JP2005504058A5 - - Google Patents

Info

Publication number

JP2005504058A5

JP2005504058A5 JP2003523245A JP2003523245A JP2005504058A5 JP 2005504058 A5 JP2005504058 A5 JP 2005504058A5 JP 2003523245 A JP2003523245 A JP 2003523245A JP 2003523245 A JP2003523245 A JP 2003523245A JP 2005504058 A5 JP2005504058 A5 JP 2005504058A5

Authority

JP

Japan

Prior art keywords

azabicyclo

hept

carboxamide

thiophene

thiazole

Prior art date

2002-08-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• -1 and R 2 is H Chemical group 0.000 claims description 78
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
• 208000019901 Anxiety disease Diseases 0.000 claims description 5
• 230000036506 anxiety Effects 0.000 claims description 3
• 208000028017 Psychotic disease Diseases 0.000 claims description 2
• 125000001072 heteroaryl group Chemical group 0.000 claims description 2
• 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 2
• 125000000217 alkyl group Chemical group 0.000 claims 49
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 38
• 125000000753 cycloalkyl group Chemical group 0.000 claims 36
• 150000001875 compounds Chemical class 0.000 claims 28
• 125000001424 substituent group Chemical group 0.000 claims 24
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
• 125000000547 substituted alkyl group Chemical group 0.000 claims 12
• 125000003118 aryl group Chemical group 0.000 claims 10
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 9
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 7
• 229910052757 nitrogen Inorganic materials 0.000 claims 7
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
• 125000003342 alkenyl group Chemical group 0.000 claims 6
• 125000000304 alkynyl group Chemical group 0.000 claims 6
• 229910052760 oxygen Inorganic materials 0.000 claims 6
• 229910052717 sulfur Inorganic materials 0.000 claims 6
• 241000124008 Mammalia Species 0.000 claims 5
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
• 150000003839 salts Chemical class 0.000 claims 5
• 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 5
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
• 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 4
• 150000001350 alkyl halides Chemical class 0.000 claims 4
• 230000037396 body weight Effects 0.000 claims 4
• 229910052799 carbon Inorganic materials 0.000 claims 4
• 125000005842 heteroatom Chemical group 0.000 claims 4
• 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 4
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 4
• 208000024891 symptom Diseases 0.000 claims 4
• 125000003396 thiol group Chemical group [H]S* 0.000 claims 4
• ZYHQGITXIJDDKC-UHFFFAOYSA-N 2-[2-(2-aminophenyl)ethyl]aniline Chemical group NC1=CC=CC=C1CCC1=CC=CC=C1N ZYHQGITXIJDDKC-UHFFFAOYSA-N 0.000 claims 3
• 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 3
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 3
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 3
• CVICEEPAFUYBJG-UHFFFAOYSA-N 5-chloro-2,2-difluoro-1,3-benzodioxole Chemical group C1=C(Cl)C=C2OC(F)(F)OC2=C1 CVICEEPAFUYBJG-UHFFFAOYSA-N 0.000 claims 3
• 208000024827 Alzheimer disease Diseases 0.000 claims 3
• 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 3
• 229910052739 hydrogen Inorganic materials 0.000 claims 3
• 125000005017 substituted alkenyl group Chemical group 0.000 claims 3
• 125000004426 substituted alkynyl group Chemical group 0.000 claims 3
• 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 3
• 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 claims 2
• LJGHYPLBDBRCRZ-UHFFFAOYSA-N 3-(3-aminophenyl)sulfonylaniline Chemical group NC1=CC=CC(S(=O)(=O)C=2C=C(N)C=CC=2)=C1 LJGHYPLBDBRCRZ-UHFFFAOYSA-N 0.000 claims 2
• 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims 2
• 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 2
• 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 2
• 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• SNZSSCZJMVIOCR-UHFFFAOYSA-N 7-azabicyclo[2.2.1]heptane Chemical group C1CC2CCC1N2 SNZSSCZJMVIOCR-UHFFFAOYSA-N 0.000 claims 2
• 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
• 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
• 206010012289 Dementia Diseases 0.000 claims 2
• 208000010412 Glaucoma Diseases 0.000 claims 2
• 208000019022 Mood disease Diseases 0.000 claims 2
• YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene Natural products C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 claims 2
• DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims 2
• 239000000654 additive Substances 0.000 claims 2
• 230000000996 additive effect Effects 0.000 claims 2
• 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
• UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 125000005647 linker group Chemical group 0.000 claims 2
• 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 2
• ZQMWCOZHPBMYAF-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloropyridin-4-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=NC(Cl)=C1 ZQMWCOZHPBMYAF-ADEWGFFLSA-N 0.000 claims 2
• WUXDEGQWSFVUQG-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloropyridin-4-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=NC(Cl)=C1 WUXDEGQWSFVUQG-ADEWGFFLSA-N 0.000 claims 2
• GKBVLMXIZUSZBS-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-3-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CN=C1F GKBVLMXIZUSZBS-DVVUODLYSA-N 0.000 claims 2
• UFINMAAKGKATOZ-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(Cl)C=N1 UFINMAAKGKATOZ-GRYCIOLGSA-N 0.000 claims 2
• MZPHJMKTDIUGCJ-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(Cl)C=N1 MZPHJMKTDIUGCJ-GRYCIOLGSA-N 0.000 claims 2
• CHVHKCKUGONQEE-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylthiophen-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C)S1 CHVHKCKUGONQEE-GRYCIOLGSA-N 0.000 claims 2
• OFRJLKOCLIZDSV-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-3-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(Cl)N=C1 OFRJLKOCLIZDSV-ADEWGFFLSA-N 0.000 claims 2
• YNXCSYUXPRVOIE-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-3-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(Cl)N=C1 YNXCSYUXPRVOIE-ADEWGFFLSA-N 0.000 claims 2
• KKLYYHDOLZFJDX-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-thiophen-3-ylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C=1C=CSC=1 KKLYYHDOLZFJDX-GRYCIOLGSA-N 0.000 claims 2
• 125000001624 naphthyl group Chemical group 0.000 claims 2
• 230000004770 neurodegeneration Effects 0.000 claims 2
• 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 2
• 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 2
• 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
• 125000006239 protecting group Chemical group 0.000 claims 2
• 125000004505 1,2,4-oxadiazol-5-yl group Chemical group O1N=CN=C1* 0.000 claims 1
• 125000001305 1,2,4-triazol-3-yl group Chemical group [H]N1N=C([*])N=C1[H] 0.000 claims 1
• CGEVZNOVCLMCAE-UHFFFAOYSA-N 1-$l^{1}-sulfanyl-4-methoxybenzene Chemical compound COC1=CC=C([S])C=C1 CGEVZNOVCLMCAE-UHFFFAOYSA-N 0.000 claims 1
• KJHXFHOJCCIKLD-UHFFFAOYSA-N 1-$l^{1}-sulfanyl-4-methylbenzene Chemical compound CC1=CC=C([S])C=C1 KJHXFHOJCCIKLD-UHFFFAOYSA-N 0.000 claims 1
• 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 1
• KRZIKTDUSDABCF-BYCMXARLSA-N 2-(2-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1NC(C)=O KRZIKTDUSDABCF-BYCMXARLSA-N 0.000 claims 1
• LDJCHUPMLADDAG-JIMOISOXSA-N 2-(2-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1N LDJCHUPMLADDAG-JIMOISOXSA-N 0.000 claims 1
• YZHVBUJLQLWNJC-QLFBSQMISA-N 2-(3-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(NC(C)=O)=C1 YZHVBUJLQLWNJC-QLFBSQMISA-N 0.000 claims 1
• AQTWOQREGFOFQL-FRRDWIJNSA-N 2-(3-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(N)=C1 AQTWOQREGFOFQL-FRRDWIJNSA-N 0.000 claims 1
• VROBRBFBUXDWKY-QLFBSQMISA-N 2-(4-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(NC(C)=O)C=C1 VROBRBFBUXDWKY-QLFBSQMISA-N 0.000 claims 1
• GODWTBHWMIEYKP-FRRDWIJNSA-N 2-(4-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(N)C=C1 GODWTBHWMIEYKP-FRRDWIJNSA-N 0.000 claims 1
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
• 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
• 125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 claims 1
• 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
• PIEAJWIQPXRDBZ-XOKHGSTOSA-N 4-(3-acetamidophenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1SC1=CC=CC(NC(C)=O)=C1 PIEAJWIQPXRDBZ-XOKHGSTOSA-N 0.000 claims 1
• 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
• 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
• BVHIKSYSNBOIQX-BYCMXARLSA-N 5-(2-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1NC(C)=O BVHIKSYSNBOIQX-BYCMXARLSA-N 0.000 claims 1
• ARIUNWKWJWHVQQ-PZPSRYQVSA-N 5-(2-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1NC(C)=O ARIUNWKWJWHVQQ-PZPSRYQVSA-N 0.000 claims 1
• CGHNFDNKZNIZOH-UHOFOFEASA-N 5-(2-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1NC(C)=O CGHNFDNKZNIZOH-UHOFOFEASA-N 0.000 claims 1
• ZBZUWSBCDJYLOC-VNHYZAJKSA-N 5-(2-acetamidophenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1NC(C)=O ZBZUWSBCDJYLOC-VNHYZAJKSA-N 0.000 claims 1
• JPTQVTOVUUFVHU-BYCMXARLSA-N 5-(2-amino-4-methylphenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(C)C=C1N JPTQVTOVUUFVHU-BYCMXARLSA-N 0.000 claims 1
• YTMJMSNYARYAJY-JIMOISOXSA-N 5-(2-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1N YTMJMSNYARYAJY-JIMOISOXSA-N 0.000 claims 1
• SOWSDRNODSEIMV-JIMOISOXSA-N 5-(2-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1N SOWSDRNODSEIMV-JIMOISOXSA-N 0.000 claims 1
• DNAVVEVSPWIZAX-FUEDEBDSSA-N 5-(2-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1N DNAVVEVSPWIZAX-FUEDEBDSSA-N 0.000 claims 1
• NBZHKKMLFRNQRS-QLFBSQMISA-N 5-(3-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(NC(C)=O)=C1 NBZHKKMLFRNQRS-QLFBSQMISA-N 0.000 claims 1
• ZUNNZOCYADWMGB-QLFBSQMISA-N 5-(3-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(NC(C)=O)=C1 ZUNNZOCYADWMGB-QLFBSQMISA-N 0.000 claims 1
• OPBIEEAWTCRPGO-IXDOHACOSA-N 5-(3-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(NC(C)=O)=C1 OPBIEEAWTCRPGO-IXDOHACOSA-N 0.000 claims 1
• OYOZVWQWXUALTI-UWWQBHOKSA-N 5-(3-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(NC(C)=O)=C1 OYOZVWQWXUALTI-UWWQBHOKSA-N 0.000 claims 1
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• MQCOCIDHWLRMKT-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-bromophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1Br MQCOCIDHWLRMKT-JIMOISOXSA-N 0.000 claims 1
• SEXJYMLYNIWGPW-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-chlorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1Cl SEXJYMLYNIWGPW-JIMOISOXSA-N 0.000 claims 1
• JTCKJPYZMQVWEB-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-cyanophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1C#N JTCKJPYZMQVWEB-KWCYVHTRSA-N 0.000 claims 1
• MOYLQHNHNIULQM-XNQXYUBBSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-fluoro-1h-pyridin-2-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1(F)NC=CC=C1 MOYLQHNHNIULQM-XNQXYUBBSA-N 0.000 claims 1
• BXPPJIIXPJALFB-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-fluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1F BXPPJIIXPJALFB-JIMOISOXSA-N 0.000 claims 1
• TXUGRCDIPROZEY-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-fluoropyridin-3-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CN=C1F TXUGRCDIPROZEY-DVVUODLYSA-N 0.000 claims 1
• HERAVWYMFNHJIC-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-fluoropyridin-4-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=NC(F)=C1 HERAVWYMFNHJIC-OUAUKWLOSA-N 0.000 claims 1
• UYOKACXDYOCQSN-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-methoxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1OC UYOKACXDYOCQSN-KGYLQXTDSA-N 0.000 claims 1
• UMCCWGYSXQEGIR-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-methylphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1C UMCCWGYSXQEGIR-KWCYVHTRSA-N 0.000 claims 1
• HWSNWBMHJRVUKM-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-nitrophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1[N+]([O-])=O HWSNWBMHJRVUKM-ADEWGFFLSA-N 0.000 claims 1
• XDCDYLBNLMMACV-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3,4-difluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(F)C(F)=C1 XDCDYLBNLMMACV-JIMOISOXSA-N 0.000 claims 1
• SYJWQOWIGPINNU-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3,5-difluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC(F)=CC(F)=C1 SYJWQOWIGPINNU-FRRDWIJNSA-N 0.000 claims 1
• NWPKMKRXVVFMFV-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-bromophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(Br)=C1 NWPKMKRXVVFMFV-FRRDWIJNSA-N 0.000 claims 1
• RCIGYHPFOPFFGM-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-chlorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(Cl)=C1 RCIGYHPFOPFFGM-FRRDWIJNSA-N 0.000 claims 1
• RWUGYZZRRFONMI-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-cyanophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(C#N)=C1 RWUGYZZRRFONMI-HZSPNIEDSA-N 0.000 claims 1
• DFPKQGLUVDQGCO-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-fluoropyridin-2-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=NC=CC=C1F DFPKQGLUVDQGCO-DVVUODLYSA-N 0.000 claims 1
