JP2005502408A5 - - Google Patents

Info

Publication number

JP2005502408A5

JP2005502408A5 JP2003527732A JP2003527732A JP2005502408A5 JP 2005502408 A5 JP2005502408 A5 JP 2005502408A5 JP 2003527732 A JP2003527732 A JP 2003527732A JP 2003527732 A JP2003527732 A JP 2003527732A JP 2005502408 A5 JP2005502408 A5 JP 2005502408A5

Authority

JP

Japan

Prior art keywords

therapeutic compound

projectile

formulation containing

precursor

formulation

Prior art date

2002-09-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims description 95
• 230000001225 therapeutic effect Effects 0.000 claims description 95
• 239000000203 mixture Substances 0.000 claims description 56
• 238000009472 formulation Methods 0.000 claims description 55
• 239000002243 precursor Substances 0.000 claims description 25
• 238000002347 injection Methods 0.000 claims description 19
• 239000007924 injection Substances 0.000 claims description 19
• 238000001802 infusion Methods 0.000 claims description 12
• 241001465754 Metazoa Species 0.000 claims description 11
• 239000007787 solid Substances 0.000 claims description 11
• 239000007788 liquid Substances 0.000 claims description 6
• 239000000463 material Substances 0.000 claims description 5
• 238000000034 method Methods 0.000 claims 15
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 8
• 150000002632 lipids Chemical class 0.000 claims 6
• 230000004888 barrier function Effects 0.000 claims 4
• 230000000149 penetrating effect Effects 0.000 claims 4
• 239000011805 ball Substances 0.000 claims 3
• 239000013078 crystal Substances 0.000 claims 3
• 239000008187 granular material Substances 0.000 claims 3
• 239000002245 particle Substances 0.000 claims 3
• 238000001125 extrusion Methods 0.000 claims 1
• 239000007943 implant Substances 0.000 claims 1
• 230000000977 initiatory effect Effects 0.000 claims 1
• 230000035515 penetration Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 4
• 210000003491 skin Anatomy 0.000 description 4
• 239000004480 active ingredient Substances 0.000 description 3
• 239000003814 drug Substances 0.000 description 2
• 229940079593 drug Drugs 0.000 description 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
• 102000004877 Insulin Human genes 0.000 description 1
• 108090001061 Insulin Proteins 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 210000004207 dermis Anatomy 0.000 description 1
• 210000000624 ear auricle Anatomy 0.000 description 1
• 210000002615 epidermis Anatomy 0.000 description 1
• 239000000499 gel Substances 0.000 description 1
• 210000003128 head Anatomy 0.000 description 1
• 229940125396 insulin Drugs 0.000 description 1
• 210000001640 nerve ending Anatomy 0.000 description 1
• 230000037368 penetrate the skin Effects 0.000 description 1
• 230000000704 physical effect Effects 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 210000003813 thumb Anatomy 0.000 description 1