JP2004536810A5 - - Google Patents

Info

Publication number

JP2004536810A5

JP2004536810A5 JP2003501462A JP2003501462A JP2004536810A5 JP 2004536810 A5 JP2004536810 A5 JP 2004536810A5 JP 2003501462 A JP2003501462 A JP 2003501462A JP 2003501462 A JP2003501462 A JP 2003501462A JP 2004536810 A5 JP2004536810 A5 JP 2004536810A5

Authority

JP

Japan

Prior art keywords

inclusion complex

cyclodextrin

complex

omeprazole

substantially pure

Prior art date

2002-06-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 229920000858 Cyclodextrin Polymers 0.000 claims 7
• 238000000034 method Methods 0.000 claims 7
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 6
• 229960000381 omeprazole Drugs 0.000 claims 5
• 239000000243 solution Substances 0.000 claims 4
• 239000007864 aqueous solution Substances 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 230000001376 precipitating effect Effects 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 239000001116 FEMA 4028 Substances 0.000 claims 1
• 208000017189 Gastrointestinal inflammatory disease Diseases 0.000 claims 1
• 241001465754 Metazoa Species 0.000 claims 1
• 206010057969 Reflux gastritis Diseases 0.000 claims 1
• 208000007107 Stomach Ulcer Diseases 0.000 claims 1
• WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 1
• 235000011175 beta-cyclodextrine Nutrition 0.000 claims 1
• 229960004853 betadex Drugs 0.000 claims 1
• KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 1
• 239000004327 boric acid Substances 0.000 claims 1
• 238000001816 cooling Methods 0.000 claims 1
• 238000007865 diluting Methods 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 208000000718 duodenal ulcer Diseases 0.000 claims 1
• 210000004211 gastric acid Anatomy 0.000 claims 1
• 201000005917 gastric ulcer Diseases 0.000 claims 1
• 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 208000000689 peptic esophagitis Diseases 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1