• ROQAXCRJIGVFMH-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-hydroxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(O)=C1 ROQAXCRJIGVFMH-KGYLQXTDSA-N 0.000 claims 1
• NUWIVOMPLGTKLY-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-methoxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(OC)=C1 NUWIVOMPLGTKLY-KWCYVHTRSA-N 0.000 claims 1
• DUCYXJYWPVZISX-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-methylphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(C)=C1 DUCYXJYWPVZISX-HZSPNIEDSA-N 0.000 claims 1
• ZDWCLMJYMVINRS-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-nitrophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC([N+]([O-])=O)=C1 ZDWCLMJYMVINRS-KGYLQXTDSA-N 0.000 claims 1
• HTDIWNCFXNJZKI-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-bromophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(Br)C=C1 HTDIWNCFXNJZKI-FRRDWIJNSA-N 0.000 claims 1
• URWVRLVVDYMVAI-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-chlorophenoxy)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1OC1=CC=C(Cl)C=C1 URWVRLVVDYMVAI-KGYLQXTDSA-N 0.000 claims 1
• UWPVMAJZZSPZND-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-chlorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(Cl)C=C1 UWPVMAJZZSPZND-FRRDWIJNSA-N 0.000 claims 1
• HFXDFEKLINUAKP-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-chlorophenyl)sulfanyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1SC1=CC=C(Cl)C=C1 HFXDFEKLINUAKP-KGYLQXTDSA-N 0.000 claims 1
• WUSVKEZDADWIDN-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-cyanophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(C#N)C=C1 WUSVKEZDADWIDN-HZSPNIEDSA-N 0.000 claims 1
• MDUCAYJRKPTPBH-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-fluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(F)C=C1 MDUCAYJRKPTPBH-FRRDWIJNSA-N 0.000 claims 1
• SNRBYEOYHWHTND-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-fluorophenyl)sulfanyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1SC1=CC=C(F)C=C1 SNRBYEOYHWHTND-KGYLQXTDSA-N 0.000 claims 1
• NRFUKHIDYJHELM-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-fluoropyridin-2-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC(F)=CC=N1 NRFUKHIDYJHELM-OUAUKWLOSA-N 0.000 claims 1
• HKKCCAMVFLHFNF-JFUSQASVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-fluoropyridin-3-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CN=CC=C1F HKKCCAMVFLHFNF-JFUSQASVSA-N 0.000 claims 1
• SVJSZQSVAJWKTQ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methoxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(OC)C=C1 SVJSZQSVAJWKTQ-KWCYVHTRSA-N 0.000 claims 1
• HMWIGTFLWBIWRD-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(C)C=C1 HMWIGTFLWBIWRD-HZSPNIEDSA-N 0.000 claims 1
• FHLFAEVEZDWOQG-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-nitrophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C([N+]([O-])=O)C=C1 FHLFAEVEZDWOQG-KGYLQXTDSA-N 0.000 claims 1
• SLKTWJWRXCSIEH-YZGWKJHDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-phenylmethoxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C(C=C1)=CC=C1OCC1=CC=CC=C1 SLKTWJWRXCSIEH-YZGWKJHDSA-N 0.000 claims 1
• MAMGUEPYGOVVFS-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(5-fluoropyridin-2-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(F)C=N1 MAMGUEPYGOVVFS-JFGNBEQYSA-N 0.000 claims 1
• UYKFASSRGXRROF-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(5-fluoropyridin-3-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CN=CC(F)=C1 UYKFASSRGXRROF-GRYCIOLGSA-N 0.000 claims 1
• AQXPYVMTZFBBGW-WCABBAIRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(6-fluoropyridin-2-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(F)=N1 AQXPYVMTZFBBGW-WCABBAIRSA-N 0.000 claims 1
• KQKZAOBGQIHBAZ-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(6-fluoropyridin-3-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(F)N=C1 KQKZAOBGQIHBAZ-OUAUKWLOSA-N 0.000 claims 1
• QGYWBSBYJQCQHD-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[2-(methanesulfonamido)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1NS(C)(=O)=O QGYWBSBYJQCQHD-DDTOSNHZSA-N 0.000 claims 1
• XCRVZONNSSTOAS-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[2-(methylamino)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1NC XCRVZONNSSTOAS-DDTOSNHZSA-N 0.000 claims 1
• ZHLTVDHVVASYKZ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[3-(methanesulfonamido)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(NS(C)(=O)=O)=C1 ZHLTVDHVVASYKZ-KWCYVHTRSA-N 0.000 claims 1
• REPRESUAYWEAPI-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[3-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(OC(F)(F)F)=C1 REPRESUAYWEAPI-KGYLQXTDSA-N 0.000 claims 1
• AHCSKOYWFFYVJK-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[4-(methanesulfonamido)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(NS(C)(=O)=O)C=C1 AHCSKOYWFFYVJK-HZSPNIEDSA-N 0.000 claims 1
• IMQTXFXWPBDJQF-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(OC(F)(F)F)C=C1 IMQTXFXWPBDJQF-KGYLQXTDSA-N 0.000 claims 1
• ABVNCJNQSFZDMF-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfanyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CN=C(SC)S1 ABVNCJNQSFZDMF-GJMOJQLCSA-N 0.000 claims 1
• JOYNUVUNKJWLHL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-phenyl-1,3-oxazole-4-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=1)=COC=1C1=CC=CC=C1 JOYNUVUNKJWLHL-FRRDWIJNSA-N 0.000 claims 1
• YUHYSIFFWLRCQR-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-phenyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1 YUHYSIFFWLRCQR-FRRDWIJNSA-N 0.000 claims 1
• GCKRRVSLCXQSBW-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-phenylsulfanyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1SC1=CC=CC=C1 GCKRRVSLCXQSBW-KGYLQXTDSA-N 0.000 claims 1
• KZZFFQVODHDDRC-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyridin-2-yl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=N1 KZZFFQVODHDDRC-JFGNBEQYSA-N 0.000 claims 1
• RRJGBBSTBFAECN-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyridin-3-yl-1,3-thiazole-4-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=1)=CSC=1C1=CC=CN=C1 RRJGBBSTBFAECN-GRYCIOLGSA-N 0.000 claims 1
• KXIXYYASDARJML-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyridin-3-yl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CN=C1 KXIXYYASDARJML-GRYCIOLGSA-N 0.000 claims 1
• OZULRBITLYGCQZ-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyridin-4-yl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=NC=C1 OZULRBITLYGCQZ-GRYCIOLGSA-N 0.000 claims 1
• JDVYWRRMBJNIIC-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-phenyl-1,2,4-oxadiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(ON=1)=NC=1C1=CC=CC=C1 JDVYWRRMBJNIIC-GRYCIOLGSA-N 0.000 claims 1
• GKOXQLORWXIFFD-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-phenyl-1h-1,2,4-triazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=1)=NNC=1C1=CC=CC=C1 GKOXQLORWXIFFD-GRYCIOLGSA-N 0.000 claims 1
• JLQRWSDJVKFSON-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4,5-dimethylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(C)=C(C)O1 JLQRWSDJVKFSON-OUAUKWLOSA-N 0.000 claims 1
• OADLCNHXUNVXIE-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-(2-methylpyridin-4-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1OC1=CC=NC(C)=C1 OADLCNHXUNVXIE-BYCMXARLSA-N 0.000 claims 1
• AMKCIIACDSTQJY-MHSYXAOVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-bromo-5-chlorothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(Br)=C(Cl)S1 AMKCIIACDSTQJY-MHSYXAOVSA-N 0.000 claims 1
• HCCNSKARINCVAG-BWVDBABLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-chloro-5-cyanothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(Cl)=C(C#N)S1 HCCNSKARINCVAG-BWVDBABLSA-N 0.000 claims 1
• CACGIFFKCMIPNJ-FKTZTGRPSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-chloro-5-methylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(Cl)=C(C)S1 CACGIFFKCMIPNJ-FKTZTGRPSA-N 0.000 claims 1
• CWFJRIOMGGYJSS-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-chloro-5-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC(Cl)=C1C1=CC=CC=C1 CWFJRIOMGGYJSS-KWCYVHTRSA-N 0.000 claims 1
• YULIKEUTJUTDGX-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-cyano-5-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC(C#N)=C1C1=CC=CC=C1 YULIKEUTJUTDGX-QLFBSQMISA-N 0.000 claims 1
• MKTAAAVNCWVIBP-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methoxy-5-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC(OC)=C1C1=CC=CC=C1 MKTAAAVNCWVIBP-HZSPNIEDSA-N 0.000 claims 1
• URUVEEZWFVRANU-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(=C(N=1)C)SC=1C1=CC=CC=C1 URUVEEZWFVRANU-HZSPNIEDSA-N 0.000 claims 1
• CZQHUXFBMCKQDK-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-2-pyridin-2-yl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(=C(N=1)C)SC=1C1=CC=CC=N1 CZQHUXFBMCKQDK-NTZNESFSSA-N 0.000 claims 1
• LDIZWTXOXLZHSB-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-2-pyridin-4-yl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(=C(N=1)C)SC=1C1=CC=NC=C1 LDIZWTXOXLZHSB-FRRDWIJNSA-N 0.000 claims 1
• VLSORDDLKXBYDM-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-5-phenyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC=C1 VLSORDDLKXBYDM-HZSPNIEDSA-N 0.000 claims 1
• INFDWMFQNOSTRJ-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-5-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC(C)=C1C1=CC=CC=C1 INFDWMFQNOSTRJ-QLFBSQMISA-N 0.000 claims 1
• HHRRXOQEBMODNO-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-5-thiophen-2-yl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CS1 HHRRXOQEBMODNO-OUAUKWLOSA-N 0.000 claims 1
• DZNYSDDYURJSSX-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1C1=CC=CC=C1 DZNYSDDYURJSSX-QLFBSQMISA-N 0.000 claims 1
• BGMUHOFLKDVFDW-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-pyridin-2-yloxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1OC1=CC=CC=N1 BGMUHOFLKDVFDW-KGYLQXTDSA-N 0.000 claims 1
• MSBBOIMFDFEYAL-WCABBAIRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,2-oxazol-3-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C=1C=CON=1 MSBBOIMFDFEYAL-WCABBAIRSA-N 0.000 claims 1
• KHLPEBHGVTYQRA-WCABBAIRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,2-thiazol-3-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C=1C=CSN=1 KHLPEBHGVTYQRA-WCABBAIRSA-N 0.000 claims 1
• NJQWDEIYJLMFCZ-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=CS1 NJQWDEIYJLMFCZ-HRDYMLBCSA-N 0.000 claims 1
• VJEUFUSTALLKMG-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3,4-thiadiazol-2-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NN=CS1 VJEUFUSTALLKMG-HRDYMLBCSA-N 0.000 claims 1
• FDFRHORQQFCDNB-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3,4-thiadiazol-2-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=CS1 FDFRHORQQFCDNB-HRDYMLBCSA-N 0.000 claims 1
• DUXRDCHYSITVEL-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=CO1 DUXRDCHYSITVEL-KXUCPTDWSA-N 0.000 claims 1
• YRGXLBJKSNGTBL-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-2-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=CO1 YRGXLBJKSNGTBL-KXUCPTDWSA-N 0.000 claims 1
• QVYLFSPQHPNHFO-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-2-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=CO1 QVYLFSPQHPNHFO-KXUCPTDWSA-N 0.000 claims 1
• KIWFCBLAASUFRP-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=CO1 KIWFCBLAASUFRP-KXUCPTDWSA-N 0.000 claims 1
• XQGOOWPPHPCWNW-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-5-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=CO1 XQGOOWPPHPCWNW-KXUCPTDWSA-N 0.000 claims 1
• FXHSFMUNGKCIKA-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-5-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=CO1 FXHSFMUNGKCIKA-KXUCPTDWSA-N 0.000 claims 1
• PSLPBMLFDSFPFR-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=CS1 PSLPBMLFDSFPFR-KXUCPTDWSA-N 0.000 claims 1
• JPXMJPKSXOLELV-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-2-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=CS1 JPXMJPKSXOLELV-KXUCPTDWSA-N 0.000 claims 1
• LDWRPXOCKKITBY-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-2-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=CS1 LDWRPXOCKKITBY-KXUCPTDWSA-N 0.000 claims 1
• RNFNTZBIHFMBCJ-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=CS1 RNFNTZBIHFMBCJ-KXUCPTDWSA-N 0.000 claims 1
• RIHNCJRLZBMACS-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-5-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=CS1 RIHNCJRLZBMACS-KXUCPTDWSA-N 0.000 claims 1
• FJSLRNIFAPJRME-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-5-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=CS1 FJSLRNIFAPJRME-KXUCPTDWSA-N 0.000 claims 1
• DFERGAXJJVDIOT-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1-benzofuran-2-yl)furan-2-carboxamide Chemical compound C1=CC=C2OC(C3=CC=C(O3)C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 DFERGAXJJVDIOT-HZSPNIEDSA-N 0.000 claims 1
• LQAQUGBRTKGKRT-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1-benzothiophen-2-yl)furan-2-carboxamide Chemical compound C1=CC=C2SC(C3=CC=C(O3)C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 LQAQUGBRTKGKRT-HZSPNIEDSA-N 0.000 claims 1
