JP2005501825A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005501825A5 JP2005501825A5 JP2003513533A JP2003513533A JP2005501825A5 JP 2005501825 A5 JP2005501825 A5 JP 2005501825A5 JP 2003513533 A JP2003513533 A JP 2003513533A JP 2003513533 A JP2003513533 A JP 2003513533A JP 2005501825 A5 JP2005501825 A5 JP 2005501825A5
- Authority
- JP
- Japan
- Prior art keywords
- bond
- enteral
- hydroxy
- effective amount
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 amino, monosubstituted amino Chemical group 0.000 description 7
- 125000000217 alkyl group Chemical group 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000534944 Thia Species 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 125000001841 imino group Chemical group [H]N=* 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 150000001204 N-oxides Chemical class 0.000 description 1
- KUGRPPRAQNPSQD-UHFFFAOYSA-N OOOOO Chemical compound OOOOO KUGRPPRAQNPSQD-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 125000001589 carboacyl group Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000012792 lyophilization process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 238000009496 sugar coating process Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- YCOYDOIWSSHVCK-UHFFFAOYSA-N vatalanib Chemical compound C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 YCOYDOIWSSHVCK-UHFFFAOYSA-N 0.000 description 1
- 229950000578 vatalanib Drugs 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30655901P | 2001-07-19 | 2001-07-19 | |
| US30657101P | 2001-07-19 | 2001-07-19 | |
| US30656001P | 2001-07-19 | 2001-07-19 | |
| PCT/EP2002/008020 WO2003007924A2 (en) | 2001-07-19 | 2002-07-18 | Combinations comprising epothilones and pharmaceutical uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010044000A Division JP2010159271A (ja) | 2001-07-19 | 2010-03-01 | エポシロンを含有する組合せ剤およびその医薬上の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005501825A JP2005501825A (ja) | 2005-01-20 |
| JP2005501825A5 true JP2005501825A5 (https=) | 2006-01-05 |
Family
ID=27405180
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003513533A Withdrawn JP2005501825A (ja) | 2001-07-19 | 2002-07-18 | エポシロンを含有する組合せ剤およびその医薬上の使用 |
| JP2010044000A Pending JP2010159271A (ja) | 2001-07-19 | 2010-03-01 | エポシロンを含有する組合せ剤およびその医薬上の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010044000A Pending JP2010159271A (ja) | 2001-07-19 | 2010-03-01 | エポシロンを含有する組合せ剤およびその医薬上の使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20040235796A1 (https=) |
| EP (2) | EP2210643A3 (https=) |
| JP (2) | JP2005501825A (https=) |
| KR (2) | KR20040030808A (https=) |
| CN (2) | CN1283248C (https=) |
| AU (2) | AU2002328921B2 (https=) |
| BR (1) | BR0211271A (https=) |
| CA (1) | CA2453108A1 (https=) |
| CO (1) | CO5560565A2 (https=) |
| EC (2) | ECSP084948A (https=) |
| HU (1) | HUP0401153A3 (https=) |
| IL (2) | IL159517A0 (https=) |
| MX (1) | MXPA04000567A (https=) |
| NO (1) | NO20040214L (https=) |
| NZ (2) | NZ550174A (https=) |
| PL (1) | PL365030A1 (https=) |
| RU (1) | RU2375058C2 (https=) |
| TW (1) | TWI315982B (https=) |
| WO (1) | WO2003007924A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| CA2273083C (en) | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| IL157443A0 (en) | 2001-03-14 | 2004-03-28 | Bristol Myers Squibb Co | Pharmaceutical compositions for the treatment of cancer including an epothilone analog and a chemotherapeutic agent |
| TWI315982B (en) * | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| CN101693031A (zh) | 2003-11-18 | 2010-04-14 | 诺瓦提斯公司 | Kit突变形式的抑制剂 |
| US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
| EP1640004A1 (en) * | 2004-09-24 | 2006-03-29 | Schering Aktiengesellschaft | Use of epothilones in the treatment of bone metastases and bone tumors or cancers |
| US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
| CA2606716C (en) | 2005-05-02 | 2013-07-23 | Novartis Ag | Use of pyrimidylaminobenzamide derivatives for the treatment of systematic mastocytosis |
| CN100384419C (zh) * | 2005-12-02 | 2008-04-30 | 菏泽睿鹰制药集团有限公司 | 一种埃坡霉素缓释植入组合物及应用 |
| US20110300150A1 (en) | 2010-05-18 | 2011-12-08 | Scott Eliasof | Compositions and methods for treatment of autoimmune and other disease |
