JP2005504053A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005504053A5 JP2005504053A5 JP2003522514A JP2003522514A JP2005504053A5 JP 2005504053 A5 JP2005504053 A5 JP 2005504053A5 JP 2003522514 A JP2003522514 A JP 2003522514A JP 2003522514 A JP2003522514 A JP 2003522514A JP 2005504053 A5 JP2005504053 A5 JP 2005504053A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- halogen
- substituted
- cycloalkyl
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229910052736 halogen Inorganic materials 0.000 claims 45
- 150000002367 halogens Chemical class 0.000 claims 45
- 125000003118 aryl group Chemical group 0.000 claims 42
- 229910052739 hydrogen Inorganic materials 0.000 claims 37
- 239000001257 hydrogen Substances 0.000 claims 37
- 125000000753 cycloalkyl group Chemical group 0.000 claims 31
- -1 amidine compound Chemical class 0.000 claims 30
- 150000002431 hydrogen Chemical class 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 26
- 239000000126 substance Substances 0.000 claims 23
- 125000000623 heterocyclic group Chemical group 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 125000002947 alkylene group Chemical group 0.000 claims 21
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims 19
- 125000006730 (C2-C5) alkynyl group Chemical group 0.000 claims 19
- 125000001072 heteroaryl group Chemical group 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 19
- 125000003545 alkoxy group Chemical group 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 229910004013 NO 2 Inorganic materials 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 125000002877 alkyl aryl group Chemical group 0.000 claims 12
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 12
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 12
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 12
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims 12
- 125000000304 alkynyl group Chemical group 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 11
- 125000003710 aryl alkyl group Chemical group 0.000 claims 11
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 11
- 125000004104 aryloxy group Chemical group 0.000 claims 11
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 11
- 125000004001 thioalkyl group Chemical group 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000000732 arylene group Chemical group 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000004429 atom Chemical group 0.000 claims 6
- 125000005549 heteroarylene group Chemical group 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 6
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 5
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 4
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims 4
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 125000004419 alkynylene group Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000004434 sulfur atom Chemical group 0.000 claims 4
- 150000001408 amides Chemical class 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 230000003941 amyloidogenesis Effects 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 230000003920 cognitive function Effects 0.000 claims 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 1
- 206010061818 Disease progression Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 150000001409 amidines Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 230000005750 disease progression Effects 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 201000008319 inclusion body myositis Diseases 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000000565 sulfonamide group Chemical group 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31676101P | 2001-08-31 | 2001-08-31 | |
| US38700102P | 2002-06-07 | 2002-06-07 | |
| PCT/CA2002/001353 WO2003017994A1 (en) | 2001-08-31 | 2002-09-03 | Amidine derivatives for treating amyloidosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005504053A JP2005504053A (ja) | 2005-02-10 |
