JP2005504759A5 - - Google Patents
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- Publication number
- JP2005504759A5 JP2005504759A5 JP2003518543A JP2003518543A JP2005504759A5 JP 2005504759 A5 JP2005504759 A5 JP 2005504759A5 JP 2003518543 A JP2003518543 A JP 2003518543A JP 2003518543 A JP2003518543 A JP 2003518543A JP 2005504759 A5 JP2005504759 A5 JP 2005504759A5
- Authority
- JP
- Japan
- Prior art keywords
- cyp3a5 gene
- patient
- cyp3a5
- composition
- irinotecan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 101150052538 CYP3A5 gene Proteins 0.000 claims 45
- 108700028369 Alleles Proteins 0.000 claims 35
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 22
- 229960004768 irinotecan Drugs 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 22
- 108091033319 polynucleotide Proteins 0.000 claims 20
- 102000040430 polynucleotide Human genes 0.000 claims 20
- 239000002157 polynucleotide Substances 0.000 claims 20
- 238000000034 method Methods 0.000 claims 14
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 10
- 238000006467 substitution reaction Methods 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 230000003247 decreasing effect Effects 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 108091026890 Coding region Proteins 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 3
- 206010018338 Glioma Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 206010017758 gastric cancer Diseases 0.000 claims 3
- 208000029824 high grade glioma Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 201000011614 malignant glioma Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 201000011549 stomach cancer Diseases 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 208000009011 Cytochrome P-450 CYP3A Inhibitors Diseases 0.000 claims 2
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 2
- 102000003849 Cytochrome P450 Human genes 0.000 claims 2
- 102100039205 Cytochrome P450 3A4 Human genes 0.000 claims 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 2
- 101000745711 Homo sapiens Cytochrome P450 3A4 Proteins 0.000 claims 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- HBNPJJILLOYFJU-VMPREFPWSA-N Mibefradil Chemical compound C1CC2=CC(F)=CC=C2[C@H](C(C)C)[C@@]1(OC(=O)COC)CCN(C)CCCC1=NC2=CC=CC=C2N1 HBNPJJILLOYFJU-VMPREFPWSA-N 0.000 claims 1
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 claims 1
- 229960001380 cimetidine Drugs 0.000 claims 1
- 229960003405 ciprofloxacin Drugs 0.000 claims 1
- 229960002626 clarithromycin Drugs 0.000 claims 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims 1
- WHBIGIKBNXZKFE-UHFFFAOYSA-N delavirdine mesylate Natural products CC(C)NC1=CC=CN=C1N1CCN(C(=O)C=2NC3=CC=C(NS(C)(=O)=O)C=C3C=2)CC1 WHBIGIKBNXZKFE-UHFFFAOYSA-N 0.000 claims 1
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims 1
- 229960004166 diltiazem Drugs 0.000 claims 1
- 229960003276 erythromycin Drugs 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims 1
- 229960004884 fluconazole Drugs 0.000 claims 1
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 claims 1
- 229960004038 fluvoxamine Drugs 0.000 claims 1
- 235000015201 grapefruit juice Nutrition 0.000 claims 1
- 229960004130 itraconazole Drugs 0.000 claims 1
