CA2458375A1 - Substituted-heteroaryl-7-aza¬2.2.1|bicycloheptanes for the treatment of disease - Google Patents

Info

Publication number

CA2458375A1

CA2458375A1 CA002458375A CA2458375A CA2458375A1 CA 2458375 A1 CA2458375 A1 CA 2458375A1 CA 002458375 A CA002458375 A CA 002458375A CA 2458375 A CA2458375 A CA 2458375A CA 2458375 A1 CA2458375 A1 CA 2458375A1

Authority

CA

Canada

Prior art keywords

azabicyclo

carboxamide

hept

thiophene

furan

Prior art date

2001-08-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 71
• 201000010099 disease Diseases 0.000 title claims abstract description 58
• 238000011282 treatment Methods 0.000 title description 36
• 150000001875 compounds Chemical class 0.000 claims abstract description 153
• 239000003814 drug Substances 0.000 claims abstract description 89
• 150000003839 salts Chemical class 0.000 claims abstract description 35
• 125000000217 alkyl group Chemical group 0.000 claims description 168
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 124
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 111
• 125000001424 substituent group Chemical group 0.000 claims description 109
• -1 -C(O)N(R11)2 Chemical group 0.000 claims description 91
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 85
• 229940079593 drug Drugs 0.000 claims description 77
• 229910052794 bromium Inorganic materials 0.000 claims description 75
• 229910052731 fluorine Inorganic materials 0.000 claims description 71
• 229910052801 chlorine Inorganic materials 0.000 claims description 70
• 229910052740 iodine Inorganic materials 0.000 claims description 47
• 208000024891 symptom Diseases 0.000 claims description 46
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 45
• 125000000547 substituted alkyl group Chemical group 0.000 claims description 41
• 229910052757 nitrogen Inorganic materials 0.000 claims description 36
• 239000000164 antipsychotic agent Substances 0.000 claims description 34
• 239000008194 pharmaceutical composition Substances 0.000 claims description 33
• 125000003118 aryl group Chemical group 0.000 claims description 32
• 208000024827 Alzheimer disease Diseases 0.000 claims description 30
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 29
• 201000000980 schizophrenia Diseases 0.000 claims description 26
• 125000000304 alkynyl group Chemical group 0.000 claims description 25
• 241000124008 Mammalia Species 0.000 claims description 24
• 125000003342 alkenyl group Chemical group 0.000 claims description 24
• 125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 24
• 230000006735 deficit Effects 0.000 claims description 23
• 208000019901 Anxiety disease Diseases 0.000 claims description 21
• 208000028017 Psychotic disease Diseases 0.000 claims description 21
• 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 20
• 229910052760 oxygen Inorganic materials 0.000 claims description 20
• 229910052717 sulfur Inorganic materials 0.000 claims description 20
• 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 19
• 229910052799 carbon Inorganic materials 0.000 claims description 19
• 208000019022 Mood disease Diseases 0.000 claims description 18
• 208000010412 Glaucoma Diseases 0.000 claims description 17
• 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims description 17
• 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims description 17
• 208000002193 Pain Diseases 0.000 claims description 17
• 230000001149 cognitive effect Effects 0.000 claims description 17
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 16
• 208000010877 cognitive disease Diseases 0.000 claims description 16
• 206010043118 Tardive Dyskinesia Diseases 0.000 claims description 15
• 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims description 15
• 230000004770 neurodegeneration Effects 0.000 claims description 15
• 206010012289 Dementia Diseases 0.000 claims description 14
• IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical group CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 14
• 239000003795 chemical substances by application Substances 0.000 claims description 14
• 230000036506 anxiety Effects 0.000 claims description 13
• 125000005842 heteroatom Chemical group 0.000 claims description 13
• 238000002360 preparation method Methods 0.000 claims description 13
• SNZSSCZJMVIOCR-UHFFFAOYSA-N 7-azabicyclo[2.2.1]heptane Chemical group C1CC2CCC1N2 SNZSSCZJMVIOCR-UHFFFAOYSA-N 0.000 claims description 12
• 125000004429 atom Chemical group 0.000 claims description 12
• 208000027061 mild cognitive impairment Diseases 0.000 claims description 12
• 208000028173 post-traumatic stress disease Diseases 0.000 claims description 12
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 12
• 206010064930 age-related macular degeneration Diseases 0.000 claims description 11
• 230000003542 behavioural effect Effects 0.000 claims description 11
• 208000002780 macular degeneration Diseases 0.000 claims description 11
• 125000001624 naphthyl group Chemical group 0.000 claims description 11
• 125000005017 substituted alkenyl group Chemical group 0.000 claims description 11
• 201000010374 Down Syndrome Diseases 0.000 claims description 10
• 208000023105 Huntington disease Diseases 0.000 claims description 10
• 206010039966 Senile dementia Diseases 0.000 claims description 10
• 206010044688 Trisomy 21 Diseases 0.000 claims description 10
• 231100000870 cognitive problem Toxicity 0.000 claims description 10
• 230000008482 dysregulation Effects 0.000 claims description 10
• 230000037406 food intake Effects 0.000 claims description 10
• 235000012631 food intake Nutrition 0.000 claims description 10
• 229910052739 hydrogen Inorganic materials 0.000 claims description 10
• 125000004426 substituted alkynyl group Chemical group 0.000 claims description 10
• 208000000103 Anorexia Nervosa Diseases 0.000 claims description 9
• 201000011240 Frontotemporal dementia Diseases 0.000 claims description 9
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 9
• 125000001072 heteroaryl group Chemical group 0.000 claims description 9
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
• 208000003174 Brain Neoplasms Diseases 0.000 claims description 8
• 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 8
• 206010036631 Presenile dementia Diseases 0.000 claims description 8
• 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 8
• 208000030886 Traumatic Brain injury Diseases 0.000 claims description 8
• 231100000871 behavioral problem Toxicity 0.000 claims description 8
• 230000037396 body weight Effects 0.000 claims description 8
• 208000030963 borderline personality disease Diseases 0.000 claims description 8
• 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims description 8
• 125000005647 linker group Chemical group 0.000 claims description 8
• 230000036651 mood Effects 0.000 claims description 8
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 8
• 125000006239 protecting group Chemical group 0.000 claims description 8
• 230000009529 traumatic brain injury Effects 0.000 claims description 8
• 229940122578 Acetylcholine receptor agonist Drugs 0.000 claims description 7
• 208000018737 Parkinson disease Diseases 0.000 claims description 7
• 208000000323 Tourette Syndrome Diseases 0.000 claims description 7
• 239000002552 dosage form Substances 0.000 claims description 7
• 210000004558 lewy body Anatomy 0.000 claims description 7
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 6
• 206010065040 AIDS dementia complex Diseases 0.000 claims description 6
• 230000005586 smoking cessation Effects 0.000 claims description 6
• 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 5
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 5
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 5
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
• 239000003937 drug carrier Substances 0.000 claims description 5
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 5
• 239000001301 oxygen Substances 0.000 claims description 5
• 239000011593 sulfur Substances 0.000 claims description 5
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 4
• 125000002619 bicyclic group Chemical group 0.000 claims description 4
• 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 4
• 230000001404 mediated effect Effects 0.000 claims description 3
• AMUUSWWYGANZEX-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-cyanophenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1C#N AMUUSWWYGANZEX-HZSPNIEDSA-N 0.000 claims description 3
• MZPHJMKTDIUGCJ-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(Cl)C=N1 MZPHJMKTDIUGCJ-GRYCIOLGSA-N 0.000 claims description 3
• OFRJLKOCLIZDSV-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-3-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(Cl)N=C1 OFRJLKOCLIZDSV-ADEWGFFLSA-N 0.000 claims description 3
• YNXCSYUXPRVOIE-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-3-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(Cl)N=C1 YNXCSYUXPRVOIE-ADEWGFFLSA-N 0.000 claims description 3
• PYPOMBCGVKRMPL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenyl-1,2-oxazole-3-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(=NO1)C=C1C1=CC=CC=C1 PYPOMBCGVKRMPL-FRRDWIJNSA-N 0.000 claims description 3
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 3
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
• KRZIKTDUSDABCF-BYCMXARLSA-N 2-(2-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1NC(C)=O KRZIKTDUSDABCF-BYCMXARLSA-N 0.000 claims description 2
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 2
• 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
• 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
• ARIUNWKWJWHVQQ-PZPSRYQVSA-N 5-(2-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1NC(C)=O ARIUNWKWJWHVQQ-PZPSRYQVSA-N 0.000 claims description 2
• BQJRVTLHFGXZIT-UHOFOFEASA-N 5-(2-acetylphenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1C(C)=O BQJRVTLHFGXZIT-UHOFOFEASA-N 0.000 claims description 2
• FFDUCKBGCPBVJK-KGYLQXTDSA-N 5-(2-aminophenoxy)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1N FFDUCKBGCPBVJK-KGYLQXTDSA-N 0.000 claims description 2
• XPDDKFOXCDRRJT-BYCMXARLSA-N 5-(2-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1N XPDDKFOXCDRRJT-BYCMXARLSA-N 0.000 claims description 2
• TVYHUYBMKDFHEN-VNQPRFMTSA-N 5-(3-acetamidophenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(NC(C)=O)=C1 TVYHUYBMKDFHEN-VNQPRFMTSA-N 0.000 claims description 2
• RCZLLSOJIOSNFF-JIMOISOXSA-N 5-(3-amino-2-chlorophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(N)=C1Cl RCZLLSOJIOSNFF-JIMOISOXSA-N 0.000 claims description 2
• ARGAMWUYBDKJTL-JIMOISOXSA-N 5-(3-amino-2-fluorophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(N)=C1F ARGAMWUYBDKJTL-JIMOISOXSA-N 0.000 claims description 2
• VRQGNQMYZHSXPQ-QLFBSQMISA-N 5-(3-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(N)=C1 VRQGNQMYZHSXPQ-QLFBSQMISA-N 0.000 claims description 2
• PBTYFOFUBCUAIN-OWCLPIDISA-N 5-(4-acetylphenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C(C)=O)C=C1 PBTYFOFUBCUAIN-OWCLPIDISA-N 0.000 claims description 2
• DBABQUYXHCKJNN-QLFBSQMISA-N 5-(4-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(N)C=C1 DBABQUYXHCKJNN-QLFBSQMISA-N 0.000 claims description 2
• XAXMNQCSOMSHJQ-FKTZTGRPSA-N 5-(aminomethyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(CN)S1 XAXMNQCSOMSHJQ-FKTZTGRPSA-N 0.000 claims description 2
• SPTOJFGDNWDEHM-KXUCPTDWSA-N 5-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(C(C)=O)S1 SPTOJFGDNWDEHM-KXUCPTDWSA-N 0.000 claims description 2
• ZUSWDTWYONAOPH-UHFFFAOYSA-N [2-(trifluoromethyl)phenyl]hydrazine;hydrochloride Chemical group [Cl-].[NH3+]NC1=CC=CC=C1C(F)(F)F ZUSWDTWYONAOPH-UHFFFAOYSA-N 0.000 claims description 2
• BINSPFYIWJMQEM-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-(2-methylphenyl)pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1C BINSPFYIWJMQEM-VNQPRFMTSA-N 0.000 claims description 2
• WMWPOKBVEWJYMZ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-(2-nitrophenyl)pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1[N+]([O-])=O WMWPOKBVEWJYMZ-KWCYVHTRSA-N 0.000 claims description 2
• JSQUICKWOCDDMY-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-(3-nitrophenyl)pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC([N+]([O-])=O)=C1 JSQUICKWOCDDMY-VHDGCEQUSA-N 0.000 claims description 2
• RSFHOJGVEUQWGE-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-(4-methylphenyl)pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(C)C=C1 RSFHOJGVEUQWGE-OWCLPIDISA-N 0.000 claims description 2
• DOKCULLXPVHZEN-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-(4-nitrophenyl)pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C([N+]([O-])=O)C=C1 DOKCULLXPVHZEN-VHDGCEQUSA-N 0.000 claims description 2
• BXNGQEGPQWZLMM-MBNYWOFBSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-pyridin-2-ylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=N1 BXNGQEGPQWZLMM-MBNYWOFBSA-N 0.000 claims description 2
• KPHJEYVTFPRTST-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C=1SC(C)=NC=1C KPHJEYVTFPRTST-KXUCPTDWSA-N 0.000 claims description 2
• LUXLWQRVLBZISS-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2,4-difluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(F)C=C1F LUXLWQRVLBZISS-JIMOISOXSA-N 0.000 claims description 2
• MQYGPZRJODPJEG-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2,5-difluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC(F)=CC=C1F MQYGPZRJODPJEG-JIMOISOXSA-N 0.000 claims description 2
• MQCOCIDHWLRMKT-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-bromophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1Br MQCOCIDHWLRMKT-JIMOISOXSA-N 0.000 claims description 2
• JTCKJPYZMQVWEB-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-cyanophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1C#N JTCKJPYZMQVWEB-KWCYVHTRSA-N 0.000 claims description 2
• RWUGYZZRRFONMI-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-cyanophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(C#N)=C1 RWUGYZZRRFONMI-HZSPNIEDSA-N 0.000 claims description 2
• HTDIWNCFXNJZKI-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-bromophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(Br)C=C1 HTDIWNCFXNJZKI-FRRDWIJNSA-N 0.000 claims description 2
• FHLFAEVEZDWOQG-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-nitrophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C([N+]([O-])=O)C=C1 FHLFAEVEZDWOQG-KGYLQXTDSA-N 0.000 claims description 2
• SLKTWJWRXCSIEH-YZGWKJHDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-phenylmethoxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C(C=C1)=CC=C1OCC1=CC=CC=C1 SLKTWJWRXCSIEH-YZGWKJHDSA-N 0.000 claims description 2
• KHCVJDHIQVTYHC-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[3-[(2,2,2-trifluoroacetyl)amino]phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(NC(=O)C(F)(F)F)=C1 KHCVJDHIQVTYHC-FRRDWIJNSA-N 0.000 claims description 2
• JOYNUVUNKJWLHL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-phenyl-1,3-oxazole-4-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=1)=COC=1C1=CC=CC=C1 JOYNUVUNKJWLHL-FRRDWIJNSA-N 0.000 claims description 2
• GKOXQLORWXIFFD-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-phenyl-1h-1,2,4-triazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=1)=NNC=1C1=CC=CC=C1 GKOXQLORWXIFFD-GRYCIOLGSA-N 0.000 claims description 2
• OADLCNHXUNVXIE-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-(2-methylpyridin-4-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1OC1=CC=NC(C)=C1 OADLCNHXUNVXIE-BYCMXARLSA-N 0.000 claims description 2
• AMKCIIACDSTQJY-MHSYXAOVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-bromo-5-chlorothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(Br)=C(Cl)S1 AMKCIIACDSTQJY-MHSYXAOVSA-N 0.000 claims description 2
• YJHUJJDJVASCDF-BWVDBABLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-chloro-5-methylsulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(Cl)=C(SC)S1 YJHUJJDJVASCDF-BWVDBABLSA-N 0.000 claims description 2
• YULIKEUTJUTDGX-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-cyano-5-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC(C#N)=C1C1=CC=CC=C1 YULIKEUTJUTDGX-QLFBSQMISA-N 0.000 claims description 2
• BGMUHOFLKDVFDW-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-pyridin-2-yloxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1OC1=CC=CC=N1 BGMUHOFLKDVFDW-KGYLQXTDSA-N 0.000 claims description 2
• MSBBOIMFDFEYAL-WCABBAIRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,2-oxazol-3-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C=1C=CON=1 MSBBOIMFDFEYAL-WCABBAIRSA-N 0.000 claims description 2
• OREJTOISRSNDNM-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=CO1 OREJTOISRSNDNM-HRDYMLBCSA-N 0.000 claims description 2
• NJQWDEIYJLMFCZ-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=CS1 NJQWDEIYJLMFCZ-HRDYMLBCSA-N 0.000 claims description 2
• PSLPBMLFDSFPFR-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=CS1 PSLPBMLFDSFPFR-KXUCPTDWSA-N 0.000 claims description 2
• JPXMJPKSXOLELV-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-2-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=CS1 JPXMJPKSXOLELV-KXUCPTDWSA-N 0.000 claims description 2
• FNNRZRIUFZQIQB-OXHMUOHRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4,5-trichlorophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC(Cl)=C(Cl)C=C1Cl FNNRZRIUFZQIQB-OXHMUOHRSA-N 0.000 claims description 2
