JP2005501840A - 癌の改良された治療のための手段および方法 - Google Patents

癌の改良された治療のための手段および方法 Download PDF

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JP2005501840A
JP2005501840A JP2003518546A JP2003518546A JP2005501840A JP 2005501840 A JP2005501840 A JP 2005501840A JP 2003518546 A JP2003518546 A JP 2003518546A JP 2003518546 A JP2003518546 A JP 2003518546A JP 2005501840 A JP2005501840 A JP 2005501840A
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gene
deposit number
position corresponding
ugt1a1
polypeptide
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JP2005501840A5 (https=
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ヘインリッヒ,グンター
ケルブ,レインホルド
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エピダウロス・バイオテクノロジー・アクチェンゲゼルシャフト
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2003518546A 2001-07-23 2002-07-23 癌の改良された治療のための手段および方法 Withdrawn JP2005501840A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01117608 2001-07-23
EP02011710 2002-05-24
PCT/EP2002/008218 WO2003013537A2 (en) 2001-07-23 2002-07-23 Irinotecan for treatment of cancer

Publications (2)

Publication Number Publication Date
JP2005501840A true JP2005501840A (ja) 2005-01-20
JP2005501840A5 JP2005501840A5 (https=) 2006-01-05

Family

ID=26076655

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2003518546A Withdrawn JP2005501840A (ja) 2001-07-23 2002-07-23 癌の改良された治療のための手段および方法
JP2003518543A Withdrawn JP2005504759A (ja) 2001-07-23 2002-07-23 Cyp3a5に基づいたがんの改善治療の手段及び方法
JP2003518542A Withdrawn JP2005506971A (ja) 2001-07-23 2002-07-23 Mrp1に基づいたがんの改善治療の手段及び方法
JP2003518545A Withdrawn JP2005505526A (ja) 2001-07-23 2002-07-23 Ugt1a1に基づいたがんの改善治療の手段及び方法
JP2003518544A Withdrawn JP2005508312A (ja) 2001-07-23 2002-07-23 Mdr1に基づいた癌治療の改善のための手段および方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2003518543A Withdrawn JP2005504759A (ja) 2001-07-23 2002-07-23 Cyp3a5に基づいたがんの改善治療の手段及び方法
JP2003518542A Withdrawn JP2005506971A (ja) 2001-07-23 2002-07-23 Mrp1に基づいたがんの改善治療の手段及び方法
JP2003518545A Withdrawn JP2005505526A (ja) 2001-07-23 2002-07-23 Ugt1a1に基づいたがんの改善治療の手段及び方法
JP2003518544A Withdrawn JP2005508312A (ja) 2001-07-23 2002-07-23 Mdr1に基づいた癌治療の改善のための手段および方法

Country Status (6)

Country Link
US (1) US20050032724A1 (https=)
EP (5) EP1408973A2 (https=)
JP (5) JP2005501840A (https=)
AU (5) AU2002328945A1 (https=)
CA (5) CA2454627A1 (https=)
WO (5) WO2003013537A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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WO2008066136A1 (fr) * 2006-11-30 2008-06-05 Arkray, Inc. Ensemble d'amorces pour l'amplification du gène ugt1a1, réactif pour l'amplification du gène ugt1a1 comprenant cet ensemble d'amorces, et utilisation de cet ensemble d'amorces

