JP2005206602A5 - - Google Patents
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- Publication number
- JP2005206602A5 JP2005206602A5 JP2005013897A JP2005013897A JP2005206602A5 JP 2005206602 A5 JP2005206602 A5 JP 2005206602A5 JP 2005013897 A JP2005013897 A JP 2005013897A JP 2005013897 A JP2005013897 A JP 2005013897A JP 2005206602 A5 JP2005206602 A5 JP 2005206602A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- arginine
- producing
- buffer
- purified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001483 arginine derivatives Chemical class 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 5
- 239000004475 Arginine Substances 0.000 claims 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
- QYPPJABKJHAVHS-UHFFFAOYSA-N Agmatine Natural products NCCCCNC(N)=N QYPPJABKJHAVHS-UHFFFAOYSA-N 0.000 claims 2
- BMFMQGXDDJALKQ-BYPYZUCNSA-N Argininic acid Chemical compound NC(N)=NCCC[C@H](O)C(O)=O BMFMQGXDDJALKQ-BYPYZUCNSA-N 0.000 claims 2
- 238000001042 affinity chromatography Methods 0.000 claims 2
- QYPPJABKJHAVHS-UHFFFAOYSA-P agmatinium(2+) Chemical compound NC(=[NH2+])NCCCC[NH3+] QYPPJABKJHAVHS-UHFFFAOYSA-P 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- CLEWTIUJJAUEGU-ZETCQYMHSA-N (2S)-5-(diaminomethylideneamino)-2-(2,2-dimethylpropanoylamino)pentanoic acid Chemical compound CC(C)(C)C(=O)N[C@H](C(O)=O)CCCN=C(N)N CLEWTIUJJAUEGU-ZETCQYMHSA-N 0.000 claims 1
- XHXFSMZBXZZZIT-ZETCQYMHSA-N (2s)-2-(butanoylamino)-5-(diaminomethylideneamino)pentanoic acid Chemical group CCCC(=O)N[C@H](C(O)=O)CCCNC(N)=N XHXFSMZBXZZZIT-ZETCQYMHSA-N 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53750304P | 2004-01-21 | 2004-01-21 | |
| US60/537503 | 2004-01-21 | ||
| US63140704P | 2004-11-30 | 2004-11-30 | |
| US60/631407 | 2004-11-30 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005206602A JP2005206602A (ja) | 2005-08-04 |
| JP2005206602A5 true JP2005206602A5 (enExample) | 2008-03-06 |
| JP4826995B2 JP4826995B2 (ja) | 2011-11-30 |
Family
ID=34753090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005013897A Expired - Lifetime JP4826995B2 (ja) | 2004-01-21 | 2005-01-21 | 抗体の変質を防止する精製方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8084032B2 (enExample) |
| EP (1) | EP1568710B1 (enExample) |
| JP (1) | JP4826995B2 (enExample) |
| CN (1) | CN1680426B (enExample) |
| DE (1) | DE602005018406D1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8084032B2 (en) | 2004-01-21 | 2011-12-27 | Ajinomoto Co., Inc. | Purification method which prevents denaturation of an antibody |
| DE602006003108D1 (de) * | 2005-03-03 | 2008-11-27 | Ajinomoto Kk | Methode zur Verbesserung der Ausbeute bei der Proteinreinigung mittels Gelfiltrationschromatographie und Arginin |
| US7993853B2 (en) * | 2005-05-06 | 2011-08-09 | Gen-Probe Incorporated | Methods of nucleic acid target capture |
| CN101506222B (zh) * | 2006-07-14 | 2013-10-02 | 健泰科生物技术公司 | 重组蛋白的重折叠 |
| TW200821026A (en) | 2006-09-08 | 2008-05-16 | Wyeth Corp | Arginine wash in protein purification using affinity chromatography |
| TW201516149A (zh) | 2006-09-13 | 2015-05-01 | Abbvie Inc | 細胞培養改良 |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| DK2089429T3 (en) * | 2006-10-19 | 2015-01-12 | Janssen Biotech Inc | PROCEDURE FOR MANUFACTURING NON-AGGREGATED ANTIBODY-FC DOMAINS |