• UMYGJNNUQMSKAY-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1h-imidazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=CN1 UMYGJNNUQMSKAY-KXUCPTDWSA-N 0.000 claims 1
• HBHLMRBDQPVKFX-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1h-indol-5-yl)furan-2-carboxamide Chemical compound C1=C2NC=CC2=CC(C2=CC=C(O2)C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HBHLMRBDQPVKFX-VNQPRFMTSA-N 0.000 claims 1
• MQKHUWKMLCLDEO-IJEWVQPXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1h-indol-6-yl)furan-2-carboxamide Chemical compound C1=C2C=CNC2=CC(C2=CC=C(O2)C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 MQKHUWKMLCLDEO-IJEWVQPXSA-N 0.000 claims 1
• OJNUEKXACSBHJD-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1h-pyrrol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CN1 OJNUEKXACSBHJD-JFGNBEQYSA-N 0.000 claims 1
• RDKDNQFFMXMBLF-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,3-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(Cl)=C1Cl RDKDNQFFMXMBLF-JIMOISOXSA-N 0.000 claims 1
• SRVOZKQSPOKUMJ-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,3-dichlorophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(Cl)=C1Cl SRVOZKQSPOKUMJ-ADEWGFFLSA-N 0.000 claims 1
• JTJYFTRLQFJHIH-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,3-difluorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(F)=C1F JTJYFTRLQFJHIH-JIMOISOXSA-N 0.000 claims 1
• MGONXQCWRGCIDI-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-dichlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=C(Cl)C=C1Cl MGONXQCWRGCIDI-ADEWGFFLSA-N 0.000 claims 1
• RKZAZNWWAJJILD-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-dichlorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(Cl)C=C1Cl RKZAZNWWAJJILD-JIMOISOXSA-N 0.000 claims 1
• DXCPTOPXBIJRGA-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-dichlorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(Cl)C=C1Cl DXCPTOPXBIJRGA-JIMOISOXSA-N 0.000 claims 1
• KJYYWHZVQTZMAH-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-dichlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(Cl)C=C1Cl KJYYWHZVQTZMAH-FUEDEBDSSA-N 0.000 claims 1
• VZFUYIQDLSSWLH-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(Cl)C=C1Cl VZFUYIQDLSSWLH-DDTOSNHZSA-N 0.000 claims 1
• KNCREAOTWLDYIE-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(F)C=C1F KNCREAOTWLDYIE-JIMOISOXSA-N 0.000 claims 1
• IVQCUDNGURIIDE-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(F)C=C1F IVQCUDNGURIIDE-JIMOISOXSA-N 0.000 claims 1
• HNSFVGIQDTXBSR-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(F)C=C1F HNSFVGIQDTXBSR-BYCMXARLSA-N 0.000 claims 1
• HBQKRPYCAHORRH-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(F)C=C1F HBQKRPYCAHORRH-FUEDEBDSSA-N 0.000 claims 1
• VUEARMNTRGZDOW-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(F)C=C1F VUEARMNTRGZDOW-DDTOSNHZSA-N 0.000 claims 1
• AFFXNPRKONACJE-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenyl)sulfanyl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1SC1=CC=C(F)C=C1F AFFXNPRKONACJE-ADEWGFFLSA-N 0.000 claims 1
• YOLJAPMGGDUXDU-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(F)C=C1F YOLJAPMGGDUXDU-KGYLQXTDSA-N 0.000 claims 1
• HOEQYUQAKKUHCZ-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,5-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC(Cl)=CC=C1Cl HOEQYUQAKKUHCZ-DDTOSNHZSA-N 0.000 claims 1
• KPSBHMCOIXOXTR-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,5-difluorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC(F)=CC=C1F KPSBHMCOIXOXTR-DDTOSNHZSA-N 0.000 claims 1
• FOKADOMVWNIZRJ-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,6-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=C(Cl)C=CC=C1Cl FOKADOMVWNIZRJ-JIMOISOXSA-N 0.000 claims 1
• FVESZSWDRKLALG-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,6-difluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=C(F)C=CC=C1F FVESZSWDRKLALG-DDTOSNHZSA-N 0.000 claims 1
• OPXSSCNGXWSTQT-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-bromophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1Br OPXSSCNGXWSTQT-JIMOISOXSA-N 0.000 claims 1
• KZRKSOFEIFKDLW-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-bromophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1Br KZRKSOFEIFKDLW-JIMOISOXSA-N 0.000 claims 1
• DKGDDBFVPMARBG-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-bromophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1Br DKGDDBFVPMARBG-FUEDEBDSSA-N 0.000 claims 1
• SUGJKGYGXYYBNW-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-carbamoylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1C(N)=O SUGJKGYGXYYBNW-KGYLQXTDSA-N 0.000 claims 1
• HIKLFKLNDBPCAU-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-carbamoylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1C(N)=O HIKLFKLNDBPCAU-DDTOSNHZSA-N 0.000 claims 1
• BPUOLRUCAODKOQ-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloro-1,3-oxazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(Cl)O1 BPUOLRUCAODKOQ-HRDYMLBCSA-N 0.000 claims 1
• JQOSBNCZQPMZNO-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloro-1,3-thiazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(Cl)S1 JQOSBNCZQPMZNO-HRDYMLBCSA-N 0.000 claims 1
• YICVJRKCYYXPBX-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=CC=C1Cl YICVJRKCYYXPBX-ADEWGFFLSA-N 0.000 claims 1
• KJPOLQVILHDHMZ-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC=C1Cl KJPOLQVILHDHMZ-ADEWGFFLSA-N 0.000 claims 1
• HTPRFGZCCWMRIR-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1Cl HTPRFGZCCWMRIR-JIMOISOXSA-N 0.000 claims 1
• IRJFIWGLFVUZAA-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1Cl IRJFIWGLFVUZAA-JIMOISOXSA-N 0.000 claims 1
• CLAOGANUQUGRKV-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1Cl CLAOGANUQUGRKV-FUEDEBDSSA-N 0.000 claims 1
• GDHMHUVFKQYJTG-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)sulfanyl-1,3,4-thiadiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NN=C1SC1=CC=CC=C1Cl GDHMHUVFKQYJTG-DVVUODLYSA-N 0.000 claims 1
• QYVHVHLEKPXEMH-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=CC=C1Cl QYVHVHLEKPXEMH-ADEWGFFLSA-N 0.000 claims 1
• YERNQVHQXPAZEJ-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)sulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=CC=C1Cl YERNQVHQXPAZEJ-KGYLQXTDSA-N 0.000 claims 1
• HNSBETKMDMAYMQ-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CN=C1Cl HNSBETKMDMAYMQ-ADEWGFFLSA-N 0.000 claims 1
• GAUWNJCYXFSFIO-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloropyridin-4-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=NC(Cl)=C1 GAUWNJCYXFSFIO-GRYCIOLGSA-N 0.000 claims 1
• PFNWYCKMTOZVLQ-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloropyridin-4-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=NC(Cl)=C1 PFNWYCKMTOZVLQ-GRYCIOLGSA-N 0.000 claims 1
• LPDLFOOLNXGPDA-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-cyanophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1C#N LPDLFOOLNXGPDA-KWCYVHTRSA-N 0.000 claims 1
• QUPLLSJAVORCQP-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-cyanophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1C#N QUPLLSJAVORCQP-KWCYVHTRSA-N 0.000 claims 1
• NRPHFEAAWGHSNL-ISTRZQFTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-cyanophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1C#N NRPHFEAAWGHSNL-ISTRZQFTSA-N 0.000 claims 1
• QVYQFXJKKNTWKG-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoro-3-methoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(OC)=C1F QVYQFXJKKNTWKG-KGYLQXTDSA-N 0.000 claims 1
• GXUBEWJIRQISNW-WKPIXPDZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoro-4-methoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(OC)C=C1F GXUBEWJIRQISNW-WKPIXPDZSA-N 0.000 claims 1
• DLMHCZHEYZQPII-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoro-4-methylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(C)C=C1F DLMHCZHEYZQPII-BYCMXARLSA-N 0.000 claims 1
• FEMYCQFRYAPIPV-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=CC=C1F FEMYCQFRYAPIPV-ADEWGFFLSA-N 0.000 claims 1
• KJLCOJRDIYHVII-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC=C1F KJLCOJRDIYHVII-ADEWGFFLSA-N 0.000 claims 1
• CDVSSIWMNUUXID-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenoxy)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1OC1=CC=CC=C1F CDVSSIWMNUUXID-KGYLQXTDSA-N 0.000 claims 1
• DIKZAUZQOQEIKB-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1F DIKZAUZQOQEIKB-JIMOISOXSA-N 0.000 claims 1
• ALJPOIASFYFWFQ-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1F ALJPOIASFYFWFQ-JIMOISOXSA-N 0.000 claims 1
• CEZZQFDDLYEIDE-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1F CEZZQFDDLYEIDE-BYCMXARLSA-N 0.000 claims 1
• WZBGJOODTYVIPT-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1F WZBGJOODTYVIPT-FUEDEBDSSA-N 0.000 claims 1
• FCNMDDOMIMEWMT-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)-4-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC=C1F FCNMDDOMIMEWMT-DDTOSNHZSA-N 0.000 claims 1
• XKRAECRQARLUJH-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=CC=C1F XKRAECRQARLUJH-ADEWGFFLSA-N 0.000 claims 1
• QLPPJIQIIBBQKU-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)sulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=CC=C1F QLPPJIQIIBBQKU-KGYLQXTDSA-N 0.000 claims 1
• AGNHZDJOIUTLLI-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-3-yl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CN=C1F AGNHZDJOIUTLLI-DVVUODLYSA-N 0.000 claims 1
• YFUPDWSTRWYTKI-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-3-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CN=C1F YFUPDWSTRWYTKI-KGYLQXTDSA-N 0.000 claims 1
• HVGIKPQXSCVYPI-LJWDBELGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-3-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CN=C1F HVGIKPQXSCVYPI-LJWDBELGSA-N 0.000 claims 1
• NDDOFQJLHHDQDA-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CN=C1F NDDOFQJLHHDQDA-ADEWGFFLSA-N 0.000 claims 1
• DYHNOEVKXXGGRW-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-4-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=NC(F)=C1 DYHNOEVKXXGGRW-OUAUKWLOSA-N 0.000 claims 1
• QOOYWAFPRRLTNH-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-4-yl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=NC(F)=C1 QOOYWAFPRRLTNH-OUAUKWLOSA-N 0.000 claims 1
• QGQHZWCKERRORC-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-4-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=NC(F)=C1 QGQHZWCKERRORC-FRRDWIJNSA-N 0.000 claims 1
• SSEMRGWSBRJWEL-SCDSUCTJSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-4-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=NC(F)=C1 SSEMRGWSBRJWEL-SCDSUCTJSA-N 0.000 claims 1
• YLYCRUSFRHUQEW-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-4-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=NC(F)=C1 YLYCRUSFRHUQEW-GRYCIOLGSA-N 0.000 claims 1
• IRFLWGJHBGXDBE-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1O IRFLWGJHBGXDBE-GRYCIOLGSA-N 0.000 claims 1
• FJIPJZBCLWJAAZ-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1O FJIPJZBCLWJAAZ-ADEWGFFLSA-N 0.000 claims 1
• LLTQIRZFKIEYLP-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1O LLTQIRZFKIEYLP-ADEWGFFLSA-N 0.000 claims 1
• QFVRYSXTCRZUNL-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1O QFVRYSXTCRZUNL-KWCYVHTRSA-N 0.000 claims 1
• MPHKQHJIFIRDFD-RIEGTJTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1O MPHKQHJIFIRDFD-RIEGTJTDSA-N 0.000 claims 1
• KQNLPFGHHVTZQV-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1O KQNLPFGHHVTZQV-KGYLQXTDSA-N 0.000 claims 1
• AWCLLQYKMPVIDT-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1O AWCLLQYKMPVIDT-KGYLQXTDSA-N 0.000 claims 1
• HQDZHCLKXVUYNR-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxy-1,3-oxazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(OC)O1 HQDZHCLKXVUYNR-KXUCPTDWSA-N 0.000 claims 1
• JNTIBMSLOONHIP-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxy-1,3-thiazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(OC)S1 JNTIBMSLOONHIP-KXUCPTDWSA-N 0.000 claims 1
• VIYRNRRCBONDMO-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC=C1OC VIYRNRRCBONDMO-GRYCIOLGSA-N 0.000 claims 1
• NWWPJUUTHZOBHL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1OC NWWPJUUTHZOBHL-FRRDWIJNSA-N 0.000 claims 1
• HTMAAIPEPASEPV-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1OC HTMAAIPEPASEPV-KGYLQXTDSA-N 0.000 claims 1
• MIBBOMLJHHONKJ-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1OC MIBBOMLJHHONKJ-KGYLQXTDSA-N 0.000 claims 1
• ARXGMAOJNJIEKC-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1OC ARXGMAOJNJIEKC-VHDGCEQUSA-N 0.000 claims 1
• HNIHDUNECDALDY-DIOULYMOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1OC HNIHDUNECDALDY-DIOULYMOSA-N 0.000 claims 1
• QYRPRWZTKMBTAC-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)-4-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC=C1OC QYRPRWZTKMBTAC-KWCYVHTRSA-N 0.000 claims 1
• KYHQHEFXKBOXQU-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxypyridin-4-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=NC(OC)=C1 KYHQHEFXKBOXQU-KGYLQXTDSA-N 0.000 claims 1
• URCXUOQWFQNBQO-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxypyridin-4-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=NC(OC)=C1 URCXUOQWFQNBQO-KGYLQXTDSA-N 0.000 claims 1
