JP2004537553A - アルドステロン受容体アンタゴニストおよびHMGCo−Aレダクターゼ阻害剤の組合せ薬剤 - Google Patents

アルドステロン受容体アンタゴニストおよびHMGCo−Aレダクターゼ阻害剤の組合せ薬剤 Download PDF

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JP2004537553A
JP2004537553A JP2003513598A JP2003513598A JP2004537553A JP 2004537553 A JP2004537553 A JP 2004537553A JP 2003513598 A JP2003513598 A JP 2003513598A JP 2003513598 A JP2003513598 A JP 2003513598A JP 2004537553 A JP2004537553 A JP 2004537553A
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hmg
reductase inhibitor
receptor antagonist
aldosterone receptor
eplerenone
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JP2004537553A5 (https=
Inventor
ブラッドリー・ティー・ケラー
エレン・ジー・マクマーホン
リカード・ローチャ
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ファルマシア・コーポレーション
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    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/585Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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JP2003513598A 2001-07-19 2002-07-18 アルドステロン受容体アンタゴニストおよびHMGCo−Aレダクターゼ阻害剤の組合せ薬剤 Pending JP2004537553A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30633601P 2001-07-19 2001-07-19
PCT/US2002/022896 WO2003007993A1 (en) 2001-07-19 2002-07-18 Combination of an aldosterone receptor antagonist and an hmg coa reductase inhibitor

Publications (2)

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JP2004537553A true JP2004537553A (ja) 2004-12-16
JP2004537553A5 JP2004537553A5 (https=) 2006-01-05

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US (2) US20030149010A1 (https=)
EP (1) EP1406660B1 (https=)
JP (1) JP2004537553A (https=)
KR (1) KR20040023660A (https=)
CN (1) CN1537019A (https=)
AP (1) AP2004002951A0 (https=)
AT (1) ATE363917T1 (https=)
BR (1) BR0211274A (https=)
CA (1) CA2452678A1 (https=)
CO (1) CO5550464A2 (https=)
DE (1) DE60220522T2 (https=)
EA (1) EA200400029A1 (https=)
EC (1) ECSP044950A (https=)
ES (1) ES2286270T3 (https=)
GE (1) GEP20063811B (https=)
IL (1) IL159588A0 (https=)
IS (1) IS7093A (https=)
MA (1) MA27050A1 (https=)
MX (1) MXPA04000586A (https=)
NO (1) NO20040211L (https=)
OA (1) OA12983A (https=)
PL (1) PL367417A1 (https=)
TN (1) TNSN04001A1 (https=)
UA (1) UA76475C2 (https=)
WO (1) WO2003007993A1 (https=)
ZA (1) ZA200400288B (https=)

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JP2009514848A (ja) * 2005-11-08 2009-04-09 ランバクシー ラボラトリーズ リミテッド 医薬組成物

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CN1310941C (zh) * 2005-07-13 2007-04-18 南京大学 依普利酮的合成方法
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WO2008021666A2 (en) * 2006-08-18 2008-02-21 Morton Grove Pharmaceuticals, Inc. Stable liquid levetiracetam compositions and methods
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EP2135607A1 (en) 2008-06-18 2009-12-23 Pharnext Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders
CA2744817C (en) * 2008-11-26 2020-07-07 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of obesity and diabetes
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EP2322163A1 (en) * 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
BR112012012999A2 (pt) * 2009-11-30 2019-04-02 Aptalis Pharmatech, Inc. Composição farmacêutica, e composição de tablete de desintegração oral (odt) outablete de dispersão rápida (rdt)
EP2575821B1 (en) 2010-05-26 2015-08-12 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
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US9107983B2 (en) 2010-10-27 2015-08-18 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising statins
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
US9241933B2 (en) 2011-03-01 2016-01-26 Pharnext Compositions for treating amyotrophic lateral sclerosis
TR201809351T4 (tr) 2011-03-01 2018-07-23 Pharnext Nörolojik bozuklukların baklofen ve akamprosat tabanlı terapisi.
US10010515B2 (en) 2011-03-01 2018-07-03 Pharnext Therapeutic approaches for treating Parkinson's disease
DE102011015142A1 (de) * 2011-03-17 2012-09-20 Eberhard-Karls-Universität Tübingen Universitätsklinikum Agens zur Prophylaxe und Behandlung altersassoziierter Krankheiten und Störungen sowie zur Verlängerung der Lebensdauer
US9308190B2 (en) 2011-06-06 2016-04-12 Warsaw Orthopedic, Inc. Methods and compositions to enhance bone growth comprising a statin
CA2852957C (en) 2011-10-28 2020-08-04 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
CN104023727B (zh) 2011-10-28 2017-04-05 鲁美纳医药公司 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂
US20140275090A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
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Publication number Priority date Publication date Assignee Title
JP2009514848A (ja) * 2005-11-08 2009-04-09 ランバクシー ラボラトリーズ リミテッド 医薬組成物

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US20030149010A1 (en) 2003-08-07
IS7093A (is) 2003-12-23
US20060003975A1 (en) 2006-01-05
DE60220522T2 (de) 2007-09-27
WO2003007993A1 (en) 2003-01-30
ECSP044950A (es) 2004-02-26
ZA200400288B (en) 2005-06-29
IL159588A0 (en) 2004-06-01
CO5550464A2 (es) 2005-08-31
DE60220522D1 (de) 2007-07-19
AP2004002951A0 (en) 2004-03-31
TNSN04001A1 (fr) 2006-06-01
CN1537019A (zh) 2004-10-13
CA2452678A1 (en) 2003-01-30
EP1406660B1 (en) 2007-06-06
GEP20063811B (en) 2006-05-10
MA27050A1 (fr) 2004-12-20
EA200400029A1 (ru) 2004-08-26
OA12983A (en) 2006-10-13
PL367417A1 (en) 2005-02-21
MXPA04000586A (es) 2004-04-20
ES2286270T3 (es) 2007-12-01
KR20040023660A (ko) 2004-03-18
UA76475C2 (en) 2006-08-15
EP1406660A1 (en) 2004-04-14
NO20040211L (no) 2004-03-16
BR0211274A (pt) 2004-08-03
ATE363917T1 (de) 2007-06-15

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