JP2005504846A5 - - Google Patents
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- Publication number
- JP2005504846A5 JP2005504846A5 JP2003534427A JP2003534427A JP2005504846A5 JP 2005504846 A5 JP2005504846 A5 JP 2005504846A5 JP 2003534427 A JP2003534427 A JP 2003534427A JP 2003534427 A JP2003534427 A JP 2003534427A JP 2005504846 A5 JP2005504846 A5 JP 2005504846A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ring
- aliphatic ring
- alkylamino
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 125000003545 alkoxy group Chemical group 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 8
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 7
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- 125000005530 alkylenedioxy group Chemical group 0.000 claims description 4
- 125000006715 (C1-C5) alkylthio group Chemical group 0.000 claims description 3
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims description 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 3
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
- 150000002431 hydrogen Chemical class 0.000 claims description 3
- -1 hydroxy, mercapto Chemical class 0.000 claims description 3
- 125000001624 naphthyl group Chemical group 0.000 claims description 3
- 125000003302 alkenyloxy group Chemical group 0.000 claims description 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 2
- 125000001188 haloalkyl group Chemical group 0.000 claims description 2
- 125000001072 heteroaryl group Chemical group 0.000 claims description 2
- 125000001931 aliphatic group Chemical group 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000006557 (C2-C5) alkylene group Chemical group 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 3
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 1
- 125000004957 naphthylene group Chemical group 0.000 description 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01123908 | 2001-10-05 | ||
| PCT/EP2002/010722 WO2003031444A1 (en) | 2001-10-05 | 2002-09-25 | Polycyclic compounds having anti-tumor activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005504846A JP2005504846A (ja) | 2005-02-17 |
| JP2005504846A5 true JP2005504846A5 (OSRAM) | 2008-11-13 |
| JP4369229B2 JP4369229B2 (ja) | 2009-11-18 |
Family
ID=8178868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003534427A Expired - Fee Related JP4369229B2 (ja) | 2001-10-05 | 2002-09-25 | 抗腫瘍活性を有する多環式化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6680326B2 (OSRAM) |
| EP (1) | EP1436293B1 (OSRAM) |
| JP (1) | JP4369229B2 (OSRAM) |
| KR (1) | KR100676114B1 (OSRAM) |
| CN (1) | CN1284781C (OSRAM) |
| AR (1) | AR037327A1 (OSRAM) |
| AT (1) | ATE316971T1 (OSRAM) |
| AU (1) | AU2002342752B2 (OSRAM) |
| BR (1) | BR0213122A (OSRAM) |
| CA (1) | CA2461572C (OSRAM) |
| DE (1) | DE60209029T2 (OSRAM) |
| ES (1) | ES2256552T3 (OSRAM) |
| MX (1) | MXPA04003173A (OSRAM) |
| PL (1) | PL370530A1 (OSRAM) |
| RU (1) | RU2315050C2 (OSRAM) |
| WO (1) | WO2003031444A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6946472B2 (en) * | 2002-04-30 | 2005-09-20 | Hoffman-La Roche Inc. | Polycyclic compounds exhibiting anti-tumor activities |
| US20060189893A1 (en) * | 2005-01-06 | 2006-08-24 | Diamics, Inc. | Systems and methods for detecting abnormal cells |
| US20060161076A1 (en) * | 2005-01-06 | 2006-07-20 | Diamics, Inc. | Systems and methods for collection of cell clusters |
| CN103204781B (zh) * | 2013-03-14 | 2015-04-01 | 武汉大学 | 2,7–二取代芴酮衍生物及其制备方法与应用 |
| CN110448555B (zh) * | 2019-09-10 | 2020-10-23 | 河南省人民医院 | 多环化合物在制备抗肿瘤药物中的应用及抗肿瘤药物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW440562B (en) * | 1994-05-20 | 2001-06-16 | Taiho Pharmaceutical Co Ltd | Condensed-indan derivative and pharmaceutically acceptable salts thereof |
| WO1998045272A1 (en) | 1997-04-07 | 1998-10-15 | Latrobe University | Topoisomerase inhibitors |
| FR2801309B1 (fr) * | 1999-11-18 | 2002-01-04 | Adir | Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2002
- 2002-09-25 CA CA2461572A patent/CA2461572C/en not_active Expired - Fee Related
- 2002-09-25 EP EP02779413A patent/EP1436293B1/en not_active Expired - Lifetime
- 2002-09-25 US US10/254,951 patent/US6680326B2/en not_active Expired - Fee Related
- 2002-09-25 AU AU2002342752A patent/AU2002342752B2/en not_active Ceased
- 2002-09-25 AT AT02779413T patent/ATE316971T1/de active
- 2002-09-25 WO PCT/EP2002/010722 patent/WO2003031444A1/en not_active Ceased
- 2002-09-25 BR BR0213122-6A patent/BR0213122A/pt not_active IP Right Cessation
- 2002-09-25 ES ES02779413T patent/ES2256552T3/es not_active Expired - Lifetime
- 2002-09-25 JP JP2003534427A patent/JP4369229B2/ja not_active Expired - Fee Related
- 2002-09-25 CN CNB028197712A patent/CN1284781C/zh not_active Expired - Fee Related
- 2002-09-25 MX MXPA04003173A patent/MXPA04003173A/es active IP Right Grant
- 2002-09-25 PL PL02370530A patent/PL370530A1/xx not_active Application Discontinuation
- 2002-09-25 RU RU2004114245/04A patent/RU2315050C2/ru not_active IP Right Cessation
- 2002-09-25 DE DE60209029T patent/DE60209029T2/de not_active Expired - Lifetime
- 2002-09-25 KR KR1020047004899A patent/KR100676114B1/ko not_active Expired - Fee Related
- 2002-10-02 AR ARP020103723A patent/AR037327A1/es unknown
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