- 229960004125 ketoconazole Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960004438 mibefradil Drugs 0.000 claims 1
- VKHAHZOOUSRJNA-GCNJZUOMSA-N mifepristone Chemical compound C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=CC=C(N(C)C)C=C1 VKHAHZOOUSRJNA-GCNJZUOMSA-N 0.000 claims 1
- 229960003248 mifepristone Drugs 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- VRBKIVRKKCLPHA-UHFFFAOYSA-N nefazodone Chemical compound O=C1N(CCOC=2C=CC=CC=2)C(CC)=NN1CCCN(CC1)CCN1C1=CC=CC(Cl)=C1 VRBKIVRKKCLPHA-UHFFFAOYSA-N 0.000 claims 1
- 229960001800 nefazodone Drugs 0.000 claims 1
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 claims 1
- 229960001180 norfloxacin Drugs 0.000 claims 1
- WIQRCHMSJFFONW-UHFFFAOYSA-N norfluoxetine Chemical compound C=1C=CC=CC=1C(CCN)OC1=CC=C(C(F)(F)F)C=C1 WIQRCHMSJFFONW-UHFFFAOYSA-N 0.000 claims 1
- 238000011369 optimal treatment Methods 0.000 claims 1
- 229960000311 ritonavir Drugs 0.000 claims 1
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims 1
- 229960001852 saquinavir Drugs 0.000 claims 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 229960005041 troleandomycin Drugs 0.000 claims 1
- LQCLVBQBTUVCEQ-QTFUVMRISA-N troleandomycin Chemical compound O1[C@@H](C)[C@H](OC(C)=O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(C)=O)[C@H]1C LQCLVBQBTUVCEQ-QTFUVMRISA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01117608 | 2001-07-23 | ||
| EP02011710 | 2002-05-24 | ||
| PCT/EP2002/008219 WO2003013534A2 (en) | 2001-07-23 | 2002-07-23 | Methods for the treatment of cancer with irinotecan based on cyp3a5 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005504759A JP2005504759A (ja) | 2005-02-17 |
| JP2005504759A5 true JP2005504759A5 (https=) | 2006-01-05 |
Family
ID=26076655
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003518543A Withdrawn JP2005504759A (ja) | 2001-07-23 | 2002-07-23 | Ｃｙｐ３ａ５に基づいたがんの改善治療の手段及び方法 |
| JP2003518545A Withdrawn JP2005505526A (ja) | 2001-07-23 | 2002-07-23 | Ｕｇｔ１ａ１に基づいたがんの改善治療の手段及び方法 |
| JP2003518542A Withdrawn JP2005506971A (ja) | 2001-07-23 | 2002-07-23 | Ｍｒｐ１に基づいたがんの改善治療の手段及び方法 |
| JP2003518546A Withdrawn JP2005501840A (ja) | 2001-07-23 | 2002-07-23 | 癌の改良された治療のための手段および方法 |
| JP2003518544A Withdrawn JP2005508312A (ja) | 2001-07-23 | 2002-07-23 | Ｍｄｒ１に基づいた癌治療の改善のための手段および方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003518545A Withdrawn JP2005505526A (ja) | 2001-07-23 | 2002-07-23 | Ｕｇｔ１ａ１に基づいたがんの改善治療の手段及び方法 |
| JP2003518542A Withdrawn JP2005506971A (ja) | 2001-07-23 | 2002-07-23 | Ｍｒｐ１に基づいたがんの改善治療の手段及び方法 |
| JP2003518546A Withdrawn JP2005501840A (ja) | 2001-07-23 | 2002-07-23 | 癌の改良された治療のための手段および方法 |
| JP2003518544A Withdrawn JP2005508312A (ja) | 2001-07-23 | 2002-07-23 | Ｍｄｒ１に基づいた癌治療の改善のための手段および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050032724A1 (https=) |
| EP (5) | EP1408972A2 (https=) |
| JP (5) | JP2005504759A (https=) |
| AU (5) | AU2002328945A1 (https=) |
| CA (5) | CA2454640A1 (https=) |
| WO (5) | WO2003013534A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4096037B2 (ja) * | 2002-08-12 | 2008-06-04 | 国立大学法人滋賀医科大学 | グルクロン酸転移酵素遺伝子の変異解析による薬剤代謝活性の予測方法 |
