JP2005502712A5 - - Google Patents
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- JP2005502712A5 JP2005502712A5 JP2003528119A JP2003528119A JP2005502712A5 JP 2005502712 A5 JP2005502712 A5 JP 2005502712A5 JP 2003528119 A JP2003528119 A JP 2003528119A JP 2003528119 A JP2003528119 A JP 2003528119A JP 2005502712 A5 JP2005502712 A5 JP 2005502712A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- adipose tissue
- separating
- matrix material
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims description 56
- 210000000130 stem cell Anatomy 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 43
- 210000000577 adipose tissue Anatomy 0.000 claims description 30
- 239000011159 matrix material Substances 0.000 claims description 23
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 20
- 238000001816 cooling Methods 0.000 claims description 13
- 238000005138 cryopreservation Methods 0.000 claims description 13
- 239000002577 cryoprotective agent Substances 0.000 claims description 13
- 230000001225 therapeutic effect Effects 0.000 claims description 12
- 238000010257 thawing Methods 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 230000003204 osmotic effect Effects 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 239000002537 cosmetic Substances 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 102000009027 Albumins Human genes 0.000 claims description 3
- 108010088751 Albumins Proteins 0.000 claims description 3
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 3
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 3
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 230000000959 cryoprotective effect Effects 0.000 claims description 3
- 229940050526 hydroxyethylstarch Drugs 0.000 claims description 3
- 239000012071 phase Substances 0.000 claims description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 230000003833 cell viability Effects 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 210000001789 adipocyte Anatomy 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 239000006285 cell suspension Substances 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- 238000005119 centrifugation Methods 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 230000000717 retained effect Effects 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 239000007790 solid phase Substances 0.000 claims 2
- 238000009987 spinning Methods 0.000 claims 2
- 238000010792 warming Methods 0.000 claims 2
- 102000029816 Collagenase Human genes 0.000 claims 1
- 108060005980 Collagenase Proteins 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 108090000526 Papain Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 229960002424 collagenase Drugs 0.000 claims 1
- 238000005188 flotation Methods 0.000 claims 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 229940055729 papain Drugs 0.000 claims 1
- 235000019834 papain Nutrition 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000010008 shearing Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- 229960001322 trypsin Drugs 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 6
- 238000007710 freezing Methods 0.000 description 5
- 230000008014 freezing Effects 0.000 description 5
- 230000035899 viability Effects 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000012620 biological material Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 239000000644 isotonic solution Substances 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000003409 anti-rejection Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000003021 clonogenic effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002064 heart cell Anatomy 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000007443 liposuction Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000003211 trypan blue cell staining Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32207001P | 2001-09-14 | 2001-09-14 | |
| US10/242,094 US20030054331A1 (en) | 2001-09-14 | 2002-09-12 | Preservation of non embryonic cells from non hematopoietic tissues |
| PCT/US2002/029207 WO2003024215A1 (en) | 2001-09-14 | 2002-09-13 | Preservation of non embryonic cells from non hematopoietic tissues |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009189198A Division JP2009269930A (ja) | 2001-09-14 | 2009-08-18 | 非造血組織由来の非胚性細胞の保存 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005502712A JP2005502712A (ja) | 2005-01-27 |
| JP2005502712A5 true JP2005502712A5 (https=) | 2006-08-17 |
Family
ID=26934818
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003528119A Pending JP2005502712A (ja) | 2001-09-14 | 2002-09-13 | 非造血組織由来の非胚性細胞の保存 |
| JP2009189198A Pending JP2009269930A (ja) | 2001-09-14 | 2009-08-18 | 非造血組織由来の非胚性細胞の保存 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009189198A Pending JP2009269930A (ja) | 2001-09-14 | 2009-08-18 | 非造血組織由来の非胚性細胞の保存 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030054331A1 (https=) |
| EP (1) | EP1427279A1 (https=) |
| JP (2) | JP2005502712A (https=) |
| KR (1) | KR100779812B1 (https=) |
| CN (1) | CN1585602A (https=) |
| AU (1) | AU2002326901B2 (https=) |
| CA (1) | CA2460402A1 (https=) |
| WO (1) | WO2003024215A1 (https=) |
Families Citing this family (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001288468A1 (en) * | 2000-08-28 | 2002-03-13 | Ebox.Com, Inc. | A high security wireless key for asynchronous delivery drop boxes |
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| US7514075B2 (en) | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
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| US9597395B2 (en) | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
| KR20040094910A (ko) * | 2002-04-03 | 2004-11-10 | 아르테셀 사이언스, 인크. | 개선된 지방세포 분화된 지방 유래 성체 줄기세포 및 이의용도 |
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- 2002-09-12 US US10/242,094 patent/US20030054331A1/en not_active Abandoned
- 2002-09-13 KR KR1020047003710A patent/KR100779812B1/ko not_active Expired - Fee Related
- 2002-09-13 CA CA002460402A patent/CA2460402A1/en not_active Abandoned
- 2002-09-13 WO PCT/US2002/029207 patent/WO2003024215A1/en not_active Ceased
- 2002-09-13 EP EP02761654A patent/EP1427279A1/en not_active Withdrawn
- 2002-09-13 CN CNA028226283A patent/CN1585602A/zh active Pending
- 2002-09-13 JP JP2003528119A patent/JP2005502712A/ja active Pending
- 2002-09-13 AU AU2002326901A patent/AU2002326901B2/en not_active Ceased
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2009
- 2009-08-18 JP JP2009189198A patent/JP2009269930A/ja active Pending
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