JP2005206602A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005206602A5 JP2005206602A5 JP2005013897A JP2005013897A JP2005206602A5 JP 2005206602 A5 JP2005206602 A5 JP 2005206602A5 JP 2005013897 A JP2005013897 A JP 2005013897A JP 2005013897 A JP2005013897 A JP 2005013897A JP 2005206602 A5 JP2005206602 A5 JP 2005206602A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- arginine
- producing
- buffer
- purified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001483 arginine derivatives Chemical class 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 5
- 239000004475 Arginine Substances 0.000 claims 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
- QYPPJABKJHAVHS-UHFFFAOYSA-N Agmatine Natural products NCCCCNC(N)=N QYPPJABKJHAVHS-UHFFFAOYSA-N 0.000 claims 2
- BMFMQGXDDJALKQ-BYPYZUCNSA-N Argininic acid Chemical compound NC(N)=NCCC[C@H](O)C(O)=O BMFMQGXDDJALKQ-BYPYZUCNSA-N 0.000 claims 2
- 238000001042 affinity chromatography Methods 0.000 claims 2
- QYPPJABKJHAVHS-UHFFFAOYSA-P agmatinium(2+) Chemical compound NC(=[NH2+])NCCCC[NH3+] QYPPJABKJHAVHS-UHFFFAOYSA-P 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- CLEWTIUJJAUEGU-ZETCQYMHSA-N (2S)-5-(diaminomethylideneamino)-2-(2,2-dimethylpropanoylamino)pentanoic acid Chemical compound CC(C)(C)C(=O)N[C@H](C(O)=O)CCCN=C(N)N CLEWTIUJJAUEGU-ZETCQYMHSA-N 0.000 claims 1
- XHXFSMZBXZZZIT-ZETCQYMHSA-N (2s)-2-(butanoylamino)-5-(diaminomethylideneamino)pentanoic acid Chemical group CCCC(=O)N[C@H](C(O)=O)CCCNC(N)=N XHXFSMZBXZZZIT-ZETCQYMHSA-N 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53750304P | 2004-01-21 | 2004-01-21 | |
| US60/537503 | 2004-01-21 | ||
| US63140704P | 2004-11-30 | 2004-11-30 | |
| US60/631407 | 2004-11-30 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005206602A JP2005206602A (ja) | 2005-08-04 |
| JP2005206602A5 true JP2005206602A5 (enExample) | 2008-03-06 |
| JP4826995B2 JP4826995B2 (ja) | 2011-11-30 |
Family
ID=34753090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005013897A Expired - Lifetime JP4826995B2 (ja) | 2004-01-21 | 2005-01-21 | 抗体の変質を防止する精製方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8084032B2 (enExample) |
| EP (1) | EP1568710B1 (enExample) |
| JP (1) | JP4826995B2 (enExample) |
| CN (1) | CN1680426B (enExample) |
| DE (1) | DE602005018406D1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8084032B2 (en) | 2004-01-21 | 2011-12-27 | Ajinomoto Co., Inc. | Purification method which prevents denaturation of an antibody |
| DE602006003108D1 (de) * | 2005-03-03 | 2008-11-27 | Ajinomoto Kk | Methode zur Verbesserung der Ausbeute bei der Proteinreinigung mittels Gelfiltrationschromatographie und Arginin |
| ATE551433T1 (de) * | 2005-05-06 | 2012-04-15 | Gen Probe Inc | Verfahren und produkte zum erfassen von nukleinsäurezielen |
| AR062069A1 (es) * | 2006-07-14 | 2008-10-15 | Genentech Inc | Replegado de proteinas recombinantes |
| CN101511387A (zh) * | 2006-09-08 | 2009-08-19 | 惠氏公司 | 使用亲和色谱法纯化蛋白质的精氨酸洗涤液 |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| AU2007294731B2 (en) | 2006-09-13 | 2014-04-17 | Abbvie Inc. | Cell culture improvements |
| EP2089429B1 (en) * | 2006-10-19 | 2014-11-26 | Janssen Biotech, Inc. | Process for preparing unaggregated antibody fc domains |
| US8669045B2 (en) * | 2007-02-13 | 2014-03-11 | Ajinomoto Co., Inc. | Method for inactivating viruses with slightly acidic arginine |
| CN102089319B (zh) * | 2008-05-08 | 2013-11-13 | 味之素株式会社 | 蛋白质的重折叠方法 |
| JP4542172B2 (ja) * | 2008-05-19 | 2010-09-08 | 日本電波工業株式会社 | 感知装置及び感知方法 |
| SG2013061528A (en) * | 2008-08-14 | 2015-03-30 | Merck Sharp & Dohme | Methods for purifying antibodies using protein a affinity chromatography |
| BRPI0920572A8 (pt) | 2008-10-20 | 2015-10-27 | Abbott Lab | Inativação viral durante a purificação dos anticorpos |
| NZ592095A (en) | 2008-10-20 | 2013-01-25 | Abbott Lab | Isolation and purification of il-12 and tnf-alpha antibodies using protein a affinity chromatography |
