JP2005503393A - インドール誘導体の製造方法 - Google Patents

インドール誘導体の製造方法 Download PDF

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Publication number
JP2005503393A
JP2005503393A JP2003523219A JP2003523219A JP2005503393A JP 2005503393 A JP2005503393 A JP 2005503393A JP 2003523219 A JP2003523219 A JP 2003523219A JP 2003523219 A JP2003523219 A JP 2003523219A JP 2005503393 A JP2005503393 A JP 2005503393A
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JP
Japan
Prior art keywords
hydrogen
unsubstituted
substituted
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2003523219A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005503393A5 (enExample
Inventor
ヴォレブ，ハインツ
ヴォレブ，アンネマリー
ファン・デル・スハーフ，パウル・アドリアーン
コリー，ロマン
エンド，ニコル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba Spezialitaetenchemie Holding AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Spezialitaetenchemie Holding AG filed Critical Ciba Spezialitaetenchemie Holding AG
Publication of JP2005503393A publication Critical patent/JP2005503393A/ja
Publication of JP2005503393A5 publication Critical patent/JP2005503393A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Indole Compounds (AREA)
JP2003523219A 2001-08-22 2002-08-13 インドール誘導体の製造方法 Withdrawn JP2005503393A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01810817 2001-08-22
PCT/EP2002/009046 WO2003018555A1 (en) 2001-08-22 2002-08-13 Process for the preparation of indole derivatives

Publications (2)

Publication Number Publication Date
JP2005503393A true JP2005503393A (ja) 2005-02-03
JP2005503393A5 JP2005503393A5 (enExample) 2006-01-05

Family

ID=8184102

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003523219A Withdrawn JP2005503393A (ja) 2001-08-22 2002-08-13 インドール誘導体の製造方法

Country Status (7)

Country Link
US (1) US20050032875A1 (enExample)
EP (1) EP1423365A1 (enExample)
JP (1) JP2005503393A (enExample)
CN (1) CN1545502A (enExample)
CA (1) CA2455842A1 (enExample)
IL (1) IL160043A0 (enExample)
WO (1) WO2003018555A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008530117A (ja) * 2005-02-11 2008-08-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ２，３−ジ置換インドール類の製造方法

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100888408B1 (ko) 2001-07-13 2009-03-13 아스트라제네카 유케이 리미티드 아미노피리미딘 화합물의 제조 방법
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2004080963A1 (en) * 2003-03-13 2004-09-23 Ciba Specialty Chemicals Holding Inc. Process for the preparation of indole derivatives by enzymatic acylation
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
WO2005037787A1 (en) * 2003-10-16 2005-04-28 Ciba Specialty Chemicals Holding Inc. Crystalline form of fluvastatin sodium
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
CN1922174A (zh) * 2004-02-20 2007-02-28 贝林格尔·英格海姆国际有限公司 病毒聚合酶抑制剂
WO2006030304A2 (en) * 2004-09-17 2006-03-23 Ranbaxy Laboratories Limited Novel forms of fluvastatin sodium, processes for preparation and pharmaceutical compositions thereof
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
CA2618682C (en) * 2005-08-12 2011-06-21 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
HUE025730T2 (en) * 2011-01-18 2016-04-28 Dsm Sinochem Pharm Nl Bv A method for producing statins using a base
CN110944965A (zh) * 2017-07-28 2020-03-31 隆萨有限公司 非均相钴催化制备烷基化或氟代烷基化、氯代烷基化、和氟代氯代烷基化化合物的方法
CN118772052A (zh) * 2024-09-10 2024-10-15 湖南九维生物医药有限公司 一种医药中间体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5354772A (en) * 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
US5102893A (en) * 1986-07-07 1992-04-07 Warner-Lambert Company Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4808621A (en) * 1986-07-07 1989-02-28 Warner-Lambert Company Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
MX9909255A (en) * 1997-04-09 2000-06-01 Commw Scient Ind Res Org Process for covalently coupling organic compounds utilizing diboron derivatives for preparation of an aryl boronic acid
ES2183532T3 (es) * 1998-03-18 2003-03-16 Ciba Sc Holding Ag Reacciones de copulacion con catalizadores de paladio.
CN1217930C (zh) * 2000-05-26 2005-09-07 西巴特殊化学品控股有限公司 吲哚衍生物的制备方法和该方法的中间体

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008530117A (ja) * 2005-02-11 2008-08-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ２，３−ジ置換インドール類の製造方法
JP2012184243A (ja) * 2005-02-11 2012-09-27 Boehringer Ingelheim Internatl Gmbh ２，３−ジ置換インドール類の製造方法

Also Published As

Publication number Publication date
CA2455842A1 (en) 2003-03-06
CN1545502A (zh) 2004-11-10
EP1423365A1 (en) 2004-06-02
IL160043A0 (en) 2004-06-20
WO2003018555A1 (en) 2003-03-06
US20050032875A1 (en) 2005-02-10

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