JP2005504513A5 - - Google Patents
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- JP2005504513A5 JP2005504513A5 JP2002586886A JP2002586886A JP2005504513A5 JP 2005504513 A5 JP2005504513 A5 JP 2005504513A5 JP 2002586886 A JP2002586886 A JP 2002586886A JP 2002586886 A JP2002586886 A JP 2002586886A JP 2005504513 A5 JP2005504513 A5 JP 2005504513A5
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- JP
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- Prior art keywords
- patient
- polypeptide
- polynucleotide
- isolated
- oligonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 13
- 229920000023 polynucleotide Polymers 0.000 claims 11
- 239000002157 polynucleotide Substances 0.000 claims 11
- 229920000272 Oligonucleotide Polymers 0.000 claims 5
- 210000004027 cells Anatomy 0.000 claims 5
- 210000001744 T-Lymphocytes Anatomy 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 210000000612 Antigen-Presenting Cells Anatomy 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 102000004965 antibodies Human genes 0.000 claims 3
- 108090001123 antibodies Proteins 0.000 claims 3
- 238000009007 Diagnostic Kit Methods 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 102000037240 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 230000004936 stimulating Effects 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000038129 antigens Human genes 0.000 claims 1
- 108091007172 antigens Proteins 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000003344 immunostimulant Effects 0.000 claims 1
- 239000003022 immunostimulating agent Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
Claims (17)
- 配列番号:113に記載のポリペプチド配列を有するポリペプチドの免疫原性部分を含んでなる単離されたポリペプチドフラグメントにおいて、当該免疫原性部分が配列番号:113のアミノ酸残基464−472を含む、単離されたポリペプチドフラグメント。
- 請求項1に記載のポリペプチドフラグメントをコードする単離されたポリヌクレオチド。
- 発現制御配列に作用可能に連結された、請求項2に記載のポリヌクレオチドを含んで成る発現ベクター。
- 請求項3に記載の発現ベクターによりトランスフェクトされた宿主細胞。
- 請求項1に記載のポリペプチドに特異的に結合する、単離された抗体又はその抗原結合フラグメント。
- 患者における癌の存在を検出する方法において、
(a)患者からの生物学的サンプルを、請求項1に記載のポリペプチドに結合する結合剤と接触せしめ;
(b)前記サンプル中の、前記結合剤に結合するポリペプチドの量を検出し;そして
(c)前記ポリペプチドの量をあらかじめ定めたカット−オフ値と比較し、そしてその結果から患者における癌の存在を決定する;
ことを含んで成る方法。 - 請求項1に記載のポリペプチドフラグメントを含んで成る融合タンパク質。
- 腫瘍タンパク質に対して特異的なT細胞を生体外で刺激及び/又は拡大する方法において、
(a)請求項1に記載のポリペプチド;
(b)請求項2に記載のポリヌクレオチド;及び
(c)請求項2に記載のポリヌクレオチドを発現する抗原提示細胞;
から成る群から選択される少なくとも1つの成分を、T細胞の刺激及び/拡大を可能にするのに十分な条件下で及び時間に亘り、T細胞と接触せしめる、ことを含んでなる方法。 - 請求項8に記載の方法により得ることができるT細胞を含んで成る単離されたT細胞集団。
- (A)生理学的に許容されるキャリアー及び免疫刺激物質から成る群から選択される第一成分、並びに
(B)(a)請求項1に記載のポリペプチド;
(b)請求項2に記載のポリヌクレオチド;
(c)請求項5に記載の抗体;
(d)請求項7に記載の融合タンパク質;
(e)請求項9に記載のT細胞集団;及び
(f)請求項2に記載のポリヌクレオチドを発現する抗原提示細胞;
から成る群から選択された第二成分、
を含んで成る組成物。 - 患者において免疫応答を刺激するための、請求項10に記載の組成物。
- 患者において前立腺癌を治療するための、請求項10に記載の組成物。
- 請求項2に記載のポリヌクレオチドに高緊縮条件下でハイブリダイズするオリゴヌクレオチド。
- 患者における癌の存在を決定する方法において、
(a)患者から得た生物学的サンプルを、請求項13に記載のオリゴヌクレオチドと接触せしめ;
(b)前記サンプル中の、前記オリゴヌクレオチドとハイブリダイズするポリヌクレオチドの量を検出し;そして
(c)前記オリゴヌクレオチドにハイブリダイズするポリヌクレオチドの量をあらかじめ定めたカット−オフ値と比較し、その結果から患者における癌の存在を検出する:
工程を含んで成る方法。 - 請求項13に記載の少なくとも1種のオリゴヌクレオチドを含んでなる診断キット。
- 請求項5に記載の少なくとも1種の抗体、及びレポーター基を含む検出試薬、を含んで成る診断キット。
- 患者における前立腺癌の治療方法において使用するための、
(a)請求項1に記載のポリペプチド;
(b)請求項2に記載のポリヌクレオチド;及び
(c)請求項2に記載のポリヌクレオチドを発現する抗原提示細胞;
から成る群から選択された少なくとも1種の成分であって、前記の治療方法が、患者から単離されたCD4+及び/又はCD8+T細胞を、上記の少なくとも1種の成分と共にインキュベートし、そして当該インキュベートされたT細胞を患者に投与し、これにより患者における前立腺がんの発達を阻害することを含んである、前記成分。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85291101A | 2001-05-09 | 2001-05-09 | |
US09/895,814 US20020193296A1 (en) | 1997-02-25 | 2001-06-29 | Compositions and methods for the therapy and diagnosis of prostate cancer |
US10/012,896 US6943236B2 (en) | 1997-02-25 | 2001-12-10 | Compositions and methods for the therapy and diagnosis of prostate cancer |
PCT/US2002/014753 WO2002089747A2 (en) | 2001-05-09 | 2002-05-09 | Compositions and methods for the therapy and diagnosis of prostate cancer |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008126447A Division JP2008271978A (ja) | 2001-05-09 | 2008-05-13 | 前立腺癌の治療及び診断のための組成物及び方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005504513A JP2005504513A (ja) | 2005-02-17 |
JP2005504513A5 true JP2005504513A5 (ja) | 2006-01-05 |
Family
ID=27359724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002586886A Pending JP2005504513A (ja) | 2001-05-09 | 2002-05-09 | 前立腺癌の治療及び診断のための組成物及び方法 |
Country Status (4)
Country | Link |
---|---|
EP (2) | EP1988097A1 (ja) |
JP (1) | JP2005504513A (ja) |
CA (1) | CA2446788A1 (ja) |
WO (1) | WO2002089747A2 (ja) |
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2002
- 2002-05-09 JP JP2002586886A patent/JP2005504513A/ja active Pending
- 2002-05-09 WO PCT/US2002/014753 patent/WO2002089747A2/en active Search and Examination
- 2002-05-09 EP EP08011769A patent/EP1988097A1/en not_active Withdrawn
- 2002-05-09 CA CA002446788A patent/CA2446788A1/en not_active Abandoned
- 2002-05-09 EP EP02725984A patent/EP1515982A4/en not_active Withdrawn
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