| JP2011041475A (ja) * | 2009-08-19 | 2011-03-03 | Asahi Kasei Medical Co Ltd | 抗体製造方法 |
| ES2982297T3 (es) | 2009-12-18 | 2024-10-15 | Novartis Ag | Método de cromatografía de afinidad |
| SG182553A1 (en) | 2010-01-22 | 2012-08-30 | Boehringer Ingelheim Int | Chromatographic method for purifying fc-containing proteins |
| JP5838969B2 (ja) | 2010-02-26 | 2016-01-06 | 味の素株式会社 | 低分子化合物とアルギニンとを含有するウイルス不活化用組成物 |
| EP2583973B1 (en) * | 2010-06-21 | 2018-03-21 | Kyowa Hakko Kirin Co., Ltd. | Method for purifying protein using amino acid |
| EP2714714B1 (en) * | 2011-06-01 | 2018-06-20 | Novartis AG | Wash solution and method for affinity chromatography |
| WO2012176919A1 (ja) | 2011-06-23 | 2012-12-27 | 味の素株式会社 | 免疫グロブリン折りたたみ構造を持つタンパク質と、サブユニット構造となりうるタンパク質とを融合させた単量体タンパク質からなる多量体タンパク質の調製方法 |
| JPWO2014003137A1 (ja) * | 2012-06-27 | 2016-06-02 | 旭化成メディカル株式会社 | 高アフィニティー抗体、及びその製造方法 |
| WO2014054744A1 (ja) * | 2012-10-03 | 2014-04-10 | 協和発酵キリン株式会社 | 培養液にアミノ酸を添加することによるポリペプチドの還元防止方法 |
| RS57864B1 (sr) | 2013-06-17 | 2018-12-31 | De Staat Der Nederlanden Vert Door De Minister Van Vws Ministerie Van Volksgezondheid Welzijn En Spo | Postupci za sprečavanje agregacije virusnih komponenti |
| JP6236948B2 (ja) * | 2013-07-17 | 2017-11-29 | 東ソー株式会社 | 抗体精製用溶出液および当該溶出液を用いた抗体精製方法 |
| CN105273041A (zh) * | 2014-07-08 | 2016-01-27 | 上海中信国健药业股份有限公司 | 一种蛋白质亲和层析洗脱方法 |
| AR102198A1 (es) | 2014-10-09 | 2017-02-08 | Regeneron Pharma | Proceso para reducir partículas subvisibles en una formulación farmacéutica |
| WO2016065181A1 (en) | 2014-10-23 | 2016-04-28 | Amgen Inc. | Reducing viscosity of pharmaceutical formulations |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US20180273582A1 (en) * | 2015-11-09 | 2018-09-27 | University Of Notre Dame | Small molecule affinity membrane purification systems and uses thereof |
| HRP20160086A2 (hr) | 2016-01-27 | 2017-08-11 | Sveučilište u Zagrebu | Eluens za imunoafinitetnu kromatografiju virusa i proteina |
| US11186858B1 (en) | 2016-03-15 | 2021-11-30 | Fresenius Kabi Deutschland Gmbh | Methods for increasing biosimilarity |
| WO2017194592A1 (en) | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Method of storing a separation matrix |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10513537B2 (en) | 2016-05-11 | 2019-12-24 | Ge Healthcare Bioprocess R&D Ab | Separation matrix |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| WO2017194593A1 (en) | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Method of cleaning and/or sanitizing a separation matrix |
| CA3031028C (en) | 2016-07-25 | 2024-02-13 | Lu Wang | Affinity chromatography wash buffer |
| US11020686B2 (en) | 2016-08-16 | 2021-06-01 | Regeneron Pharmaceuticals, Inc. | Methods for quantitating individual antibodies from a mixture |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| JP7102401B2 (ja) | 2016-10-25 | 2022-07-19 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | クロマトグラフィーデータ解析のための方法およびシステム |
| JP7377596B2 (ja) | 2017-02-22 | 2023-11-10 | アムジエン・インコーポレーテツド | 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法 |
| JP6897761B2 (ja) * | 2017-04-07 | 2021-07-07 | コニカミノルタ株式会社 | タンパク質修飾蛍光体集積粒子の精製物を製造する方法、蛍光染色液の製造方法、タンパク質修飾蛍光体集積粒子の精製物、蛍光染色液およびタンパク質修飾蛍光体集積粒子精製用フィルター |
| CA3073935A1 (en) | 2017-09-19 | 2019-03-28 | Regeneron Pharmaceuticals, Inc. | Methods of reducing particle formation and compositions formed thereby |
| JP7158015B2 (ja) * | 2017-11-09 | 2022-10-21 | 国立研究開発法人産業技術総合研究所 | ポリペプチドの凝集化抑制方法 |
| WO2019183334A1 (en) | 2018-03-21 | 2019-09-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbents, devices and methods |
| TWI853823B (zh) | 2018-07-02 | 2024-09-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| EA202192422A1 (ru) | 2019-03-05 | 2021-12-09 | Ридженерон Фармасьютикалз, Инк. | Человеческий сывороточный альбумин в составах |
| WO2021023619A1 (en) | 2019-08-02 | 2021-02-11 | UCB Biopharma SRL | Methods for purifying antibodies |
