CN1283248C - 包含埃坡霉素的组合及其药学应用 - Google Patents

包含埃坡霉素的组合及其药学应用 Download PDF

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Publication number
CN1283248C
CN1283248C CNB028144147A CN02814414A CN1283248C CN 1283248 C CN1283248 C CN 1283248C CN B028144147 A CNB028144147 A CN B028144147A CN 02814414 A CN02814414 A CN 02814414A CN 1283248 C CN1283248 C CN 1283248C
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China
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combination
lower alkyl
hydrogen
cancer
ptk787
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Expired - Fee Related
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CNB028144147A
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English (en)
Chinese (zh)
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CN1533293A (zh
Inventor
陈恬玲
D·格里利
J·D·罗瑟梅尔
M·瓦特曼
J·M·伍德
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Novartis AG
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB028144147A 2001-07-19 2002-07-18 包含埃坡霉素的组合及其药学应用 Expired - Fee Related CN1283248C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US30655901P 2001-07-19 2001-07-19
US30657101P 2001-07-19 2001-07-19
US30656001P 2001-07-19 2001-07-19
US60/306,560 2001-07-19
US60/306,559 2001-07-19
US60/306,571 2001-07-19

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN200910168406A Division CN101791308A (zh) 2001-07-19 2002-07-18 包含埃坡霉素的组合及其药学应用
CN 200610151425 Division CN1911218A (zh) 2001-07-19 2002-07-18 包含埃坡霉素的组合及其药学应用

Publications (2)

Publication Number Publication Date
CN1533293A CN1533293A (zh) 2004-09-29
CN1283248C true CN1283248C (zh) 2006-11-08

Family

ID=27405180

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB028144147A Expired - Fee Related CN1283248C (zh) 2001-07-19 2002-07-18 包含埃坡霉素的组合及其药学应用
CN200910168406A Pending CN101791308A (zh) 2001-07-19 2002-07-18 包含埃坡霉素的组合及其药学应用

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CN200910168406A Pending CN101791308A (zh) 2001-07-19 2002-07-18 包含埃坡霉素的组合及其药学应用

Country Status (19)

Country Link
US (3) US20040235796A1 (https=)
EP (2) EP2210643A3 (https=)
JP (2) JP2005501825A (https=)
KR (2) KR20040030808A (https=)
CN (2) CN1283248C (https=)
AU (2) AU2002328921B2 (https=)
BR (1) BR0211271A (https=)
CA (1) CA2453108A1 (https=)
CO (1) CO5560565A2 (https=)
EC (2) ECSP084948A (https=)
HU (1) HUP0401153A3 (https=)
IL (2) IL159517A0 (https=)
MX (1) MXPA04000567A (https=)
NO (1) NO20040214L (https=)
NZ (2) NZ550174A (https=)
PL (1) PL365030A1 (https=)
RU (1) RU2375058C2 (https=)
TW (1) TWI315982B (https=)
WO (1) WO2003007924A2 (https=)

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US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
IL157443A0 (en) 2001-03-14 2004-03-28 Bristol Myers Squibb Co Pharmaceutical compositions for the treatment of cancer including an epothilone analog and a chemotherapeutic agent
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US20050215604A1 (en) * 2004-03-26 2005-09-29 Kosan Biosciences, Inc. Combination therapies with epothilones and carboplatin
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CA2606716C (en) 2005-05-02 2013-07-23 Novartis Ag Use of pyrimidylaminobenzamide derivatives for the treatment of systematic mastocytosis
CN100384419C (zh) * 2005-12-02 2008-04-30 菏泽睿鹰制药集团有限公司 一种埃坡霉素缓释植入组合物及应用
US20110300150A1 (en) 2010-05-18 2011-12-08 Scott Eliasof Compositions and methods for treatment of autoimmune and other disease
RU2478407C1 (ru) * 2011-09-05 2013-04-10 Федеральное государственное бюджетное учреждение Министерства здравоохранения и социального развития Российской Федерации "Медицинский радиологический научный центр" (ФГБУ МРНЦ Минздравсоцразвития России) Способ комбинированного лечения местно-распространенного рака желудка

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Also Published As

Publication number Publication date
HUP0401153A2 (hu) 2004-10-28
EP2210643A2 (en) 2010-07-28
US7612052B2 (en) 2009-11-03
KR20090040925A (ko) 2009-04-27
KR20040030808A (ko) 2004-04-09
US20040235796A1 (en) 2004-11-25
ECSP094948A (es) 2009-12-28
RU2004105144A (ru) 2005-04-20
WO2003007924A3 (en) 2003-09-25
MXPA04000567A (es) 2004-04-20
JP2005501825A (ja) 2005-01-20
EP2210643A3 (en) 2010-11-24
NO20040214L (no) 2004-03-18
EP1412029A2 (en) 2004-04-28
JP2010159271A (ja) 2010-07-22
CN1533293A (zh) 2004-09-29
CA2453108A1 (en) 2003-01-30
CO5560565A2 (es) 2005-09-30
IL159517A (en) 2012-04-30
AU2005246964A1 (en) 2006-01-12
US8008330B2 (en) 2011-08-30
AU2002328921B2 (en) 2006-11-02
HUP0401153A3 (en) 2008-01-28
ECSP084948A (es) 2008-08-29
BR0211271A (pt) 2004-08-03
CN101791308A (zh) 2010-08-04
PL365030A1 (en) 2004-12-27
RU2375058C2 (ru) 2009-12-10
IL159517A0 (en) 2004-06-01
TWI315982B (en) 2009-10-21
NZ550174A (en) 2008-04-30
US20080119529A1 (en) 2008-05-22
NZ530572A (en) 2006-11-30
US20090318390A1 (en) 2009-12-24
AU2005246964B2 (en) 2008-04-24
WO2003007924A2 (en) 2003-01-30

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