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JP4096037B2 (ja) * 2002-08-12 2008-06-04 国立大学法人滋賀医科大学 グルクロン酸転移酵素遺伝子の変異解析による薬剤代謝活性の予測方法
US6916627B2 (en) 2002-11-27 2005-07-12 St. Jude Children's Research Hospital ATM kinase compositions and methods
US7108992B2 (en) 2002-11-27 2006-09-19 St. Jude Children's Research Hospital ATM kinase compositions and methods
ES2308208T3 (es) 2003-05-30 2008-12-01 University Of Chicago Metodos y composiciones para predecir la toxicidad del irinotecano.
WO2005028645A1 (ja) * 2003-09-24 2005-03-31 Kyushu Tlo Company, Limited MDR1遺伝子の5’制御領域におけるSNPs
BRPI0415079A (pt) * 2003-10-06 2006-12-12 Novartis Ag biomarcadores para prognóstico de diarréia induzida por droga
JP2005245362A (ja) * 2004-03-05 2005-09-15 Kyowa Medex Co Ltd 肺癌および頭頸部癌の発症危険率を予測する方法
US20070207149A1 (en) * 2004-04-27 2007-09-06 Wellstat Biologics Corporation Cancer treatment using viruses and camptothecins
ES2429041T3 (es) * 2004-06-18 2013-11-12 Genentech, Inc. Combinación de un agente quimioterapéutico y un antagonista de un producto génico para tratar tumores
WO2006076288A2 (en) * 2005-01-11 2006-07-20 Five Prime Therapeutics, Inc. Dna constructs for long-term expression of intravascularly injected naked dna
JP2007060967A (ja) * 2005-08-30 2007-03-15 Tokyo Institute Of Technology 遺伝子多型の検出方法および薬物のスクリーニング方法
US20090325156A1 (en) * 2005-11-10 2009-12-31 Government of the United States of America, as Represented by Secretary, Dept. of Human Services Materials and methods for abcb1 polymorphic variant screening, diagnosis, and treatment
WO2010099508A1 (en) * 2009-02-26 2010-09-02 Theraquest Biosciences, Inc. Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use
WO2011031974A1 (en) * 2009-09-10 2011-03-17 Southern Research Institute Acridine analogs in the treatment of gliomas
EP2542155B1 (en) 2010-03-01 2015-11-04 TAU Therapeutics LLC Method for imaging a disease
JP2011250726A (ja) * 2010-06-01 2011-12-15 Toyo Kohan Co Ltd イリノテカンの副作用の発生危険度を判定する方法及びそのためのキット
JP5945270B2 (ja) 2010-07-20 2016-07-05 バヴァリアン・ノルディック・アクティーゼルスカブ 発現産物を採取するための方法
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
KR102271848B1 (ko) * 2013-11-01 2021-07-01 피트니 파마슈티컬스 피티와이 리미티드 암 치료용 약학적 배합물
CA2962476C (en) * 2014-09-26 2023-09-26 Hi-Stem Ggmbh Novel methods for sub-typing and treating cancer
JP2016088919A (ja) * 2014-11-11 2016-05-23 国立研究開発法人産業技術総合研究所 イベルメクチン又はミルベマイシンdを有効成分として含む抗癌剤
CN107208163B (zh) * 2015-02-17 2021-01-08 国立大学法人山口大学 辅助对伊立替康副作用的发生风险的预测的方法
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
JP7042739B2 (ja) 2015-08-20 2022-03-28 イプセン バイオファーム リミティド 癌処置のためのリポソーム型イリノテカン及びparp阻害薬を使用する併用療法
TW202400181A (zh) 2015-08-21 2024-01-01 英商益普生生物製藥有限公司 使用包含微脂伊立替康(irinotecan)及奧沙利鉑(oxaliplatin)之組合療法治療轉移性胰臟癌的方法
CN110402163A (zh) 2016-11-02 2019-11-01 易普森生物制药有限公司 使用包括脂质体伊立替康、奥沙利铂、5-氟尿嘧啶(和甲酰四氢叶酸)的组合疗法治疗胃癌
CN109939115B (zh) * 2019-05-06 2021-11-02 河南中医药大学 一种治疗放射性直肠炎的复方栓剂
US20230310478A1 (en) * 2020-09-02 2023-10-05 Ann And Robert H. Lurie Children's Hospital Of Chicago Methods and compositions for the treatment of pulmonary hypertension and cancer
CN114224875B (zh) * 2021-11-04 2023-08-11 中南大学湘雅医院 醇类化合物的新用途及抗肿瘤药物

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WO1998037892A1 (en) * 1997-02-27 1998-09-03 Pharmacia & Upjohn Company Tamoxifen as a therapy to reduce irinotecan hydrochloride-induced diarrhea
AU2592600A (en) * 1998-12-23 2000-07-31 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6395481B1 (en) * 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter
CA2295429A1 (en) * 2000-01-06 2001-07-06 Michael Michael Treatment or prevention of diarrhea
DE60120917T2 (de) * 2000-01-26 2007-01-25 Schering Corp. Kombinationspräparat zur krebstherapie
EP1286671B1 (en) * 2000-05-15 2006-04-05 Celgene Corporation Compositions for the treatment of colorectal cancer comprising thalidomide and irinotecan
WO2002028380A2 (en) * 2000-10-06 2002-04-11 Bristol-Myers Squibb Company Oral dosage forms for administration of the combination of tegafur, uracil, folinic acid, and irinotecan and method of using the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008066136A1 (fr) * 2006-11-30 2008-06-05 Arkray, Inc. Ensemble d'amorces pour l'amplification du gène ugt1a1, réactif pour l'amplification du gène ugt1a1 comprenant cet ensemble d'amorces, et utilisation de cet ensemble d'amorces

Also Published As

Publication number Publication date
JP2005508312A (ja) 2005-03-31
WO2003013536A3 (en) 2003-12-18
EP1408975A2 (en) 2004-04-21
EP1408972A2 (en) 2004-04-21
WO2003013537A9 (en) 2004-04-29
WO2003013533A3 (en) 2003-10-09
AU2002328953A1 (en) 2003-02-24
CA2454637A1 (en) 2003-02-20
WO2003013535A2 (en) 2003-02-20
WO2003013534A9 (en) 2004-04-29
WO2003013535A9 (en) 2004-04-29
AU2002331290A1 (en) 2003-02-24
WO2003013537A3 (en) 2003-09-25
WO2003013537A2 (en) 2003-02-20
CA2454640A1 (en) 2003-02-20
US20050032724A1 (en) 2005-02-10
JP2005506971A (ja) 2005-03-10
AU2002328952A1 (en) 2003-02-24
EP1438050A2 (en) 2004-07-21
CA2454627A1 (en) 2003-02-20
WO2003013534A3 (en) 2003-10-09
CA2454643A1 (en) 2003-02-20
AU2002328945A1 (en) 2003-02-24
WO2003013535A3 (en) 2003-09-25
WO2003013536A9 (en) 2004-04-29
JP2005504759A (ja) 2005-02-17
EP1408974A2 (en) 2004-04-21
EP1408973A2 (en) 2004-04-21
WO2003013533A2 (en) 2003-02-20
WO2003013533A9 (en) 2004-04-29
JP2005505526A (ja) 2005-02-24
CA2454648A1 (en) 2003-02-20
AU2002328950A1 (en) 2003-02-24
WO2003013534A2 (en) 2003-02-20
WO2003013536A2 (en) 2003-02-20

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