| US7108992B2 (en) | 2002-11-27 | 2006-09-19 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| US6916627B2 (en) | 2002-11-27 | 2005-07-12 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| JP2006526412A (ja) | 2003-05-30 | 2006-11-24 | ユニバーシティ オブ シカゴ | イリノテカン毒性を推定する方法および組成物 |
| JPWO2005028645A1 (ja) * | 2003-09-24 | 2007-11-15 | 株式会社産学連携機構九州 | ＭＤＲ１遺伝子の５’制御領域におけるＳＮＰｓ |
| BRPI0415079A (pt) * | 2003-10-06 | 2006-12-12 | Novartis Ag | biomarcadores para prognóstico de diarréia induzida por droga |
| JP2005245362A (ja) * | 2004-03-05 | 2005-09-15 | Kyowa Medex Co Ltd | 肺癌および頭頸部癌の発症危険率を予測する方法 |
| NZ550430A (en) * | 2004-04-27 | 2009-06-26 | Wellstat Biologics Corp | Cancer treatment using viruses and camptothecins |
| WO2006009805A2 (en) * | 2004-06-18 | 2006-01-26 | Genentech, Inc. | Combination of a chemotherapeutic agent and an antagonist of a gene product for treating tumors |
| WO2006076288A2 (en) * | 2005-01-11 | 2006-07-20 | Five Prime Therapeutics, Inc. | Dna constructs for long-term expression of intravascularly injected naked dna |
| JP2007060967A (ja) * | 2005-08-30 | 2007-03-15 | Tokyo Institute Of Technology | 遺伝子多型の検出方法および薬物のスクリーニング方法 |
| JP2009515524A (ja) * | 2005-11-10 | 2009-04-16 | アメリカ合衆国 | Ａｂｃｂ１多型バリアントスクリーニング、診断及び処置のための物質及び方法 |
| EP2463365B1 (en) | 2006-11-30 | 2013-09-18 | ARKRAY, Inc. | Probes for detection of UGT1A1 gene, reagent for detection of UGT1A1 gene comprising the same, and uses thereof |
| EP2448406B1 (en) * | 2009-02-26 | 2016-04-20 | Relmada Therapeutics, Inc. | Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use |
| WO2011031974A1 (en) * | 2009-09-10 | 2011-03-17 | Southern Research Institute | Acridine analogs in the treatment of gliomas |
| AU2011223883B2 (en) | 2010-03-01 | 2015-10-08 | Cavion, Inc. | Cancer diagnosis and imaging |
| JP2011250726A (ja) * | 2010-06-01 | 2011-12-15 | Toyo Kohan Co Ltd | イリノテカンの副作用の発生危険度を判定する方法及びそのためのキット |
| AU2011281982B2 (en) | 2010-07-20 | 2015-12-17 | Bavarian Nordic A/S | Method for harvesting expression products |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| KR102271848B1 (ko) * | 2013-11-01 | 2021-07-01 | 피트니 파마슈티컬스 피티와이 리미티드 | 암 치료용 약학적 배합물 |
| ES2843829T3 (es) * | 2014-09-26 | 2021-07-20 | Hi Stem Ggmbh Im Deutschen Krebsforschungszentrum Dkfz | Nuevos métodos para la subtipificación y el tratamiento del cáncer |
| JP2016088919A (ja) * | 2014-11-11 | 2016-05-23 | 国立研究開発法人産業技術総合研究所 | イベルメクチン又はミルベマイシンｄを有効成分として含む抗癌剤 |
| CN107208163B (zh) | 2015-02-17 | 2021-01-08 | 国立大学法人山口大学 | 辅助对伊立替康副作用的发生风险的预测的方法 |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| EP3337467B1 (en) | 2015-08-20 | 2020-12-09 | Ipsen Biopharm Ltd. | Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment |
| MX385425B (es) | 2015-08-21 | 2025-03-18 | Ipsen Biopharm Ltd | Irinotecán liposomal y oxaliplatino, 5-fluoroacilo y leucovorina para usarse en el tratamiento de cáncer pancreático metastásico. |
| EP3535026A1 (en) | 2016-11-02 | 2019-09-11 | Ipsen Biopharm Limited | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin) |
| CN109939115B (zh) * | 2019-05-06 | 2021-11-02 | 河南中医药大学 | 一种治疗放射性直肠炎的复方栓剂 |
| US20230310478A1 (en) * | 2020-09-02 | 2023-10-05 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Methods and compositions for the treatment of pulmonary hypertension and cancer |