• HWEMKCVGQKTDBQ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxypyridin-4-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=NC(OC)=C1 HWEMKCVGQKTDBQ-FRRDWIJNSA-N 0.000 claims 1
• XVZLQVLKQUZDDE-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methyl-1,3-oxazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(C)O1 XVZLQVLKQUZDDE-OUAUKWLOSA-N 0.000 claims 1
• YIQHQPREHFAFBM-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methyl-1,3-thiazol-4-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CSC(C)=N1 YIQHQPREHFAFBM-OUAUKWLOSA-N 0.000 claims 1
• SOEUQISBXQRZSF-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methyl-1,3-thiazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(C)S1 SOEUQISBXQRZSF-OUAUKWLOSA-N 0.000 claims 1
• OVNTYDJEWVFGRN-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC=C1C OVNTYDJEWVFGRN-FRRDWIJNSA-N 0.000 claims 1
• OBQREIIJUHOPGH-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1C OBQREIIJUHOPGH-KWCYVHTRSA-N 0.000 claims 1
• IBGOFZUYBBGBDT-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1C IBGOFZUYBBGBDT-KWCYVHTRSA-N 0.000 claims 1
• NUSUXINGHQUCRY-ISTRZQFTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1C NUSUXINGHQUCRY-ISTRZQFTSA-N 0.000 claims 1
• ULQWQGCFJDTGSW-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=CC=C1C ULQWQGCFJDTGSW-FRRDWIJNSA-N 0.000 claims 1
• MXHBYNNDAQOBQM-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylpyridin-4-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=NC(C)=C1 MXHBYNNDAQOBQM-KWCYVHTRSA-N 0.000 claims 1
• YITMBOMGUFNCJD-HYVNUMGLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-morpholin-4-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1N1CCOCC1 YITMBOMGUFNCJD-HYVNUMGLSA-N 0.000 claims 1
• SGJFVCHKIWIFJU-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-nitrophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1[N+]([O-])=O SGJFVCHKIWIFJU-ADEWGFFLSA-N 0.000 claims 1
• GUKZDVHGHQEBPH-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-nitrophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1[N+]([O-])=O GUKZDVHGHQEBPH-ADEWGFFLSA-N 0.000 claims 1
• HLTGHKOMDGQKFI-RIEGTJTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-nitrophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1[N+]([O-])=O HLTGHKOMDGQKFI-RIEGTJTDSA-N 0.000 claims 1
• DFFOPSCSQCNPMJ-AYOQOUSVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-phenoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1OC1=CC=CC=C1 DFFOPSCSQCNPMJ-AYOQOUSVSA-N 0.000 claims 1
• YYSJWUDWNTYLDT-AYOQOUSVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-phenylsulfanylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1SC1=CC=CC=C1 YYSJWUDWNTYLDT-AYOQOUSVSA-N 0.000 claims 1
• GTVGLSFDPPFSMK-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-piperidin-1-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1N1CCCCC1 GTVGLSFDPPFSMK-BPQIPLTHSA-N 0.000 claims 1
• WJLGLNFEKHQSQJ-HYVNUMGLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-pyrrolidin-1-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1N1CCCC1 WJLGLNFEKHQSQJ-HYVNUMGLSA-N 0.000 claims 1
• WYVWQUBJSXNUNC-OXHMUOHRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-dichlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=C(Cl)C(Cl)=C1 WYVWQUBJSXNUNC-OXHMUOHRSA-N 0.000 claims 1
• DWZONRNPLFQSSA-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-dichlorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(Cl)C(Cl)=C1 DWZONRNPLFQSSA-JIMOISOXSA-N 0.000 claims 1
• FUZGBJMJEGEFDL-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-dichlorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(Cl)C(Cl)=C1 FUZGBJMJEGEFDL-BYCMXARLSA-N 0.000 claims 1
• GNPLHALLJWGZMH-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-dichlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(Cl)C(Cl)=C1 GNPLHALLJWGZMH-FUEDEBDSSA-N 0.000 claims 1
• MXJOFSXDSMGGOK-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(Cl)C(Cl)=C1 MXJOFSXDSMGGOK-DDTOSNHZSA-N 0.000 claims 1
• XQHLYFZOVWTHSY-BIGNPOOSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-dichlorophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(Cl)C(Cl)=C1 XQHLYFZOVWTHSY-BIGNPOOSSA-N 0.000 claims 1
• GHAYXKVDIKTECE-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-difluorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(F)C(F)=C1 GHAYXKVDIKTECE-JIMOISOXSA-N 0.000 claims 1
• SVUIPEJAEOWALX-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-difluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(F)C(F)=C1 SVUIPEJAEOWALX-BYCMXARLSA-N 0.000 claims 1
• GPVXSPBCBWIKAR-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-difluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(F)C(F)=C1 GPVXSPBCBWIKAR-FUEDEBDSSA-N 0.000 claims 1
• GIGGHSROYWNDBH-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-difluorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(F)C(F)=C1 GIGGHSROYWNDBH-DDTOSNHZSA-N 0.000 claims 1
• HAYJJQMXXVTKRR-OXHMUOHRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-difluorophenyl)sulfanyl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1SC1=CC=C(F)C(F)=C1 HAYJJQMXXVTKRR-OXHMUOHRSA-N 0.000 claims 1
• FXPQKSCOKCOYRW-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-dichlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC(Cl)=CC(Cl)=C1 FXPQKSCOKCOYRW-KGYLQXTDSA-N 0.000 claims 1
• WPAYGPFPWZCNKS-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-dichlorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC(Cl)=CC(Cl)=C1 WPAYGPFPWZCNKS-FRRDWIJNSA-N 0.000 claims 1
• YSBQTKVARKWNGC-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-dichlorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC(Cl)=CC(Cl)=C1 YSBQTKVARKWNGC-FRRDWIJNSA-N 0.000 claims 1
• LKQXRISEDLUHBK-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-dichlorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC(Cl)=CC(Cl)=C1 LKQXRISEDLUHBK-QLFBSQMISA-N 0.000 claims 1
• VZXKHRJAAVNCET-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-dichlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC(Cl)=CC(Cl)=C1 VZXKHRJAAVNCET-IVMMDQJWSA-N 0.000 claims 1
• QDVXHDGMGOGZDC-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC(Cl)=CC(Cl)=C1 QDVXHDGMGOGZDC-HZSPNIEDSA-N 0.000 claims 1
• BDEPEUCZAQNGPJ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-difluorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC(F)=CC(F)=C1 BDEPEUCZAQNGPJ-FRRDWIJNSA-N 0.000 claims 1
• NCQSLUGQVUZGKT-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-difluorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC(F)=CC(F)=C1 NCQSLUGQVUZGKT-FRRDWIJNSA-N 0.000 claims 1
• ILQIHRKDNPUHAJ-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-difluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC(F)=CC(F)=C1 ILQIHRKDNPUHAJ-QLFBSQMISA-N 0.000 claims 1
• QMAVKZGHBIZMKQ-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-difluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC(F)=CC(F)=C1 QMAVKZGHBIZMKQ-IVMMDQJWSA-N 0.000 claims 1
• FTTZGKAOSKLVKA-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-difluorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC(F)=CC(F)=C1 FTTZGKAOSKLVKA-HZSPNIEDSA-N 0.000 claims 1
• XCUCMXYGXUSRLI-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-difluorophenyl)sulfanyl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1SC1=CC(F)=CC(F)=C1 XCUCMXYGXUSRLI-KGYLQXTDSA-N 0.000 claims 1
• SICSGNJFDWOFMR-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-bromophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(Br)=C1 SICSGNJFDWOFMR-FRRDWIJNSA-N 0.000 claims 1
• FRPFCPWRPAREKS-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-bromophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(Br)=C1 FRPFCPWRPAREKS-FRRDWIJNSA-N 0.000 claims 1
• SEXCXRSNYNVUAX-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-bromophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(Br)=C1 SEXCXRSNYNVUAX-IVMMDQJWSA-N 0.000 claims 1
• UDKAQRQBICWDOE-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-carbamoylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(C(N)=O)=C1 UDKAQRQBICWDOE-KWCYVHTRSA-N 0.000 claims 1
• GCEYKEQRKSZLIW-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-carbamoylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(C(N)=O)=C1 GCEYKEQRKSZLIW-HZSPNIEDSA-N 0.000 claims 1
• JGSTYJGNISRLJX-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=CC(Cl)=C1 JGSTYJGNISRLJX-KGYLQXTDSA-N 0.000 claims 1
• VUQNXUDVQLFMGD-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC(Cl)=C1 VUQNXUDVQLFMGD-KGYLQXTDSA-N 0.000 claims 1
• ZYKFGRZNPNQBQX-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(Cl)=C1 ZYKFGRZNPNQBQX-FRRDWIJNSA-N 0.000 claims 1
• ASLSRAGTHIDIFM-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(Cl)=C1 ASLSRAGTHIDIFM-FRRDWIJNSA-N 0.000 claims 1
• IPPWWQQJTGCKLD-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(Cl)=C1 IPPWWQQJTGCKLD-IVMMDQJWSA-N 0.000 claims 1
• CDWUNIUMRHDTLY-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)sulfanyl-1,3,4-thiadiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NN=C1SC1=CC=CC(Cl)=C1 CDWUNIUMRHDTLY-ADEWGFFLSA-N 0.000 claims 1
• VLEUSTAIFHSEJW-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=CC(Cl)=C1 VLEUSTAIFHSEJW-KGYLQXTDSA-N 0.000 claims 1
• MUHVTFBTZRYINT-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)sulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=CC(Cl)=C1 MUHVTFBTZRYINT-KWCYVHTRSA-N 0.000 claims 1
• MXQTVINLTJXZFV-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(Cl)=C1 MXQTVINLTJXZFV-KWCYVHTRSA-N 0.000 claims 1
• QAEWWDCJDDOIRA-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chloropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=NC=CC=C1Cl QAEWWDCJDDOIRA-ADEWGFFLSA-N 0.000 claims 1
• JUTLNGZFTQXKPN-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chloropyridin-4-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=NC=C1Cl JUTLNGZFTQXKPN-JIMOISOXSA-N 0.000 claims 1
• MHCZJBUTUPDMGC-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-cyanophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(C#N)=C1 MHCZJBUTUPDMGC-HZSPNIEDSA-N 0.000 claims 1
• MSRIFEYRJHAXJW-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-cyanophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(C#N)=C1 MSRIFEYRJHAXJW-HZSPNIEDSA-N 0.000 claims 1
• RGQCLRRELVAYOC-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-cyanophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(C#N)=C1 RGQCLRRELVAYOC-UKPHBRMFSA-N 0.000 claims 1
• JGAXNJHCZJZLBB-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoro-4-hydroxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(O)C(F)=C1 JGAXNJHCZJZLBB-KGYLQXTDSA-N 0.000 claims 1
• ITJVZUPHHYAISN-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoro-4-methoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(OC)C(F)=C1 ITJVZUPHHYAISN-KWCYVHTRSA-N 0.000 claims 1
• SSODURVNFZWBND-YZGWKJHDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoro-4-phenylmethoxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C(C=C1F)=CC=C1OCC1=CC=CC=C1 SSODURVNFZWBND-YZGWKJHDSA-N 0.000 claims 1
• WYHXSVMKSVXGIK-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=CC(F)=C1 WYHXSVMKSVXGIK-KGYLQXTDSA-N 0.000 claims 1
• MNZOUEUFEYOJAQ-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC(F)=C1 MNZOUEUFEYOJAQ-KGYLQXTDSA-N 0.000 claims 1
• KMCQVBNBOVGXHA-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenoxy)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1OC1=CC=CC(F)=C1 KMCQVBNBOVGXHA-KWCYVHTRSA-N 0.000 claims 1
• PGVXODQCHXJWCH-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(F)=C1 PGVXODQCHXJWCH-FRRDWIJNSA-N 0.000 claims 1
• WIGJKIWKEBEAHT-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(F)=C1 WIGJKIWKEBEAHT-FRRDWIJNSA-N 0.000 claims 1
• ROHPSPIZQMPCKP-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(F)=C1 ROHPSPIZQMPCKP-QLFBSQMISA-N 0.000 claims 1
• VTRWANFPPFXUSC-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(F)=C1 VTRWANFPPFXUSC-IVMMDQJWSA-N 0.000 claims 1
• CQNCLJGNOACIGZ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)-4-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC(F)=C1 CQNCLJGNOACIGZ-HZSPNIEDSA-N 0.000 claims 1
• DOAKKVZGJFJVLO-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)sulfanyl-1,3,4-thiadiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NN=C1SC1=CC=CC(F)=C1 DOAKKVZGJFJVLO-ADEWGFFLSA-N 0.000 claims 1
• LLFNKPAHKCDNJU-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=CC(F)=C1 LLFNKPAHKCDNJU-KGYLQXTDSA-N 0.000 claims 1
• OKYDZCHFGITDTA-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-2-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=NC=CC=C1F OKYDZCHFGITDTA-DVVUODLYSA-N 0.000 claims 1
• WPMNJAQFMHHPBA-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-2-yl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=NC=CC=C1F WPMNJAQFMHHPBA-DVVUODLYSA-N 0.000 claims 1
• MRGSHWMQWNGPMV-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-2-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=NC=CC=C1F MRGSHWMQWNGPMV-KGYLQXTDSA-N 0.000 claims 1
• DQLKJRYEKLOHQU-OLUVUFQESA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-2-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=NC=CC=C1F DQLKJRYEKLOHQU-OLUVUFQESA-N 0.000 claims 1
• MYAHTNZKSBTKJT-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=NC=CC=C1F MYAHTNZKSBTKJT-ADEWGFFLSA-N 0.000 claims 1