| JP2005504053A5 true JP2005504053A5 (https=) | 2005-12-22 |
Family
ID=26980581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003522514A Withdrawn JP2005504053A (ja) | 2001-08-31 | 2002-09-03 | アミロイドーシス治療のためのアミジン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20040006092A1 (https=) |
| EP (1) | EP1420773A1 (https=) |
| JP (1) | JP2005504053A (https=) |
| KR (1) | KR20040036908A (https=) |
| CN (1) | CN1658852A (https=) |
| BR (1) | BR0212078A (https=) |
| CA (1) | CA2455497A1 (https=) |
| EA (1) | EA200400135A1 (https=) |
| IL (1) | IL160208A0 (https=) |
| MX (1) | MXPA04001153A (https=) |
| WO (1) | WO2003017994A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL146143A0 (en) * | 1999-04-28 | 2002-07-25 | Univ Kingston | Compositions and methods for treating amyloidosis |
| EP1237547A2 (en) * | 1999-07-09 | 2002-09-11 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
| EP1337510A4 (en) * | 2000-11-06 | 2005-02-23 | Univ North Carolina | SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW DICATIONIC REVERSED AMIDINES |
| US6737440B2 (en) | 2000-11-06 | 2004-05-18 | The University Of North Carolina At Chapel Hill | Synthesis and antimicrobial activity of novel dicationic “reversed amidines” |
| EP1572129A4 (en) * | 2002-06-07 | 2007-03-28 | Univ North Carolina | AMIDINE DERIVATIVES FOR THE TREATMENT OF AMYLOIDOSE |
| US20050020945A1 (en) * | 2002-07-02 | 2005-01-27 | Tosaya Carol A. | Acoustically-aided cerebrospinal-fluid manipulation for neurodegenerative disease therapy |
| US20040049134A1 (en) * | 2002-07-02 | 2004-03-11 | Tosaya Carol A. | System and methods for treatment of alzheimer's and other deposition-related disorders of the brain |
| US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| JP2007521237A (ja) * | 2003-09-05 | 2007-08-02 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 微生物感染症処置用の新規アミジン化合物 |
| JP2007509176A (ja) * | 2003-10-24 | 2007-04-12 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 抗原虫薬としてのジカチオン性トリアリール類似体 |
| CA2549736A1 (en) * | 2003-12-05 | 2005-06-23 | The University Of North Carolina At Chapel Hill | Cationic substituted benzofurans as antimicrobial agents |
| US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| WO2005079780A1 (en) * | 2004-01-23 | 2005-09-01 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| BRPI0519243A2 (pt) | 2004-12-22 | 2009-01-06 | Neurochem Int Ltd | mÉtodos e composiÇÕes para tratar doenÇas relacionadas a amilàide |
| TW200716088A (en) * | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
| AU2006201739A1 (en) * | 2005-05-05 | 2006-11-23 | The University Of North Carolina At Chapel Hill | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles |
| WO2007023389A2 (en) * | 2005-07-21 | 2007-03-01 | Neurochem (International) Limited | Polymorphic forms of 3-amino-1-propanesulfonic acid |
| JP5301999B2 (ja) * | 2005-10-31 | 2013-09-25 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｃｅｔｐ阻害薬 |
| MX2008008213A (es) * | 2005-12-22 | 2008-09-03 | Neurochem Int Ltd | Tratamiento de trastornos renales, nefropatia diabetica y dislipidemias. |
| DK2089417T3 (en) | 2006-10-12 | 2015-03-23 | Bhi Ltd Partnership | Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid |
| CN101730529A (zh) * | 2006-12-22 | 2010-06-09 | 贝鲁斯健康(国际)有限公司 | 用于治疗代谢疾病和糖尿病的方法、化合物和组合物 |
| CA2676715A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| EP2247558B2 (en) | 2008-02-14 | 2024-07-03 | Eli Lilly and Company | Novel imaging agents for detecting neurological dysfunction |
| EP2116236A1 (en) * | 2008-04-21 | 2009-11-11 | Université de Mons-Hainaut | Bisbenzamidine derivatives for use as antioxidant |
| FR2933692B1 (fr) * | 2008-07-10 | 2022-12-02 | Univ Nancy 1 Henri Poincare | Nouveaux composes, leur utilisation comme medicaments, et leur procede de preparation |
