JP2005082587A - ニコチン及びダイオキシン解毒作用を持つ生薬抽出物の組成物 - Google Patents
ニコチン及びダイオキシン解毒作用を持つ生薬抽出物の組成物 Download PDFInfo
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Abstract
【解決手段】 本組成物は、体内ニコチン及びダイオキシンに対する分解効果を有する、黒豆、蒲公英及び金銀花の抽出物からなる。前記組成物は、ドクダミ、決明子及び甘草からなる群から選ばれる1つ以上の生薬抽出物をさらに含むことができる。致死量のニコチンをマウスに腹腔注射した場合、本発明による組成物を服用した処理群は一般の飼料のみを摂取した対照群に比べて麻痺開始時間が遅延され、発作持続時間は減少し、生存率は一層高くなるなど高い解毒効果を示した。ダイオキシン(TCDD)で急性毒性を誘導したラットの実験においても、血液、肝臓、すい臓、腎臓、及び心臓機能を分析できる臨床数値から前記組成物の摂取がダイオキシンによる臨床指数の変化を正常数値に近くまで戻すことが分かった。
【選択図】図2
Description
本発明の第4の態様によれば、本発明の第1及び第2の態様による組成物を含む食品を提供することを特徴とする。
まず、本発明による組成物の製造方法は、前記第1または第2の態様によるそれぞれの生薬を洗浄、乾燥し、細切りした後、生薬の重量の約10〜30倍程度のエタノールを添加して、30〜50℃で30〜50時間程度還流抽出することによって、各生薬抽出液を得、これらを各々所定の固形分含量になるまで減圧濃縮することによって、各生薬抽出エキスを得、かくして得られた抽出エキスを各々凍結乾燥することによって、各生薬抽出物の粉末を得た後、これらの粉末を成分に応じて一定量ずつ混合して製造することができる。ここで、この技術分野における通常の知識を有する者なら、生薬抽出のための還流時において還流時間は、還流温度によって適宜調節できることが分かる。
ニコチン急性毒性試験方法
人体内でのニコチン解毒効果の確認方法
12: 163-71(1998))。
コチニン定量法
ダイオキシン急性毒性試験方法
y=0.0009x+0.1344(R2=0.992) ....(1)
このように血液の臨床化学指数の変化から見て、TCDD投与は、血液とすい臓に対する毒性作用が、肝臓、腎臓及び心臓に対する作用に比べて一層著しく発現され、本発明による6種の生薬抽出物による毒性軽減作用は、肝臓及びすい臓において著しく発現され、TCDD投与による臨床指数の変化を定常数値に近く回復させることが確認され、本発明による生薬抽出物が体内代謝及び機能障害を一部回復させる物質であることを確認することができた。
Claims (10)
- 体内ニコチン及びダイオキシンに対する分解効果を有する、黒豆、蒲公英及び金銀花の抽出物からなることを特徴とする組成物。
- ドクダミ、決明子及び甘草からなる群から選ばれる一つ又は二つ以上の生薬抽出物をさらに含むことを特徴とする請求項1に記載の組成物。
- 前記各抽出物は、いずれも同一の固形分含量を有するように濃縮されたものを基準にして、1〜20重量部の黒豆抽出物、5〜30重量部の蒲公英抽出物、及び5〜30重量部の金銀花抽出物からなることを特徴とする請求項1に記載の組成物。
- 体内ニコチン及びダイオキシンに対する分解効果を有する、黒豆、蒲公英、金銀花、ドクダミ、決明子及び甘草の抽出物からなることを特徴とする組成物。
- 前記各抽出物は、いずれも同一の固形分含量を有するように濃縮されたものを基準にして、1〜20重量部の黒豆抽出物、5〜30重量部の蒲公英抽出物、5〜30重量部の金銀花抽出物、10〜50重量部のドクダミ抽出物、5〜30重量部の決明子抽出物及び1〜20重量部の甘草抽出物からなることを特徴とする請求項4に記載の組成物。
- 経口投与を目的とすることを特徴とする請求項1乃至5のいずれかに記載の組成物。
- 各生薬抽出物は、抽出液を濃縮し乾燥させた粉末状態であることを特徴とする請求項1乃至5のいずれかに記載の組成物。
- 請求項1乃至5のいずれかに記載の組成物を含むことを特徴とする食品。
- 前記食品は、ガム、ゼリー、キャンディー、菓子、スナック及び飲み物からなる群から選ばれるいずれか一形態で製造されることを特徴とする請求項8に記載の食品。
- 請求項1又は請求項2に記載の生薬各々を洗浄乾燥した後、細切りして、各生薬重量の10〜30倍のエタノールで各生薬を還流抽出し、抽出された各生薬抽出物を濃縮し凍結乾燥させるか、凍結乾燥させない状態で混合してなることを特徴とする請求項1又は請求項2に記載の組成物の製造方法。
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KR970000075A (ko) * | 1995-06-21 | 1997-01-21 | 김윤동 | 해독차 및 그 제조방법 |