| JP2022550837A (ja) * | 2019-10-04 | 2022-12-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | プロテインａアフィニティークロマトグラフィーにおけるモノクローナル抗体の溶離 |
| CN112898413A (zh) * | 2021-04-07 | 2021-06-04 | 杭州奕安济世生物药业有限公司 | 采用亲和层析纯化减少抗体聚集的方法 |
| CN113980092B (zh) * | 2021-12-09 | 2024-05-14 | 上海药明生物技术有限公司 | 一种蛋白质亲和纯化方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1323567C (en) | 1987-10-05 | 1993-10-26 | Gene R. Nathans | Method for purification of antibodies |
| JPH02273194A (ja) | 1989-04-14 | 1990-11-07 | Sumitomo Chem Co Ltd | ヒトモノクローナル抗体の安定な精製法 |
| WO1994007912A1 (en) | 1992-10-02 | 1994-04-14 | The General Hospital Corporation | Affinity purification methods involving amino acid mimetics as elution reagents |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| ES2321539T3 (es) | 2001-06-05 | 2009-06-08 | Genetics Institute, Llc | Procedimientos relativos a la purificacion de proteinas altamente anionicas. |
| US8084032B2 (en) | 2004-01-21 | 2011-12-27 | Ajinomoto Co., Inc. | Purification method which prevents denaturation of an antibody |
| DE602006003108D1 (de) | 2005-03-03 | 2008-11-27 | Ajinomoto Kk | Methode zur Verbesserung der Ausbeute bei der Proteinreinigung mittels Gelfiltrationschromatographie und Arginin |
| US8669045B2 (en) | 2007-02-13 | 2014-03-11 | Ajinomoto Co., Inc. | Method for inactivating viruses with slightly acidic arginine |
| CN102089319B (zh) | 2008-05-08 | 2013-11-13 | 味之素株式会社 | 蛋白质的重折叠方法 |
-
2005
- 2005-01-07 US US11/030,088 patent/US8084032B2/en active Active
- 2005-01-21 JP JP2005013897A patent/JP4826995B2/ja not_active Expired - Lifetime
- 2005-01-21 EP EP05250296A patent/EP1568710B1/en not_active Expired - Lifetime
- 2005-01-21 CN CN200510004669.9A patent/CN1680426B/zh not_active Expired - Lifetime
- 2005-01-21 DE DE602005018406T patent/DE602005018406D1/de not_active Expired - Lifetime
-
2011
- 2011-11-29 US US13/306,087 patent/US8435527B2/en not_active Expired - Fee Related
-
2012
- 2012-06-26 US US13/533,238 patent/US8470328B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005206602A5 (enExample) | ||
| WO2006138553A3 (en) | Methods of purifying fc region containing proteins | |
| CA2482097A1 (en) | Methods for isolating nucleic acids | |
| DE602005014969D1 (de) | Verfahren zur aufreinigung von albumin-konjugaten | |
| NZ587511A (en) | Purified lymphotoxin-beta-receptor immunoglobulin fusion proteins and methods of their purification | |
| EP1568710A3 (en) | Antibody purification method | |
| WO2005047860A3 (en) | Antibodies to alpha-synuclein | |
| JP2012018171A5 (enExample) | ||
| EP1477800A4 (en) | Method and apparatus for analyzing amino acid, peptide, protein, saccharide or lipid | |
| WO2001083515A3 (en) | Simulated activity of protein a displayed by ligands attached to a cellulose bead surface | |
| WO2008081938A1 (ja) | 耐熱性ビオチン結合性タンパク質の利用法、および当該タンパク質が結合した固体担体 | |
| WO2009139601A3 (en) | Method and affinity column for purifying proteins | |
| ATE417056T1 (de) | Verfahren zur proteinreinigung | |
| WO2008003707A3 (en) | Minimized small peptides with high affinity for factor viii and factor viii-like proteins | |
| EP1780537A4 (en) | PROTEOMANALYSIS PROCESS FOR PHOSPHORYLATED PROTEIN | |
| ATE464566T1 (de) | Verfahren zur markierung phosphorylierten peptiden, komplexverbindunger, verfahren zu deren herstellung und zwischenprodukte | |
| ATE335816T1 (de) | Verfahren zum nachweis prokaryontischer dna | |
| Acikara et al. | Affinity chromatography and importance in drug discovery | |
| WO2007065691A3 (en) | Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins | |
| JP2009518428A5 (enExample) | ||
| JP2009133739A5 (enExample) | ||
| RU2004103098A (ru) | Способ прижизненного определения острой фазы стафилококкового среднего отита в эксперименте | |
| Van Essche et al. | VENTURE™ A-High Performance Analytical Column for the Purification of Antibodies | |
| RU2003136353A (ru) | Способ фракционирования эритроцитов в градиенте плотности раствора агарозы | |
| JP2005104906A (ja) | 銅結合性ペプチド及びその使用 |