| ES2355031B2 (es) * | 2009-07-15 | 2011-12-26 | Universidade De Santiago De Compostela | Derivados de bis-benzamidinios y su uso como agentes de reconocimiento de secuencias de adn. |
| ES2368276B2 (es) * | 2010-04-27 | 2012-06-28 | Universidad De Santiago De Compostela | Compuestos derivados de bis-benzamidinios como agentes fluorogénicos para señalizar secuencias específicas de adn de doble cadena. |
| CN103012200B (zh) * | 2011-09-20 | 2014-12-17 | 北京大学 | 具有β-分泌酶抑制功能的化合物及其制备方法与应用 |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| CN109553608B (zh) * | 2017-09-26 | 2020-12-08 | 北京大学 | 一类五元六元杂环化合物及其制备方法和治疗肿瘤的用途 |
| US12595251B2 (en) | 2018-06-14 | 2026-04-07 | Georgia State University Research Foundation, Inc. | Amidines and amidine analogs for the treatment of bacterial infections and potentiation antibiotics |
| WO2021127452A1 (en) | 2019-12-19 | 2021-06-24 | Georgia State University Research Foundation, Inc. | Compounds for the treatment of bacterial infections and potentiation of antibiotics |
| CN113264925A (zh) * | 2020-02-14 | 2021-08-17 | 上海美悦生物科技发展有限公司 | 一种杂环化合物及其制备方法和用途 |
| US20250382261A1 (en) * | 2021-11-05 | 2025-12-18 | The Broad Institute, Inc. | Pentamidine analogs |
| CN115850219B (zh) * | 2022-11-30 | 2024-05-28 | 三峡大学 | 泽兰素开链多聚体，制备方法及用途 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4397863A (en) * | 1980-08-26 | 1983-08-09 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
| US4324794A (en) * | 1980-08-26 | 1982-04-13 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
| US4515625A (en) * | 1980-09-16 | 1985-05-07 | Eli Lilly And Company | Benzamides, compositions and agricultural method |
| US4619942A (en) * | 1982-04-08 | 1986-10-28 | University Of North Carolina | Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds |
| US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5374548A (en) * | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| US5547841A (en) * | 1987-10-08 | 1996-08-20 | The Mclean Hospital Corporation | In vitro method for screening for drugs that inhibit production or degradation of human A4-amyloid |
| US4940723A (en) * | 1988-10-20 | 1990-07-10 | University Of North Carolina, Chapel Hill | Use of bis-(5-amidino-2-benzimidazolyl) methane (BABIM) to treat arthritis |
| US4933347A (en) * | 1988-10-25 | 1990-06-12 | University Of North Carolina At Chapel Hill | Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia |
| US4963589A (en) * | 1988-10-25 | 1990-10-16 | The University Of North Carolina At Chapel Hill | Methods for treating Giardia lamblia |
| US5202320A (en) * | 1989-04-06 | 1993-04-13 | Tidwell Richard R | Method for treating leishmaniasis |
| US5206236A (en) * | 1989-04-06 | 1993-04-27 | Tidwell Richard R | Method for the treatment of malaria |
| ES2217250T3 (es) * | 1990-06-15 | 2004-11-01 | Scios Inc. | Mamifero transgenico, no humano que muestra la patologia de formacion amiloides de la enfermedad de alzheimer. |
| US5246965A (en) * | 1991-06-11 | 1993-09-21 | Ciba-Geigy | Arylethers, their manufacture and methods of treatment |
| US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
| US5434050A (en) * | 1991-08-13 | 1995-07-18 | Regents Of The University Of Minnesota | Labelled β-amyloid peptide and methods of screening for Alzheimer's disease |
| JP3008615B2 (ja) * | 1991-11-15 | 2000-02-14 | 大同特殊鋼株式会社 | ラジアル異方性リング磁石及びその製造方法 |
| AU671093B2 (en) * | 1992-01-07 | 1996-08-15 | Elan Pharmaceuticals, Inc. | Transgenic animal models for alzheimer's disease |
| US5538845A (en) * | 1992-02-05 | 1996-07-23 | Athena Neurosciences, Inc. | Beta-amyloid peptide production inhibitors and methods for their identification |
| CA2427890A1 (en) * | 1992-02-05 | 1993-08-19 | Ralf Anderskewitz | New amidine derivatives, the preparation and use thereof |
| US5441870A (en) * | 1992-04-15 | 1995-08-15 | Athena Neurosciences, Inc. | Methods for monitoring cellular processing of β-amyloid precursor protein |