| RU2478407C1 (ru) * | 2011-09-05 | 2013-04-10 | Федеральное государственное бюджетное учреждение Министерства здравоохранения и социального развития Российской Федерации "Медицинский радиологический научный центр" (ФГБУ МРНЦ Минздравсоцразвития России) | Способ комбинированного лечения местно-распространенного рака желудка |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2409754A (en) * | 1946-10-22 | Method for obtaining hydantoins | ||
| US3475486A (en) * | 1966-09-12 | 1969-10-28 | Monsanto Co | Process for preparing phosphonic acids |
| NL7304882A (https=) | 1972-04-10 | 1973-10-12 | ||
| CH605550A5 (https=) | 1972-06-08 | 1978-09-29 | Research Corp | |
| DE2405254C2 (de) * | 1974-02-04 | 1982-05-27 | Henkel KGaA, 4000 Düsseldorf | Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper |
| FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| IT1187828B (it) * | 1985-05-24 | 1987-12-23 | Gentili Ist Spa | Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| FR2694558B1 (fr) * | 1992-08-05 | 1994-10-28 | Sanofi Elf | Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant. |
| AU687727B2 (en) | 1992-10-28 | 1998-03-05 | Genentech Inc. | Vascular endothelial cell growth factor antagonists |
| EP0675723A4 (en) | 1992-12-23 | 1998-08-05 | Merck & Co Inc | THERAPY USING BISPHOSPHONATES AND STROGENS TO TREAT AND PREVENT BONE RESORPTION. |
| AU2989695A (en) | 1994-08-08 | 2000-03-07 | Debiopharm S.A. | Pharmaceutically stable oxaliplatinum preparation |
| ATE289199T1 (de) * | 1995-06-06 | 2005-03-15 | Merck & Co Inc | Formulierungen mit dem wasserfreien mononatriumsalz von alendronat und deren verwendung zur behandlung von knochenkrankheiten |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| JP4183099B2 (ja) * | 1995-11-17 | 2008-11-19 | ゲゼルシャフト・フュア・ビオテヒノロジッシェ・フォルシュング・ミット・ベシュレンクテル・ハフツング（ゲー・ベー・エフ） | エポチロンｃおよびｄ、製造法ならびに組成物 |
| AU716610B2 (en) | 1996-08-30 | 2000-03-02 | Novartis Ag | Method for producing epothilones, and intermediate products obtained during the production process |
| DE19638745C2 (de) | 1996-09-11 | 2001-05-10 | Schering Ag | Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR) |
| ES2312695T3 (es) | 1996-11-18 | 2009-03-01 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Epotilones e y f. |
| CA2273083C (en) * | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| TR200002299T2 (tr) * | 1998-02-05 | 2000-11-21 | Novartis Ag | Epotilon kompozisyonları. |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
| CA2322157C (en) | 1998-02-25 | 2012-05-29 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| WO2000000485A1 (de) * | 1998-06-30 | 2000-01-06 | Schering Aktiengesellschaft | Epothilon-derivate, verfahren zu deren herstellung, zwischenprodukte und ihre pharmazeutische verwendung |
| PT1107964E (pt) | 1998-08-11 | 2010-06-11 | Novartis Ag | Derivados de isoquinolina com actividade inibidora da angiogénese |
| DE19845798A1 (de) * | 1998-09-29 | 2000-04-13 | Schering Ag | Verwendung von Neoangiogenese-Markern für Diagnose und Therapie von Tumoren, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| WO2000031247A2 (en) | 1998-11-20 | 2000-06-02 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| DK1140173T4 (da) | 1998-12-22 | 2013-06-10 | Genentech Inc | Vaskulære endothelcellevækstfaktorantagonister og anvendelser deraf |
| EP1156823B1 (en) | 1999-02-12 | 2008-10-29 | The Scripps Research Institute | Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies |
| DE19908760A1 (de) * | 1999-02-18 | 2000-08-24 | Schering Ag | Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
| CN1660840A (zh) | 1999-03-30 | 2005-08-31 | 诺瓦提斯公司 | 治疗炎性疾病的酞嗪衍生物 |
| GB9907908D0 (en) * | 1999-04-07 | 1999-06-02 | Bataille Regis | Organic compounds |
| KR100763064B1 (ko) * | 1999-05-21 | 2007-10-04 | 노파르티스 아게 | 제약 조성물 및 용도 |
| EP1267888A4 (en) * | 2000-01-04 | 2005-12-28 | Univ California | USE OF LOW DOSE BISPHOSPHONATES TO INHIBIT CARDIAC AND ARTERIAL CALCIFICATION |
| GB0001930D0 (en) | 2000-01-27 | 2000-03-22 | Novartis Ag | Organic compounds |
| PT1254138E (pt) | 2000-02-09 | 2005-09-30 | Novartis Ag | Derivados de piridina que inibem a angiogenese e/ou o receptor de tirosina cinase do vegf |
