 | Pfizer Ltd | Novel polypeptide |
-
1999
- 1999-10-13 CA CA002348377A patent/CA2348377C/en not_active Expired - Fee Related
- 1999-10-13 NZ NZ527622A patent/NZ527622A/en not_active IP Right Cessation
- 1999-10-13 EP EP07008841A patent/EP1849866B1/en not_active Expired - Lifetime
- 1999-10-13 DK DK99972682T patent/DK1133559T3/da active
- 1999-10-13 NZ NZ537625A patent/NZ537625A/en not_active IP Right Cessation
- 1999-10-13 ES ES05003040T patent/ES2289610T3/es not_active Expired - Lifetime
- 1999-10-13 DK DK07008841T patent/DK1849866T3/da active
- 1999-10-13 PT PT05003040T patent/PT1584683E/pt unknown
- 1999-10-13 EP EP10010658A patent/EP2295574A1/en not_active Withdrawn
- 1999-10-13 DK DK05003040T patent/DK1584683T3/da active
- 1999-10-13 KR KR1020017006279A patent/KR100765039B1/ko not_active Expired - Fee Related
- 1999-10-13 KR KR1020077018185A patent/KR100926208B1/ko not_active Expired - Fee Related
- 1999-10-13 WO PCT/US1999/023687 patent/WO2000031258A2/en not_active Ceased
- 1999-10-13 PT PT07008841T patent/PT1849866E/pt unknown
- 1999-10-13 EP EP05005946A patent/EP1580271A3/en not_active Ceased
- 1999-10-13 EP EP99972682A patent/EP1133559B1/en not_active Expired - Lifetime
- 1999-10-13 EP EP10008862A patent/EP2295572A1/en not_active Withdrawn
- 1999-10-13 ES ES07008841T patent/ES2308759T3/es not_active Expired - Lifetime
- 1999-10-13 KR KR1020087003578A patent/KR100963367B1/ko not_active Expired - Fee Related
- 1999-10-13 EP EP07001452A patent/EP1780280A1/en not_active Ceased
- 1999-10-13 AT AT99972682T patent/ATE301673T1/de active
- 1999-10-13 CA CA002645717A patent/CA2645717A1/en not_active Withdrawn
- 1999-10-13 AU AU37904/00A patent/AU770056B2/en not_active Ceased
- 1999-10-13 PT PT99972682T patent/PT1133559E/pt unknown
- 1999-10-13 AT AT07008841T patent/ATE396400T1/de active
- 1999-10-13 IL IL14253899A patent/IL142538A0/xx unknown
- 1999-10-13 EP EP10010303A patent/EP2295573A1/en not_active Withdrawn
- 1999-10-13 NZ NZ511087A patent/NZ511087A/en not_active IP Right Cessation
- 1999-10-13 AT AT05003040T patent/ATE366815T1/de active
- 1999-10-13 KR KR1020087003575A patent/KR100926209B1/ko not_active Expired - Fee Related
- 1999-10-13 JP JP2000584067A patent/JP2003534767A/ja not_active Withdrawn
- 1999-10-13 EP EP05003040A patent/EP1584683B1/en not_active Expired - Lifetime
- 1999-10-13 ES ES99972682T patent/ES2243095T3/es not_active Expired - Lifetime
- 1999-10-13 KR KR1020087024998A patent/KR20080104062A/ko not_active Withdrawn
-
2001
- 2001-04-11 IL IL142538A patent/IL142538A/en not_active IP Right Cessation
-
2004
- 2004-04-28 JP JP2004132989A patent/JP2004267216A/ja not_active Withdrawn
- 2004-05-12 AU AU2004202147A patent/AU2004202147A1/en not_active Abandoned
-
2007
- 2007-05-15 JP JP2007129923A patent/JP2007209352A/ja active Pending
-
2008
- 2008-02-14 JP JP2008033839A patent/JP2008133300A/ja active Pending
-
2009
- 2009-07-03 JP JP2009159339A patent/JP2009298791A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004267216A5 (cg-RX-API-DMAC7.html) | ||
| Guo et al. | Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor | |
| KR102483242B1 (ko) | Mg53 돌연변이체, 및 그의 제조 방법 및 그의 용도 | |
| JP2005052158A5 (cg-RX-API-DMAC7.html) | ||
| JP7427208B2 (ja) | 視覚機能再生剤又は視覚機能低下予防剤 | |
| JP2011509093A5 (cg-RX-API-DMAC7.html) | ||
| JP2003530124A5 (cg-RX-API-DMAC7.html) | ||
| JPH03155795A (ja) | マウス・インターロイキン―６レセプター蛋白質 | |
| Yang et al. | Molecular basis of transferrin polymorphism in goldfish (Carassius auratus) | |
| JP2003530821A5 (cg-RX-API-DMAC7.html) | ||
| Jaso-Friedmann et al. | The antigen receptor (NCCRP-1) on catfish and zebrafish nonspecific cytotoxic cells belongs to a new gene family characterized by an F-box-associated domain | |
| JP2020127419A5 (cg-RX-API-DMAC7.html) | ||
| JP2004537284A5 (cg-RX-API-DMAC7.html) | ||
| JP2013502217A5 (cg-RX-API-DMAC7.html) | ||
| WO2000077211A1 (en) | Pyrexia-associated genes and pyrexia-associated proteins of plant | |
| JP2004290197A5 (cg-RX-API-DMAC7.html) | ||
| JP2003514549A5 (cg-RX-API-DMAC7.html) | ||
| JP2005507651A5 (cg-RX-API-DMAC7.html) | ||
| JP2005507245A5 (cg-RX-API-DMAC7.html) | ||
| CN101245345A (zh) | 山羊S6K1基因cDNA编码区核苷酸序列 | |
| RU2007111137A (ru) | Гонадотропный гормон, полученный из беспозвоночных, и его синтез | |
| JP2003525018A5 (cg-RX-API-DMAC7.html) | ||
| Ling et al. | Molecular characters and expression analysis of a new isoform of the myocyte enhancer factor 2 gene from the silkworm, Bombyx mori | |
| Rashid et al. | Isolation of growth hormone gene from the Malaysian mahseer, Tor tambroides | |
| CN102250930B (zh) | 家蚕蜕皮激素氧化酶eo基因 |