• MGONXQCWRGCIDI-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-dichlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=C(Cl)C=C1Cl MGONXQCWRGCIDI-ADEWGFFLSA-N 0.000 claims description 2
• YOLJAPMGGDUXDU-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(F)C=C1F YOLJAPMGGDUXDU-KGYLQXTDSA-N 0.000 claims description 2
• HOEQYUQAKKUHCZ-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,5-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC(Cl)=CC=C1Cl HOEQYUQAKKUHCZ-DDTOSNHZSA-N 0.000 claims description 2
• FOKADOMVWNIZRJ-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,6-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=C(Cl)C=CC=C1Cl FOKADOMVWNIZRJ-JIMOISOXSA-N 0.000 claims description 2
• HIKLFKLNDBPCAU-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-carbamoylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1C(N)=O HIKLFKLNDBPCAU-DDTOSNHZSA-N 0.000 claims description 2
• BPUOLRUCAODKOQ-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloro-1,3-oxazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(Cl)O1 BPUOLRUCAODKOQ-HRDYMLBCSA-N 0.000 claims description 2
• HTPRFGZCCWMRIR-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1Cl HTPRFGZCCWMRIR-JIMOISOXSA-N 0.000 claims description 2
• CXFJFSILHSHBFG-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-cyanophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C#N CXFJFSILHSHBFG-VHDGCEQUSA-N 0.000 claims description 2
• CDVSSIWMNUUXID-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenoxy)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1OC1=CC=CC=C1F CDVSSIWMNUUXID-KGYLQXTDSA-N 0.000 claims description 2
• ALJPOIASFYFWFQ-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1F ALJPOIASFYFWFQ-JIMOISOXSA-N 0.000 claims description 2
• WZBGJOODTYVIPT-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1F WZBGJOODTYVIPT-FUEDEBDSSA-N 0.000 claims description 2
• YCMDNWDHCRHBGT-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1F YCMDNWDHCRHBGT-DDTOSNHZSA-N 0.000 claims description 2
• DYHNOEVKXXGGRW-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-4-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=NC(F)=C1 DYHNOEVKXXGGRW-OUAUKWLOSA-N 0.000 claims description 2
• YLYCRUSFRHUQEW-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-4-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=NC(F)=C1 YLYCRUSFRHUQEW-GRYCIOLGSA-N 0.000 claims description 2
• HQDZHCLKXVUYNR-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxy-1,3-oxazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(OC)O1 HQDZHCLKXVUYNR-KXUCPTDWSA-N 0.000 claims description 2
• JNXAKAGTDPTFFX-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1OC JNXAKAGTDPTFFX-KWCYVHTRSA-N 0.000 claims description 2
• YIQHQPREHFAFBM-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methyl-1,3-thiazol-4-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CSC(C)=N1 YIQHQPREHFAFBM-OUAUKWLOSA-N 0.000 claims description 2
• KYWMHGVNVKFFDF-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1C KYWMHGVNVKFFDF-HZSPNIEDSA-N 0.000 claims description 2
• VJFMMJOOSWREAY-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylpyridin-4-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=NC(C)=C1 VJFMMJOOSWREAY-KWCYVHTRSA-N 0.000 claims description 2
• SGJFVCHKIWIFJU-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-nitrophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1[N+]([O-])=O SGJFVCHKIWIFJU-ADEWGFFLSA-N 0.000 claims description 2
• LNXMJCAEBQIVNK-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-nitrophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1[N+]([O-])=O LNXMJCAEBQIVNK-KGYLQXTDSA-N 0.000 claims description 2
• PEFGBOVLLILHCB-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-nitrophenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1[N+]([O-])=O PEFGBOVLLILHCB-KGYLQXTDSA-N 0.000 claims description 2
• FEKULWQIZFWSPK-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-sulfamoylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1S(N)(=O)=O FEKULWQIZFWSPK-GRYCIOLGSA-N 0.000 claims description 2
• MXJOFSXDSMGGOK-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(Cl)C(Cl)=C1 MXJOFSXDSMGGOK-DDTOSNHZSA-N 0.000 claims description 2
• XQHLYFZOVWTHSY-BIGNPOOSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-dichlorophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(Cl)C(Cl)=C1 XQHLYFZOVWTHSY-BIGNPOOSSA-N 0.000 claims description 2
• GPVXSPBCBWIKAR-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-difluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(F)C(F)=C1 GPVXSPBCBWIKAR-FUEDEBDSSA-N 0.000 claims description 2
• GIGGHSROYWNDBH-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-difluorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(F)C(F)=C1 GIGGHSROYWNDBH-DDTOSNHZSA-N 0.000 claims description 2
• VZXKHRJAAVNCET-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-dichlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC(Cl)=CC(Cl)=C1 VZXKHRJAAVNCET-IVMMDQJWSA-N 0.000 claims description 2
• QDVXHDGMGOGZDC-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC(Cl)=CC(Cl)=C1 QDVXHDGMGOGZDC-HZSPNIEDSA-N 0.000 claims description 2
• WWCZCLOTKBPISK-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenoxy)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1OC1=CC=CC(Cl)=C1 WWCZCLOTKBPISK-KWCYVHTRSA-N 0.000 claims description 2
• IEOUJBVWMVNKAO-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(Cl)=C1 IEOUJBVWMVNKAO-HZSPNIEDSA-N 0.000 claims description 2
• LVHVYDSHPBKXFW-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-cyanophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(C#N)=C1 LVHVYDSHPBKXFW-OWCLPIDISA-N 0.000 claims description 2
• MRGSHWMQWNGPMV-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-2-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=NC=CC=C1F MRGSHWMQWNGPMV-KGYLQXTDSA-N 0.000 claims description 2
• DQLKJRYEKLOHQU-OLUVUFQESA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-2-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=NC=CC=C1F DQLKJRYEKLOHQU-OLUVUFQESA-N 0.000 claims description 2
• OKMZURFFXHWVJD-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(O)=C1 OKMZURFFXHWVJD-KWCYVHTRSA-N 0.000 claims description 2
• BJDOZGXKCIINHJ-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC(OC)=C1 BJDOZGXKCIINHJ-DDTOSNHZSA-N 0.000 claims description 2
• WXAQOJMJPVNEAR-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=CC(OC)=C1 WXAQOJMJPVNEAR-DDTOSNHZSA-N 0.000 claims description 2
• WMOAOHMYRYBLQQ-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(C)=C1 WMOAOHMYRYBLQQ-UKPHBRMFSA-N 0.000 claims description 2
• NYOLVTGFPAANIN-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-morpholin-4-ylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC(C=1)=CC=CC=1N1CCOCC1 NYOLVTGFPAANIN-FHLIZLRMSA-N 0.000 claims description 2
• SZRJPVJCGDPIME-DIOULYMOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-nitrophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC([N+]([O-])=O)=C1 SZRJPVJCGDPIME-DIOULYMOSA-N 0.000 claims description 2
• ZBFHJSUQIRWIPW-LSTHTHJFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-phenoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1OC1=CC=CC=C1 ZBFHJSUQIRWIPW-LSTHTHJFSA-N 0.000 claims description 2
• DONAVHYJNBCDMN-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloro-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(Cl)=CS1 DONAVHYJNBCDMN-HRDYMLBCSA-N 0.000 claims description 2
• PMOKUSARGPHTJQ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenoxy)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1OC1=CC=C(Cl)C=C1 PMOKUSARGPHTJQ-KWCYVHTRSA-N 0.000 claims description 2
• MUCXIGFZGMTTTP-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(Cl)C=C1 MUCXIGFZGMTTTP-KWCYVHTRSA-N 0.000 claims description 2
• JNMDVZZTEKNQJV-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-cyanophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(C#N)C=C1 JNMDVZZTEKNQJV-UKPHBRMFSA-N 0.000 claims description 2
• JYVCQFGAMBGDKT-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=C(F)C=C1 JYVCQFGAMBGDKT-KGYLQXTDSA-N 0.000 claims description 2
• KDNZSZPFOBKPBS-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(F)C=C1 KDNZSZPFOBKPBS-IVMMDQJWSA-N 0.000 claims description 2
• LGELFNPMLUHMMD-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC(F)=CC=N1 LGELFNPMLUHMMD-GRYCIOLGSA-N 0.000 claims description 2
• JFICGJXMROBZCF-JFUSQASVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-3-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CN=CC=C1F JFICGJXMROBZCF-JFUSQASVSA-N 0.000 claims description 2
• ZTFGLCVEMMZEQF-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(O)C=C1 ZTFGLCVEMMZEQF-DDTOSNHZSA-N 0.000 claims description 2
• KFXKNGGNQFDUDC-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(O)C=C1 KFXKNGGNQFDUDC-VHDGCEQUSA-N 0.000 claims description 2
• KKVNGOTUOGOJPX-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(O)C=C1 KKVNGOTUOGOJPX-KWCYVHTRSA-N 0.000 claims description 2
• YPPIVFMRHCNEPR-ISTRZQFTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(OC)C=C1 YPPIVFMRHCNEPR-ISTRZQFTSA-N 0.000 claims description 2
• VSPSPLBZAJBABU-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(OC)C=C1 VSPSPLBZAJBABU-VHDGCEQUSA-N 0.000 claims description 2
• WYDUFUXFTJFGOX-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(C)C=C1 WYDUFUXFTJFGOX-UKPHBRMFSA-N 0.000 claims description 2
• GJQVLSBGDFMBNV-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(C)C=C1 GJQVLSBGDFMBNV-QLFBSQMISA-N 0.000 claims description 2
• ZQGOVWPWVIRYMB-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C)C=C1 ZQGOVWPWVIRYMB-VHDGCEQUSA-N 0.000 claims description 2
• HZYFIHLYTQOMJS-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C)C=C1 HZYFIHLYTQOMJS-QLFBSQMISA-N 0.000 claims description 2
• REXRSDVNDPSRFE-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-nitrophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C([N+]([O-])=O)C=C1 REXRSDVNDPSRFE-KWCYVHTRSA-N 0.000 claims description 2
• ILHRXCIUSRIHDE-LSTHTHJFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-phenylsulfanylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1SC1=CC=CC=C1 ILHRXCIUSRIHDE-LSTHTHJFSA-N 0.000 claims description 2
• AKBUNAFLDVSWFN-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorofuran-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(Cl)O1 AKBUNAFLDVSWFN-KXUCPTDWSA-N 0.000 claims description 2
• TZFZSUJRUVOXNA-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(F)C=N1 TZFZSUJRUVOXNA-NTZNESFSSA-N 0.000 claims description 2
• JIHLFWXKVUOSCN-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxyfuran-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(OC)O1 JIHLFWXKVUOSCN-OUAUKWLOSA-N 0.000 claims description 2
• GXSQXBZUDYCCDN-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxythiophen-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(OC)S1 GXSQXBZUDYCCDN-OUAUKWLOSA-N 0.000 claims description 2
• BNRDBTSKQTUVAM-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methyl-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(C)O1 BNRDBTSKQTUVAM-OUAUKWLOSA-N 0.000 claims description 2
• RQXSGCOVDFAFCV-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methyl-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(C)S1 RQXSGCOVDFAFCV-OUAUKWLOSA-N 0.000 claims description 2
• ZPFBPZXTACSBOF-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylthiophen-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C)S1 ZPFBPZXTACSBOF-GRYCIOLGSA-N 0.000 claims description 2
• DSUPXDCPVCWYHO-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylthiophen-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C)S1 DSUPXDCPVCWYHO-GRYCIOLGSA-N 0.000 claims description 2
• AECUNKQMGIWZLQ-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(Cl)=N1 AECUNKQMGIWZLQ-OUAUKWLOSA-N 0.000 claims description 2
• FADHVNNKMKAINP-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-2-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(F)=N1 FADHVNNKMKAINP-NTZNESFSSA-N 0.000 claims description 2
• GJEAPZFAODDCQB-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-3-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(F)N=C1 GJEAPZFAODDCQB-OUAUKWLOSA-N 0.000 claims description 2
• INWLVFWZCOBNET-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-methylpyridin-3-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C)N=C1 INWLVFWZCOBNET-KWCYVHTRSA-N 0.000 claims description 2
• CPYUHFYYVAGCMR-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(furan-3-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C=1C=COC=1 CPYUHFYYVAGCMR-GRYCIOLGSA-N 0.000 claims description 2
• GKLBTVRNYPEQIJ-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methyl-1,3-oxazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(C)O1 GKLBTVRNYPEQIJ-OUAUKWLOSA-N 0.000 claims description 2
• MHIJLKFQBCPOBL-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methoxy-1,3-thiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC(OC)=CS1 MHIJLKFQBCPOBL-KXUCPTDWSA-N 0.000 claims description 2
• FCMMVPMZIIXLSI-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC(C)=CS1 FCMMVPMZIIXLSI-OUAUKWLOSA-N 0.000 claims description 2
• YGSRKTWTPBRFTB-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(1,3-thiazol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C1=NC=CS1 YGSRKTWTPBRFTB-UHOFOFEASA-N 0.000 claims description 2
• OKXFMDVZRSCWQK-JEBQAFNWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(1h-pyrrol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C1=CC=CN1 OKXFMDVZRSCWQK-JEBQAFNWSA-N 0.000 claims description 2
• VTBHPEPHPQPVLO-HYVNUMGLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(3-chlorophenyl)ethenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C=CC1=CC=CC(Cl)=C1 VTBHPEPHPQPVLO-HYVNUMGLSA-N 0.000 claims description 2
• YJBJYDQSQAKQMG-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(5-methylfuran-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C1=CC=C(C)O1 YJBJYDQSQAKQMG-FHLIZLRMSA-N 0.000 claims description 2
• ATZTYLGVQCRWJX-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(furan-3-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C=1C=COC=1 ATZTYLGVQCRWJX-FHLIZLRMSA-N 0.000 claims description 2
• FSVXSOAHFSBKAT-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methylcarbamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C(=O)NC FSVXSOAHFSBKAT-BYCMXARLSA-N 0.000 claims description 2
• SPEOYRKTEUKOQP-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(trifluoromethyl)phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1C(F)(F)F SPEOYRKTEUKOQP-KGYLQXTDSA-N 0.000 claims description 2
• ZHTUSWNFMQJKDK-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(trifluoromethylsulfonylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1NS(=O)(=O)C(F)(F)F ZHTUSWNFMQJKDK-DDTOSNHZSA-N 0.000 claims description 2
• MSBBLVCIFRSLIB-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-[(2,2,2-trifluoroacetyl)amino]phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1NC(=O)C(F)(F)F MSBBLVCIFRSLIB-DDTOSNHZSA-N 0.000 claims description 2
• LQVJHVFELMMXKW-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-[(2,2-difluoroacetyl)amino]phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1NC(=O)C(F)F LQVJHVFELMMXKW-DDTOSNHZSA-N 0.000 claims description 2
• KZKAQWRGIIPBHL-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(trifluoromethyl)phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(C(F)(F)F)=C1 KZKAQWRGIIPBHL-KWCYVHTRSA-N 0.000 claims description 2
• QYOINLSKEJZJKK-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(trifluoromethylsulfonylamino)phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(NS(=O)(=O)C(F)(F)F)=C1 QYOINLSKEJZJKK-DDTOSNHZSA-N 0.000 claims description 2
• DFDKAUDXIZNBLC-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(trifluoromethylsulfonylamino)phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(NS(=O)(=O)C(F)(F)F)=C1 DFDKAUDXIZNBLC-KWCYVHTRSA-N 0.000 claims description 2
• OQANFTNAHOIALQ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-[(2,2-difluoroacetyl)amino]phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(NC(=O)C(F)F)=C1 OQANFTNAHOIALQ-KWCYVHTRSA-N 0.000 claims description 2
• BEPUEKYNJYOSPF-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(1,3-oxazol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C1=NC=CO1 BEPUEKYNJYOSPF-OWCLPIDISA-N 0.000 claims description 2
• HIVAKIPEHYOQKD-VOQZNFBZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(1h-indol-3-yl)phenyl]furan-2-carboxamide Chemical compound C1=CC=C2C(C3=CC=C(C=C3)C3=CC=C(O3)C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CNC2=C1 HIVAKIPEHYOQKD-VOQZNFBZSA-N 0.000 claims description 2
• IHYKYKHVWZRDHD-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(1h-pyrrol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C1=CC=CN1 IHYKYKHVWZRDHD-BPQIPLTHSA-N 0.000 claims description 2
• BZDXRXRRAOULNN-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(ethylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(NCC)C=C1 BZDXRXRRAOULNN-OWCLPIDISA-N 0.000 claims description 2
• FLYYCSCZNDXHOP-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(furan-3-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C=1C=COC=1 FLYYCSCZNDXHOP-FGTMMUONSA-N 0.000 claims description 2
• DXNCCXOCGOETOO-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 DXNCCXOCGOETOO-HZSPNIEDSA-N 0.000 claims description 2