| US8669045B2 (en) | 2007-02-13 | 2014-03-11 | Ajinomoto Co., Inc. | Method for inactivating viruses with slightly acidic arginine |
| CN102089319B (zh) * | 2008-05-08 | 2013-11-13 | 味之素株式会社 | 蛋白质的重折叠方法 |
| JP4542172B2 (ja) * | 2008-05-19 | 2010-09-08 | 日本電波工業株式会社 | 感知装置及び感知方法 |
| JP5529869B2 (ja) * | 2008-08-14 | 2014-06-25 | メルク・シャープ・アンド・ドーム・コーポレーション | プロテインａアフィニティークロマトグラフィーを用いる抗体の精製方法 |
| CN104974251A (zh) | 2008-10-20 | 2015-10-14 | Abbvie公司 | 在抗体纯化过程中的病毒灭活 |
| CA2932207A1 (en) | 2008-10-20 | 2010-12-09 | Abbvie Inc. | Isolation and purification of antibodies using protein a affinity chromatography |
| JP2011041475A (ja) * | 2009-08-19 | 2011-03-03 | Asahi Kasei Medical Co Ltd | 抗体製造方法 |
| BR112012014937B1 (pt) * | 2009-12-18 | 2021-01-19 | Novartis Ag | método de produção de um anticorpo, fragmento de anticorpo ou proteína de fusão fc purificada usando uma matriz de cromatografia de afinidade |
| EP2526114B1 (de) * | 2010-01-22 | 2014-06-18 | Boehringer Ingelheim International GmbH | Chromatographisches verfahren zur aufreinigung von fc enthaltenden proteinen |
| EP2538790B1 (en) | 2010-02-26 | 2015-07-29 | Ajinomoto Co., Inc. | Virus-inactivating composition containing low-molecular weight compound and arginine |
| EP2583973B1 (en) * | 2010-06-21 | 2018-03-21 | Kyowa Hakko Kirin Co., Ltd. | Method for purifying protein using amino acid |
| KR101953405B1 (ko) | 2011-06-01 | 2019-02-28 | 노파르티스 아게 | 친화성 크로마토그래피를 위한 세척 용액 및 방법 |
| CN103608463A (zh) | 2011-06-23 | 2014-02-26 | 味之素株式会社 | 由使具有免疫球蛋白折叠结构的蛋白和能够形成亚单元结构的蛋白融合而得到的单体蛋白组成的多聚体蛋白的制备方法 |
| WO2014003137A1 (ja) * | 2012-06-27 | 2014-01-03 | 旭化成メディカル株式会社 | 高アフィニティー抗体、及びその製造方法 |
| WO2014054744A1 (ja) * | 2012-10-03 | 2014-04-10 | 協和発酵キリン株式会社 | 培養液にアミノ酸を添加することによるポリペプチドの還元防止方法 |
| RS57864B1 (sr) | 2013-06-17 | 2018-12-31 | De Staat Der Nederlanden Vert Door De Minister Van Vws Ministerie Van Volksgezondheid Welzijn En Spo | Postupci za sprečavanje agregacije virusnih komponenti |
| JP6236948B2 (ja) * | 2013-07-17 | 2017-11-29 | 東ソー株式会社 | 抗体精製用溶出液および当該溶出液を用いた抗体精製方法 |
| CN105273041A (zh) * | 2014-07-08 | 2016-01-27 | 上海中信国健药业股份有限公司 | 一种蛋白质亲和层析洗脱方法 |
| AR102198A1 (es) | 2014-10-09 | 2017-02-08 | Regeneron Pharma | Proceso para reducir partículas subvisibles en una formulación farmacéutica |
| ES2964713T3 (es) | 2014-10-23 | 2024-04-09 | Amgen Inc | Reducción de la viscosidad de formulaciones farmacéuticas |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| EP3374371A4 (en) * | 2015-11-09 | 2019-12-11 | University of Notre Dame | SMALL MOLECULE AFFINITY MEMBRANE PURIFICATION SYSTEMS AND USE THEREOF |
| HRP20160086A2 (hr) | 2016-01-27 | 2017-08-11 | Sveučilište u Zagrebu | Eluens za imunoafinitetnu kromatografiju virusa i proteina |
| US11186858B1 (en) | 2016-03-15 | 2021-11-30 | Fresenius Kabi Deutschland Gmbh | Methods for increasing biosimilarity |
| JP7122974B2 (ja) | 2016-05-11 | 2022-08-22 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 変異免疫グロブリン結合ポリペプチド |
| EP3455241B1 (en) | 2016-05-11 | 2022-02-23 | Cytiva BioProcess R&D AB | Method of cleaning and/or sanitizing a separation matrix |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| WO2017194592A1 (en) | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Method of storing a separation matrix |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| WO2018022628A1 (en) | 2016-07-25 | 2018-02-01 | Cephalon, Inc. | Affinity chromatography wash buffer |
