JP2005002129A5 - - Google Patents

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Publication number
JP2005002129A5
JP2005002129A5 JP2004225107A JP2004225107A JP2005002129A5 JP 2005002129 A5 JP2005002129 A5 JP 2005002129A5 JP 2004225107 A JP2004225107 A JP 2004225107A JP 2004225107 A JP2004225107 A JP 2004225107A JP 2005002129 A5 JP2005002129 A5 JP 2005002129A5
Authority
JP
Japan
Prior art keywords
treatment
benzyloxycarbonyl
amino
use according
tetrahydrothieno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004225107A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005002129A (ja
Filing date
Publication date
Priority claimed from US08/959,758 external-priority patent/US5939432A/en
Priority claimed from US09/156,077 external-priority patent/US6323214B1/en
Application filed filed Critical
Publication of JP2005002129A publication Critical patent/JP2005002129A/ja
Publication of JP2005002129A5 publication Critical patent/JP2005002129A5/ja
Pending legal-status Critical Current

Links

JP2004225107A 1997-10-29 2004-08-02 アロステリックアデノシン受容体修飾物質 Pending JP2005002129A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/959,758 US5939432A (en) 1997-10-29 1997-10-29 Thiophenes useful for modulating the adenosine receptor
US09/156,077 US6323214B1 (en) 1997-10-29 1998-09-17 Allosteric adenosine receptor modulators

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2000517772A Division JP2003517429A (ja) 1997-10-29 1998-09-30 アロステリックアデノシン受容体修飾物質

Publications (2)

Publication Number Publication Date
JP2005002129A JP2005002129A (ja) 2005-01-06
JP2005002129A5 true JP2005002129A5 (enExample) 2005-11-17

Family

ID=25502368

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000517772A Pending JP2003517429A (ja) 1997-10-29 1998-09-30 アロステリックアデノシン受容体修飾物質
JP2004225107A Pending JP2005002129A (ja) 1997-10-29 2004-08-02 アロステリックアデノシン受容体修飾物質

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2000517772A Pending JP2003517429A (ja) 1997-10-29 1998-09-30 アロステリックアデノシン受容体修飾物質

Country Status (7)

Country Link
US (3) US5939432A (enExample)
EP (1) EP1025106B1 (enExample)
JP (2) JP2003517429A (enExample)
AT (1) ATE330959T1 (enExample)
AU (1) AU9671798A (enExample)
CA (1) CA2302396C (enExample)
WO (1) WO1999021617A2 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6727258B2 (en) * 1997-10-29 2004-04-27 King Pharmaceutical Research & Development, Inc. Allosteric adenosine receptor modulators
DE19947154A1 (de) * 1999-10-01 2001-10-04 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
JP4548882B2 (ja) * 1999-11-30 2010-09-22 興和創薬株式会社 ４，５，６，７−テトラヒドロチエノ〔２，３−ｃ〕ピリジン化合物
JP4502435B2 (ja) * 1999-11-30 2010-07-14 興和創薬株式会社 ４，５，６，７−テトラヒドロチエノ〔２，３−ｃ〕ピリジン系化合物
JP4548884B2 (ja) * 1999-12-03 2010-09-22 興和創薬株式会社 ４，５，６，７−テトラヒドロチエノ〔２，３−ｃ〕ピリジン誘導体
US7732484B2 (en) * 2000-08-01 2010-06-08 University Of Virginia Patent Foundation Use of selective adenosine A1 receptor allosteric enhancers to manipulate angiogenesis
US6489356B2 (en) * 2000-09-05 2002-12-03 Edward Leung Method for treating pain in humans
US6248774B1 (en) * 2000-09-05 2001-06-19 King Pharmaceuticals Research & Development, Inc. Method for treating hyper-excited sensory nerve functions in humans
GB0100621D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds VI
GB0100624D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds VII
GB0100622D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds V111
GB0100620D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical cokpounds V
US20020115635A1 (en) * 2001-02-21 2002-08-22 Pnina Fishman Modulation of GSK-3beta activity and its different uses
CA2443135C (en) * 2001-03-30 2010-07-13 Allan R. Moorman Pharmaceutically active compounds and methods of use
US6713638B2 (en) * 2001-05-18 2004-03-30 Joel M. Linden 2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors
EP1456196B1 (en) * 2001-12-12 2009-01-07 F. Hoffmann-La Roche Ag Benzothiophenes as adenosine receptor modulators
US7485655B2 (en) * 2002-01-16 2009-02-03 University Of Virginia Patent Foundation 2-Aminothiazole allosteric enhancers of A1 adenosine receptors
US20040121406A1 (en) * 2002-05-23 2004-06-24 Wilson Constance Neely Methods and formulations for increasing the affinity of a1 adenosine receptor ligands for the a1 adenosine receptor
EP1633756B1 (en) 2003-04-09 2008-12-24 Biogen Idec MA Inc. A2a adenosine receptor antagonists
EP1615931A1 (en) 2003-04-09 2006-01-18 Biogen Idec MA Inc. Triazolopyrazines and methods of making and using the same
WO2004092170A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
US8062272B2 (en) * 2004-05-21 2011-11-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US7855209B2 (en) * 2006-11-13 2010-12-21 King Pharmaceuticals Research And Development, Inc. Allosteric modulators of the A1 adenosine receptor
US7897596B2 (en) * 2006-11-13 2011-03-01 King Pharmaceuticals Research & Development, Inc. Allosteric modulators of the A1 adenosine receptor
JP2010509402A (ja) * 2006-11-13 2010-03-25 キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド Ａ１アデノシン受容体のアロステリック調節剤
PA8801401A1 (es) * 2007-10-25 2009-05-15 Janssen Pharmaceutica Nv Arilindenopirimidinas y su uso como adenosina a2a
GB0722340D0 (en) * 2007-11-14 2007-12-27 Univ Leiden Sphingosine-1-phosphate (S1P) receptor compounds
US20090281145A1 (en) * 2008-05-08 2009-11-12 Pier Giovanni Baraldi Allosteric enhancers of the a1 adenosine receptor
GB0906579D0 (en) 2009-04-16 2009-05-20 Vernalis R&D Ltd Pharmaceuticals, compositions and methods of making and using the same
US20100093763A1 (en) * 2008-10-13 2010-04-15 Barbay J Kent PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
US20100093714A1 (en) * 2008-10-13 2010-04-15 Devraj Chakravarty AMIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
US20100093702A1 (en) * 2008-10-13 2010-04-15 Barbay J Kent METHYLENE AMINES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
US9199102B2 (en) 2009-07-21 2015-12-01 Oradin Pharmaceutical Ltd. A3 adenosine receptor ligands for modulation of pigmentation
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
AU2022242770A1 (en) 2021-03-26 2023-11-09 Chiesi Farmaceutici S.P.A. Tetrahydrothieno pyridine derivatives as ddrs inhibitors