| IL157443A0 (en) | 2001-03-14 | 2004-03-28 | Bristol Myers Squibb Co | Pharmaceutical compositions for the treatment of cancer including an epothilone analog and a chemotherapeutic agent |
| TWI315982B (en) * | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
-
2002
- 2002-07-17 TW TW091115929A patent/TWI315982B/zh not_active IP Right Cessation
- 2002-07-18 CN CNB028144147A patent/CN1283248C/zh not_active Expired - Fee Related
- 2002-07-18 JP JP2003513533A patent/JP2005501825A/ja not_active Withdrawn
- 2002-07-18 CA CA002453108A patent/CA2453108A1/en not_active Abandoned
- 2002-07-18 NZ NZ550174A patent/NZ550174A/en not_active IP Right Cessation
- 2002-07-18 IL IL15951702A patent/IL159517A0/xx unknown
- 2002-07-18 KR KR10-2004-7000700A patent/KR20040030808A/ko not_active Ceased
- 2002-07-18 AU AU2002328921A patent/AU2002328921B2/en not_active Ceased
- 2002-07-18 HU HU0401153A patent/HUP0401153A3/hu unknown
- 2002-07-18 MX MXPA04000567A patent/MXPA04000567A/es active IP Right Grant
- 2002-07-18 PL PL02365030A patent/PL365030A1/xx not_active IP Right Cessation
- 2002-07-18 WO PCT/EP2002/008020 patent/WO2003007924A2/en not_active Ceased
- 2002-07-18 BR BR0211271-0A patent/BR0211271A/pt not_active Application Discontinuation
- 2002-07-18 EP EP10157876A patent/EP2210643A3/en not_active Withdrawn
- 2002-07-18 RU RU2004105144/15A patent/RU2375058C2/ru not_active IP Right Cessation
- 2002-07-18 US US10/484,482 patent/US20040235796A1/en not_active Abandoned
- 2002-07-18 NZ NZ530572A patent/NZ530572A/en not_active IP Right Cessation
- 2002-07-18 KR KR1020097006647A patent/KR20090040925A/ko not_active Ceased
- 2002-07-18 EP EP02764726A patent/EP1412029A2/en not_active Withdrawn
- 2002-07-18 CN CN200910168406A patent/CN101791308A/zh active Pending
-
2003
- 2003-12-22 IL IL159517A patent/IL159517A/en not_active IP Right Cessation
-
2004
- 2004-01-16 NO NO20040214A patent/NO20040214L/no not_active Application Discontinuation
- 2004-02-11 CO CO04011525A patent/CO5560565A2/es not_active Application Discontinuation
-
2005
- 2005-12-20 AU AU2005246964A patent/AU2005246964B2/en not_active Ceased
-
2008
- 2008-01-24 US US12/019,294 patent/US7612052B2/en not_active Expired - Fee Related
- 2008-07-04 EC EC2008004948A patent/ECSP084948A/es unknown
-
2009
- 2009-08-28 US US12/549,947 patent/US8008330B2/en not_active Expired - Fee Related
- 2009-11-19 EC EC2009004948A patent/ECSP094948A/es unknown
-
2010
- 2010-03-01 JP JP2010044000A patent/JP2010159271A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005501825A5 (https=) | ||
| US5721263A (en) | Pharmaceutical composition for angiotensin II-mediated diseases | |
| US6693125B2 (en) | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders | |
| RU2008133654A (ru) | Способ и лекарственное средство для лечения тяжелой сердечной недостаточности | |
| JP2005504111A5 (https=) | ||
| KR100214453B1 (ko) | 경피적 관상동맥 형성술 후의 재협착 억제제 | |
| JP2003503385A5 (https=) | ||
| JP2023533485A5 (https=) | ||
| JP2002537258A5 (https=) | ||
| JP3465824B2 (ja) | 腫瘍治療用医薬組成物 | |
| RU2004131214A (ru) | Способы лечения когнитивных расстройств | |
| JP2001515041A5 (https=) | ||
| RU2007131435A (ru) | Противоопухолевое средство | |
| RU2334517C2 (ru) | Средство, потенцирующее противоопухолевый эффект, и противоопухолевое средство | |
| EA006295B1 (ru) | Применение производных дистамицина для противоопухолевой терапии | |
| RU2004121687A (ru) | Композиции, содержащие эпотилоны, и их применение для лечения карциноидного синдрома | |
| SK103797A3 (en) | Mixture of compounds and pharmaceutical composition containing the same | |
| US6509330B2 (en) | Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors | |
| CA2504665A1 (en) | Combination of a nitrogen mustard analogue and imatinib for the treatment of chronic lymphocytic leukemia | |
| JP2899861B2 (ja) | ショック治療用ピリミドン類及びイミダゾリノン類 | |
| WO1999051242A1 (fr) | Compositions medicinales pour traiter les oedemes | |
| RU99107562A (ru) | Новые производные 2,4-диоксопирролидина и 2,4-диоксотетрагидрофурана и лекарственные средства, содержащие их в качестве активного ингредиента | |
| JP2006502195A5 (https=) | ||
| CN100355423C (zh) | 用于治疗肿瘤的包含血管抑制化合物和烷化剂的组合 | |
| JP2621382B2 (ja) | 尿酸排泄剤 |