KR100581216B1 (ko) * | 1998-12-31 | 2006-08-18 | 주식회사 태평양 | 니코틴 제거효과가 있는 기호성이 우수한 혼합차 |
JP3482558B2 (ja) * | 2000-03-13 | 2003-12-22 | 有限会社日中医学研究所 | 発酵大豆から抽出した、ゲニステインを主要原料とする抗ダイオキシン健康食品。 |
KR100464140B1 (ko) * | 2001-02-21 | 2005-01-03 | 주식회사 리젠 바이오텍 | 니코틴 분해용 기능성 제제 및 그의 제조방법 |
KR20030010259A (ko) * | 2001-07-26 | 2003-02-05 | 남정춘 | 생약 해독제 및 그 제조 방법 |
-
2003
- 2003-09-05 KR KR10-2003-0062115A patent/KR100526760B1/ko active IP Right Grant
- 2003-09-26 JP JP2003336533A patent/JP4100623B2/ja not_active Expired - Fee Related
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US8741348B2 (en) | 2002-12-20 | 2014-06-03 | Niconovum Ab | Physically and chemically stable nicotine-containing particulate material |
US11547660B2 (en) | 2006-03-16 | 2023-01-10 | Niconovum Usa, Inc. | Snuff composition |
US11129792B2 (en) | 2006-03-16 | 2021-09-28 | Modoral Brands Inc. | Snuff composition |
US9402809B2 (en) | 2006-03-16 | 2016-08-02 | Niconovum Usa, Inc. | Snuff composition |
US10219999B2 (en) | 2006-03-16 | 2019-03-05 | Niconovum Usa, Inc. | Snuff composition |
JP2008056589A (ja) * | 2006-08-30 | 2008-03-13 | Masaki Hattori | 生薬組成物 |
WO2009031730A1 (en) * | 2007-09-07 | 2009-03-12 | Ok Soo Oh | Method of manufacturing a smoking cessation aiding drink and a smoking cessation aiding drink manufactured by the same |
CN103933492A (zh) * | 2013-01-21 | 2014-07-23 | 郭继进 | 一种治疗顽固性呃逆的药及其制备方法 |
CN104082291A (zh) * | 2014-07-02 | 2014-10-08 | 谭丕和 | 一种有机植物解毒剂 |
JP2016079124A (ja) * | 2014-10-16 | 2016-05-16 | フジッコ株式会社 | むくみ抑制または改善剤 |
CN105816508A (zh) * | 2015-01-22 | 2016-08-03 | 韩国科学技术研究院 | 小黑豆提取物在制备用于预防、改善或治疗视网膜疾病的组合物中的用途 |
CN105213975A (zh) * | 2015-10-19 | 2016-01-06 | 青岛市中心医院 | 一种治疗肝硬化的药物组合物及其应用 |
CN105311585A (zh) * | 2015-12-08 | 2016-02-10 | 李朝彬 | 一种治疗肝硬化的中药组合物 |
CN107320542A (zh) * | 2017-07-12 | 2017-11-07 | 狄振起 | 去舌苔的中药制剂及其制备方法 |
Also Published As
Publication number | Publication date |
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JP4100623B2 (ja) | 2008-06-11 |
KR100526760B1 (ko) | 2005-11-08 |
KR20050024884A (ko) | 2005-03-11 |
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