• SSXYVKPZVRGQLD-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-4-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=NC=C1F SSXYVKPZVRGQLD-DDTOSNHZSA-N 0.000 claims 1
• KFZVVWBYZSHVCI-ZDBHGNHJSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-4-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=NC=C1F KFZVVWBYZSHVCI-ZDBHGNHJSA-N 0.000 claims 1
• YFLXSTTVFDUATP-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-4-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=NC=C1F YFLXSTTVFDUATP-JIMOISOXSA-N 0.000 claims 1
• BAJYUQXMPJLZDV-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(O)=C1 BAJYUQXMPJLZDV-KGYLQXTDSA-N 0.000 claims 1
• ODYBBTIYXKPUHN-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(O)=C1 ODYBBTIYXKPUHN-KGYLQXTDSA-N 0.000 claims 1
• HSMPTTFARXYIKY-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(O)=C1 HSMPTTFARXYIKY-VHDGCEQUSA-N 0.000 claims 1
• WDFBSILDMBSLAF-DIOULYMOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(O)=C1 WDFBSILDMBSLAF-DIOULYMOSA-N 0.000 claims 1
• OKMZURFFXHWVJD-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(O)=C1 OKMZURFFXHWVJD-KWCYVHTRSA-N 0.000 claims 1
• MLAUYNIBMLNGSW-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(O)=C1 MLAUYNIBMLNGSW-KWCYVHTRSA-N 0.000 claims 1
• AEENTNWRHQQOJQ-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(OC)=C1 AEENTNWRHQQOJQ-BYCMXARLSA-N 0.000 claims 1
• ULNSABLGFFJRKX-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(OC)=C1 ULNSABLGFFJRKX-KWCYVHTRSA-N 0.000 claims 1
• YPGUQBATGVHKHN-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(OC)=C1 YPGUQBATGVHKHN-KWCYVHTRSA-N 0.000 claims 1
• MPQBZCZHSRZOGU-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(OC)=C1 MPQBZCZHSRZOGU-VNQPRFMTSA-N 0.000 claims 1
• WAIJDRQDMMASHP-ISTRZQFTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(OC)=C1 WAIJDRQDMMASHP-ISTRZQFTSA-N 0.000 claims 1
• BFHDKFLFNWTJPJ-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)-4-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC(OC)=C1 BFHDKFLFNWTJPJ-VHDGCEQUSA-N 0.000 claims 1
• DCINOUJSUAXFMJ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC(C)=C1 DCINOUJSUAXFMJ-KWCYVHTRSA-N 0.000 claims 1
• CHNZMLIOHLEVQY-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(C)=C1 CHNZMLIOHLEVQY-HZSPNIEDSA-N 0.000 claims 1
• WMOAOHMYRYBLQQ-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(C)=C1 WMOAOHMYRYBLQQ-UKPHBRMFSA-N 0.000 claims 1
• CWUKOQALGULDSC-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=CC(C)=C1 CWUKOQALGULDSC-KWCYVHTRSA-N 0.000 claims 1
• SJWTUKBCBVVKTP-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylsulfanylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(SC)=C1 SJWTUKBCBVVKTP-VHDGCEQUSA-N 0.000 claims 1
• KKOXNMOKVWTMSS-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-nitrophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC([N+]([O-])=O)=C1 KKOXNMOKVWTMSS-KGYLQXTDSA-N 0.000 claims 1
• HHMGEQKVVBUMBC-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-nitrophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC([N+]([O-])=O)=C1 HHMGEQKVVBUMBC-KGYLQXTDSA-N 0.000 claims 1
• SZRJPVJCGDPIME-DIOULYMOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-nitrophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC([N+]([O-])=O)=C1 SZRJPVJCGDPIME-DIOULYMOSA-N 0.000 claims 1
• ZBFHJSUQIRWIPW-LSTHTHJFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-phenoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1OC1=CC=CC=C1 ZBFHJSUQIRWIPW-LSTHTHJFSA-N 0.000 claims 1
• XAQVNNUGWULCEZ-LSTHTHJFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-phenylsulfanylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1SC1=CC=CC=C1 XAQVNNUGWULCEZ-LSTHTHJFSA-N 0.000 claims 1
• QNQUAFIZRBQFEG-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-pyrrolidin-1-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1N1CCCC1 QNQUAFIZRBQFEG-BPQIPLTHSA-N 0.000 claims 1
• JBCYODZVNQKTGY-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-bromophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(Br)C=C1 JBCYODZVNQKTGY-FRRDWIJNSA-N 0.000 claims 1
• JLZDLQJKKOAEEE-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-bromophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(Br)C=C1 JLZDLQJKKOAEEE-FRRDWIJNSA-N 0.000 claims 1
• IPZLIQKSVDYYLE-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-bromophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(Br)C=C1 IPZLIQKSVDYYLE-IVMMDQJWSA-N 0.000 claims 1
• OYNOOGVMYISBTQ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-carbamoylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C(N)=O)C=C1 OYNOOGVMYISBTQ-KWCYVHTRSA-N 0.000 claims 1
• IRQLBHQKGUVLOU-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-carbamoylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C(N)=O)C=C1 IRQLBHQKGUVLOU-HZSPNIEDSA-N 0.000 claims 1
• IJISIGBCBGNXCB-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloro-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(Cl)=CO1 IJISIGBCBGNXCB-HRDYMLBCSA-N 0.000 claims 1
• DONAVHYJNBCDMN-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloro-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(Cl)=CS1 DONAVHYJNBCDMN-HRDYMLBCSA-N 0.000 claims 1
• ADJUUHGEXTVZFU-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloro-2-nitrophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(Cl)C=C1[N+]([O-])=O ADJUUHGEXTVZFU-KGYLQXTDSA-N 0.000 claims 1
• VFATYYDBYALETN-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenoxy)-1,3,4-thiadiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NN=C1OC1=CC=C(Cl)C=C1 VFATYYDBYALETN-ADEWGFFLSA-N 0.000 claims 1
• RFBQGNVNALKYFO-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=C(Cl)C=C1 RFBQGNVNALKYFO-KGYLQXTDSA-N 0.000 claims 1
• JQWXVJXUNDHKCE-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=C(Cl)C=C1 JQWXVJXUNDHKCE-KGYLQXTDSA-N 0.000 claims 1
• KCCMHPLBWRWNOH-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(Cl)C=C1 KCCMHPLBWRWNOH-FRRDWIJNSA-N 0.000 claims 1
• DHAGXGSGIACDSC-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(Cl)C=C1 DHAGXGSGIACDSC-FRRDWIJNSA-N 0.000 claims 1
• SNIQVFBWHCRHIC-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(Cl)C=C1 SNIQVFBWHCRHIC-IVMMDQJWSA-N 0.000 claims 1
• SMWMKAAVSYXLQT-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)sulfanyl-1,3,4-thiadiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NN=C1SC1=CC=C(Cl)C=C1 SMWMKAAVSYXLQT-ADEWGFFLSA-N 0.000 claims 1
• AETGCORJQNDOHX-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=C(Cl)C=C1 AETGCORJQNDOHX-KGYLQXTDSA-N 0.000 claims 1
• WQVGWPNXGRDITG-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)sulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=C(Cl)C=C1 WQVGWPNXGRDITG-KWCYVHTRSA-N 0.000 claims 1
• LDCKWMISCYMDAG-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC(Cl)=CC=N1 LDCKWMISCYMDAG-GRYCIOLGSA-N 0.000 claims 1
• GLJCTQRJBXNCMK-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloropyridin-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC(Cl)=CC=N1 GLJCTQRJBXNCMK-GRYCIOLGSA-N 0.000 claims 1
• RKWWVCBIBFZMRA-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloropyridin-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC(Cl)=CC=N1 RKWWVCBIBFZMRA-GRYCIOLGSA-N 0.000 claims 1
• BGHQJNAOVIHSEO-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloropyridin-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC(Cl)=CC=N1 BGHQJNAOVIHSEO-GRYCIOLGSA-N 0.000 claims 1
• FTRPLXFPNRUQJV-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CN=CC=C1Cl FTRPLXFPNRUQJV-JIMOISOXSA-N 0.000 claims 1
• XEDYZXRFASEBFM-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-cyanophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(C#N)C=C1 XEDYZXRFASEBFM-HZSPNIEDSA-N 0.000 claims 1
• ZPGQKSFZYBUYSZ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-cyanophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(C#N)C=C1 ZPGQKSFZYBUYSZ-HZSPNIEDSA-N 0.000 claims 1
• JNMDVZZTEKNQJV-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-cyanophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(C#N)C=C1 JNMDVZZTEKNQJV-UKPHBRMFSA-N 0.000 claims 1
• BDYFCWKQUODZOI-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoro-3-methylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(F)C(C)=C1 BDYFCWKQUODZOI-VHDGCEQUSA-N 0.000 claims 1
• YVRYTMQKNRWDER-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenoxy)-1,3,4-thiadiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NN=C1OC1=CC=C(F)C=C1 YVRYTMQKNRWDER-ADEWGFFLSA-N 0.000 claims 1
• JYVCQFGAMBGDKT-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=C(F)C=C1 JYVCQFGAMBGDKT-KGYLQXTDSA-N 0.000 claims 1
• LBZHNBYLNHKNFR-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=C(F)C=C1 LBZHNBYLNHKNFR-KGYLQXTDSA-N 0.000 claims 1
• ZUYNNKSHJQOFQQ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenoxy)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1OC1=CC=C(F)C=C1 ZUYNNKSHJQOFQQ-KWCYVHTRSA-N 0.000 claims 1
• UFWGODXWDZFASH-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(F)C=C1 UFWGODXWDZFASH-FRRDWIJNSA-N 0.000 claims 1
• HJFNYARAPAUFJX-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(F)C=C1 HJFNYARAPAUFJX-FRRDWIJNSA-N 0.000 claims 1
• KDNZSZPFOBKPBS-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(F)C=C1 KDNZSZPFOBKPBS-IVMMDQJWSA-N 0.000 claims 1
• FKWKJHBIGTYZOB-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)sulfanyl-1,3,4-thiadiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NN=C1SC1=CC=C(F)C=C1 FKWKJHBIGTYZOB-ADEWGFFLSA-N 0.000 claims 1
• HYEMNDKNKPCWNJ-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=C(F)C=C1 HYEMNDKNKPCWNJ-KGYLQXTDSA-N 0.000 claims 1
• RVAPUCJVJIUEQS-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)sulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=C(F)C=C1 RVAPUCJVJIUEQS-KWCYVHTRSA-N 0.000 claims 1
• OGQGVZHBWJESDN-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-2-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC(F)=CC=N1 OGQGVZHBWJESDN-OUAUKWLOSA-N 0.000 claims 1
• LPSRZCVCXQFQAG-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-2-yl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC(F)=CC=N1 LPSRZCVCXQFQAG-OUAUKWLOSA-N 0.000 claims 1
• BQFMBWQVGPQEEL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-2-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC(F)=CC=N1 BQFMBWQVGPQEEL-FRRDWIJNSA-N 0.000 claims 1
• ULXRVMKVFLDPFC-IFUGULHKSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-2-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC(F)=CC=N1 ULXRVMKVFLDPFC-IFUGULHKSA-N 0.000 claims 1
• LGELFNPMLUHMMD-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC(F)=CC=N1 LGELFNPMLUHMMD-GRYCIOLGSA-N 0.000 claims 1
• JFICGJXMROBZCF-JFUSQASVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-3-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CN=CC=C1F JFICGJXMROBZCF-JFUSQASVSA-N 0.000 claims 1
• FSWWAEBDDGKIAY-JFUSQASVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-3-yl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CN=CC=C1F FSWWAEBDDGKIAY-JFUSQASVSA-N 0.000 claims 1
• LGZRCDQTIGLMLD-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-3-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CN=CC=C1F LGZRCDQTIGLMLD-DDTOSNHZSA-N 0.000 claims 1
• MJPWOIHLOFAWRH-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CN=CC=C1F MJPWOIHLOFAWRH-JIMOISOXSA-N 0.000 claims 1
• OXDLLQBNIGYKSM-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=C(O)C=C1 OXDLLQBNIGYKSM-JIMOISOXSA-N 0.000 claims 1
• ZTFGLCVEMMZEQF-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(O)C=C1 ZTFGLCVEMMZEQF-DDTOSNHZSA-N 0.000 claims 1
• JJUMFJLHTQZTRH-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(O)C=C1 JJUMFJLHTQZTRH-KGYLQXTDSA-N 0.000 claims 1
• FJKRUWVQDPCUOR-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(O)C=C1 FJKRUWVQDPCUOR-KGYLQXTDSA-N 0.000 claims 1
• KFXKNGGNQFDUDC-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(O)C=C1 KFXKNGGNQFDUDC-VHDGCEQUSA-N 0.000 claims 1
• JBWKTMIEYPUOCL-DIOULYMOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(O)C=C1 JBWKTMIEYPUOCL-DIOULYMOSA-N 0.000 claims 1
• KKVNGOTUOGOJPX-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(O)C=C1 KKVNGOTUOGOJPX-KWCYVHTRSA-N 0.000 claims 1
• JXQDZDNQDQMVEG-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=C(O)C=C1 JXQDZDNQDQMVEG-JIMOISOXSA-N 0.000 claims 1
• ABXKBGYXJYBHMU-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxy-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(OC)=CO1 ABXKBGYXJYBHMU-KXUCPTDWSA-N 0.000 claims 1
• XAOVMPLEQGOLAA-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxy-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(OC)=CS1 XAOVMPLEQGOLAA-KXUCPTDWSA-N 0.000 claims 1
• OFFZBKGWVPRXCE-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=C(OC)C=C1 OFFZBKGWVPRXCE-DDTOSNHZSA-N 0.000 claims 1
• FBXWRBRGYSVOTM-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(OC)C=C1 FBXWRBRGYSVOTM-BYCMXARLSA-N 0.000 claims 1
• IEIVZQARKNEHTK-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(OC)C=C1 IEIVZQARKNEHTK-KWCYVHTRSA-N 0.000 claims 1
• LHRJYNFOTYHYBB-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(OC)C=C1 LHRJYNFOTYHYBB-VNQPRFMTSA-N 0.000 claims 1
• YPPIVFMRHCNEPR-ISTRZQFTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(OC)C=C1 YPPIVFMRHCNEPR-ISTRZQFTSA-N 0.000 claims 1
• FITYWFNZHOGGFU-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(OC)C=C1 FITYWFNZHOGGFU-VHDGCEQUSA-N 0.000 claims 1
