JP2005052149A5 - - Google Patents

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Publication number
JP2005052149A5
JP2005052149A5 JP2004293969A JP2004293969A JP2005052149A5 JP 2005052149 A5 JP2005052149 A5 JP 2005052149A5 JP 2004293969 A JP2004293969 A JP 2004293969A JP 2004293969 A JP2004293969 A JP 2004293969A JP 2005052149 A5 JP2005052149 A5 JP 2005052149A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004293969A
Other languages
Japanese (ja)
Other versions
JP2005052149A (ja
Filing date
Publication date
Priority claimed from GBGB9815879.3A external-priority patent/GB9815879D0/en
Priority claimed from GBGB9906712.6A external-priority patent/GB9906712D0/en
Priority claimed from GBGB9909494.8A external-priority patent/GB9909494D0/en
Application filed filed Critical
Publication of JP2005052149A publication Critical patent/JP2005052149A/ja
Publication of JP2005052149A5 publication Critical patent/JP2005052149A5/ja
Pending legal-status Critical Current

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JP2004293969A 1998-07-21 2004-10-06 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド Pending JP2005052149A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9815879.3A GB9815879D0 (en) 1998-07-21 1998-07-21 A polynucleotide
US10768898P 1998-11-09 1998-11-09
GBGB9906712.6A GB9906712D0 (en) 1999-03-23 1999-03-23 A polynucleotide
US12741099P 1999-04-01 1999-04-01
GBGB9909494.8A GB9909494D0 (en) 1999-04-23 1999-04-23 A plasmid
US13401699P 1999-05-12 1999-05-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2000561339A Division JP4220673B2 (ja) 1998-07-21 1999-07-21 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007285560A Division JP2008109931A (ja) 1998-07-21 2007-11-01 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド

Publications (2)

Publication Number Publication Date
JP2005052149A JP2005052149A (ja) 2005-03-03
JP2005052149A5 true JP2005052149A5 (enExample) 2005-09-29

Family

ID=27547316

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2000561339A Expired - Lifetime JP4220673B2 (ja) 1998-07-21 1999-07-21 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2004293969A Pending JP2005052149A (ja) 1998-07-21 2004-10-06 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2007285560A Withdrawn JP2008109931A (ja) 1998-07-21 2007-11-01 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2008305611A Withdrawn JP2009102331A (ja) 1998-07-21 2008-11-28 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2000561339A Expired - Lifetime JP4220673B2 (ja) 1998-07-21 1999-07-21 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2007285560A Withdrawn JP2008109931A (ja) 1998-07-21 2007-11-01 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2008305611A Withdrawn JP2009102331A (ja) 1998-07-21 2008-11-28 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド

Country Status (8)

Country Link
EP (2) EP2348118A1 (enExample)
JP (4) JP4220673B2 (enExample)
KR (3) KR100795626B1 (enExample)
CN (1) CN100365127C (enExample)
AU (1) AU771111B2 (enExample)
CA (1) CA2333852C (enExample)
MX (1) MXPA01000830A (enExample)
WO (1) WO2000005393A2 (enExample)