| CN114224875B (zh) * | 2021-11-04 | 2023-08-11 | 中南大学湘雅医院 | 醇类化合物的新用途及抗肿瘤药物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2280855A1 (en) * | 1997-02-27 | 1998-09-03 | Pharmacia & Upjohn Company | Tamoxifen as a therapy to reduce irinotecan hydrochloride-induced diarrhea |
| BR9916536A (pt) * | 1998-12-23 | 2002-01-02 | Searle & Co | Método para o tratamento ou prevenção de um distúrbio de neoplasia em um mamìfero em necessidade deste tratamento ou prevenção, e, combinação |
| US6395481B1 (en) * | 1999-02-16 | 2002-05-28 | Arch Development Corp. | Methods for detection of promoter polymorphism in a UGT gene promoter |
| CA2295429A1 (en) * | 2000-01-06 | 2001-07-06 | Michael Michael | Treatment or prevention of diarrhea |
| EP1251850B1 (en) * | 2000-01-26 | 2006-06-21 | Schering Corporation | Use of a combination preparation in cancer therapy |
| WO2001087306A2 (en) * | 2000-05-15 | 2001-11-22 | Celgene Corp. | Compositions and methods for the treatment of colorectal cancer |
| US20020169141A1 (en) * | 2000-10-06 | 2002-11-14 | Christophe Martin | Oral dosage forms for administration of the combination of tegafur, uracil, folinic acid, and irinotecan and method of using the same |
-
2002
- 2002-07-23 AU AU2002328945A patent/AU2002328945A1/en not_active Abandoned
- 2002-07-23 CA CA002454640A patent/CA2454640A1/en not_active Abandoned
- 2002-07-23 CA CA002454643A patent/CA2454643A1/en not_active Abandoned
- 2002-07-23 EP EP02764764A patent/EP1408972A2/en not_active Ceased
- 2002-07-23 EP EP02764763A patent/EP1438050A2/en not_active Withdrawn
- 2002-07-23 AU AU2002331290A patent/AU2002331290A1/en not_active Abandoned
- 2002-07-23 EP EP02767255A patent/EP1408975A2/en not_active Withdrawn
- 2002-07-23 AU AU2002328952A patent/AU2002328952A1/en not_active Abandoned
- 2002-07-23 EP EP02764762A patent/EP1408974A2/en not_active Withdrawn
- 2002-07-23 AU AU2002328950A patent/AU2002328950A1/en not_active Abandoned
- 2002-07-23 CA CA002454637A patent/CA2454637A1/en not_active Abandoned
- 2002-07-23 JP JP2003518543A patent/JP2005504759A/ja not_active Withdrawn
- 2002-07-23 JP JP2003518545A patent/JP2005505526A/ja not_active Withdrawn
- 2002-07-23 WO PCT/EP2002/008219 patent/WO2003013534A2/en not_active Ceased
- 2002-07-23 WO PCT/EP2002/008220 patent/WO2003013535A2/en not_active Ceased
- 2002-07-23 WO PCT/EP2002/008218 patent/WO2003013537A2/en not_active Ceased
- 2002-07-23 EP EP02764757A patent/EP1408973A2/en not_active Withdrawn
- 2002-07-23 JP JP2003518542A patent/JP2005506971A/ja not_active Withdrawn
- 2002-07-23 US US10/484,577 patent/US20050032724A1/en not_active Abandoned
- 2002-07-23 JP JP2003518546A patent/JP2005501840A/ja not_active Withdrawn
- 2002-07-23 AU AU2002328953A patent/AU2002328953A1/en not_active Abandoned
- 2002-07-23 WO PCT/EP2002/008217 patent/WO2003013536A2/en not_active Ceased
- 2002-07-23 CA CA002454648A patent/CA2454648A1/en not_active Abandoned
- 2002-07-23 WO PCT/EP2002/008200 patent/WO2003013533A2/en not_active Ceased
- 2002-07-23 CA CA002454627A patent/CA2454627A1/en not_active Abandoned
- 2002-07-23 JP JP2003518544A patent/JP2005508312A/ja not_active Withdrawn
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| Publication | Publication Date | Title |
|---|---|---|
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