| US5428051A (en) * | 1992-10-13 | 1995-06-27 | University Of North Carolina | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
| US5605811A (en) * | 1992-10-26 | 1997-02-25 | Athena Neurosciences, Inc. | Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein |
| US5726197A (en) * | 1992-11-02 | 1998-03-10 | Syntex (U.S.A.) Inc. | Isoindolinyl derivatives |
| US5840294A (en) * | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
| US5643562A (en) * | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
| US5972328A (en) * | 1993-03-29 | 1999-10-26 | Queen's University At Kingston | Method for treating amyloidosis |
| US5552426A (en) * | 1994-04-29 | 1996-09-03 | Eli Lilly And Company | Methods for treating a physiological disorder associated with β-amyloid peptide |
| US5723288A (en) * | 1994-05-06 | 1998-03-03 | The University Of North Carolina At Chapel Hill | Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor |
| US5667975A (en) * | 1994-05-06 | 1997-09-16 | The University Of North Carolina | Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans |
| US5602172A (en) * | 1994-05-06 | 1997-02-11 | The University Of North Carolina At Chapel Hill | Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor |
| US5521189A (en) * | 1994-05-06 | 1996-05-28 | The University Of Nc At Ch | Methods of treating pneumocystis carinii pneumonia |
| DE4424714A1 (de) * | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff |
| DE4424713A1 (de) * | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe |
| FR2726558B1 (fr) * | 1994-11-03 | 1996-12-06 | Adir | Nouvelles 5-(aryloxymethyl) oxazolines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5612363A (en) * | 1995-06-02 | 1997-03-18 | Berlex Laboratories, Inc. | N,N-di(aryl) cyclic urea derivatives as anti-coagulants |
| US5668166A (en) * | 1995-06-07 | 1997-09-16 | Georgia State University Research Foundation, Inc. | Methods of inhibiting pneumocystis carinii pneumonia and compounds useful therefor |
| US5643935A (en) * | 1995-06-07 | 1997-07-01 | The University Of North Carolina At Chapel Hill | Method of combatting infectious diseases using dicationic bis-benzimidazoles |
| US5574059A (en) * | 1995-10-27 | 1996-11-12 | Cornell Research Foundation, Inc. | Treating disorders mediated by vascular smooth muscle cell proliferation |
| US5723495A (en) * | 1995-11-16 | 1998-03-03 | The University Of North Carolina At Chapel Hill | Benzamidoxime prodrugs as antipneumocystic agents |
| DE19546452A1 (de) * | 1995-12-13 | 1997-06-19 | Boehringer Ingelheim Kg | Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel |
| DE19636689A1 (de) * | 1996-09-10 | 1998-03-12 | Boehringer Ingelheim Kg | Neue Benzamidinderivate |
| AU4432597A (en) * | 1996-09-25 | 1998-04-17 | Regents Of The University Of California, The | Methods of using agmatine to reduce intracellular polyamine levels and to inhibit inducible nitric oxide synthase |
| US6133281A (en) * | 1996-10-24 | 2000-10-17 | Harbor-Ucla Research And Education Institute | NMDA receptor blockers in the therapy of urogenital disease |
| US5871924A (en) * | 1997-01-27 | 1999-02-16 | Nexstar Pharmaceuticals, Inc. | Method for the production of ligands capable of facilitating aminoacyl-RNA synthesis |
| US5935982A (en) * | 1997-02-28 | 1999-08-10 | The University Of North Carolina At Chapel Hill | Methods of treating retroviral infection and compounds useful therefor |
| US6008247A (en) * | 1998-02-27 | 1999-12-28 | The University Of North Carolina At Chapel Hill | 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii agents |
| US6635668B1 (en) * | 1998-07-22 | 2003-10-21 | The University Of North Carolina At Chapel Hill | Imidazoline receptor binding compounds |
| AU758563B2 (en) * | 1998-08-20 | 2003-03-27 | University Of North Carolina At Chapel Hill, The | Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof |
| ES2275362T3 (es) * | 1998-09-17 | 2007-06-01 | The University Of North Carolina At Chapel Hill | Actividad antifungica de moleculas dicationicas. |
| US6319944B1 (en) * | 1999-05-10 | 2001-11-20 | Merck & Co., Inc. | Aryl amidines, compositions containing such compounds and methods of use |
| US6627647B1 (en) * | 2000-03-23 | 2003-09-30 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)imidazoles and their use as anti-inflammatory agents |
| US20010036949A1 (en) * | 2000-05-09 | 2001-11-01 | Coe Jotham Wadsworth | Pharmaceutical composition and method of treatment of diseases of cognitive dysfunction in a mammal |
| US6625612B1 (en) * | 2000-06-14 | 2003-09-23 | Ezchip Technologies Ltd. | Deterministic search algorithm |
| WO2002002516A2 (en) * | 2000-06-30 | 2002-01-10 | Thomas Jefferson University | Inhibitors of hiv integrase |
| US6737440B2 (en) * | 2000-11-06 | 2004-05-18 | The University Of North Carolina At Chapel Hill | Synthesis and antimicrobial activity of novel dicationic “reversed amidines” |
| JP4368582B2 (ja) * | 2001-01-13 | 2009-11-18 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 牛ウイルス性下痢ウイルス（ｂｖｄｖ）感染およびｃ型肝炎ウイルス（ｈｃｖ）感染を処置するのに有用な化合物、方法、および組成物 |
-
2002
- 2002-09-03 EA EA200400135A patent/EA200400135A1/ru unknown
- 2002-09-03 KR KR10-2004-7002085A patent/KR20040036908A/ko not_active Ceased
- 2002-09-03 BR BR0212078-0A patent/BR0212078A/pt not_active IP Right Cessation
- 2002-09-03 JP JP2003522514A patent/JP2005504053A/ja not_active Withdrawn
- 2002-09-03 IL IL16020802A patent/IL160208A0/xx unknown
- 2002-09-03 WO PCT/CA2002/001353 patent/WO2003017994A1/en not_active Ceased
- 2002-09-03 EP EP02758012A patent/EP1420773A1/en not_active Withdrawn
- 2002-09-03 CA CA002455497A patent/CA2455497A1/en not_active Abandoned
- 2002-09-03 CN CN028157702A patent/CN1658852A/zh active Pending
- 2002-09-03 US US10/234,643 patent/US20040006092A1/en not_active Abandoned
- 2002-09-03 MX MXPA04001153A patent/MXPA04001153A/es not_active Application Discontinuation
-
2003
- 2003-12-05 US US10/731,463 patent/US20040147531A1/en not_active Abandoned
-
2006
- 2006-01-19 US US11/335,171 patent/US20070021483A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005504053A5 (https=) | ||
| AU709323B2 (en) | Method for preventing and treating peripheral neuropathy by administering selegiline | |
| RU96104356A (ru) | Производные амидина, обладающие активностью против синтетазы оксида азота (у) | |
| JP2001526218A5 (https=) | ||
| RU2000113729A (ru) | Гетероциклические соединения для ингибирования секреции желудочной кислоты, способы их получения и их фармацевтические компоозиции | |
| JP2007520452A5 (https=) | ||
| RU2002131941A (ru) | 3-азот-6,7-дикислородсодержащие стероиды и их применение | |
| CA2373093A1 (en) | Methods and compounds for inhibiting amyloid deposits | |
| RU2003110577A (ru) | Гетероциклические соединения, связывающиеся с хемокиновыми рецепторами | |
| RU2004139111A (ru) | Новые конденсированные производные имидазола | |
| JP2006526590A5 (https=) | ||
| RU2007101653A (ru) | Производные 1-азабицикло[3.3.1]нонанов | |
| JP2010500376A5 (https=) | ||
| RU99100397A (ru) | Новые соединения | |
| US20240067635A1 (en) | Cromolyn derivatives and uses thereof | |
| RU2001135802A (ru) | Антагонисты рецептора брадикинина | |
| JP2025509507A5 (https=) | ||
| JP2005519885A5 (https=) | ||
| RU2006103858A (ru) | Способ лечения пролиферативных заболеваний | |
| JP2005511594A5 (https=) | ||
| RU2004122427A (ru) | Пирролидин-2-оны в качестве ингибиторов фактора ха | |
| JP2008521934A5 (https=) | ||
| JP2004504377A5 (https=) | ||
| RU2007125130A (ru) | Применение атазанавира для улучшения фармакокинетики лекарственных средств, метаболизируемых ugt1a1 | |
| RU96103685A (ru) | 1,2,5-тиадиазольные производные индолилалкил-пиридинил- и пиримидинил-пиперазинов, способ лечения или предотвращения развития сосудистой головной боли и фармацевтическая композиция |