• BUTFGEGZLWRDEM-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-bromofuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(Br)O1 BUTFGEGZLWRDEM-GJMOJQLCSA-N 0.000 claims description 2
• XIUVJQSPGBLYPO-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-chloro-4-methylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(C)=C(Cl)S1 XIUVJQSPGBLYPO-HRDYMLBCSA-N 0.000 claims description 2
• LAKQVOWBCIBMBC-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-chloro-4-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1Cl)=CC=1C1=CC=CC=C1 LAKQVOWBCIBMBC-KWCYVHTRSA-N 0.000 claims description 2
• JQMLZPFGPGOZFL-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-chlorothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(Cl)S1 JQMLZPFGPGOZFL-GJMOJQLCSA-N 0.000 claims description 2
• PSLCUMGZTBXKPX-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-cyano-4-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1C#N)=CC=1C1=CC=CC=C1 PSLCUMGZTBXKPX-VHDGCEQUSA-N 0.000 claims description 2
• HVOGABNCHUZXON-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-methyl-4-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1C)=CC=1C1=CC=CC=C1 HVOGABNCHUZXON-VNQPRFMTSA-N 0.000 claims description 2
• XIZDLIZXDULYJX-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-methylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(C)S1 XIZDLIZXDULYJX-KXUCPTDWSA-N 0.000 claims description 2
• MJWVOMIYGCDSJD-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-nitrothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C([N+]([O-])=O)S1 MJWVOMIYGCDSJD-GJMOJQLCSA-N 0.000 claims description 2
• AASUMVPOMHXCNZ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenoxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1 AASUMVPOMHXCNZ-KWCYVHTRSA-N 0.000 claims description 2
• SWQMSBMIMHUONE-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylsulfanyl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1SC1=CC=CC=C1 SWQMSBMIMHUONE-KGYLQXTDSA-N 0.000 claims description 2
• MAKRSGVBMAOKJQ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylthiophene-2-carbothioamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=S)C(S1)=CC=C1C1=CC=CC=C1 MAKRSGVBMAOKJQ-HZSPNIEDSA-N 0.000 claims description 2
• FBVMILPJHPRIQY-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-pyridin-4-yl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=NC=C1 FBVMILPJHPRIQY-GRYCIOLGSA-N 0.000 claims description 2
• HJSAPAKAFDDPPR-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-pyridin-4-ylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=NC=C1 HJSAPAKAFDDPPR-FRRDWIJNSA-N 0.000 claims description 2
• WUXDEGQWSFVUQG-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloropyridin-4-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=NC(Cl)=C1 WUXDEGQWSFVUQG-ADEWGFFLSA-N 0.000 claims 2
• GKBVLMXIZUSZBS-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-3-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CN=C1F GKBVLMXIZUSZBS-DVVUODLYSA-N 0.000 claims 2
• UECFPTCBHAOQAZ-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-cyanophenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(C#N)=C1 UECFPTCBHAOQAZ-VHDGCEQUSA-N 0.000 claims 2
• XDPIBQXANRUEHV-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-cyanophenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C#N)C=C1 XDPIBQXANRUEHV-VHDGCEQUSA-N 0.000 claims 2
• UFINMAAKGKATOZ-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(Cl)C=N1 UFINMAAKGKATOZ-GRYCIOLGSA-N 0.000 claims 2
• PZTVZRXNNPIOKU-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorothiophen-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(Cl)S1 PZTVZRXNNPIOKU-KXUCPTDWSA-N 0.000 claims 2
• CHVHKCKUGONQEE-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylthiophen-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C)S1 CHVHKCKUGONQEE-GRYCIOLGSA-N 0.000 claims 2
• KKLYYHDOLZFJDX-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-thiophen-3-ylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C=1C=CSC=1 KKLYYHDOLZFJDX-GRYCIOLGSA-N 0.000 claims 2
• LDJCHUPMLADDAG-JIMOISOXSA-N 2-(2-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1N LDJCHUPMLADDAG-JIMOISOXSA-N 0.000 claims 1
• YZHVBUJLQLWNJC-QLFBSQMISA-N 2-(3-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(NC(C)=O)=C1 YZHVBUJLQLWNJC-QLFBSQMISA-N 0.000 claims 1
• AQTWOQREGFOFQL-FRRDWIJNSA-N 2-(3-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(N)=C1 AQTWOQREGFOFQL-FRRDWIJNSA-N 0.000 claims 1
• VROBRBFBUXDWKY-QLFBSQMISA-N 2-(4-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(NC(C)=O)C=C1 VROBRBFBUXDWKY-QLFBSQMISA-N 0.000 claims 1
• GODWTBHWMIEYKP-FRRDWIJNSA-N 2-(4-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(N)C=C1 GODWTBHWMIEYKP-FRRDWIJNSA-N 0.000 claims 1
• NTQCKYJGVCBXTE-XOKHGSTOSA-N 4-(2-acetylphenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1C1=CC=CC=C1C(C)=O NTQCKYJGVCBXTE-XOKHGSTOSA-N 0.000 claims 1
• PIEAJWIQPXRDBZ-XOKHGSTOSA-N 4-(3-acetamidophenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1SC1=CC=CC(NC(C)=O)=C1 PIEAJWIQPXRDBZ-XOKHGSTOSA-N 0.000 claims 1
• CWDFYXWKAVGPDM-VNHYZAJKSA-N 5-(2-acetamidophenoxy)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1NC(C)=O CWDFYXWKAVGPDM-VNHYZAJKSA-N 0.000 claims 1
• BVHIKSYSNBOIQX-BYCMXARLSA-N 5-(2-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1NC(C)=O BVHIKSYSNBOIQX-BYCMXARLSA-N 0.000 claims 1
• XVDFJFZVUPWARX-XOKHGSTOSA-N 5-(2-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1NC(C)=O XVDFJFZVUPWARX-XOKHGSTOSA-N 0.000 claims 1
• CGHNFDNKZNIZOH-UHOFOFEASA-N 5-(2-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1NC(C)=O CGHNFDNKZNIZOH-UHOFOFEASA-N 0.000 claims 1
• ZBZUWSBCDJYLOC-VNHYZAJKSA-N 5-(2-acetamidophenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1NC(C)=O ZBZUWSBCDJYLOC-VNHYZAJKSA-N 0.000 claims 1
• FCYDLVGTCIHBGQ-UHOFOFEASA-N 5-(2-acetylphenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C(C)=O FCYDLVGTCIHBGQ-UHOFOFEASA-N 0.000 claims 1
• YTMJMSNYARYAJY-JIMOISOXSA-N 5-(2-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1N YTMJMSNYARYAJY-JIMOISOXSA-N 0.000 claims 1
• DNAVVEVSPWIZAX-FUEDEBDSSA-N 5-(2-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1N DNAVVEVSPWIZAX-FUEDEBDSSA-N 0.000 claims 1
• MYBRGPWPOUGZCP-DDTOSNHZSA-N 5-(2-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1N MYBRGPWPOUGZCP-DDTOSNHZSA-N 0.000 claims 1
• BSIUYBPXDCEXNL-KGYLQXTDSA-N 5-(2-aminophenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1N BSIUYBPXDCEXNL-KGYLQXTDSA-N 0.000 claims 1
• KFPDIECZYVVMJD-LSTHTHJFSA-N 5-(2-anilinophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1NC1=CC=CC=C1 KFPDIECZYVVMJD-LSTHTHJFSA-N 0.000 claims 1
• ZUPSBZJCJZMZHB-VNQPRFMTSA-N 5-(3-acetamidophenoxy)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(NC(C)=O)=C1 ZUPSBZJCJZMZHB-VNQPRFMTSA-N 0.000 claims 1
• NBZHKKMLFRNQRS-QLFBSQMISA-N 5-(3-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(NC(C)=O)=C1 NBZHKKMLFRNQRS-QLFBSQMISA-N 0.000 claims 1
• OPBIEEAWTCRPGO-IXDOHACOSA-N 5-(3-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(NC(C)=O)=C1 OPBIEEAWTCRPGO-IXDOHACOSA-N 0.000 claims 1
• OYOZVWQWXUALTI-UWWQBHOKSA-N 5-(3-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(NC(C)=O)=C1 OYOZVWQWXUALTI-UWWQBHOKSA-N 0.000 claims 1
• QXKXIAAXHKVFCR-OWCLPIDISA-N 5-(3-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(NC(C)=O)=C1 QXKXIAAXHKVFCR-OWCLPIDISA-N 0.000 claims 1
• UJYYSDRAYVXYET-VNQPRFMTSA-N 5-(3-acetylphenoxy)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(C(C)=O)=C1 UJYYSDRAYVXYET-VNQPRFMTSA-N 0.000 claims 1
• RFQRPYCNTZQUIN-OWCLPIDISA-N 5-(3-acetylphenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(C(C)=O)=C1 RFQRPYCNTZQUIN-OWCLPIDISA-N 0.000 claims 1
• HYFHNJXDQALWPD-OWCLPIDISA-N 5-(3-acetylphenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(C(C)=O)=C1 HYFHNJXDQALWPD-OWCLPIDISA-N 0.000 claims 1
• XMYJCPFESYMZBV-VNQPRFMTSA-N 5-(3-acetylphenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(C(C)=O)=C1 XMYJCPFESYMZBV-VNQPRFMTSA-N 0.000 claims 1
• RNIBDCQOYKJQRO-KWCYVHTRSA-N 5-(3-aminophenoxy)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(N)=C1 RNIBDCQOYKJQRO-KWCYVHTRSA-N 0.000 claims 1
• VVVJMQQQANECPH-FRRDWIJNSA-N 5-(3-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(N)=C1 VVVJMQQQANECPH-FRRDWIJNSA-N 0.000 claims 1
• AILOSMZTPSBZRI-IVMMDQJWSA-N 5-(3-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(N)=C1 AILOSMZTPSBZRI-IVMMDQJWSA-N 0.000 claims 1
• YYOKLJKXWRKJSM-HZSPNIEDSA-N 5-(3-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(N)=C1 YYOKLJKXWRKJSM-HZSPNIEDSA-N 0.000 claims 1
• WNYFFQPESOJETF-KWCYVHTRSA-N 5-(3-aminophenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(N)=C1 WNYFFQPESOJETF-KWCYVHTRSA-N 0.000 claims 1
• REXBWQYBRLGSOE-VHDGCEQUSA-N 5-(4-acetamidophenoxy)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=C(NC(C)=O)C=C1 REXBWQYBRLGSOE-VHDGCEQUSA-N 0.000 claims 1
• RPSWOUNQJDJXRL-VNQPRFMTSA-N 5-(4-acetamidophenoxy)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(NC(C)=O)C=C1 RPSWOUNQJDJXRL-VNQPRFMTSA-N 0.000 claims 1
• DFRQQNJNLQKKDZ-QLFBSQMISA-N 5-(4-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(NC(C)=O)C=C1 DFRQQNJNLQKKDZ-QLFBSQMISA-N 0.000 claims 1
• AZHFKHSXRPWHLZ-QLFBSQMISA-N 5-(4-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(NC(C)=O)C=C1 AZHFKHSXRPWHLZ-QLFBSQMISA-N 0.000 claims 1
• KVZKVYVWLOVJLV-IXDOHACOSA-N 5-(4-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(NC(C)=O)C=C1 KVZKVYVWLOVJLV-IXDOHACOSA-N 0.000 claims 1
• TYORLZBWQKAENB-UWWQBHOKSA-N 5-(4-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(NC(C)=O)C=C1 TYORLZBWQKAENB-UWWQBHOKSA-N 0.000 claims 1
• HZJAOXZQWMZSHB-OWCLPIDISA-N 5-(4-acetamidophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(NC(C)=O)C=C1 HZJAOXZQWMZSHB-OWCLPIDISA-N 0.000 claims 1
• FOVCGQVDSPCJQU-VHDGCEQUSA-N 5-(4-acetamidophenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=C(NC(C)=O)C=C1 FOVCGQVDSPCJQU-VHDGCEQUSA-N 0.000 claims 1
• GAZWMGYUEFRJAL-VNQPRFMTSA-N 5-(4-acetamidophenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(NC(C)=O)C=C1 GAZWMGYUEFRJAL-VNQPRFMTSA-N 0.000 claims 1
• JJNINPQOVHHWRM-VNQPRFMTSA-N 5-(4-acetylphenoxy)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C(C)=O)C=C1 JJNINPQOVHHWRM-VNQPRFMTSA-N 0.000 claims 1
• IUURPECTHMJPNK-OWCLPIDISA-N 5-(4-acetylphenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(C(C)=O)C=C1 IUURPECTHMJPNK-OWCLPIDISA-N 0.000 claims 1
• NRPNKEYTFKEOLR-VNQPRFMTSA-N 5-(4-acetylphenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C(C)=O)C=C1 NRPNKEYTFKEOLR-VNQPRFMTSA-N 0.000 claims 1
• NRELVCRYYKDRDV-DDTOSNHZSA-N 5-(4-amino-2-chlorophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(N)C=C1Cl NRELVCRYYKDRDV-DDTOSNHZSA-N 0.000 claims 1
• VMIFLSWGEYFFFL-DDTOSNHZSA-N 5-(4-amino-2-fluorophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(N)C=C1F VMIFLSWGEYFFFL-DDTOSNHZSA-N 0.000 claims 1
• NYEIABZJNHMKIY-KGYLQXTDSA-N 5-(4-aminophenoxy)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=C(N)C=C1 NYEIABZJNHMKIY-KGYLQXTDSA-N 0.000 claims 1
• LPGZHVFPZXPMAD-KWCYVHTRSA-N 5-(4-aminophenoxy)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(N)C=C1 LPGZHVFPZXPMAD-KWCYVHTRSA-N 0.000 claims 1
• LXANEQUHGWDJGA-FRRDWIJNSA-N 5-(4-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(N)C=C1 LXANEQUHGWDJGA-FRRDWIJNSA-N 0.000 claims 1
• OPCKCDFYCAPECE-IVMMDQJWSA-N 5-(4-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(N)C=C1 OPCKCDFYCAPECE-IVMMDQJWSA-N 0.000 claims 1
• SVSBRZOVULTPST-HZSPNIEDSA-N 5-(4-aminophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(N)C=C1 SVSBRZOVULTPST-HZSPNIEDSA-N 0.000 claims 1
• OUTAAIPIFWMSMU-KGYLQXTDSA-N 5-(4-aminophenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=C(N)C=C1 OUTAAIPIFWMSMU-KGYLQXTDSA-N 0.000 claims 1
• AYLQMEJUDZCJJA-KWCYVHTRSA-N 5-(4-aminophenyl)sulfanyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(N)C=C1 AYLQMEJUDZCJJA-KWCYVHTRSA-N 0.000 claims 1
• VGNCNOLRDFQGQG-HSALFYBXSA-N 5-(4-anilinophenyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1NC1=CC=CC=C1 VGNCNOLRDFQGQG-HSALFYBXSA-N 0.000 claims 1
• VUJLXZOBWPFSII-KXUCPTDWSA-N 5-acetamido-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(NC(C)=O)O1 VUJLXZOBWPFSII-KXUCPTDWSA-N 0.000 claims 1
• QSRVWNFIYPTZPZ-ADEWGFFLSA-N N-[(1S,2R,4R)-7-azabicyclo[2.2.1]heptan-2-yl]-2-(2-hydroxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1O QSRVWNFIYPTZPZ-ADEWGFFLSA-N 0.000 claims 1
• SIXFODDTIGPMKA-KGYLQXTDSA-N N-[(1S,2R,4R)-7-azabicyclo[2.2.1]heptan-2-yl]-2-(4-hydroxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(O)C=C1 SIXFODDTIGPMKA-KGYLQXTDSA-N 0.000 claims 1
• PURGGVAFBYSADR-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-(2,4,6-trifluorophenyl)pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=C(F)C=C(F)C=C1F PURGGVAFBYSADR-DDTOSNHZSA-N 0.000 claims 1
• YSKJSVRNHWNBLG-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-(2-methylsulfanylphenyl)pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1SC YSKJSVRNHWNBLG-VHDGCEQUSA-N 0.000 claims 1
• LGHBXOSHRZOYCH-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-(3-methylphenyl)pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(C)=C1 LGHBXOSHRZOYCH-OWCLPIDISA-N 0.000 claims 1
• WMFHHMFXCKKBJO-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-(4-methylsulfanylphenyl)pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(SC)C=C1 WMFHHMFXCKKBJO-VNQPRFMTSA-N 0.000 claims 1
• RLISZURSCNJMOA-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-[2-(methylamino)phenyl]pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1NC RLISZURSCNJMOA-UHOFOFEASA-N 0.000 claims 1
• GFCUPBQUQZQEFL-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-[3-(methylamino)phenyl]pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(NC)=C1 GFCUPBQUQZQEFL-OWCLPIDISA-N 0.000 claims 1
• IARGEEQPEVLFIK-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-[4-(methylamino)phenyl]pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(NC)C=C1 IARGEEQPEVLFIK-OWCLPIDISA-N 0.000 claims 1
• MZZJFNGDZMNCCH-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-phenylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1 MZZJFNGDZMNCCH-QLFBSQMISA-N 0.000 claims 1
• TYCDRGMDRAXQFJ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-pyridin-3-ylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CN=C1 TYCDRGMDRAXQFJ-HZSPNIEDSA-N 0.000 claims 1
• PQYRLMNVNGLCMY-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-methyl-5-pyridin-4-ylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=NC=C1 PQYRLMNVNGLCMY-HZSPNIEDSA-N 0.000 claims 1
• KTOWBOYTONXYPZ-JFUSQASVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2,3-difluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(F)=C1F KTOWBOYTONXYPZ-JFUSQASVSA-N 0.000 claims 1
• LYIMGICEVAIMGN-JFUSQASVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=C(F)C=CC=C1F LYIMGICEVAIMGN-JFUSQASVSA-N 0.000 claims 1
• SEXJYMLYNIWGPW-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-chlorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1Cl SEXJYMLYNIWGPW-JIMOISOXSA-N 0.000 claims 1
• MOYLQHNHNIULQM-XNQXYUBBSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-fluoro-1h-pyridin-2-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1(F)NC=CC=C1 MOYLQHNHNIULQM-XNQXYUBBSA-N 0.000 claims 1
• BXPPJIIXPJALFB-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-fluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1F BXPPJIIXPJALFB-JIMOISOXSA-N 0.000 claims 1
• UYOKACXDYOCQSN-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-methoxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1OC UYOKACXDYOCQSN-KGYLQXTDSA-N 0.000 claims 1
• UMCCWGYSXQEGIR-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-methylphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1C UMCCWGYSXQEGIR-KWCYVHTRSA-N 0.000 claims 1
• HWSNWBMHJRVUKM-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-nitrophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1[N+]([O-])=O HWSNWBMHJRVUKM-ADEWGFFLSA-N 0.000 claims 1
• XDCDYLBNLMMACV-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3,4-difluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(F)C(F)=C1 XDCDYLBNLMMACV-JIMOISOXSA-N 0.000 claims 1
• SYJWQOWIGPINNU-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3,5-difluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC(F)=CC(F)=C1 SYJWQOWIGPINNU-FRRDWIJNSA-N 0.000 claims 1
• NWPKMKRXVVFMFV-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-bromophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(Br)=C1 NWPKMKRXVVFMFV-FRRDWIJNSA-N 0.000 claims 1
• RCIGYHPFOPFFGM-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-chlorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(Cl)=C1 RCIGYHPFOPFFGM-FRRDWIJNSA-N 0.000 claims 1
• DFPKQGLUVDQGCO-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-fluoropyridin-2-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=NC=CC=C1F DFPKQGLUVDQGCO-DVVUODLYSA-N 0.000 claims 1
• ROQAXCRJIGVFMH-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-hydroxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(O)=C1 ROQAXCRJIGVFMH-KGYLQXTDSA-N 0.000 claims 1
• NUWIVOMPLGTKLY-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-methoxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(OC)=C1 NUWIVOMPLGTKLY-KWCYVHTRSA-N 0.000 claims 1
• DUCYXJYWPVZISX-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-methylphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(C)=C1 DUCYXJYWPVZISX-HZSPNIEDSA-N 0.000 claims 1