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Publication number Priority date Publication date Assignee Title
CH540247A (de) 1967-04-21 1973-09-28 Ciba Geigy Ag Verfahren zur Herstellung von heterocyclischen, Asthylendoppelbindungen enthaltenden Verbindungen
ES393101A1 (es) 1971-07-09 1974-05-16 Made Labor Sa Procedimiento para la preparacion de derivados de tieno- diazepina.
FI54312C (fi) 1972-05-09 1978-11-10 Sumitomo Chemical Co Foerfarande foer framstaellning av tieno-(2,3-d)pyrimidinderivat med avsoendring av urinsyra i urin utoekande
JPS5342400B2 (enExample) * 1973-05-30 1978-11-10
PH30676A (en) 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
CH677511A5 (enExample) * 1988-10-12 1991-05-31 Mefina Sa
US5026698A (en) 1988-11-02 1991-06-25 Nissan Chemical Industries, Ltd. Thienopyridine type mevalonolactones
CA2020806A1 (en) 1989-07-12 1991-01-13 Karl-Heinz Weber Thienodiazepine derivatives
JP3239364B2 (ja) 1991-10-11 2001-12-17 ウェルファイド株式会社 骨粗鬆症治療薬およびジアゼピン化合物
JPH05345785A (ja) 1992-01-16 1993-12-27 Yoshitomi Pharmaceut Ind Ltd トリアゾロオキサゼピン化合物
TW263498B (enExample) * 1993-11-10 1995-11-21 Takeda Pharm Industry Co Ltd
JPH07304755A (ja) 1994-05-12 1995-11-21 Yamanouchi Pharmaceut Co Ltd 縮合ジアゼピン誘導体
WO1996014319A1 (en) * 1994-11-08 1996-05-17 Takeda Chemical Industries, Ltd. Thienopyridine or thienopyrimidine derivatives and their use
US5585538A (en) 1995-03-08 1996-12-17 Pioneer Hi-Bred International, Inc. Hybrid maize plant & seed (3936)
JPH08337583A (ja) * 1995-04-13 1996-12-24 Takeda Chem Ind Ltd 複素環化合物およびその製造法
US5757486A (en) * 1996-11-22 1998-05-26 Eastman Kodak Company Digital camera image sensor positioning apparatus including a non-coherent light interferometer

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