| AU2017312785B2 (en) | 2016-08-16 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Methods for quantitating individual antibodies from a mixture |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| KR102759512B1 (ko) | 2016-10-25 | 2025-02-03 | 리제너론 파아마슈티컬스, 인크. | 크로마토그래피 데이터 분석을 위한 방법 및 시스템 |
| JP7377596B2 (ja) | 2017-02-22 | 2023-11-10 | アムジエン・インコーポレーテツド | 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法 |
| JP6897761B2 (ja) * | 2017-04-07 | 2021-07-07 | コニカミノルタ株式会社 | タンパク質修飾蛍光体集積粒子の精製物を製造する方法、蛍光染色液の製造方法、タンパク質修飾蛍光体集積粒子の精製物、蛍光染色液およびタンパク質修飾蛍光体集積粒子精製用フィルター |
| WO2019060062A1 (en) | 2017-09-19 | 2019-03-28 | Regeneron Pharmaceuticals Inc. | METHODS OF REDUCING PARTICLE FORMATION AND COMPOSITIONS FORMED THEREFROM |
| JP7158015B2 (ja) * | 2017-11-09 | 2022-10-21 | 国立研究開発法人産業技術総合研究所 | ポリペプチドの凝集化抑制方法 |
| US11155575B2 (en) | 2018-03-21 | 2021-10-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbent, devices and methods |
| TWI919355B (zh) | 2018-07-02 | 2026-03-21 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| EA202192422A1 (ru) | 2019-03-05 | 2021-12-09 | Ридженерон Фармасьютикалз, Инк. | Человеческий сывороточный альбумин в составах |
| SG11202112846RA (en) | 2019-08-02 | 2021-12-30 | UCB Biopharma SRL | Methods for purifying antibodies |
| CN114466861A (zh) * | 2019-10-04 | 2022-05-10 | 默克专利股份有限公司 | 蛋白a亲和色谱中单克隆抗体的洗脱 |
| CN112898413A (zh) * | 2021-04-07 | 2021-06-04 | 杭州奕安济世生物药业有限公司 | 采用亲和层析纯化减少抗体聚集的方法 |
| CN113980092B (zh) * | 2021-12-09 | 2024-05-14 | 上海药明生物技术有限公司 | 一种蛋白质亲和纯化方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1323567C (en) | 1987-10-05 | 1993-10-26 | Gene R. Nathans | Method for purification of antibodies |
| JPH02273194A (ja) | 1989-04-14 | 1990-11-07 | Sumitomo Chem Co Ltd | ヒトモノクローナル抗体の安定な精製法 |
| EP0663925A4 (en) | 1992-10-02 | 1997-11-19 | Gen Hospital Corp | AFFINITY PURIFICATION METHODS USING AMINO ACID MIMETISMS AS ELUTION REAGENTS. |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| EP1404428B1 (en) | 2001-06-05 | 2006-07-19 | Genetics Institute, LLC | Methods for purifying highly anionic proteins |
| US8084032B2 (en) | 2004-01-21 | 2011-12-27 | Ajinomoto Co., Inc. | Purification method which prevents denaturation of an antibody |
| DE602006003108D1 (de) | 2005-03-03 | 2008-11-27 | Ajinomoto Kk | Methode zur Verbesserung der Ausbeute bei der Proteinreinigung mittels Gelfiltrationschromatographie und Arginin |
| US8669045B2 (en) | 2007-02-13 | 2014-03-11 | Ajinomoto Co., Inc. | Method for inactivating viruses with slightly acidic arginine |
| CN102089319B (zh) | 2008-05-08 | 2013-11-13 | 味之素株式会社 | 蛋白质的重折叠方法 |
-
2005
- 2005-01-07 US US11/030,088 patent/US8084032B2/en active Active
- 2005-01-21 JP JP2005013897A patent/JP4826995B2/ja not_active Expired - Lifetime
- 2005-01-21 DE DE602005018406T patent/DE602005018406D1/de not_active Expired - Lifetime
- 2005-01-21 EP EP05250296A patent/EP1568710B1/en not_active Expired - Lifetime
- 2005-01-21 CN CN200510004669.9A patent/CN1680426B/zh not_active Expired - Lifetime
-
2011
- 2011-11-29 US US13/306,087 patent/US8435527B2/en not_active Expired - Fee Related
-
2012
- 2012-06-26 US US13/533,238 patent/US8470328B2/en not_active Expired - Fee Related
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