• ZDWCLMJYMVINRS-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-nitrophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC([N+]([O-])=O)=C1 ZDWCLMJYMVINRS-KGYLQXTDSA-N 0.000 claims 1
• UWPVMAJZZSPZND-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-chlorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(Cl)C=C1 UWPVMAJZZSPZND-FRRDWIJNSA-N 0.000 claims 1
• CDXMWJZBQAPGPN-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(=C(N=1)C)SC=1C1=CC=C(Cl)C=C1 CDXMWJZBQAPGPN-HZSPNIEDSA-N 0.000 claims 1
• HFXDFEKLINUAKP-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-chlorophenyl)sulfanyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1SC1=CC=C(Cl)C=C1 HFXDFEKLINUAKP-KGYLQXTDSA-N 0.000 claims 1
• WUSVKEZDADWIDN-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-cyanophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(C#N)C=C1 WUSVKEZDADWIDN-HZSPNIEDSA-N 0.000 claims 1
• MDUCAYJRKPTPBH-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-fluorophenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(F)C=C1 MDUCAYJRKPTPBH-FRRDWIJNSA-N 0.000 claims 1
• SNRBYEOYHWHTND-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-fluorophenyl)sulfanyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1SC1=CC=C(F)C=C1 SNRBYEOYHWHTND-KGYLQXTDSA-N 0.000 claims 1
• NRFUKHIDYJHELM-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-fluoropyridin-2-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC(F)=CC=N1 NRFUKHIDYJHELM-OUAUKWLOSA-N 0.000 claims 1
• SVJSZQSVAJWKTQ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methoxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(OC)C=C1 SVJSZQSVAJWKTQ-KWCYVHTRSA-N 0.000 claims 1
• HMWIGTFLWBIWRD-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylphenyl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(C)C=C1 HMWIGTFLWBIWRD-HZSPNIEDSA-N 0.000 claims 1
• MAMGUEPYGOVVFS-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(5-fluoropyridin-2-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(F)C=N1 MAMGUEPYGOVVFS-JFGNBEQYSA-N 0.000 claims 1
• AQXPYVMTZFBBGW-WCABBAIRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(6-fluoropyridin-2-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(F)=N1 AQXPYVMTZFBBGW-WCABBAIRSA-N 0.000 claims 1
• KQKZAOBGQIHBAZ-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(6-fluoropyridin-3-yl)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(F)N=C1 KQKZAOBGQIHBAZ-OUAUKWLOSA-N 0.000 claims 1
• RNDTYINSPWQPRV-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(methylamino)-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CN=C(NC)S1 RNDTYINSPWQPRV-GJMOJQLCSA-N 0.000 claims 1
• QGYWBSBYJQCQHD-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[2-(methanesulfonamido)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1NS(C)(=O)=O QGYWBSBYJQCQHD-DDTOSNHZSA-N 0.000 claims 1
• XCRVZONNSSTOAS-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[2-(methylamino)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1NC XCRVZONNSSTOAS-DDTOSNHZSA-N 0.000 claims 1
• MSOBDOBIEPQQOL-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[2-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1OC(F)(F)F MSOBDOBIEPQQOL-ADEWGFFLSA-N 0.000 claims 1
• KWSCORWSRKQOTC-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[2-[(2,2,2-trifluoroacetyl)amino]phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1NC(=O)C(F)(F)F KWSCORWSRKQOTC-JIMOISOXSA-N 0.000 claims 1
• ZHLTVDHVVASYKZ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[3-(methanesulfonamido)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(NS(C)(=O)=O)=C1 ZHLTVDHVVASYKZ-KWCYVHTRSA-N 0.000 claims 1
• WTTLBCZHRJHHBP-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[3-(methylamino)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(NC)=C1 WTTLBCZHRJHHBP-HZSPNIEDSA-N 0.000 claims 1
• REPRESUAYWEAPI-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[3-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC(OC(F)(F)F)=C1 REPRESUAYWEAPI-KGYLQXTDSA-N 0.000 claims 1
• AHCSKOYWFFYVJK-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[4-(methanesulfonamido)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(NS(C)(=O)=O)C=C1 AHCSKOYWFFYVJK-HZSPNIEDSA-N 0.000 claims 1
• WGGLCYZVCPDMKV-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[4-(methylamino)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(NC)C=C1 WGGLCYZVCPDMKV-HZSPNIEDSA-N 0.000 claims 1
• IMQTXFXWPBDJQF-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(OC(F)(F)F)C=C1 IMQTXFXWPBDJQF-KGYLQXTDSA-N 0.000 claims 1
• RSCQNQFZABSOJG-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[4-[(2,2,2-trifluoroacetyl)amino]phenyl]-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=C(NC(=O)C(F)(F)F)C=C1 RSCQNQFZABSOJG-FRRDWIJNSA-N 0.000 claims 1
• UPITVXMWYLELKP-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-phenoxy-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1OC1=CC=CC=C1 UPITVXMWYLELKP-KGYLQXTDSA-N 0.000 claims 1
• TVGBCOIURYAUQZ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-phenyl-1,3-oxazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CN=C1C1=CC=CC=C1 TVGBCOIURYAUQZ-FRRDWIJNSA-N 0.000 claims 1
• YUHYSIFFWLRCQR-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-phenyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=C1 YUHYSIFFWLRCQR-FRRDWIJNSA-N 0.000 claims 1
• KZZFFQVODHDDRC-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyridin-2-yl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CC=N1 KZZFFQVODHDDRC-JFGNBEQYSA-N 0.000 claims 1
• RRJGBBSTBFAECN-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyridin-3-yl-1,3-thiazole-4-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=1)=CSC=1C1=CC=CN=C1 RRJGBBSTBFAECN-GRYCIOLGSA-N 0.000 claims 1
• KXIXYYASDARJML-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyridin-3-yl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=CN=C1 KXIXYYASDARJML-GRYCIOLGSA-N 0.000 claims 1
• OZULRBITLYGCQZ-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyridin-4-yl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CN=C1C1=CC=NC=C1 OZULRBITLYGCQZ-GRYCIOLGSA-N 0.000 claims 1
• JDVYWRRMBJNIIC-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-phenyl-1,2,4-oxadiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(ON=1)=NC=1C1=CC=CC=C1 JDVYWRRMBJNIIC-GRYCIOLGSA-N 0.000 claims 1
• UDNFKSAFEJPIRV-WKPIXPDZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-(4-hydroxyphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1SC1=CC=C(O)C=C1 UDNFKSAFEJPIRV-WKPIXPDZSA-N 0.000 claims 1
• QBYLUVPJVPMKKK-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-[2-(methanesulfonamido)phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1C1=CC=CC=C1NS(C)(=O)=O QBYLUVPJVPMKKK-UHOFOFEASA-N 0.000 claims 1
• XPYFPLIJZWPORB-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-[4-(trifluoromethyl)phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1C1=CC=C(C(F)(F)F)C=C1 XPYFPLIJZWPORB-QLFBSQMISA-N 0.000 claims 1
• CACGIFFKCMIPNJ-FKTZTGRPSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-chloro-5-methylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(Cl)=C(C)S1 CACGIFFKCMIPNJ-FKTZTGRPSA-N 0.000 claims 1
• CWFJRIOMGGYJSS-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-chloro-5-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC(Cl)=C1C1=CC=CC=C1 CWFJRIOMGGYJSS-KWCYVHTRSA-N 0.000 claims 1
• MKTAAAVNCWVIBP-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methoxy-5-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC(OC)=C1C1=CC=CC=C1 MKTAAAVNCWVIBP-HZSPNIEDSA-N 0.000 claims 1
• URUVEEZWFVRANU-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(=C(N=1)C)SC=1C1=CC=CC=C1 URUVEEZWFVRANU-HZSPNIEDSA-N 0.000 claims 1
• CZQHUXFBMCKQDK-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-2-pyridin-2-yl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(=C(N=1)C)SC=1C1=CC=CC=N1 CZQHUXFBMCKQDK-NTZNESFSSA-N 0.000 claims 1
• LDIZWTXOXLZHSB-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-2-pyridin-4-yl-1,3-thiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(=C(N=1)C)SC=1C1=CC=NC=C1 LDIZWTXOXLZHSB-FRRDWIJNSA-N 0.000 claims 1
• VLSORDDLKXBYDM-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-5-phenyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC=C1 VLSORDDLKXBYDM-HZSPNIEDSA-N 0.000 claims 1
• INFDWMFQNOSTRJ-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-5-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC(C)=C1C1=CC=CC=C1 INFDWMFQNOSTRJ-QLFBSQMISA-N 0.000 claims 1
• HHRRXOQEBMODNO-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methyl-5-thiophen-2-yl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CS1 HHRRXOQEBMODNO-OUAUKWLOSA-N 0.000 claims 1
• DZNYSDDYURJSSX-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1)=CC=1C1=CC=CC=C1 DZNYSDDYURJSSX-QLFBSQMISA-N 0.000 claims 1
• KHLPEBHGVTYQRA-WCABBAIRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,2-thiazol-3-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C=1C=CSN=1 KHLPEBHGVTYQRA-WCABBAIRSA-N 0.000 claims 1
• GYWGWZQQUKCCOZ-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3,4-oxadiazol-2-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NN=CO1 GYWGWZQQUKCCOZ-HRDYMLBCSA-N 0.000 claims 1
• KNOZVIUWPWZWDM-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3,4-oxadiazol-2-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=CO1 KNOZVIUWPWZWDM-HRDYMLBCSA-N 0.000 claims 1
• VJEUFUSTALLKMG-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3,4-thiadiazol-2-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NN=CS1 VJEUFUSTALLKMG-HRDYMLBCSA-N 0.000 claims 1
• FDFRHORQQFCDNB-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3,4-thiadiazol-2-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=CS1 FDFRHORQQFCDNB-HRDYMLBCSA-N 0.000 claims 1
• DUXRDCHYSITVEL-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=CO1 DUXRDCHYSITVEL-KXUCPTDWSA-N 0.000 claims 1
• YRGXLBJKSNGTBL-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-2-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=CO1 YRGXLBJKSNGTBL-KXUCPTDWSA-N 0.000 claims 1
• QVYLFSPQHPNHFO-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-2-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=CO1 QVYLFSPQHPNHFO-KXUCPTDWSA-N 0.000 claims 1
• KIWFCBLAASUFRP-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=CO1 KIWFCBLAASUFRP-KXUCPTDWSA-N 0.000 claims 1
• XQGOOWPPHPCWNW-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-5-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=CO1 XQGOOWPPHPCWNW-KXUCPTDWSA-N 0.000 claims 1
• FXHSFMUNGKCIKA-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-oxazol-5-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=CO1 FXHSFMUNGKCIKA-KXUCPTDWSA-N 0.000 claims 1
• LDWRPXOCKKITBY-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-2-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=CS1 LDWRPXOCKKITBY-KXUCPTDWSA-N 0.000 claims 1
• RNFNTZBIHFMBCJ-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=CS1 RNFNTZBIHFMBCJ-KXUCPTDWSA-N 0.000 claims 1
• RIHNCJRLZBMACS-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-5-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=CS1 RIHNCJRLZBMACS-KXUCPTDWSA-N 0.000 claims 1
• FJSLRNIFAPJRME-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1,3-thiazol-5-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=CS1 FJSLRNIFAPJRME-KXUCPTDWSA-N 0.000 claims 1
• UMYGJNNUQMSKAY-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1h-imidazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=CN1 UMYGJNNUQMSKAY-KXUCPTDWSA-N 0.000 claims 1
• HBHLMRBDQPVKFX-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1h-indol-5-yl)furan-2-carboxamide Chemical compound C1=C2NC=CC2=CC(C2=CC=C(O2)C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HBHLMRBDQPVKFX-VNQPRFMTSA-N 0.000 claims 1
• OJNUEKXACSBHJD-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(1h-pyrrol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CN1 OJNUEKXACSBHJD-JFGNBEQYSA-N 0.000 claims 1
• RDKDNQFFMXMBLF-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,3-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(Cl)=C1Cl RDKDNQFFMXMBLF-JIMOISOXSA-N 0.000 claims 1
• SRVOZKQSPOKUMJ-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,3-dichlorophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(Cl)=C1Cl SRVOZKQSPOKUMJ-ADEWGFFLSA-N 0.000 claims 1
• CHVUIOUSXSQZPQ-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,3-difluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(F)=C1F CHVUIOUSXSQZPQ-DDTOSNHZSA-N 0.000 claims 1
• DXCPTOPXBIJRGA-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-dichlorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(Cl)C=C1Cl DXCPTOPXBIJRGA-JIMOISOXSA-N 0.000 claims 1
• IRQFQBBQWFDXDC-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-dichlorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(Cl)C=C1Cl IRQFQBBQWFDXDC-BYCMXARLSA-N 0.000 claims 1
• KJYYWHZVQTZMAH-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-dichlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(Cl)C=C1Cl KJYYWHZVQTZMAH-FUEDEBDSSA-N 0.000 claims 1
• VZFUYIQDLSSWLH-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-dichlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(Cl)C=C1Cl VZFUYIQDLSSWLH-DDTOSNHZSA-N 0.000 claims 1
• BZRRHFYDVFVULE-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=C(F)C=C1F BZRRHFYDVFVULE-ADEWGFFLSA-N 0.000 claims 1
• IVQCUDNGURIIDE-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(F)C=C1F IVQCUDNGURIIDE-JIMOISOXSA-N 0.000 claims 1
• HNSFVGIQDTXBSR-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(F)C=C1F HNSFVGIQDTXBSR-BYCMXARLSA-N 0.000 claims 1
• HBQKRPYCAHORRH-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,4-difluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(F)C=C1F HBQKRPYCAHORRH-FUEDEBDSSA-N 0.000 claims 1
• FVESZSWDRKLALG-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2,6-difluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=C(F)C=CC=C1F FVESZSWDRKLALG-DDTOSNHZSA-N 0.000 claims 1
• PEJDBZKDEVJXFH-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-bromophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1Br PEJDBZKDEVJXFH-BYCMXARLSA-N 0.000 claims 1
• DKGDDBFVPMARBG-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-bromophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1Br DKGDDBFVPMARBG-FUEDEBDSSA-N 0.000 claims 1
• QIAQUEZQNZRTDC-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-bromophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1Br QIAQUEZQNZRTDC-DDTOSNHZSA-N 0.000 claims 1
• GDTYOPGWXKXGCD-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-carbamoylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1C(N)=O GDTYOPGWXKXGCD-KGYLQXTDSA-N 0.000 claims 1
• SUGJKGYGXYYBNW-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-carbamoylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1C(N)=O SUGJKGYGXYYBNW-KGYLQXTDSA-N 0.000 claims 1
• JQOSBNCZQPMZNO-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloro-1,3-thiazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(Cl)S1 JQOSBNCZQPMZNO-HRDYMLBCSA-N 0.000 claims 1
• YICVJRKCYYXPBX-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=CC=C1Cl YICVJRKCYYXPBX-ADEWGFFLSA-N 0.000 claims 1
• LDEGBRZEBFGQOH-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenoxy)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1OC1=CC=CC=C1Cl LDEGBRZEBFGQOH-KGYLQXTDSA-N 0.000 claims 1
• KGGYKDWQVSPEBV-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1Cl KGGYKDWQVSPEBV-KGYLQXTDSA-N 0.000 claims 1
• IRJFIWGLFVUZAA-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1Cl IRJFIWGLFVUZAA-JIMOISOXSA-N 0.000 claims 1
• HEOMHDHTYYHMEP-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1Cl HEOMHDHTYYHMEP-BYCMXARLSA-N 0.000 claims 1
• CLAOGANUQUGRKV-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1Cl CLAOGANUQUGRKV-FUEDEBDSSA-N 0.000 claims 1
• AAPSYKDHVSGOAO-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)-4-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC=C1Cl AAPSYKDHVSGOAO-DDTOSNHZSA-N 0.000 claims 1
• KXACVLXXIINCBX-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1Cl KXACVLXXIINCBX-DDTOSNHZSA-N 0.000 claims 1
• YERNQVHQXPAZEJ-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)sulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=CC=C1Cl YERNQVHQXPAZEJ-KGYLQXTDSA-N 0.000 claims 1
• NNNXHNWVVRPYIH-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chlorophenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1Cl NNNXHNWVVRPYIH-DDTOSNHZSA-N 0.000 claims 1
• HNSBETKMDMAYMQ-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CN=C1Cl HNSBETKMDMAYMQ-ADEWGFFLSA-N 0.000 claims 1
• GAUWNJCYXFSFIO-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloropyridin-4-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=NC(Cl)=C1 GAUWNJCYXFSFIO-GRYCIOLGSA-N 0.000 claims 1
• ZQMWCOZHPBMYAF-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloropyridin-4-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=NC(Cl)=C1 ZQMWCOZHPBMYAF-ADEWGFFLSA-N 0.000 claims 1
• PFNWYCKMTOZVLQ-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-chloropyridin-4-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=NC(Cl)=C1 PFNWYCKMTOZVLQ-GRYCIOLGSA-N 0.000 claims 1
• QQJNXMXKJHYPHF-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-cyanophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1C#N QQJNXMXKJHYPHF-VNQPRFMTSA-N 0.000 claims 1
• NRPHFEAAWGHSNL-ISTRZQFTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-cyanophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1C#N NRPHFEAAWGHSNL-ISTRZQFTSA-N 0.000 claims 1