• RMVPBTDUSYDMKG-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=C(OC)C=C1 RMVPBTDUSYDMKG-DDTOSNHZSA-N 0.000 claims 1
• KMBWNMYKJOHTRB-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methyl-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(C)=CO1 KMBWNMYKJOHTRB-OUAUKWLOSA-N 0.000 claims 1
• UWHJDXBVEJIHOV-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methyl-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(C)=CS1 UWHJDXBVEJIHOV-OUAUKWLOSA-N 0.000 claims 1
• DAGVNWOXSHLWGX-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methyl-2-nitrophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(C)C=C1[N+]([O-])=O DAGVNWOXSHLWGX-KWCYVHTRSA-N 0.000 claims 1
• OAEAMIIORVVILX-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=C(C)C=C1 OAEAMIIORVVILX-KWCYVHTRSA-N 0.000 claims 1
• DTQRAUPUZPUDPN-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(C)C=C1 DTQRAUPUZPUDPN-HZSPNIEDSA-N 0.000 claims 1
• GYRBPRBODBPGQN-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(C)C=C1 GYRBPRBODBPGQN-HZSPNIEDSA-N 0.000 claims 1
• WYDUFUXFTJFGOX-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(C)C=C1 WYDUFUXFTJFGOX-UKPHBRMFSA-N 0.000 claims 1
• WWZRYZXBFRUWSI-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=C(C)C=C1 WWZRYZXBFRUWSI-KWCYVHTRSA-N 0.000 claims 1
• MLEACMXGRHDUCQ-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylsulfanylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(SC)C=C1 MLEACMXGRHDUCQ-VHDGCEQUSA-N 0.000 claims 1
• XIAQOWXMOCMTDQ-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-morpholin-4-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1N1CCOCC1 XIAQOWXMOCMTDQ-BPQIPLTHSA-N 0.000 claims 1
• RWVKNSAPAAKAMY-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-nitrophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C([N+]([O-])=O)C=C1 RWVKNSAPAAKAMY-KGYLQXTDSA-N 0.000 claims 1
• YYNQGZDEKGEJBE-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-nitrophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C([N+]([O-])=O)C=C1 YYNQGZDEKGEJBE-KGYLQXTDSA-N 0.000 claims 1
• BXVUPCDRFBLCHP-DIOULYMOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-nitrophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C([N+]([O-])=O)C=C1 BXVUPCDRFBLCHP-DIOULYMOSA-N 0.000 claims 1
• UUNPQLDXKIRCNQ-LSTHTHJFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-phenoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1OC1=CC=CC=C1 UUNPQLDXKIRCNQ-LSTHTHJFSA-N 0.000 claims 1
• ILHRXCIUSRIHDE-LSTHTHJFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-phenylsulfanylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1SC1=CC=CC=C1 ILHRXCIUSRIHDE-LSTHTHJFSA-N 0.000 claims 1
• DYLIPLKWFNJCPL-NZSAHSFTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-piperidin-1-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1N1CCCCC1 DYLIPLKWFNJCPL-NZSAHSFTSA-N 0.000 claims 1
• RQPAPSWKUQXHIM-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-propan-2-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(C(C)C)C=C1 RQPAPSWKUQXHIM-IXDOHACOSA-N 0.000 claims 1
• LHMMFFYRAKAUDK-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-pyrrolidin-1-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1N1CCCC1 LHMMFFYRAKAUDK-BPQIPLTHSA-N 0.000 claims 1
• UDYAPWMHHSGBCK-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-tert-butylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 UDYAPWMHHSGBCK-IXDOHACOSA-N 0.000 claims 1
• QBDVNAIUAJZPSL-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloro-1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=C(Cl)S1 QBDVNAIUAJZPSL-GJMOJQLCSA-N 0.000 claims 1
• QISXBKWSHDWYBT-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloro-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(Cl)O1 QISXBKWSHDWYBT-HRDYMLBCSA-N 0.000 claims 1
• IELJOFGIVSRPMK-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloro-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(Cl)S1 IELJOFGIVSRPMK-HRDYMLBCSA-N 0.000 claims 1
• IUYNHEVAZNBGFC-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorofuran-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(Cl)O1 IUYNHEVAZNBGFC-KXUCPTDWSA-N 0.000 claims 1
• PPFPECVROOQGHT-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorofuran-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(Cl)O1 PPFPECVROOQGHT-KXUCPTDWSA-N 0.000 claims 1
• AKBUNAFLDVSWFN-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorofuran-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(Cl)O1 AKBUNAFLDVSWFN-KXUCPTDWSA-N 0.000 claims 1
• LESINCAWZPCTFV-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(Cl)C=N1 LESINCAWZPCTFV-NTZNESFSSA-N 0.000 claims 1
• CJSXINWTETULMX-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(Cl)C=N1 CJSXINWTETULMX-NTZNESFSSA-N 0.000 claims 1
• REYJZDYRPVPKTJ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CN=CC(Cl)=C1 REYJZDYRPVPKTJ-FRRDWIJNSA-N 0.000 claims 1
• WRXFCZDHYQSEPM-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-3-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=CC(Cl)=C1 WRXFCZDHYQSEPM-KGYLQXTDSA-N 0.000 claims 1
• IEVMOSIFNGBUIL-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-3-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=CC(Cl)=C1 IEVMOSIFNGBUIL-KGYLQXTDSA-N 0.000 claims 1
• WXLTXUCHEIDYJG-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-3-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=CC(Cl)=C1 WXLTXUCHEIDYJG-FRRDWIJNSA-N 0.000 claims 1
• YYGXLLBIYAYNRO-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorothiophen-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(Cl)S1 YYGXLLBIYAYNRO-KXUCPTDWSA-N 0.000 claims 1
• KABCHQBWCVPHBN-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorothiophen-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(Cl)S1 KABCHQBWCVPHBN-KXUCPTDWSA-N 0.000 claims 1
• PZTVZRXNNPIOKU-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorothiophen-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(Cl)S1 PZTVZRXNNPIOKU-KXUCPTDWSA-N 0.000 claims 1
• ZOLDOSZCSWYMMR-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-2-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(F)C=N1 ZOLDOSZCSWYMMR-JFGNBEQYSA-N 0.000 claims 1
• FGZSWFLMLYBSET-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-2-yl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(F)C=N1 FGZSWFLMLYBSET-JFGNBEQYSA-N 0.000 claims 1
• XUPLRZMUKBFLTI-MBNYWOFBSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-2-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(F)C=N1 XUPLRZMUKBFLTI-MBNYWOFBSA-N 0.000 claims 1
• DMRVIBATKSLNHU-RIEGTJTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-2-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(F)C=N1 DMRVIBATKSLNHU-RIEGTJTDSA-N 0.000 claims 1
• TZFZSUJRUVOXNA-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(F)C=N1 TZFZSUJRUVOXNA-NTZNESFSSA-N 0.000 claims 1
• CGWHFEJGFAXUTE-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-3-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CN=CC(F)=C1 CGWHFEJGFAXUTE-GRYCIOLGSA-N 0.000 claims 1
• BSWOGPNYALUVGE-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-3-yl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CN=CC(F)=C1 BSWOGPNYALUVGE-GRYCIOLGSA-N 0.000 claims 1
• FFCFERMOLICTPK-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-3-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CN=CC(F)=C1 FFCFERMOLICTPK-HZSPNIEDSA-N 0.000 claims 1
• SKTZMRAPZSNNEC-OSAQELSMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-3-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CN=CC(F)=C1 SKTZMRAPZSNNEC-OSAQELSMSA-N 0.000 claims 1
• RUVVRTZJLMJERL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CN=CC(F)=C1 RUVVRTZJLMJERL-FRRDWIJNSA-N 0.000 claims 1
• VNKDYWPBLRBBON-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxy-1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=C(OC)S1 VNKDYWPBLRBBON-HRDYMLBCSA-N 0.000 claims 1
• CSXOWVAOPINISS-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxy-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(OC)O1 CSXOWVAOPINISS-KXUCPTDWSA-N 0.000 claims 1
• SIDHKDSUFJDOHE-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxy-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(OC)S1 SIDHKDSUFJDOHE-KXUCPTDWSA-N 0.000 claims 1
• BSKIBBNJYZMAME-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxyfuran-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(OC)O1 BSKIBBNJYZMAME-OUAUKWLOSA-N 0.000 claims 1
• XOPYIVFTALAZIH-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxyfuran-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(OC)O1 XOPYIVFTALAZIH-OUAUKWLOSA-N 0.000 claims 1
• JIHLFWXKVUOSCN-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxyfuran-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(OC)O1 JIHLFWXKVUOSCN-OUAUKWLOSA-N 0.000 claims 1
• VBCNCKJGXFRDOC-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxypyridin-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(OC)C=N1 VBCNCKJGXFRDOC-KGYLQXTDSA-N 0.000 claims 1
• PJEBMKXPMGQHHK-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxypyridin-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(OC)C=N1 PJEBMKXPMGQHHK-KGYLQXTDSA-N 0.000 claims 1
• VYRCORDMWVLSBG-SCDSUCTJSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxypyridin-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(OC)C=N1 VYRCORDMWVLSBG-SCDSUCTJSA-N 0.000 claims 1
• QNYHRVQERJQMAL-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxythiophen-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(OC)S1 QNYHRVQERJQMAL-OUAUKWLOSA-N 0.000 claims 1
• BYCKXKYBOSASHD-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxythiophen-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(OC)S1 BYCKXKYBOSASHD-OUAUKWLOSA-N 0.000 claims 1
• GXSQXBZUDYCCDN-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxythiophen-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(OC)S1 GXSQXBZUDYCCDN-OUAUKWLOSA-N 0.000 claims 1
• JYHHCZBTFNLVHC-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methyl-1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=C(C)S1 JYHHCZBTFNLVHC-KXUCPTDWSA-N 0.000 claims 1
• BNRDBTSKQTUVAM-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methyl-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(C)O1 BNRDBTSKQTUVAM-OUAUKWLOSA-N 0.000 claims 1
• RQXSGCOVDFAFCV-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methyl-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(C)S1 RQXSGCOVDFAFCV-OUAUKWLOSA-N 0.000 claims 1
• NGAAKDRELRXDJB-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylfuran-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C)O1 NGAAKDRELRXDJB-GRYCIOLGSA-N 0.000 claims 1
• AFCXQSUMUYGNOW-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylfuran-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C)O1 AFCXQSUMUYGNOW-GRYCIOLGSA-N 0.000 claims 1
• QLQXQCYZMWOUNK-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylfuran-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C)O1 QLQXQCYZMWOUNK-GRYCIOLGSA-N 0.000 claims 1
• UEYTZEMSIOTCLI-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylpyridin-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C)C=N1 UEYTZEMSIOTCLI-FRRDWIJNSA-N 0.000 claims 1
• KWDIFPQHKFSWRJ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylpyridin-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C)C=N1 KWDIFPQHKFSWRJ-FRRDWIJNSA-N 0.000 claims 1
• ZZPYPCOIZAJFIL-MBNYWOFBSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylpyridin-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C)C=N1 ZZPYPCOIZAJFIL-MBNYWOFBSA-N 0.000 claims 1
• ZPFBPZXTACSBOF-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylthiophen-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C)S1 ZPFBPZXTACSBOF-GRYCIOLGSA-N 0.000 claims 1
• DSUPXDCPVCWYHO-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylthiophen-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C)S1 DSUPXDCPVCWYHO-GRYCIOLGSA-N 0.000 claims 1
• YVUDHESWKVSREZ-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(Cl)=N1 YVUDHESWKVSREZ-JFGNBEQYSA-N 0.000 claims 1
• AECUNKQMGIWZLQ-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(Cl)=N1 AECUNKQMGIWZLQ-OUAUKWLOSA-N 0.000 claims 1
• DEOORWSEERHKOQ-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(Cl)=N1 DEOORWSEERHKOQ-OUAUKWLOSA-N 0.000 claims 1
• OSZUFOYQSRPXBP-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(Cl)=N1 OSZUFOYQSRPXBP-JFGNBEQYSA-N 0.000 claims 1
• WOQBMPKHNCTNBM-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(Cl)N=C1 WOQBMPKHNCTNBM-GRYCIOLGSA-N 0.000 claims 1
• CBHZUWBHMRUKOG-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-3-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(Cl)N=C1 CBHZUWBHMRUKOG-GRYCIOLGSA-N 0.000 claims 1
• XDTSXGCONWPDRF-WCABBAIRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-2-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(F)=N1 XDTSXGCONWPDRF-WCABBAIRSA-N 0.000 claims 1
• LEAYPJBCMQJWBE-WCABBAIRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-2-yl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(F)=N1 LEAYPJBCMQJWBE-WCABBAIRSA-N 0.000 claims 1
• FADHVNNKMKAINP-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-2-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(F)=N1 FADHVNNKMKAINP-NTZNESFSSA-N 0.000 claims 1
• DRWJMKSYNJWDJY-LJWDBELGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-2-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(F)=N1 DRWJMKSYNJWDJY-LJWDBELGSA-N 0.000 claims 1