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CA2435972C (en) 2001-01-26 2011-09-13 University Of Lausanne Matrix attachment regions and methods for use thereof
ES2387951T3 (es) * 2001-04-05 2012-10-04 Emd Millipore Corporation Expresión génica mejorada
US7812148B2 (en) 2001-04-05 2010-10-12 Millipore Corporation Vectors comprising CpG islands without position effect varigation and having increased expression
CA2443275C (en) * 2001-04-05 2013-02-05 Ml Laboratories Plc Improved gene expression
WO2002097059A2 (en) 2001-05-30 2002-12-05 Chromos Molecular Systems, Inc. Chromosome-based platforms
EP1402006A4 (en) * 2001-06-04 2005-11-23 Ml Lab Plc COMPOSITIONS AND METHODS FOR LARGE SCALE PRODUCTION AND HIGH EFFICIENCY OF RECOMBINANT PROTEINS
ATE466943T1 (de) 2001-07-04 2010-05-15 Chromagenics Bv Dns-sequenzen mit anti-repressor aktivität
WO2003056912A2 (en) 2002-01-09 2003-07-17 Minos Biosystems Limited Inducible transposition in transgenic organism using transposon vector
WO2003106674A2 (en) 2002-06-14 2003-12-24 Chromagenics B.V. Means and methods for regulating gene expression
AU2003238719B2 (en) 2002-06-14 2008-02-21 Chromagenics B.V. A method for simultaneous production of multiple proteins, vectors and cells for use therein
ES2373549T3 (es) 2002-12-18 2012-02-06 Chromagenics B.V. Método para mejorar la producción de proteínas.
WO2004056986A2 (en) * 2002-12-20 2004-07-08 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors
EP2267140A1 (en) 2003-02-01 2010-12-29 Millipore Corporation Improved genetic elements providing high levels of expression
RU2375450C2 (ru) 2003-10-24 2009-12-10 Селексис С.А. Днк, повышающая продуцирование белка, и ее применение
US8354251B2 (en) 2003-12-31 2013-01-15 Kalobios Pharmaceuticals, Inc. Transactivation system for mammalian cells
WO2006007850A1 (en) 2004-07-20 2006-01-26 Symphogen A/S Anti-rhesus d recombinant polyclonal antibody and methods of manufacture
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20060172382A1 (en) 2004-11-08 2006-08-03 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20060195935A1 (en) 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
AU2005300503B2 (en) 2004-11-08 2010-12-16 Chromagenics B.V. Selection of host cells expressing protein at high levels
GB0504587D0 (en) 2005-03-05 2005-04-13 Ml Lab Plc Vectors comprising guinea pig CMV regulatory elements
GB0509965D0 (en) 2005-05-17 2005-06-22 Ml Lab Plc Improved expression elements
WO2007081336A1 (en) * 2006-01-13 2007-07-19 Five Prime Therapeutics, Inc. Mammalian vectors for high-level expression of recombinant proteins
WO2007107578A1 (en) 2006-03-20 2007-09-27 Chromagenics B.V. Expression augmenting dna fragments, use thereof, and methods for finding thereof
JP2010525789A (ja) * 2007-01-08 2010-07-29 ミリポア・コーポレイション １つ又はそれ以上のきょう雑物の低下したレベルの存在下で組換えタンパク質を生産するための細胞培養法
CN104531699B (zh) * 2014-10-09 2017-03-15 河南农业大学 一种增强外源基因表达的猪的ucoe调控元件片段
CA2965849A1 (en) * 2014-12-16 2016-06-23 Garvan Institute Of Medical Research Sequencing controls
WO2018175153A1 (en) 2017-03-19 2018-09-27 Applied Stemcell, Inc. Novel integration sites and uses thereof
WO2018187156A1 (en) 2017-04-03 2018-10-11 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for multiplexed quantitative analysis of cell lineages
EP3720958A1 (en) * 2017-12-07 2020-10-14 Integrity Biosolutions, LLC Engineered ubiquitous chromatin opening elements and uses thereof
US11781146B2 (en) * 2018-05-24 2023-10-10 National University Corporation Hokkaido University Vector including a translation-impaired dihydrofolate reductase gene cassette and ubiquitously acting chromatin opening element
EP3837381A1 (en) * 2018-08-15 2021-06-23 Illumina, Inc. Compositions and methods for improving library enrichment
JP2022502063A (ja) * 2018-10-02 2022-01-11 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 細胞系列の多重定量分析のための組成物および方法
US20220193266A1 (en) * 2019-04-30 2022-06-23 Chan Zuckerberg Biohub, Inc. A novel chromatin-opening element for stable long term gene expression
CN112575031B (zh) * 2019-09-29 2023-04-07 新乡医学院 一种遍在染色质开放表达元件、重组表达载体、表达系统及其制备方法、应用
CN116574735B (zh) * 2023-07-03 2023-11-10 艾米能斯(苏州)生物科技有限公司 一种多核苷酸及其应用

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EP0945515A3 (en) 1989-11-06 2002-08-21 Cell Genesys, Inc. Production of proteins using homologous recombination
DK0532525T3 (da) 1990-05-18 1995-12-04 Genentech Inc Nye protein-polykationkonjugater
AU7906691A (en) 1990-05-23 1991-12-10 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Adeno-associated virus (aav)-based eucaryotic vectors
GB9109928D0 (en) 1991-05-08 1991-07-03 Interox Chemicals Ltd Thickened compositions
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
EP0632722A4 (en) 1992-03-20 1997-07-30 Baylor College Medicine DNA TRANSPORTATION SYSTEM AND INSTRUCTIONS FOR USE.
US5583009A (en) 1992-12-08 1996-12-10 University Of Washington Method of preparing recombinant proteins in transgenic animals containing metallothionein gene elements that bestow tissue-independent copy number-dependent, position-indepedent gene expression
US5578475A (en) 1993-07-12 1996-11-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
JP2002514892A (ja) 1995-06-08 2002-05-21 コブラ セラピューティクス リミテッド 遺伝子治療における合成ウイルス様粒子の使用
WO1998007876A2 (en) 1996-08-16 1998-02-26 Medical Research Council Self-replicating episomal expression vectors conferring tissue-specific gene expression
DE19651443A1 (de) * 1996-12-11 1998-06-18 Hoechst Ag Selbstverstärkende, pharmakologisch kontrollierbare Expressionssysteme
JP2001512312A (ja) 1997-02-12 2001-08-21 コブラ セラピューティクス リミテッド 高効率トランスフェクションに関する組成物および方法

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