• XZAROWGKRUAFNK-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-cyanophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1C#N XZAROWGKRUAFNK-HZSPNIEDSA-N 0.000 claims 1
• MCNRPXQFYVJRIL-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-cyanophenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1C#N MCNRPXQFYVJRIL-VHDGCEQUSA-N 0.000 claims 1
• QVYQFXJKKNTWKG-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoro-3-methoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(OC)=C1F QVYQFXJKKNTWKG-KGYLQXTDSA-N 0.000 claims 1
• GXUBEWJIRQISNW-WKPIXPDZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoro-4-methoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(OC)C=C1F GXUBEWJIRQISNW-WKPIXPDZSA-N 0.000 claims 1
• DLMHCZHEYZQPII-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoro-4-methylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(C)C=C1F DLMHCZHEYZQPII-BYCMXARLSA-N 0.000 claims 1
• FEMYCQFRYAPIPV-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=CC=C1F FEMYCQFRYAPIPV-ADEWGFFLSA-N 0.000 claims 1
• CEZZQFDDLYEIDE-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1F CEZZQFDDLYEIDE-BYCMXARLSA-N 0.000 claims 1
• FCNMDDOMIMEWMT-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)-4-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC=C1F FCNMDDOMIMEWMT-DDTOSNHZSA-N 0.000 claims 1
• MRQXOMDPDPXUSR-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)sulfanyl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1SC1=CC=CC=C1F MRQXOMDPDPXUSR-ADEWGFFLSA-N 0.000 claims 1
• QLPPJIQIIBBQKU-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluorophenyl)sulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=CC=C1F QLPPJIQIIBBQKU-KGYLQXTDSA-N 0.000 claims 1
• YFUPDWSTRWYTKI-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-3-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CN=C1F YFUPDWSTRWYTKI-KGYLQXTDSA-N 0.000 claims 1
• HVGIKPQXSCVYPI-LJWDBELGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-3-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CN=C1F HVGIKPQXSCVYPI-LJWDBELGSA-N 0.000 claims 1
• NDDOFQJLHHDQDA-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CN=C1F NDDOFQJLHHDQDA-ADEWGFFLSA-N 0.000 claims 1
• QGQHZWCKERRORC-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-4-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=NC(F)=C1 QGQHZWCKERRORC-FRRDWIJNSA-N 0.000 claims 1
• SSEMRGWSBRJWEL-SCDSUCTJSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-fluoropyridin-4-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=NC(F)=C1 SSEMRGWSBRJWEL-SCDSUCTJSA-N 0.000 claims 1
• IRFLWGJHBGXDBE-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1O IRFLWGJHBGXDBE-GRYCIOLGSA-N 0.000 claims 1
• QFVRYSXTCRZUNL-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1O QFVRYSXTCRZUNL-KWCYVHTRSA-N 0.000 claims 1
• MPHKQHJIFIRDFD-RIEGTJTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1O MPHKQHJIFIRDFD-RIEGTJTDSA-N 0.000 claims 1
• KQNLPFGHHVTZQV-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1O KQNLPFGHHVTZQV-KGYLQXTDSA-N 0.000 claims 1
• XUYOCBGAODCQCC-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1O XUYOCBGAODCQCC-GRYCIOLGSA-N 0.000 claims 1
• AWCLLQYKMPVIDT-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-hydroxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1O AWCLLQYKMPVIDT-KGYLQXTDSA-N 0.000 claims 1
• JNTIBMSLOONHIP-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxy-1,3-thiazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(OC)S1 JNTIBMSLOONHIP-KXUCPTDWSA-N 0.000 claims 1
• VIYRNRRCBONDMO-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC=C1OC VIYRNRRCBONDMO-GRYCIOLGSA-N 0.000 claims 1
• NWWPJUUTHZOBHL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1OC NWWPJUUTHZOBHL-FRRDWIJNSA-N 0.000 claims 1
• HTMAAIPEPASEPV-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1OC HTMAAIPEPASEPV-KGYLQXTDSA-N 0.000 claims 1
• MIBBOMLJHHONKJ-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1OC MIBBOMLJHHONKJ-KGYLQXTDSA-N 0.000 claims 1
• ARXGMAOJNJIEKC-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC=C1OC ARXGMAOJNJIEKC-VHDGCEQUSA-N 0.000 claims 1
• HNIHDUNECDALDY-DIOULYMOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1OC HNIHDUNECDALDY-DIOULYMOSA-N 0.000 claims 1
• QYRPRWZTKMBTAC-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)-4-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC=C1OC QYRPRWZTKMBTAC-KWCYVHTRSA-N 0.000 claims 1
• SFTKYLPVHGQNLE-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=CC=C1OC SFTKYLPVHGQNLE-GRYCIOLGSA-N 0.000 claims 1
• FTBIMLXORLPROH-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxyphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1OC FTBIMLXORLPROH-FRRDWIJNSA-N 0.000 claims 1
• KYHQHEFXKBOXQU-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxypyridin-4-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=NC(OC)=C1 KYHQHEFXKBOXQU-KGYLQXTDSA-N 0.000 claims 1
• URCXUOQWFQNBQO-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxypyridin-4-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=NC(OC)=C1 URCXUOQWFQNBQO-KGYLQXTDSA-N 0.000 claims 1
• HWEMKCVGQKTDBQ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methoxypyridin-4-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=NC(OC)=C1 HWEMKCVGQKTDBQ-FRRDWIJNSA-N 0.000 claims 1
• XVZLQVLKQUZDDE-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methyl-1,3-oxazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(C)O1 XVZLQVLKQUZDDE-OUAUKWLOSA-N 0.000 claims 1
• SOEUQISBXQRZSF-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methyl-1,3-thiazol-5-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CN=C(C)S1 SOEUQISBXQRZSF-OUAUKWLOSA-N 0.000 claims 1
• OVNTYDJEWVFGRN-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC=C1C OVNTYDJEWVFGRN-FRRDWIJNSA-N 0.000 claims 1
• CJRVVDMANIZBQY-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1C CJRVVDMANIZBQY-HZSPNIEDSA-N 0.000 claims 1
• IBGOFZUYBBGBDT-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1C IBGOFZUYBBGBDT-KWCYVHTRSA-N 0.000 claims 1
• NUSUXINGHQUCRY-ISTRZQFTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1C NUSUXINGHQUCRY-ISTRZQFTSA-N 0.000 claims 1
• WIYZANFTPANDLG-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C WIYZANFTPANDLG-VHDGCEQUSA-N 0.000 claims 1
• ULQWQGCFJDTGSW-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=CC=C1C ULQWQGCFJDTGSW-FRRDWIJNSA-N 0.000 claims 1
• BDFKVXCNCNNVGN-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1C BDFKVXCNCNNVGN-VHDGCEQUSA-N 0.000 claims 1
• MXHBYNNDAQOBQM-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylpyridin-4-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=NC(C)=C1 MXHBYNNDAQOBQM-KWCYVHTRSA-N 0.000 claims 1
• ARMJFCSLKUFKMZ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylpyridin-4-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=NC(C)=C1 ARMJFCSLKUFKMZ-HZSPNIEDSA-N 0.000 claims 1
• ZISUVBOZSLNKNF-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-methylsulfanylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1SC ZISUVBOZSLNKNF-KWCYVHTRSA-N 0.000 claims 1
• RNOQQAPIACUFGF-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-morpholin-4-ylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1N1CCOCC1 RNOQQAPIACUFGF-OWCLPIDISA-N 0.000 claims 1
• YITMBOMGUFNCJD-HYVNUMGLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-morpholin-4-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1N1CCOCC1 YITMBOMGUFNCJD-HYVNUMGLSA-N 0.000 claims 1
• YBBGYXSRNZMXEV-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-morpholin-4-ylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1N1CCOCC1 YBBGYXSRNZMXEV-OWCLPIDISA-N 0.000 claims 1
• UAGAEYKMHXRYOU-HYVNUMGLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-morpholin-4-ylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1N1CCOCC1 UAGAEYKMHXRYOU-HYVNUMGLSA-N 0.000 claims 1
• HLTGHKOMDGQKFI-RIEGTJTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-nitrophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1[N+]([O-])=O HLTGHKOMDGQKFI-RIEGTJTDSA-N 0.000 claims 1
• DFFOPSCSQCNPMJ-AYOQOUSVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-phenoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1OC1=CC=CC=C1 DFFOPSCSQCNPMJ-AYOQOUSVSA-N 0.000 claims 1
• YYSJWUDWNTYLDT-AYOQOUSVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-phenylsulfanylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1SC1=CC=CC=C1 YYSJWUDWNTYLDT-AYOQOUSVSA-N 0.000 claims 1
• GTVGLSFDPPFSMK-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-piperidin-1-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1N1CCCCC1 GTVGLSFDPPFSMK-BPQIPLTHSA-N 0.000 claims 1
• WJLGLNFEKHQSQJ-HYVNUMGLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-pyrrolidin-1-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1N1CCCC1 WJLGLNFEKHQSQJ-HYVNUMGLSA-N 0.000 claims 1
• DBZXEYWTOWGAGH-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-sulfamoylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1S(N)(=O)=O DBZXEYWTOWGAGH-GRYCIOLGSA-N 0.000 claims 1
• DKODKFAPSNQEGU-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(2-sulfamoylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1S(N)(=O)=O DKODKFAPSNQEGU-KGYLQXTDSA-N 0.000 claims 1
• WYVWQUBJSXNUNC-OXHMUOHRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-dichlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=C(Cl)C(Cl)=C1 WYVWQUBJSXNUNC-OXHMUOHRSA-N 0.000 claims 1
• FUZGBJMJEGEFDL-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-dichlorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(Cl)C(Cl)=C1 FUZGBJMJEGEFDL-BYCMXARLSA-N 0.000 claims 1
• GNPLHALLJWGZMH-FUEDEBDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-dichlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(Cl)C(Cl)=C1 GNPLHALLJWGZMH-FUEDEBDSSA-N 0.000 claims 1
• CKIFVGBHFMXARN-OXHMUOHRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-difluorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=C(F)C(F)=C1 CKIFVGBHFMXARN-OXHMUOHRSA-N 0.000 claims 1
• SVUIPEJAEOWALX-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-difluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(F)C(F)=C1 SVUIPEJAEOWALX-BYCMXARLSA-N 0.000 claims 1
• HAYJJQMXXVTKRR-OXHMUOHRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,4-difluorophenyl)sulfanyl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1SC1=CC=C(F)C(F)=C1 HAYJJQMXXVTKRR-OXHMUOHRSA-N 0.000 claims 1
• FXPQKSCOKCOYRW-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-dichlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC(Cl)=CC(Cl)=C1 FXPQKSCOKCOYRW-KGYLQXTDSA-N 0.000 claims 1
• LKQXRISEDLUHBK-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-dichlorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC(Cl)=CC(Cl)=C1 LKQXRISEDLUHBK-QLFBSQMISA-N 0.000 claims 1
• QMHJROOAMUVGHL-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-difluorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC(F)=CC(F)=C1 QMHJROOAMUVGHL-KGYLQXTDSA-N 0.000 claims 1
• ILQIHRKDNPUHAJ-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-difluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC(F)=CC(F)=C1 ILQIHRKDNPUHAJ-QLFBSQMISA-N 0.000 claims 1
• QMAVKZGHBIZMKQ-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3,5-difluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC(F)=CC(F)=C1 QMAVKZGHBIZMKQ-IVMMDQJWSA-N 0.000 claims 1
• UFNBAQMABGRGEE-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-bromophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(Br)=C1 UFNBAQMABGRGEE-QLFBSQMISA-N 0.000 claims 1
• SEXCXRSNYNVUAX-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-bromophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(Br)=C1 SEXCXRSNYNVUAX-IVMMDQJWSA-N 0.000 claims 1
• LTGISPWKOQKGNP-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-bromophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(Br)=C1 LTGISPWKOQKGNP-HZSPNIEDSA-N 0.000 claims 1
• YAZGCFXFLXSJFP-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-carbamoylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(C(N)=O)=C1 YAZGCFXFLXSJFP-KWCYVHTRSA-N 0.000 claims 1
• UDKAQRQBICWDOE-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-carbamoylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(C(N)=O)=C1 UDKAQRQBICWDOE-KWCYVHTRSA-N 0.000 claims 1
• GCEYKEQRKSZLIW-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-carbamoylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(C(N)=O)=C1 GCEYKEQRKSZLIW-HZSPNIEDSA-N 0.000 claims 1
• AWZDAUGLRIPDJT-BIGNPOOSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chloro-4-fluorophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(F)C(Cl)=C1 AWZDAUGLRIPDJT-BIGNPOOSSA-N 0.000 claims 1
• JGSTYJGNISRLJX-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=CC(Cl)=C1 JGSTYJGNISRLJX-KGYLQXTDSA-N 0.000 claims 1
• BTVFPXLCAKDKSR-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(Cl)=C1 BTVFPXLCAKDKSR-KWCYVHTRSA-N 0.000 claims 1
• ZYKFGRZNPNQBQX-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(Cl)=C1 ZYKFGRZNPNQBQX-FRRDWIJNSA-N 0.000 claims 1
• ASLSRAGTHIDIFM-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(Cl)=C1 ASLSRAGTHIDIFM-FRRDWIJNSA-N 0.000 claims 1
• UVEJDEOTUIXOAB-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(Cl)=C1 UVEJDEOTUIXOAB-QLFBSQMISA-N 0.000 claims 1
• IPPWWQQJTGCKLD-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(Cl)=C1 IPPWWQQJTGCKLD-IVMMDQJWSA-N 0.000 claims 1
• AJWTYJHUCLOELK-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)-4-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC(Cl)=C1 AJWTYJHUCLOELK-HZSPNIEDSA-N 0.000 claims 1
• MUHVTFBTZRYINT-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)sulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=CC(Cl)=C1 MUHVTFBTZRYINT-KWCYVHTRSA-N 0.000 claims 1
• MXQTVINLTJXZFV-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chlorophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(Cl)=C1 MXQTVINLTJXZFV-KWCYVHTRSA-N 0.000 claims 1
• QAEWWDCJDDOIRA-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chloropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=NC=CC=C1Cl QAEWWDCJDDOIRA-ADEWGFFLSA-N 0.000 claims 1
• JUTLNGZFTQXKPN-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-chloropyridin-4-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=NC=C1Cl JUTLNGZFTQXKPN-JIMOISOXSA-N 0.000 claims 1
• MHCZJBUTUPDMGC-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-cyanophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(C#N)=C1 MHCZJBUTUPDMGC-HZSPNIEDSA-N 0.000 claims 1
• RGQCLRRELVAYOC-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-cyanophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(C#N)=C1 RGQCLRRELVAYOC-UKPHBRMFSA-N 0.000 claims 1
• NJBPESWYSFOICW-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-cyanophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(C#N)=C1 NJBPESWYSFOICW-QLFBSQMISA-N 0.000 claims 1
• XMYKRRCQYBSGCG-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-cyanophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(C#N)=C1 XMYKRRCQYBSGCG-VHDGCEQUSA-N 0.000 claims 1
• UMJAYKCTBZBMIX-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-cyanophenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(C#N)=C1 UMJAYKCTBZBMIX-QLFBSQMISA-N 0.000 claims 1
• JGAXNJHCZJZLBB-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoro-4-hydroxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(O)C(F)=C1 JGAXNJHCZJZLBB-KGYLQXTDSA-N 0.000 claims 1
• SSODURVNFZWBND-YZGWKJHDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoro-4-phenylmethoxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C(C=C1F)=CC=C1OCC1=CC=CC=C1 SSODURVNFZWBND-YZGWKJHDSA-N 0.000 claims 1
• WYHXSVMKSVXGIK-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=CC(F)=C1 WYHXSVMKSVXGIK-KGYLQXTDSA-N 0.000 claims 1
• MNZOUEUFEYOJAQ-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC(F)=C1 MNZOUEUFEYOJAQ-KGYLQXTDSA-N 0.000 claims 1
• KMCQVBNBOVGXHA-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenoxy)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1OC1=CC=CC(F)=C1 KMCQVBNBOVGXHA-KWCYVHTRSA-N 0.000 claims 1
• WIGJKIWKEBEAHT-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(F)=C1 WIGJKIWKEBEAHT-FRRDWIJNSA-N 0.000 claims 1
• ROHPSPIZQMPCKP-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(F)=C1 ROHPSPIZQMPCKP-QLFBSQMISA-N 0.000 claims 1
• VTRWANFPPFXUSC-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(F)=C1 VTRWANFPPFXUSC-IVMMDQJWSA-N 0.000 claims 1
• CQNCLJGNOACIGZ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)-4-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC(F)=C1 CQNCLJGNOACIGZ-HZSPNIEDSA-N 0.000 claims 1
• XXXSDYFTGLLPFS-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(F)=C1 XXXSDYFTGLLPFS-HZSPNIEDSA-N 0.000 claims 1
• JPLIKRVQUMOGJA-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)sulfanyl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1SC1=CC=CC(F)=C1 JPLIKRVQUMOGJA-KGYLQXTDSA-N 0.000 claims 1
• LLFNKPAHKCDNJU-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=CC(F)=C1 LLFNKPAHKCDNJU-KGYLQXTDSA-N 0.000 claims 1
• RXGFKGWMCOTBAK-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluorophenyl)sulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=CC(F)=C1 RXGFKGWMCOTBAK-KWCYVHTRSA-N 0.000 claims 1
• OKYDZCHFGITDTA-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-2-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=NC=CC=C1F OKYDZCHFGITDTA-DVVUODLYSA-N 0.000 claims 1