• FOFBFGDCCQKZFX-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(F)=N1 FOFBFGDCCQKZFX-JFGNBEQYSA-N 0.000 claims 1
• GJEAPZFAODDCQB-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-3-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(F)N=C1 GJEAPZFAODDCQB-OUAUKWLOSA-N 0.000 claims 1
• CCSUTQWORYXLJO-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-3-yl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(F)N=C1 CCSUTQWORYXLJO-OUAUKWLOSA-N 0.000 claims 1
• GQXCKEGTGLIVAV-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-3-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(F)N=C1 GQXCKEGTGLIVAV-FRRDWIJNSA-N 0.000 claims 1
• ALNDQHPGMWPRCF-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(F)N=C1 ALNDQHPGMWPRCF-GRYCIOLGSA-N 0.000 claims 1
• IWEDBDIHDSIQCJ-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-methoxypyridin-3-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(OC)N=C1 IWEDBDIHDSIQCJ-KGYLQXTDSA-N 0.000 claims 1
• YNLKEPWDYBQWIP-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-methoxypyridin-3-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(OC)N=C1 YNLKEPWDYBQWIP-KGYLQXTDSA-N 0.000 claims 1
• BXDZXCMWYRTUIU-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-methoxypyridin-3-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(OC)N=C1 BXDZXCMWYRTUIU-FRRDWIJNSA-N 0.000 claims 1
• TZVSSBAGSZTYBE-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-methylpyridin-3-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C)N=C1 TZVSSBAGSZTYBE-KWCYVHTRSA-N 0.000 claims 1
• INWLVFWZCOBNET-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-methylpyridin-3-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C)N=C1 INWLVFWZCOBNET-KWCYVHTRSA-N 0.000 claims 1
• SFFUEKUWCSSBPE-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-methylpyridin-3-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C)N=C1 SFFUEKUWCSSBPE-HZSPNIEDSA-N 0.000 claims 1
• FYYCEFBCUDBSMK-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(furan-3-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC=1C=COC=1 FYYCEFBCUDBSMK-ADEWGFFLSA-N 0.000 claims 1
• YCTYWMBFJBREHG-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(furan-3-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC=1C=COC=1 YCTYWMBFJBREHG-ADEWGFFLSA-N 0.000 claims 1
• LTOYWJLJMLSCBF-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-chloro-1,3-oxazol-5-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=C(Cl)O1 LTOYWJLJMLSCBF-HRDYMLBCSA-N 0.000 claims 1
• OUFZKNIFPXKLGP-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-chloro-1,3-oxazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(Cl)O1 OUFZKNIFPXKLGP-HRDYMLBCSA-N 0.000 claims 1
• DZBOURNKMONNTM-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-chloro-1,3-thiazol-5-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=C(Cl)S1 DZBOURNKMONNTM-HRDYMLBCSA-N 0.000 claims 1
• GOPJVAFJXWMTLE-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-chloro-1,3-thiazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(Cl)S1 GOPJVAFJXWMTLE-HRDYMLBCSA-N 0.000 claims 1
• BKRNXEHXCLCVLU-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methoxy-1,3-oxazol-5-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=C(OC)O1 BKRNXEHXCLCVLU-KXUCPTDWSA-N 0.000 claims 1
• CVJQMKHEHAVHGV-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methoxy-1,3-oxazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(OC)O1 CVJQMKHEHAVHGV-KXUCPTDWSA-N 0.000 claims 1
• IXZMAIUMJQSDQY-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methoxy-1,3-thiazol-5-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=C(OC)S1 IXZMAIUMJQSDQY-KXUCPTDWSA-N 0.000 claims 1
• RUKHCJHBBZCLRS-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methoxy-1,3-thiazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(OC)S1 RUKHCJHBBZCLRS-KXUCPTDWSA-N 0.000 claims 1
• FADIJQMXMMWKOL-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methyl-1,3-oxazol-5-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=C(C)O1 FADIJQMXMMWKOL-OUAUKWLOSA-N 0.000 claims 1
• GKLBTVRNYPEQIJ-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methyl-1,3-oxazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(C)O1 GKLBTVRNYPEQIJ-OUAUKWLOSA-N 0.000 claims 1
• WZCDJNLPKMLOLC-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methyl-1,3-thiazol-5-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=C(C)S1 WZCDJNLPKMLOLC-OUAUKWLOSA-N 0.000 claims 1
• KFFXDVZFQPXTFB-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methyl-1,3-thiazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(C)S1 KFFXDVZFQPXTFB-OUAUKWLOSA-N 0.000 claims 1
• FDAKDSOCTVITPX-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-chloro-1,3-oxazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC(Cl)=CO1 FDAKDSOCTVITPX-HRDYMLBCSA-N 0.000 claims 1
• PSOGYUYZBZQFFP-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-chloro-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC(Cl)=CO1 PSOGYUYZBZQFFP-HRDYMLBCSA-N 0.000 claims 1
• DZSFMTGTIYLULC-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-chloro-1,3-thiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC(Cl)=CS1 DZSFMTGTIYLULC-HRDYMLBCSA-N 0.000 claims 1
• UNSFAENZSUCWSA-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methoxy-1,3-oxazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC(OC)=CO1 UNSFAENZSUCWSA-KXUCPTDWSA-N 0.000 claims 1
• ZGDGFNLVQHBUDZ-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methoxy-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC(OC)=CO1 ZGDGFNLVQHBUDZ-KXUCPTDWSA-N 0.000 claims 1
• MHIJLKFQBCPOBL-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methoxy-1,3-thiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC(OC)=CS1 MHIJLKFQBCPOBL-KXUCPTDWSA-N 0.000 claims 1
• KKTONNGVQFRSQZ-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methoxy-1,3-thiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC(OC)=CS1 KKTONNGVQFRSQZ-KXUCPTDWSA-N 0.000 claims 1
• FFUFBOKTPVUENT-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methyl-1,3-oxazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC(C)=CO1 FFUFBOKTPVUENT-OUAUKWLOSA-N 0.000 claims 1
• BEVUFLLGUHBJDJ-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methyl-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC(C)=CO1 BEVUFLLGUHBJDJ-OUAUKWLOSA-N 0.000 claims 1
• HQLNNXYUGXDBRE-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methyl-1,3-thiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC(C)=CS1 HQLNNXYUGXDBRE-OUAUKWLOSA-N 0.000 claims 1
• FCMMVPMZIIXLSI-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC(C)=CS1 FCMMVPMZIIXLSI-OUAUKWLOSA-N 0.000 claims 1
• BHNOGGIOQJHAQJ-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3,4-thiadiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NN=C(Cl)S1 BHNOGGIOQJHAQJ-GJMOJQLCSA-N 0.000 claims 1
• LEGJXUDBNVRHID-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3,4-thiadiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=C(Cl)S1 LEGJXUDBNVRHID-GJMOJQLCSA-N 0.000 claims 1
• IRLZNACMXFYXCN-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3-oxazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(Cl)O1 IRLZNACMXFYXCN-HRDYMLBCSA-N 0.000 claims 1
• AFQSPEKTKSOTQK-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(Cl)O1 AFQSPEKTKSOTQK-HRDYMLBCSA-N 0.000 claims 1
• VZWUWOYJBUTGMY-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3-thiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(Cl)S1 VZWUWOYJBUTGMY-HRDYMLBCSA-N 0.000 claims 1
• IMURUPPDFJGWHI-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3-thiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(Cl)S1 IMURUPPDFJGWHI-HRDYMLBCSA-N 0.000 claims 1
• AGWOUQUQRRMLKJ-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3,4-thiadiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=C(OC)S1 AGWOUQUQRRMLKJ-HRDYMLBCSA-N 0.000 claims 1
• ATTCBIZXIPPOLK-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3-oxazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(OC)O1 ATTCBIZXIPPOLK-KXUCPTDWSA-N 0.000 claims 1
• OZOPDIJMIVNXCV-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(OC)O1 OZOPDIJMIVNXCV-KXUCPTDWSA-N 0.000 claims 1
• JGZWEAXIMSXDOE-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3-thiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(OC)S1 JGZWEAXIMSXDOE-KXUCPTDWSA-N 0.000 claims 1
• YJGYILZNGFWONL-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3-thiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(OC)S1 YJGYILZNGFWONL-KXUCPTDWSA-N 0.000 claims 1
• GASKUBCWCBEDEK-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3,4-thiadiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NN=C(C)S1 GASKUBCWCBEDEK-KXUCPTDWSA-N 0.000 claims 1
• CGDAIDDXBQIXIO-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=C(C)S1 CGDAIDDXBQIXIO-KXUCPTDWSA-N 0.000 claims 1
• OHMOIKMUTGAHGY-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3-oxazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(C)O1 OHMOIKMUTGAHGY-OUAUKWLOSA-N 0.000 claims 1
• YMXIZRJYIMFDEA-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(C)O1 YMXIZRJYIMFDEA-OUAUKWLOSA-N 0.000 claims 1
• VQXAJGKRELQOAG-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3-thiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(C)S1 VQXAJGKRELQOAG-OUAUKWLOSA-N 0.000 claims 1
• WHNVBCOYCFZPIA-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3-thiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(C)S1 WHNVBCOYCFZPIA-OUAUKWLOSA-N 0.000 claims 1
• AFFZRVAZSRXQEQ-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(1,2-thiazol-5-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C1=CC=NS1 AFFZRVAZSRXQEQ-UHOFOFEASA-N 0.000 claims 1
• YNHMSKSLCZLWDL-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(1,3-oxazol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C1=NC=CO1 YNHMSKSLCZLWDL-UHOFOFEASA-N 0.000 claims 1
• OKXFMDVZRSCWQK-JEBQAFNWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(1h-pyrrol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C1=CC=CN1 OKXFMDVZRSCWQK-JEBQAFNWSA-N 0.000 claims 1
• VTBHPEPHPQPVLO-HYVNUMGLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(3-chlorophenyl)ethenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C=CC1=CC=CC(Cl)=C1 VTBHPEPHPQPVLO-HYVNUMGLSA-N 0.000 claims 1
• YJBJYDQSQAKQMG-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(5-methylfuran-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C1=CC=C(C)O1 YJBJYDQSQAKQMG-FHLIZLRMSA-N 0.000 claims 1
• RROINJYELCOWHN-UIAACRFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(benzenesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1NS(=O)(=O)C1=CC=CC=C1 RROINJYELCOWHN-UIAACRFSSA-N 0.000 claims 1
• CFJDQJXEWFUTPU-XOKHGSTOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(furan-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C1=CC=CO1 CFJDQJXEWFUTPU-XOKHGSTOSA-N 0.000 claims 1
• ATZTYLGVQCRWJX-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(furan-3-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C=1C=COC=1 ATZTYLGVQCRWJX-FHLIZLRMSA-N 0.000 claims 1
• ALSJTENESBCCQO-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methanesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1NS(C)(=O)=O ALSJTENESBCCQO-BYCMXARLSA-N 0.000 claims 1
• HKCAYOVVZDVUSR-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methylamino)phenyl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1NC HKCAYOVVZDVUSR-DDTOSNHZSA-N 0.000 claims 1
• YIZMBONUGFHFRS-XQAQDONZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methylamino)phenyl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1NC YIZMBONUGFHFRS-XQAQDONZSA-N 0.000 claims 1
• FSVXSOAHFSBKAT-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methylcarbamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C(=O)NC FSVXSOAHFSBKAT-BYCMXARLSA-N 0.000 claims 1
• HRTZWOORYLQOEJ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methylsulfamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1S(=O)(=O)NC HRTZWOORYLQOEJ-KWCYVHTRSA-N 0.000 claims 1
• HGBKTMGYULUIBH-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(trifluoromethoxy)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1OC(F)(F)F HGBKTMGYULUIBH-KGYLQXTDSA-N 0.000 claims 1
• HVSNJZQVHRIIKV-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(trifluoromethyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C(F)(F)F HVSNJZQVHRIIKV-DDTOSNHZSA-N 0.000 claims 1
• ZHTUSWNFMQJKDK-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(trifluoromethylsulfonylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1NS(=O)(=O)C(F)(F)F ZHTUSWNFMQJKDK-DDTOSNHZSA-N 0.000 claims 1
• NCVJHYURFNYKNI-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-[(2,2-difluoroacetyl)amino]phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1NC(=O)C(F)F NCVJHYURFNYKNI-NTZNESFSSA-N 0.000 claims 1
• NZHIOENQHCZPHS-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC(C(F)(F)F)=NN1C NZHIOENQHCZPHS-KXUCPTDWSA-N 0.000 claims 1
• CMZFPCPXSFBSDI-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(1,2-thiazol-5-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C1=CC=NS1 CMZFPCPXSFBSDI-OWCLPIDISA-N 0.000 claims 1
• QWXNZADGDUMAPP-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(1,3-oxazol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C1=NC=CO1 QWXNZADGDUMAPP-OWCLPIDISA-N 0.000 claims 1