• MYAHTNZKSBTKJT-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=NC=CC=C1F MYAHTNZKSBTKJT-ADEWGFFLSA-N 0.000 claims 1
• SSXYVKPZVRGQLD-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-4-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=NC=C1F SSXYVKPZVRGQLD-DDTOSNHZSA-N 0.000 claims 1
• KFZVVWBYZSHVCI-ZDBHGNHJSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-4-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=NC=C1F KFZVVWBYZSHVCI-ZDBHGNHJSA-N 0.000 claims 1
• YFLXSTTVFDUATP-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-fluoropyridin-4-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=NC=C1F YFLXSTTVFDUATP-JIMOISOXSA-N 0.000 claims 1
• VBRAKZSNRYWABD-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(O)=C1 VBRAKZSNRYWABD-DDTOSNHZSA-N 0.000 claims 1
• HSMPTTFARXYIKY-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(O)=C1 HSMPTTFARXYIKY-VHDGCEQUSA-N 0.000 claims 1
• WDFBSILDMBSLAF-DIOULYMOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(O)=C1 WDFBSILDMBSLAF-DIOULYMOSA-N 0.000 claims 1
• ADZDULCGJLJMKB-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(O)=C1 ADZDULCGJLJMKB-DDTOSNHZSA-N 0.000 claims 1
• MLAUYNIBMLNGSW-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-hydroxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(O)=C1 MLAUYNIBMLNGSW-KWCYVHTRSA-N 0.000 claims 1
• AEENTNWRHQQOJQ-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(OC)=C1 AEENTNWRHQQOJQ-BYCMXARLSA-N 0.000 claims 1
• ULNSABLGFFJRKX-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(OC)=C1 ULNSABLGFFJRKX-KWCYVHTRSA-N 0.000 claims 1
• YPGUQBATGVHKHN-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(OC)=C1 YPGUQBATGVHKHN-KWCYVHTRSA-N 0.000 claims 1
• MPQBZCZHSRZOGU-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=CC(OC)=C1 MPQBZCZHSRZOGU-VNQPRFMTSA-N 0.000 claims 1
• WAIJDRQDMMASHP-ISTRZQFTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(OC)=C1 WAIJDRQDMMASHP-ISTRZQFTSA-N 0.000 claims 1
• BFHDKFLFNWTJPJ-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)-4-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC(C)=C1C1=CC=CC(OC)=C1 BFHDKFLFNWTJPJ-VHDGCEQUSA-N 0.000 claims 1
• QYIZTUZYFUDUHO-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(OC)=C1 QYIZTUZYFUDUHO-VHDGCEQUSA-N 0.000 claims 1
• RRKHUTCBYCILIZ-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(OC)=C1 RRKHUTCBYCILIZ-BYCMXARLSA-N 0.000 claims 1
• RJZXPMMKKUPZED-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methoxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(OC)=C1 RJZXPMMKKUPZED-VHDGCEQUSA-N 0.000 claims 1
• DCINOUJSUAXFMJ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=CC(C)=C1 DCINOUJSUAXFMJ-KWCYVHTRSA-N 0.000 claims 1
• BBPPYRCTUDQFJU-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(C)=C1 BBPPYRCTUDQFJU-VHDGCEQUSA-N 0.000 claims 1
• CWUKOQALGULDSC-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=CC(C)=C1 CWUKOQALGULDSC-KWCYVHTRSA-N 0.000 claims 1
• LGPVYDHXOIYNAV-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(C)=C1 LGPVYDHXOIYNAV-VHDGCEQUSA-N 0.000 claims 1
• PVBRSUKIBYSLTA-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(C)=C1 PVBRSUKIBYSLTA-QLFBSQMISA-N 0.000 claims 1
• SJWTUKBCBVVKTP-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-methylsulfanylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(SC)=C1 SJWTUKBCBVVKTP-VHDGCEQUSA-N 0.000 claims 1
• NRXPDJWSDPIPIO-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-morpholin-4-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1N1CCOCC1 NRXPDJWSDPIPIO-BPQIPLTHSA-N 0.000 claims 1
• NVMCQHICRCAWRI-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-morpholin-4-ylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC(C=1)=CC=CC=1N1CCOCC1 NVMCQHICRCAWRI-FHLIZLRMSA-N 0.000 claims 1
• OLVBGVPZYPUXSV-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-morpholin-4-ylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C(C=1)=CC=CC=1N1CCOCC1 OLVBGVPZYPUXSV-BPQIPLTHSA-N 0.000 claims 1
• KKOXNMOKVWTMSS-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-nitrophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC([N+]([O-])=O)=C1 KKOXNMOKVWTMSS-KGYLQXTDSA-N 0.000 claims 1
• HHMGEQKVVBUMBC-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-nitrophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC([N+]([O-])=O)=C1 HHMGEQKVVBUMBC-KGYLQXTDSA-N 0.000 claims 1
• HIGBNUAILGCBJO-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-nitrophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC([N+]([O-])=O)=C1 HIGBNUAILGCBJO-KWCYVHTRSA-N 0.000 claims 1
• PYJVJKYFJKYFOT-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-nitrophenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC([N+]([O-])=O)=C1 PYJVJKYFJKYFOT-KWCYVHTRSA-N 0.000 claims 1
• TWNHTQHKHJWCII-HLAWJBBLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-phenylmethoxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 TWNHTQHKHJWCII-HLAWJBBLSA-N 0.000 claims 1
• XAQVNNUGWULCEZ-LSTHTHJFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-phenylsulfanylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1SC1=CC=CC=C1 XAQVNNUGWULCEZ-LSTHTHJFSA-N 0.000 claims 1
• VFTKIDYTZVFBOZ-NZSAHSFTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-piperidin-1-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1N1CCCCC1 VFTKIDYTZVFBOZ-NZSAHSFTSA-N 0.000 claims 1
• QNQUAFIZRBQFEG-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-pyrrolidin-1-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1N1CCCC1 QNQUAFIZRBQFEG-BPQIPLTHSA-N 0.000 claims 1
• AHBYMLUWXUPOBZ-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-sulfamoylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(S(N)(=O)=O)=C1 AHBYMLUWXUPOBZ-DDTOSNHZSA-N 0.000 claims 1
• ICGKKBKODSSBPN-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-sulfamoylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(S(N)(=O)=O)=C1 ICGKKBKODSSBPN-DDTOSNHZSA-N 0.000 claims 1
• FGEBCMQMSNLLLK-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(3-sulfamoylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(S(N)(=O)=O)=C1 FGEBCMQMSNLLLK-KWCYVHTRSA-N 0.000 claims 1
• JBCYODZVNQKTGY-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-bromophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(Br)C=C1 JBCYODZVNQKTGY-FRRDWIJNSA-N 0.000 claims 1
• JLZDLQJKKOAEEE-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-bromophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(Br)C=C1 JLZDLQJKKOAEEE-FRRDWIJNSA-N 0.000 claims 1
• KOHCQVGJLNKPOG-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-bromophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(Br)C=C1 KOHCQVGJLNKPOG-QLFBSQMISA-N 0.000 claims 1
• IPZLIQKSVDYYLE-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-bromophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(Br)C=C1 IPZLIQKSVDYYLE-IVMMDQJWSA-N 0.000 claims 1
• DYJIMBWVBDQHEM-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-carbamoylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C(N)=O)C=C1 DYJIMBWVBDQHEM-KWCYVHTRSA-N 0.000 claims 1
• OYNOOGVMYISBTQ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-carbamoylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C(N)=O)C=C1 OYNOOGVMYISBTQ-KWCYVHTRSA-N 0.000 claims 1
• IJISIGBCBGNXCB-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloro-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(Cl)=CO1 IJISIGBCBGNXCB-HRDYMLBCSA-N 0.000 claims 1
• ADJUUHGEXTVZFU-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloro-2-nitrophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(Cl)C=C1[N+]([O-])=O ADJUUHGEXTVZFU-KGYLQXTDSA-N 0.000 claims 1
• RFBQGNVNALKYFO-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenoxy)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=C(Cl)C=C1 RFBQGNVNALKYFO-KGYLQXTDSA-N 0.000 claims 1
• DHAGXGSGIACDSC-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(Cl)C=C1 DHAGXGSGIACDSC-FRRDWIJNSA-N 0.000 claims 1
• CICOKRWJZSZNIM-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(Cl)C=C1 CICOKRWJZSZNIM-QLFBSQMISA-N 0.000 claims 1
• SNIQVFBWHCRHIC-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(Cl)C=C1 SNIQVFBWHCRHIC-IVMMDQJWSA-N 0.000 claims 1
• FGLPAVWSBXLUGF-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(Cl)C=C1 FGLPAVWSBXLUGF-HZSPNIEDSA-N 0.000 claims 1
• WQVGWPNXGRDITG-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)sulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=C(Cl)C=C1 WQVGWPNXGRDITG-KWCYVHTRSA-N 0.000 claims 1
• AWCROBBGALIREV-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(Cl)C=C1 AWCROBBGALIREV-KWCYVHTRSA-N 0.000 claims 1
• QHZVTDHQUYKFTN-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chlorophenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(Cl)C=C1 QHZVTDHQUYKFTN-HZSPNIEDSA-N 0.000 claims 1
• LDCKWMISCYMDAG-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC(Cl)=CC=N1 LDCKWMISCYMDAG-GRYCIOLGSA-N 0.000 claims 1
• GLJCTQRJBXNCMK-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloropyridin-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC(Cl)=CC=N1 GLJCTQRJBXNCMK-GRYCIOLGSA-N 0.000 claims 1
• RKWWVCBIBFZMRA-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloropyridin-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC(Cl)=CC=N1 RKWWVCBIBFZMRA-GRYCIOLGSA-N 0.000 claims 1
• BGHQJNAOVIHSEO-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloropyridin-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC(Cl)=CC=N1 BGHQJNAOVIHSEO-GRYCIOLGSA-N 0.000 claims 1
• FTRPLXFPNRUQJV-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-chloropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CN=CC=C1Cl FTRPLXFPNRUQJV-JIMOISOXSA-N 0.000 claims 1
• FFPUENLERXQVPB-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-cyanophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(C#N)C=C1 FFPUENLERXQVPB-OWCLPIDISA-N 0.000 claims 1
• PVSRPCQMBPSQTO-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-cyanophenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C#N)C=C1 PVSRPCQMBPSQTO-VHDGCEQUSA-N 0.000 claims 1
• ANMJPYWRAOKVJS-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-cyanophenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C#N)C=C1 ANMJPYWRAOKVJS-QLFBSQMISA-N 0.000 claims 1
• BDYFCWKQUODZOI-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoro-3-methylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(F)C(C)=C1 BDYFCWKQUODZOI-VHDGCEQUSA-N 0.000 claims 1
• ZUYNNKSHJQOFQQ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenoxy)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1OC1=CC=C(F)C=C1 ZUYNNKSHJQOFQQ-KWCYVHTRSA-N 0.000 claims 1
• UFWGODXWDZFASH-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(F)C=C1 UFWGODXWDZFASH-FRRDWIJNSA-N 0.000 claims 1
• HJFNYARAPAUFJX-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=C(F)C=C1 HJFNYARAPAUFJX-FRRDWIJNSA-N 0.000 claims 1
• OLFFEZUZFWDVOI-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(F)C=C1 OLFFEZUZFWDVOI-QLFBSQMISA-N 0.000 claims 1
• KDUVMHNEIYURDZ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(F)C=C1 KDUVMHNEIYURDZ-HZSPNIEDSA-N 0.000 claims 1
• KEGTTWBUVVRTEI-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)sulfanyl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1SC1=CC=C(F)C=C1 KEGTTWBUVVRTEI-KGYLQXTDSA-N 0.000 claims 1
• RVAPUCJVJIUEQS-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluorophenyl)sulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=C(F)C=C1 RVAPUCJVJIUEQS-KWCYVHTRSA-N 0.000 claims 1
• OGQGVZHBWJESDN-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-2-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC(F)=CC=N1 OGQGVZHBWJESDN-OUAUKWLOSA-N 0.000 claims 1
• LPSRZCVCXQFQAG-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-2-yl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC(F)=CC=N1 LPSRZCVCXQFQAG-OUAUKWLOSA-N 0.000 claims 1
• BQFMBWQVGPQEEL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-2-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC(F)=CC=N1 BQFMBWQVGPQEEL-FRRDWIJNSA-N 0.000 claims 1
• ULXRVMKVFLDPFC-IFUGULHKSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-2-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC(F)=CC=N1 ULXRVMKVFLDPFC-IFUGULHKSA-N 0.000 claims 1
• LGZRCDQTIGLMLD-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-3-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CN=CC=C1F LGZRCDQTIGLMLD-DDTOSNHZSA-N 0.000 claims 1
• TUDLSKVSDHMDNY-ZDBHGNHJSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-3-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CN=CC=C1F TUDLSKVSDHMDNY-ZDBHGNHJSA-N 0.000 claims 1
• MJPWOIHLOFAWRH-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-fluoropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CN=CC=C1F MJPWOIHLOFAWRH-JIMOISOXSA-N 0.000 claims 1
• OXDLLQBNIGYKSM-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=C(O)C=C1 OXDLLQBNIGYKSM-JIMOISOXSA-N 0.000 claims 1
• JBWKTMIEYPUOCL-DIOULYMOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(O)C=C1 JBWKTMIEYPUOCL-DIOULYMOSA-N 0.000 claims 1
• JXQDZDNQDQMVEG-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=C(O)C=C1 JXQDZDNQDQMVEG-JIMOISOXSA-N 0.000 claims 1
• UMNJSSFCOVKFOQ-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-hydroxyphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(O)C=C1 UMNJSSFCOVKFOQ-DDTOSNHZSA-N 0.000 claims 1
• ABXKBGYXJYBHMU-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxy-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(OC)=CO1 ABXKBGYXJYBHMU-KXUCPTDWSA-N 0.000 claims 1
• XAOVMPLEQGOLAA-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxy-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(OC)=CS1 XAOVMPLEQGOLAA-KXUCPTDWSA-N 0.000 claims 1
• OFFZBKGWVPRXCE-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=C(OC)C=C1 OFFZBKGWVPRXCE-DDTOSNHZSA-N 0.000 claims 1
• FBXWRBRGYSVOTM-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(OC)C=C1 FBXWRBRGYSVOTM-BYCMXARLSA-N 0.000 claims 1
• IEIVZQARKNEHTK-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenyl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(OC)C=C1 IEIVZQARKNEHTK-KWCYVHTRSA-N 0.000 claims 1
• LHRJYNFOTYHYBB-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenyl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(OC)C=C1 LHRJYNFOTYHYBB-VNQPRFMTSA-N 0.000 claims 1
• RMVPBTDUSYDMKG-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=C(OC)C=C1 RMVPBTDUSYDMKG-DDTOSNHZSA-N 0.000 claims 1
• KZJLMYFSBGBDQW-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methoxyphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(OC)C=C1 KZJLMYFSBGBDQW-BYCMXARLSA-N 0.000 claims 1
• KMBWNMYKJOHTRB-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methyl-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(C)=CO1 KMBWNMYKJOHTRB-OUAUKWLOSA-N 0.000 claims 1
• UWHJDXBVEJIHOV-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methyl-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC(C)=CS1 UWHJDXBVEJIHOV-OUAUKWLOSA-N 0.000 claims 1
• OAEAMIIORVVILX-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenoxy)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1OC1=CC=C(C)C=C1 OAEAMIIORVVILX-KWCYVHTRSA-N 0.000 claims 1
• ZPTTUMYOLCNENI-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C)C=C1 ZPTTUMYOLCNENI-VHDGCEQUSA-N 0.000 claims 1
• WWZRYZXBFRUWSI-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylphenyl)sulfanyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1SC1=CC=C(C)C=C1 WWZRYZXBFRUWSI-KWCYVHTRSA-N 0.000 claims 1
• MLEACMXGRHDUCQ-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-methylsulfanylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(SC)C=C1 MLEACMXGRHDUCQ-VHDGCEQUSA-N 0.000 claims 1
• NZIDOTMVNYJWHL-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-morpholin-4-ylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC(C=C1)=CC=C1N1CCOCC1 NZIDOTMVNYJWHL-FHLIZLRMSA-N 0.000 claims 1
• XIAQOWXMOCMTDQ-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-morpholin-4-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1N1CCOCC1 XIAQOWXMOCMTDQ-BPQIPLTHSA-N 0.000 claims 1
• KBSFKXJIHFFXTN-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-morpholin-4-ylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC(C=C1)=CC=C1N1CCOCC1 KBSFKXJIHFFXTN-FHLIZLRMSA-N 0.000 claims 1
• CMCDIBOSQISMOR-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-morpholin-4-ylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C(C=C1)=CC=C1N1CCOCC1 CMCDIBOSQISMOR-BPQIPLTHSA-N 0.000 claims 1
• BXVUPCDRFBLCHP-DIOULYMOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-nitrophenyl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C([N+]([O-])=O)C=C1 BXVUPCDRFBLCHP-DIOULYMOSA-N 0.000 claims 1
• UUNPQLDXKIRCNQ-LSTHTHJFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-phenoxyphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1OC1=CC=CC=C1 UUNPQLDXKIRCNQ-LSTHTHJFSA-N 0.000 claims 1
• UCVICHZEVAGNBY-HLAWJBBLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-phenylmethoxyphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C(C=C1)=CC=C1OCC1=CC=CC=C1 UCVICHZEVAGNBY-HLAWJBBLSA-N 0.000 claims 1
• DYLIPLKWFNJCPL-NZSAHSFTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-piperidin-1-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1N1CCCCC1 DYLIPLKWFNJCPL-NZSAHSFTSA-N 0.000 claims 1
• LHMMFFYRAKAUDK-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-pyrrolidin-1-ylphenyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1N1CCCC1 LHMMFFYRAKAUDK-BPQIPLTHSA-N 0.000 claims 1
• JHROZUJKCUKNPA-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-sulfamoylphenoxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(S(N)(=O)=O)C=C1 JHROZUJKCUKNPA-DDTOSNHZSA-N 0.000 claims 1
• FKZNYXGQXCCXMC-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-sulfamoylphenyl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(S(N)(=O)=O)C=C1 FKZNYXGQXCCXMC-DDTOSNHZSA-N 0.000 claims 1
• JPGAKBCQQMIUNM-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(4-sulfamoylphenyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(S(N)(=O)=O)C=C1 JPGAKBCQQMIUNM-KWCYVHTRSA-N 0.000 claims 1
• FBWHETHJWMXSBF-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloro-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=C(Cl)O1 FBWHETHJWMXSBF-GJMOJQLCSA-N 0.000 claims 1
• QBDVNAIUAJZPSL-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloro-1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=C(Cl)S1 QBDVNAIUAJZPSL-GJMOJQLCSA-N 0.000 claims 1
• QISXBKWSHDWYBT-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloro-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(Cl)O1 QISXBKWSHDWYBT-HRDYMLBCSA-N 0.000 claims 1
• IELJOFGIVSRPMK-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloro-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(Cl)S1 IELJOFGIVSRPMK-HRDYMLBCSA-N 0.000 claims 1
• IUYNHEVAZNBGFC-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorofuran-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(Cl)O1 IUYNHEVAZNBGFC-KXUCPTDWSA-N 0.000 claims 1
• PPFPECVROOQGHT-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorofuran-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(Cl)O1 PPFPECVROOQGHT-KXUCPTDWSA-N 0.000 claims 1
• LESINCAWZPCTFV-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(Cl)C=N1 LESINCAWZPCTFV-NTZNESFSSA-N 0.000 claims 1
• CJSXINWTETULMX-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(Cl)C=N1 CJSXINWTETULMX-NTZNESFSSA-N 0.000 claims 1
• REYJZDYRPVPKTJ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CN=CC(Cl)=C1 REYJZDYRPVPKTJ-FRRDWIJNSA-N 0.000 claims 1
• WRXFCZDHYQSEPM-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-3-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=CC(Cl)=C1 WRXFCZDHYQSEPM-KGYLQXTDSA-N 0.000 claims 1
• IEVMOSIFNGBUIL-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chloropyridin-3-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=CC(Cl)=C1 IEVMOSIFNGBUIL-KGYLQXTDSA-N 0.000 claims 1
• YYGXLLBIYAYNRO-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorothiophen-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(Cl)S1 YYGXLLBIYAYNRO-KXUCPTDWSA-N 0.000 claims 1
• KABCHQBWCVPHBN-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-chlorothiophen-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(Cl)S1 KABCHQBWCVPHBN-KXUCPTDWSA-N 0.000 claims 1
• ZOLDOSZCSWYMMR-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-2-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(F)C=N1 ZOLDOSZCSWYMMR-JFGNBEQYSA-N 0.000 claims 1
• XUPLRZMUKBFLTI-MBNYWOFBSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-2-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(F)C=N1 XUPLRZMUKBFLTI-MBNYWOFBSA-N 0.000 claims 1
• DMRVIBATKSLNHU-RIEGTJTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-2-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(F)C=N1 DMRVIBATKSLNHU-RIEGTJTDSA-N 0.000 claims 1
• CGWHFEJGFAXUTE-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-3-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CN=CC(F)=C1 CGWHFEJGFAXUTE-GRYCIOLGSA-N 0.000 claims 1
• FFCFERMOLICTPK-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-3-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CN=CC(F)=C1 FFCFERMOLICTPK-HZSPNIEDSA-N 0.000 claims 1
• SKTZMRAPZSNNEC-OSAQELSMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-3-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CN=CC(F)=C1 SKTZMRAPZSNNEC-OSAQELSMSA-N 0.000 claims 1
• RUVVRTZJLMJERL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-fluoropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CN=CC(F)=C1 RUVVRTZJLMJERL-FRRDWIJNSA-N 0.000 claims 1
• XVYKYVDVDMBFFY-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxy-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=C(OC)O1 XVYKYVDVDMBFFY-HRDYMLBCSA-N 0.000 claims 1
• VNKDYWPBLRBBON-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxy-1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=C(OC)S1 VNKDYWPBLRBBON-HRDYMLBCSA-N 0.000 claims 1
• CSXOWVAOPINISS-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxy-1,3-oxazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(OC)O1 CSXOWVAOPINISS-KXUCPTDWSA-N 0.000 claims 1
• SIDHKDSUFJDOHE-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxy-1,3-thiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NC=C(OC)S1 SIDHKDSUFJDOHE-KXUCPTDWSA-N 0.000 claims 1
• BSKIBBNJYZMAME-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxyfuran-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(OC)O1 BSKIBBNJYZMAME-OUAUKWLOSA-N 0.000 claims 1
• XOPYIVFTALAZIH-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxyfuran-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(OC)O1 XOPYIVFTALAZIH-OUAUKWLOSA-N 0.000 claims 1
• VBCNCKJGXFRDOC-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxypyridin-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(OC)C=N1 VBCNCKJGXFRDOC-KGYLQXTDSA-N 0.000 claims 1
• PJEBMKXPMGQHHK-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxypyridin-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(OC)C=N1 PJEBMKXPMGQHHK-KGYLQXTDSA-N 0.000 claims 1
• VYRCORDMWVLSBG-SCDSUCTJSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxypyridin-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(OC)C=N1 VYRCORDMWVLSBG-SCDSUCTJSA-N 0.000 claims 1
• QNYHRVQERJQMAL-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxythiophen-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(OC)S1 QNYHRVQERJQMAL-OUAUKWLOSA-N 0.000 claims 1
• BYCKXKYBOSASHD-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methoxythiophen-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(OC)S1 BYCKXKYBOSASHD-OUAUKWLOSA-N 0.000 claims 1
• QCFFGFIBKSMVEU-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methyl-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=C(C)O1 QCFFGFIBKSMVEU-KXUCPTDWSA-N 0.000 claims 1
• JYHHCZBTFNLVHC-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methyl-1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=NN=C(C)S1 JYHHCZBTFNLVHC-KXUCPTDWSA-N 0.000 claims 1
• AFCXQSUMUYGNOW-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylfuran-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C)O1 AFCXQSUMUYGNOW-GRYCIOLGSA-N 0.000 claims 1
• QLQXQCYZMWOUNK-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylfuran-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C)O1 QLQXQCYZMWOUNK-GRYCIOLGSA-N 0.000 claims 1
• UEYTZEMSIOTCLI-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylpyridin-2-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C)C=N1 UEYTZEMSIOTCLI-FRRDWIJNSA-N 0.000 claims 1
• KWDIFPQHKFSWRJ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylpyridin-2-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C)C=N1 KWDIFPQHKFSWRJ-FRRDWIJNSA-N 0.000 claims 1
• ZZPYPCOIZAJFIL-MBNYWOFBSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(5-methylpyridin-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(C)C=N1 ZZPYPCOIZAJFIL-MBNYWOFBSA-N 0.000 claims 1
• YVUDHESWKVSREZ-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(Cl)=N1 YVUDHESWKVSREZ-JFGNBEQYSA-N 0.000 claims 1
• OSZUFOYQSRPXBP-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-2-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(Cl)=N1 OSZUFOYQSRPXBP-JFGNBEQYSA-N 0.000 claims 1
• WOQBMPKHNCTNBM-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(Cl)N=C1 WOQBMPKHNCTNBM-GRYCIOLGSA-N 0.000 claims 1
• CBHZUWBHMRUKOG-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-chloropyridin-3-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(Cl)N=C1 CBHZUWBHMRUKOG-GRYCIOLGSA-N 0.000 claims 1
• XDTSXGCONWPDRF-WCABBAIRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-2-yl)-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC(F)=N1 XDTSXGCONWPDRF-WCABBAIRSA-N 0.000 claims 1
• LEAYPJBCMQJWBE-WCABBAIRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-2-yl)-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC(F)=N1 LEAYPJBCMQJWBE-WCABBAIRSA-N 0.000 claims 1
• DRWJMKSYNJWDJY-LJWDBELGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-2-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(F)=N1 DRWJMKSYNJWDJY-LJWDBELGSA-N 0.000 claims 1
• FOFBFGDCCQKZFX-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-2-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(F)=N1 FOFBFGDCCQKZFX-JFGNBEQYSA-N 0.000 claims 1
• GQXCKEGTGLIVAV-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-3-yl)-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1C)=CC=C1C1=CC=C(F)N=C1 GQXCKEGTGLIVAV-FRRDWIJNSA-N 0.000 claims 1
• XUSKNKXBAOFELV-SCDSUCTJSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-3-yl)-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(F)N=C1 XUSKNKXBAOFELV-SCDSUCTJSA-N 0.000 claims 1
• ALNDQHPGMWPRCF-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-fluoropyridin-3-yl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(F)N=C1 ALNDQHPGMWPRCF-GRYCIOLGSA-N 0.000 claims 1
• YNLKEPWDYBQWIP-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-methoxypyridin-3-yl)sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(OC)N=C1 YNLKEPWDYBQWIP-KGYLQXTDSA-N 0.000 claims 1
• BXDZXCMWYRTUIU-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-methoxypyridin-3-yl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(OC)N=C1 BXDZXCMWYRTUIU-FRRDWIJNSA-N 0.000 claims 1
• TZVSSBAGSZTYBE-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(6-methylpyridin-3-yl)oxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C)N=C1 TZVSSBAGSZTYBE-KWCYVHTRSA-N 0.000 claims 1
• FYYCEFBCUDBSMK-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(furan-3-yloxy)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC=1C=COC=1 FYYCEFBCUDBSMK-ADEWGFFLSA-N 0.000 claims 1
• YCTYWMBFJBREHG-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(furan-3-ylsulfanyl)thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC=1C=COC=1 YCTYWMBFJBREHG-ADEWGFFLSA-N 0.000 claims 1
• OKEYHFJTFJWTEF-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-(trifluoromethyl)furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(C(F)(F)F)O1 OKEYHFJTFJWTEF-GJMOJQLCSA-N 0.000 claims 1
• LTOYWJLJMLSCBF-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-chloro-1,3-oxazol-5-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=C(Cl)O1 LTOYWJLJMLSCBF-HRDYMLBCSA-N 0.000 claims 1
• OUFZKNIFPXKLGP-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-chloro-1,3-oxazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(Cl)O1 OUFZKNIFPXKLGP-HRDYMLBCSA-N 0.000 claims 1
• GOPJVAFJXWMTLE-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-chloro-1,3-thiazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(Cl)S1 GOPJVAFJXWMTLE-HRDYMLBCSA-N 0.000 claims 1
• BKRNXEHXCLCVLU-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methoxy-1,3-oxazol-5-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=C(OC)O1 BKRNXEHXCLCVLU-KXUCPTDWSA-N 0.000 claims 1
• CVJQMKHEHAVHGV-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methoxy-1,3-oxazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(OC)O1 CVJQMKHEHAVHGV-KXUCPTDWSA-N 0.000 claims 1
• IXZMAIUMJQSDQY-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methoxy-1,3-thiazol-5-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=C(OC)S1 IXZMAIUMJQSDQY-KXUCPTDWSA-N 0.000 claims 1
• RUKHCJHBBZCLRS-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methoxy-1,3-thiazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(OC)S1 RUKHCJHBBZCLRS-KXUCPTDWSA-N 0.000 claims 1
• FADIJQMXMMWKOL-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methyl-1,3-oxazol-5-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=C(C)O1 FADIJQMXMMWKOL-OUAUKWLOSA-N 0.000 claims 1
• WZCDJNLPKMLOLC-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methyl-1,3-thiazol-5-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CN=C(C)S1 WZCDJNLPKMLOLC-OUAUKWLOSA-N 0.000 claims 1
• KFFXDVZFQPXTFB-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(2-methyl-1,3-thiazol-5-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CN=C(C)S1 KFFXDVZFQPXTFB-OUAUKWLOSA-N 0.000 claims 1
• FDAKDSOCTVITPX-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-chloro-1,3-oxazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC(Cl)=CO1 FDAKDSOCTVITPX-HRDYMLBCSA-N 0.000 claims 1
• PSOGYUYZBZQFFP-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-chloro-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC(Cl)=CO1 PSOGYUYZBZQFFP-HRDYMLBCSA-N 0.000 claims 1
• NEQPMHUVZXVEAD-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-chloro-1,3-thiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC(Cl)=CS1 NEQPMHUVZXVEAD-HRDYMLBCSA-N 0.000 claims 1
• ZGDGFNLVQHBUDZ-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methoxy-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC(OC)=CO1 ZGDGFNLVQHBUDZ-KXUCPTDWSA-N 0.000 claims 1
• KKTONNGVQFRSQZ-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methoxy-1,3-thiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC(OC)=CS1 KKTONNGVQFRSQZ-KXUCPTDWSA-N 0.000 claims 1
• BEVUFLLGUHBJDJ-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methyl-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC(C)=CO1 BEVUFLLGUHBJDJ-OUAUKWLOSA-N 0.000 claims 1
• HQLNNXYUGXDBRE-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(4-methyl-1,3-thiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC(C)=CS1 HQLNNXYUGXDBRE-OUAUKWLOSA-N 0.000 claims 1
• VCOMVQZHWRKUGG-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3,4-oxadiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=C(Cl)O1 VCOMVQZHWRKUGG-GJMOJQLCSA-N 0.000 claims 1
• LEGJXUDBNVRHID-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3,4-thiadiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=C(Cl)S1 LEGJXUDBNVRHID-GJMOJQLCSA-N 0.000 claims 1
• IRLZNACMXFYXCN-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3-oxazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(Cl)O1 IRLZNACMXFYXCN-HRDYMLBCSA-N 0.000 claims 1
• AFQSPEKTKSOTQK-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(Cl)O1 AFQSPEKTKSOTQK-HRDYMLBCSA-N 0.000 claims 1
• VZWUWOYJBUTGMY-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3-thiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(Cl)S1 VZWUWOYJBUTGMY-HRDYMLBCSA-N 0.000 claims 1
• IMURUPPDFJGWHI-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-chloro-1,3-thiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(Cl)S1 IMURUPPDFJGWHI-HRDYMLBCSA-N 0.000 claims 1
• KRZJNZNXIPKRIF-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3,4-oxadiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NN=C(OC)O1 KRZJNZNXIPKRIF-HRDYMLBCSA-N 0.000 claims 1
• IWFPHWYORHIGLZ-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3,4-oxadiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=C(OC)O1 IWFPHWYORHIGLZ-HRDYMLBCSA-N 0.000 claims 1
• AGWOUQUQRRMLKJ-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3,4-thiadiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=C(OC)S1 AGWOUQUQRRMLKJ-HRDYMLBCSA-N 0.000 claims 1
• ATTCBIZXIPPOLK-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3-oxazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(OC)O1 ATTCBIZXIPPOLK-KXUCPTDWSA-N 0.000 claims 1
• OZOPDIJMIVNXCV-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(OC)O1 OZOPDIJMIVNXCV-KXUCPTDWSA-N 0.000 claims 1
• JGZWEAXIMSXDOE-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3-thiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(OC)S1 JGZWEAXIMSXDOE-KXUCPTDWSA-N 0.000 claims 1
• YJGYILZNGFWONL-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methoxy-1,3-thiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(OC)S1 YJGYILZNGFWONL-KXUCPTDWSA-N 0.000 claims 1
• XUNGBRVIYQEXCN-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=C(C)O1 XUNGBRVIYQEXCN-KXUCPTDWSA-N 0.000 claims 1
• CGDAIDDXBQIXIO-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NN=C(C)S1 CGDAIDDXBQIXIO-KXUCPTDWSA-N 0.000 claims 1
• OHMOIKMUTGAHGY-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3-oxazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(C)O1 OHMOIKMUTGAHGY-OUAUKWLOSA-N 0.000 claims 1
• YMXIZRJYIMFDEA-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3-oxazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(C)O1 YMXIZRJYIMFDEA-OUAUKWLOSA-N 0.000 claims 1
• VQXAJGKRELQOAG-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3-thiazol-2-yl)oxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=NC=C(C)S1 VQXAJGKRELQOAG-OUAUKWLOSA-N 0.000 claims 1
• WHNVBCOYCFZPIA-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[(5-methyl-1,3-thiazol-2-yl)sulfanyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=NC=C(C)S1 WHNVBCOYCFZPIA-OUAUKWLOSA-N 0.000 claims 1
• AFFZRVAZSRXQEQ-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(1,2-thiazol-5-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C1=CC=NS1 AFFZRVAZSRXQEQ-UHOFOFEASA-N 0.000 claims 1
• YNHMSKSLCZLWDL-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(1,3-oxazol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C1=NC=CO1 YNHMSKSLCZLWDL-UHOFOFEASA-N 0.000 claims 1