• MPIXYOCAKOGMSW-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(1h-pyrrol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C1=CC=CN1 MPIXYOCAKOGMSW-BPQIPLTHSA-N 0.000 claims 1
• NTKJRSZLKMEBJW-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(5-methylfuran-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C1=CC=C(C)O1 NTKJRSZLKMEBJW-FGTMMUONSA-N 0.000 claims 1
• RNGCPUOQPGSPCJ-LSTHTHJFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(benzenesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1NS(=O)(=O)C1=CC=CC=C1 RNGCPUOQPGSPCJ-LSTHTHJFSA-N 0.000 claims 1
• ADLOBFBVNMYHLJ-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(furan-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C1=CC=CO1 ADLOBFBVNMYHLJ-IXDOHACOSA-N 0.000 claims 1
• TUUCRGAIZKWVGQ-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(furan-3-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C=1C=COC=1 TUUCRGAIZKWVGQ-FGTMMUONSA-N 0.000 claims 1
• FPNJRHFELASHKF-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methanesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(NS(C)(=O)=O)=C1 FPNJRHFELASHKF-VHDGCEQUSA-N 0.000 claims 1
• SKPLPPQRMQXCDU-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methylamino)phenyl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(NC)=C1 SKPLPPQRMQXCDU-HZSPNIEDSA-N 0.000 claims 1
• SDXOSAVBNASIMF-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methylamino)phenyl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(NC)=C1 SDXOSAVBNASIMF-UKPHBRMFSA-N 0.000 claims 1
• IWSZDSUHRAICPE-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(NC)=C1 IWSZDSUHRAICPE-QLFBSQMISA-N 0.000 claims 1
• BRKGFFXYZPCSAU-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methylcarbamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(C(=O)NC)=C1 BRKGFFXYZPCSAU-QLFBSQMISA-N 0.000 claims 1
• KAYFPMNOONIPDD-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methylsulfamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(S(=O)(=O)NC)=C1 KAYFPMNOONIPDD-VHDGCEQUSA-N 0.000 claims 1
• RSIYFUUYAIUXSJ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(trifluoromethoxy)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(OC(F)(F)F)=C1 RSIYFUUYAIUXSJ-KWCYVHTRSA-N 0.000 claims 1
• HLFJGIVKFGSDTI-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(C(F)(F)F)=C1 HLFJGIVKFGSDTI-HZSPNIEDSA-N 0.000 claims 1
• GZFBJASITXTOOO-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(trifluoromethylsulfonylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(NS(=O)(=O)C(F)(F)F)=C1 GZFBJASITXTOOO-KWCYVHTRSA-N 0.000 claims 1
• QVISPPFOWIWPCE-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(1,2-thiazol-5-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C1=CC=NS1 QVISPPFOWIWPCE-OWCLPIDISA-N 0.000 claims 1
• BEPUEKYNJYOSPF-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(1,3-oxazol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C1=NC=CO1 BEPUEKYNJYOSPF-OWCLPIDISA-N 0.000 claims 1
• SMLPTWCINNDWGE-KAGYGMCKSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(1h-indol-2-yl)phenyl]furan-2-carboxamide Chemical compound C1=CC=C2NC(C3=CC=C(C=C3)C3=CC=C(O3)C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 SMLPTWCINNDWGE-KAGYGMCKSA-N 0.000 claims 1
• HIVAKIPEHYOQKD-VOQZNFBZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(1h-indol-3-yl)phenyl]furan-2-carboxamide Chemical compound C1=CC=C2C(C3=CC=C(C=C3)C3=CC=C(O3)C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CNC2=C1 HIVAKIPEHYOQKD-VOQZNFBZSA-N 0.000 claims 1
• IHYKYKHVWZRDHD-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(1h-pyrrol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C1=CC=CN1 IHYKYKHVWZRDHD-BPQIPLTHSA-N 0.000 claims 1
• NSFKRPAYAWHJJU-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(5-methylfuran-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C1=CC=C(C)O1 NSFKRPAYAWHJJU-FGTMMUONSA-N 0.000 claims 1
• FRUHTQYHHXEVGE-YZGWKJHDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(benzenesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1NS(=O)(=O)C1=CC=CC=C1 FRUHTQYHHXEVGE-YZGWKJHDSA-N 0.000 claims 1
• CHMXHPUVPQVMLF-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(furan-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C1=CC=CO1 CHMXHPUVPQVMLF-IXDOHACOSA-N 0.000 claims 1
• FLYYCSCZNDXHOP-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(furan-3-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C=1C=COC=1 FLYYCSCZNDXHOP-FGTMMUONSA-N 0.000 claims 1
• TUIJSCVEFYLENK-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methanesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(NS(C)(=O)=O)C=C1 TUIJSCVEFYLENK-QLFBSQMISA-N 0.000 claims 1
• XRZQMLUNMUNATQ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methylamino)phenyl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(NC)C=C1 XRZQMLUNMUNATQ-HZSPNIEDSA-N 0.000 claims 1
• GKMJPVJGLYDVIL-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methylamino)phenyl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(NC)C=C1 GKMJPVJGLYDVIL-UKPHBRMFSA-N 0.000 claims 1
• KDIRFGGCUXUURM-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methylcarbamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(C(=O)NC)C=C1 KDIRFGGCUXUURM-QLFBSQMISA-N 0.000 claims 1
• GDSDKTSWNPBEKL-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methylsulfamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(S(=O)(=O)NC)C=C1 GDSDKTSWNPBEKL-VHDGCEQUSA-N 0.000 claims 1
• VZMMFLIIAXFAFI-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(trifluoromethoxy)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(OC(F)(F)F)C=C1 VZMMFLIIAXFAFI-KWCYVHTRSA-N 0.000 claims 1
• JPUBVEKPYLFFJX-DSYKOEDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-bromo-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=NC=C(Br)S1 JPUBVEKPYLFFJX-DSYKOEDSSA-N 0.000 claims 1
• IYRMONLYXMGJOM-MHSYXAOVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-bromo-4-chlorothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(Cl)=C(Br)S1 IYRMONLYXMGJOM-MHSYXAOVSA-N 0.000 claims 1
• BUTFGEGZLWRDEM-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-bromofuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(Br)O1 BUTFGEGZLWRDEM-GJMOJQLCSA-N 0.000 claims 1
• HMHDAKAAGLSITC-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-bromothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(Br)S1 HMHDAKAAGLSITC-GJMOJQLCSA-N 0.000 claims 1
• PEGONVMMPHMYPK-DSYKOEDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-chloro-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=NC=C(Cl)S1 PEGONVMMPHMYPK-DSYKOEDSSA-N 0.000 claims 1
• YWWCPHAPPJTENR-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-chloro-4-methylsulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(SC)=C(Cl)S1 YWWCPHAPPJTENR-GJMOJQLCSA-N 0.000 claims 1
• XIUVJQSPGBLYPO-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-chloro-4-methylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(C)=C(Cl)S1 XIUVJQSPGBLYPO-HRDYMLBCSA-N 0.000 claims 1
• LAKQVOWBCIBMBC-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-chloro-4-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1Cl)=CC=1C1=CC=CC=C1 LAKQVOWBCIBMBC-KWCYVHTRSA-N 0.000 claims 1
• JQMLZPFGPGOZFL-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-chlorothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(Cl)S1 JQMLZPFGPGOZFL-GJMOJQLCSA-N 0.000 claims 1
• PSLCUMGZTBXKPX-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-cyano-4-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1C#N)=CC=1C1=CC=CC=C1 PSLCUMGZTBXKPX-VHDGCEQUSA-N 0.000 claims 1
• ZXRWGWCNEFUQFC-FKTZTGRPSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-cyanothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(C#N)S1 ZXRWGWCNEFUQFC-FKTZTGRPSA-N 0.000 claims 1
• YJHYIDUHKFBJEH-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-methoxy-4-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1OC)=CC=1C1=CC=CC=C1 YJHYIDUHKFBJEH-VHDGCEQUSA-N 0.000 claims 1
• SJVIZNRGXIFLBH-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-methoxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(OC)S1 SJVIZNRGXIFLBH-HRDYMLBCSA-N 0.000 claims 1
• IDDQCIKQLCEBTL-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=NC=C(C)S1 IDDQCIKQLCEBTL-HRDYMLBCSA-N 0.000 claims 1
• HVOGABNCHUZXON-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-methyl-4-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1C)=CC=1C1=CC=CC=C1 HVOGABNCHUZXON-VNQPRFMTSA-N 0.000 claims 1
• XIZDLIZXDULYJX-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-methylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(C)S1 XIZDLIZXDULYJX-KXUCPTDWSA-N 0.000 claims 1
• WYTPRAVKRUTUAM-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-nitrofuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C([N+]([O-])=O)O1 WYTPRAVKRUTUAM-GJMOJQLCSA-N 0.000 claims 1
• MJWVOMIYGCDSJD-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-nitrothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C([N+]([O-])=O)S1 MJWVOMIYGCDSJD-GJMOJQLCSA-N 0.000 claims 1
• OAOXLXJTTPLLNL-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenoxy-1,3,4-thiadiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NN=C1OC1=CC=CC=C1 OAOXLXJTTPLLNL-ADEWGFFLSA-N 0.000 claims 1
• DWLCHBHWGYJXKI-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenoxyfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1OC1=CC=CC=C1 DWLCHBHWGYJXKI-KWCYVHTRSA-N 0.000 claims 1
• AASUMVPOMHXCNZ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenoxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1 AASUMVPOMHXCNZ-KWCYVHTRSA-N 0.000 claims 1
• PYPOMBCGVKRMPL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenyl-1,2-oxazole-3-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(=NO1)C=C1C1=CC=CC=C1 PYPOMBCGVKRMPL-FRRDWIJNSA-N 0.000 claims 1
• UPMFQWWCKSWVRB-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenyl-1,3,4-oxadiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NN=C1C1=CC=CC=C1 UPMFQWWCKSWVRB-GRYCIOLGSA-N 0.000 claims 1
• VPURONWJFMLQCY-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenyl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1 VPURONWJFMLQCY-FRRDWIJNSA-N 0.000 claims 1
• QFOAXDVJCZEJRD-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1 QFOAXDVJCZEJRD-FRRDWIJNSA-N 0.000 claims 1
• TZZQUXLJNXMDKF-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenyl-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1 TZZQUXLJNXMDKF-IVMMDQJWSA-N 0.000 claims 1
• SVIMFRSPQFOAIG-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1 SVIMFRSPQFOAIG-HZSPNIEDSA-N 0.000 claims 1
• LSXXGOFYZZLOOQ-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylsulfanyl-1,3,4-thiadiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NN=C1SC1=CC=CC=C1 LSXXGOFYZZLOOQ-ADEWGFFLSA-N 0.000 claims 1
• SWQMSBMIMHUONE-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylsulfanyl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1SC1=CC=CC=C1 SWQMSBMIMHUONE-KGYLQXTDSA-N 0.000 claims 1
• NYTWHWWJXHJCOI-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylsulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=CC=C1 NYTWHWWJXHJCOI-KWCYVHTRSA-N 0.000 claims 1
• YJHZSRMIUPAREV-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylsulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1 YJHZSRMIUPAREV-KWCYVHTRSA-N 0.000 claims 1
• MAKRSGVBMAOKJQ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylthiophene-2-carbothioamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=S)C(S1)=CC=C1C1=CC=CC=C1 MAKRSGVBMAOKJQ-HZSPNIEDSA-N 0.000 claims 1
• UGLTXCUTFCBLDL-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1 UGLTXCUTFCBLDL-HZSPNIEDSA-N 0.000 claims 1
• HVSBQLGWYYYQKE-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-pyridin-2-yl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=N1 HVSBQLGWYYYQKE-JFGNBEQYSA-N 0.000 claims 1
• ZHMDWHWIVMOQAL-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-pyridin-2-yl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=N1 ZHMDWHWIVMOQAL-JFGNBEQYSA-N 0.000 claims 1
• OQWGUCKBLASIJW-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-pyridin-2-ylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=N1 OQWGUCKBLASIJW-NTZNESFSSA-N 0.000 claims 1
• YWSZQBUNCWPFBK-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-pyridin-2-yloxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=N1 YWSZQBUNCWPFBK-GRYCIOLGSA-N 0.000 claims 1
• IYSHZDMAPJQDMC-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-pyridin-2-ylsulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=N1 IYSHZDMAPJQDMC-GRYCIOLGSA-N 0.000 claims 1
• RRPWOEIOWUMYRX-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-pyridin-2-ylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=N1 RRPWOEIOWUMYRX-NTZNESFSSA-N 0.000 claims 1
• WYQYQXYNLGBWPF-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-pyridin-3-yl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CN=C1 WYQYQXYNLGBWPF-GRYCIOLGSA-N 0.000 claims 1
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• SMMHJJFBGFASSM-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-pyridin-4-ylsulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=NC=C1 SMMHJJFBGFASSM-KGYLQXTDSA-N 0.000 claims 1
• HJSAPAKAFDDPPR-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-pyridin-4-ylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=NC=C1 HJSAPAKAFDDPPR-FRRDWIJNSA-N 0.000 claims 1
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