• RROINJYELCOWHN-UIAACRFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(benzenesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1NS(=O)(=O)C1=CC=CC=C1 RROINJYELCOWHN-UIAACRFSSA-N 0.000 claims 1
• QTCWFVJZYCBQDU-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(ethylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1NCC QTCWFVJZYCBQDU-UHOFOFEASA-N 0.000 claims 1
• CFJDQJXEWFUTPU-XOKHGSTOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(furan-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1C1=CC=CO1 CFJDQJXEWFUTPU-XOKHGSTOSA-N 0.000 claims 1
• ALZFYPXSSPCZKT-MBNYWOFBSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methanesulfonamido)phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1NS(C)(=O)=O ALZFYPXSSPCZKT-MBNYWOFBSA-N 0.000 claims 1
• ALSJTENESBCCQO-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methanesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1NS(C)(=O)=O ALSJTENESBCCQO-BYCMXARLSA-N 0.000 claims 1
• MQQJZXMBDQGQII-MBNYWOFBSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methanesulfonamido)phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1NS(C)(=O)=O MQQJZXMBDQGQII-MBNYWOFBSA-N 0.000 claims 1
• CPPSILOLQUGYNQ-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methanesulfonamido)phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1NS(C)(=O)=O CPPSILOLQUGYNQ-BYCMXARLSA-N 0.000 claims 1
• YIZMBONUGFHFRS-XQAQDONZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methylamino)phenyl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1NC YIZMBONUGFHFRS-XQAQDONZSA-N 0.000 claims 1
• FPVVFRGDZQGOFW-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1NC FPVVFRGDZQGOFW-BYCMXARLSA-N 0.000 claims 1
• HRTZWOORYLQOEJ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(methylsulfamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1S(=O)(=O)NC HRTZWOORYLQOEJ-KWCYVHTRSA-N 0.000 claims 1
• MQZAVCRZKMEVCK-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(trifluoromethyl)phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1C(F)(F)F MQZAVCRZKMEVCK-KGYLQXTDSA-N 0.000 claims 1
• CXLDPSDWABMKTQ-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(trifluoromethyl)phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1C(F)(F)F CXLDPSDWABMKTQ-DDTOSNHZSA-N 0.000 claims 1
• IAVZCDWBMNXUCD-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(trifluoromethylsulfonylamino)phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1NS(=O)(=O)C(F)(F)F IAVZCDWBMNXUCD-NTZNESFSSA-N 0.000 claims 1
• SRMNGEZSFLPBOG-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(trifluoromethylsulfonylamino)phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1NS(=O)(=O)C(F)(F)F SRMNGEZSFLPBOG-NTZNESFSSA-N 0.000 claims 1
• JBNGEDOGRSNVOQ-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-(trifluoromethylsulfonylamino)phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC=C1NS(=O)(=O)C(F)(F)F JBNGEDOGRSNVOQ-DDTOSNHZSA-N 0.000 claims 1
• LFYHRXOTWSGNPB-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-[(2,2,2-trifluoroacetyl)amino]phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1NC(=O)C(F)(F)F LFYHRXOTWSGNPB-NTZNESFSSA-N 0.000 claims 1
• XJBJQHCMUNPRAF-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-[(2,2,2-trifluoroacetyl)amino]phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1NC(=O)C(F)(F)F XJBJQHCMUNPRAF-NTZNESFSSA-N 0.000 claims 1
• TWRLSUDVVXWVIS-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-[(2,2-difluoroacetyl)amino]phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC=C1NC(=O)C(F)F TWRLSUDVVXWVIS-NTZNESFSSA-N 0.000 claims 1
• NCVJHYURFNYKNI-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-[(2,2-difluoroacetyl)amino]phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1NC(=O)C(F)F NCVJHYURFNYKNI-NTZNESFSSA-N 0.000 claims 1
• NZHIOENQHCZPHS-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC(C(F)(F)F)=NN1C NZHIOENQHCZPHS-KXUCPTDWSA-N 0.000 claims 1
• QWXNZADGDUMAPP-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(1,3-oxazol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C1=NC=CO1 QWXNZADGDUMAPP-OWCLPIDISA-N 0.000 claims 1
• USOWMZVWONJSCM-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(1,3-thiazol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C1=NC=CS1 USOWMZVWONJSCM-OWCLPIDISA-N 0.000 claims 1
• MPIXYOCAKOGMSW-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(1h-pyrrol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C1=CC=CN1 MPIXYOCAKOGMSW-BPQIPLTHSA-N 0.000 claims 1
• NTKJRSZLKMEBJW-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(5-methylfuran-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C1=CC=C(C)O1 NTKJRSZLKMEBJW-FGTMMUONSA-N 0.000 claims 1
• RNGCPUOQPGSPCJ-LSTHTHJFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(benzenesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1NS(=O)(=O)C1=CC=CC=C1 RNGCPUOQPGSPCJ-LSTHTHJFSA-N 0.000 claims 1
• GSJGFNPGHOAGMR-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(ethylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(NCC)=C1 GSJGFNPGHOAGMR-OWCLPIDISA-N 0.000 claims 1
• ADLOBFBVNMYHLJ-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(furan-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C1=CC=CO1 ADLOBFBVNMYHLJ-IXDOHACOSA-N 0.000 claims 1
• TUUCRGAIZKWVGQ-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(furan-3-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=1)=CC=CC=1C=1C=COC=1 TUUCRGAIZKWVGQ-FGTMMUONSA-N 0.000 claims 1
• MTNBRHTVIAQFNW-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methanesulfonamido)phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(NS(C)(=O)=O)=C1 MTNBRHTVIAQFNW-BYCMXARLSA-N 0.000 claims 1
• FPNJRHFELASHKF-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methanesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(NS(C)(=O)=O)=C1 FPNJRHFELASHKF-VHDGCEQUSA-N 0.000 claims 1
• LZWJLBPDNNZOHF-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methanesulfonamido)phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(NS(C)(=O)=O)=C1 LZWJLBPDNNZOHF-BYCMXARLSA-N 0.000 claims 1
• KYOXRPHELMDMHD-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methanesulfonamido)phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(NS(C)(=O)=O)=C1 KYOXRPHELMDMHD-VHDGCEQUSA-N 0.000 claims 1
• SDXOSAVBNASIMF-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methylamino)phenyl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC(NC)=C1 SDXOSAVBNASIMF-UKPHBRMFSA-N 0.000 claims 1
• IWSZDSUHRAICPE-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(NC)=C1 IWSZDSUHRAICPE-QLFBSQMISA-N 0.000 claims 1
• BRKGFFXYZPCSAU-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methylcarbamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(C(=O)NC)=C1 BRKGFFXYZPCSAU-QLFBSQMISA-N 0.000 claims 1
• KAYFPMNOONIPDD-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(methylsulfamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(S(=O)(=O)NC)=C1 KAYFPMNOONIPDD-VHDGCEQUSA-N 0.000 claims 1
• HLFJGIVKFGSDTI-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(C(F)(F)F)=C1 HLFJGIVKFGSDTI-HZSPNIEDSA-N 0.000 claims 1
• KURGKCMJXHCOOZ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(trifluoromethyl)phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(C(F)(F)F)=C1 KURGKCMJXHCOOZ-KWCYVHTRSA-N 0.000 claims 1
• DSUJLXZDDNZZLY-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(trifluoromethyl)phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(C(F)(F)F)=C1 DSUJLXZDDNZZLY-HZSPNIEDSA-N 0.000 claims 1
• LPNFYQLOPSGVSR-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(trifluoromethylsulfonylamino)phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(NS(=O)(=O)C(F)(F)F)=C1 LPNFYQLOPSGVSR-DDTOSNHZSA-N 0.000 claims 1
• GZFBJASITXTOOO-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-(trifluoromethylsulfonylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC(NS(=O)(=O)C(F)(F)F)=C1 GZFBJASITXTOOO-KWCYVHTRSA-N 0.000 claims 1
• FVWCHPSMRQWTMA-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-[(2,2,2-trifluoroacetyl)amino]phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(NC(=O)C(F)(F)F)=C1 FVWCHPSMRQWTMA-KWCYVHTRSA-N 0.000 claims 1
• RGXLNCAPSHFXEW-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-[(2,2,2-trifluoroacetyl)amino]phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC(NC(=O)C(F)(F)F)=C1 RGXLNCAPSHFXEW-KWCYVHTRSA-N 0.000 claims 1
• NIAUKDPKZICYTB-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-[(2,2,2-trifluoroacetyl)amino]phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(NC(=O)C(F)(F)F)=C1 NIAUKDPKZICYTB-HZSPNIEDSA-N 0.000 claims 1
• VNGFMSIDWADLIV-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-[(2,2-difluoroacetyl)amino]phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=CC(NC(=O)C(F)F)=C1 VNGFMSIDWADLIV-KWCYVHTRSA-N 0.000 claims 1
• KEWRLSSATKRLRW-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[3-[(2,2-difluoroacetyl)amino]phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=CC(NC(=O)C(F)F)=C1 KEWRLSSATKRLRW-HZSPNIEDSA-N 0.000 claims 1
• SONOZCRERJIZPP-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(1,3-thiazol-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C1=NC=CS1 SONOZCRERJIZPP-OWCLPIDISA-N 0.000 claims 1
• NSFKRPAYAWHJJU-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(5-methylfuran-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C1=CC=C(C)O1 NSFKRPAYAWHJJU-FGTMMUONSA-N 0.000 claims 1
• FRUHTQYHHXEVGE-YZGWKJHDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(benzenesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1NS(=O)(=O)C1=CC=CC=C1 FRUHTQYHHXEVGE-YZGWKJHDSA-N 0.000 claims 1
• CHMXHPUVPQVMLF-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(furan-2-yl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C(C=C1)=CC=C1C1=CC=CO1 CHMXHPUVPQVMLF-IXDOHACOSA-N 0.000 claims 1
• CGXLCSACCCGFFC-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methanesulfonamido)phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(NS(C)(=O)=O)C=C1 CGXLCSACCCGFFC-VHDGCEQUSA-N 0.000 claims 1
• TUIJSCVEFYLENK-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methanesulfonamido)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(NS(C)(=O)=O)C=C1 TUIJSCVEFYLENK-QLFBSQMISA-N 0.000 claims 1
• HGJCFRRASYMEMP-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methanesulfonamido)phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(NS(C)(=O)=O)C=C1 HGJCFRRASYMEMP-VHDGCEQUSA-N 0.000 claims 1
• NBEUXYIGBDBFEP-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methanesulfonamido)phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(NS(C)(=O)=O)C=C1 NBEUXYIGBDBFEP-QLFBSQMISA-N 0.000 claims 1
• XRZQMLUNMUNATQ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methylamino)phenyl]-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=C(NC)C=C1 XRZQMLUNMUNATQ-HZSPNIEDSA-N 0.000 claims 1
• GKMJPVJGLYDVIL-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methylamino)phenyl]-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=C(NC)C=C1 GKMJPVJGLYDVIL-UKPHBRMFSA-N 0.000 claims 1
• DKSVXSOZTSSCJN-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(NC)C=C1 DKSVXSOZTSSCJN-QLFBSQMISA-N 0.000 claims 1
• KDIRFGGCUXUURM-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methylcarbamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(C(=O)NC)C=C1 KDIRFGGCUXUURM-QLFBSQMISA-N 0.000 claims 1
• GDSDKTSWNPBEKL-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(methylsulfamoyl)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(S(=O)(=O)NC)C=C1 GDSDKTSWNPBEKL-VHDGCEQUSA-N 0.000 claims 1
• ZMAAQSAUVPSISJ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(trifluoromethyl)phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(C(F)(F)F)C=C1 ZMAAQSAUVPSISJ-KWCYVHTRSA-N 0.000 claims 1
• COVJXUJDFGIDGN-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(trifluoromethyl)phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(C(F)(F)F)C=C1 COVJXUJDFGIDGN-KWCYVHTRSA-N 0.000 claims 1
• HLFMBSOZZBLCDR-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(trifluoromethylsulfonylamino)phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(NS(=O)(=O)C(F)(F)F)C=C1 HLFMBSOZZBLCDR-KWCYVHTRSA-N 0.000 claims 1
• SLWFGMZAEDACIV-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(trifluoromethylsulfonylamino)phenyl]furan-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=C(NS(=O)(=O)C(F)(F)F)C=C1 SLWFGMZAEDACIV-HZSPNIEDSA-N 0.000 claims 1
• JCNODQVJBOKFTP-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(trifluoromethylsulfonylamino)phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(NS(=O)(=O)C(F)(F)F)C=C1 JCNODQVJBOKFTP-KWCYVHTRSA-N 0.000 claims 1
• HQDWDAOZPUZBSD-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-(trifluoromethylsulfonylamino)phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(NS(=O)(=O)C(F)(F)F)C=C1 HQDWDAOZPUZBSD-HZSPNIEDSA-N 0.000 claims 1
• CHGMMHUTRSDSPT-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-[(2,2,2-trifluoroacetyl)amino]phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(NC(=O)C(F)(F)F)C=C1 CHGMMHUTRSDSPT-KWCYVHTRSA-N 0.000 claims 1
• FOIOMIFPHVZQQY-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-[(2,2,2-trifluoroacetyl)amino]phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(NC(=O)C(F)(F)F)C=C1 FOIOMIFPHVZQQY-KWCYVHTRSA-N 0.000 claims 1
• IZPIBIROHGLWHW-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-[(2,2,2-trifluoroacetyl)amino]phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(NC(=O)C(F)(F)F)C=C1 IZPIBIROHGLWHW-HZSPNIEDSA-N 0.000 claims 1
• VRBPAKHATJJAJL-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-[(2,2-difluoroacetyl)amino]phenoxy]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1OC1=CC=C(NC(=O)C(F)F)C=C1 VRBPAKHATJJAJL-KWCYVHTRSA-N 0.000 claims 1
• FHYNKEXJFSJAMZ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-[(2,2-difluoroacetyl)amino]phenyl]sulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=C(NC(=O)C(F)F)C=C1 FHYNKEXJFSJAMZ-KWCYVHTRSA-N 0.000 claims 1
• NAUVOKONDUEGSO-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-[4-[(2,2-difluoroacetyl)amino]phenyl]thiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1C1=CC=C(NC(=O)C(F)F)C=C1 NAUVOKONDUEGSO-HZSPNIEDSA-N 0.000 claims 1
• GRRJXHCXBUQYJB-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-bromo-1-methylpyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(Br)N1C GRRJXHCXBUQYJB-HRDYMLBCSA-N 0.000 claims 1
• IYRMONLYXMGJOM-MHSYXAOVSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-bromo-4-chlorothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(Cl)=C(Br)S1 IYRMONLYXMGJOM-MHSYXAOVSA-N 0.000 claims 1
• PEGONVMMPHMYPK-DSYKOEDSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-chloro-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=NC=C(Cl)S1 PEGONVMMPHMYPK-DSYKOEDSSA-N 0.000 claims 1
• QFPNLGULDMYTOM-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-chloro-4-cyanothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(C#N)=C(Cl)S1 QFPNLGULDMYTOM-HRDYMLBCSA-N 0.000 claims 1
• YWWCPHAPPJTENR-GJMOJQLCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-chloro-4-methylsulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC(SC)=C(Cl)S1 YWWCPHAPPJTENR-GJMOJQLCSA-N 0.000 claims 1
• ZXRWGWCNEFUQFC-FKTZTGRPSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-cyanothiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(C#N)S1 ZXRWGWCNEFUQFC-FKTZTGRPSA-N 0.000 claims 1
• YJHYIDUHKFBJEH-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-methoxy-4-phenylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(SC=1OC)=CC=1C1=CC=CC=C1 YJHYIDUHKFBJEH-VHDGCEQUSA-N 0.000 claims 1
• SJVIZNRGXIFLBH-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-methoxythiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(OC)S1 SJVIZNRGXIFLBH-HRDYMLBCSA-N 0.000 claims 1
• IDDQCIKQLCEBTL-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=NC=C(C)S1 IDDQCIKQLCEBTL-HRDYMLBCSA-N 0.000 claims 1
• LHYCFGNQENBDKF-HRDYMLBCSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-methylsulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C1=CC=C(SC)S1 LHYCFGNQENBDKF-HRDYMLBCSA-N 0.000 claims 1
• MMZHBSBOIHCTGJ-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenoxy-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1OC1=CC=CC=C1 MMZHBSBOIHCTGJ-KGYLQXTDSA-N 0.000 claims 1
• VPURONWJFMLQCY-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenyl-1,3-oxazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=NC=C1C1=CC=CC=C1 VPURONWJFMLQCY-FRRDWIJNSA-N 0.000 claims 1
• QFOAXDVJCZEJRD-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenyl-1,3-thiazole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=NC=C1C1=CC=CC=C1 QFOAXDVJCZEJRD-FRRDWIJNSA-N 0.000 claims 1
• TZZQUXLJNXMDKF-IVMMDQJWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenyl-1h-pyrrole-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N1)=CC=C1C1=CC=CC=C1 TZZQUXLJNXMDKF-IVMMDQJWSA-N 0.000 claims 1
• SVIMFRSPQFOAIG-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1C1=CC=CC=C1 SVIMFRSPQFOAIG-HZSPNIEDSA-N 0.000 claims 1
• NYTWHWWJXHJCOI-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylsulfanylfuran-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(O1)=CC=C1SC1=CC=CC=C1 NYTWHWWJXHJCOI-KWCYVHTRSA-N 0.000 claims 1
• YJHZSRMIUPAREV-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-5-phenylsulfanylthiophene-2-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(S1)=CC=C1SC1=CC=CC=C1 YJHZSRMIUPAREV-KWCYVHTRSA-N 0.000 claims 1
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