JP2006505567A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006505567A5 JP2006505567A5 JP2004545137A JP2004545137A JP2006505567A5 JP 2006505567 A5 JP2006505567 A5 JP 2006505567A5 JP 2004545137 A JP2004545137 A JP 2004545137A JP 2004545137 A JP2004545137 A JP 2004545137A JP 2006505567 A5 JP2006505567 A5 JP 2006505567A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- methoxy
- process according
- pyridinyl
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 8
- 239000003960 organic solvent Substances 0.000 claims 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- -1 4-methoxy-3,5-dimethyl-2-pyridinyl Chemical group 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- SRKVJDYNPSMHJM-UHFFFAOYSA-N 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine Chemical compound COC1=C(C)C=NC(CCl)=C1C SRKVJDYNPSMHJM-UHFFFAOYSA-N 0.000 claims 2
- XURCIPRUUASYLR-UHFFFAOYSA-N Omeprazole sulfide Chemical compound N=1C2=CC(OC)=CC=C2NC=1SCC1=NC=C(C)C(OC)=C1C XURCIPRUUASYLR-UHFFFAOYSA-N 0.000 claims 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical group ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims 2
- PSEPRWKZZJWRCB-UHFFFAOYSA-N (4-methoxy-3,5-dimethylpyridin-2-yl)methanol Chemical compound COC1=C(C)C=NC(CO)=C1C PSEPRWKZZJWRCB-UHFFFAOYSA-N 0.000 claims 1
- KOFBRZWVWJCLGM-UHFFFAOYSA-N 5-methoxy-1,3-dihydrobenzimidazole-2-thione Chemical compound COC1=CC=C2NC(S)=NC2=C1 KOFBRZWVWJCLGM-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 230000027119 gastric acid secretion Effects 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0203092A SE0203092D0 (en) | 2002-10-18 | 2002-10-18 | Method for the synthesis of a benzimidazole compound |
| PCT/SE2003/001602 WO2004035565A1 (en) | 2002-10-18 | 2003-10-15 | Method for the synthesis of a benzimidazole compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006505567A JP2006505567A (ja) | 2006-02-16 |
| JP2006505567A5 true JP2006505567A5 (enExample) | 2006-11-30 |
| JP4551221B2 JP4551221B2 (ja) | 2010-09-22 |
Family
ID=20289310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004545137A Expired - Fee Related JP4551221B2 (ja) | 2002-10-18 | 2003-10-15 | ベンゾイミダゾール化合物の合成方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US7227024B2 (enExample) |
| EP (1) | EP1556370B1 (enExample) |
| JP (1) | JP4551221B2 (enExample) |
| KR (1) | KR101065885B1 (enExample) |
| CN (2) | CN101230057B (enExample) |
| AR (1) | AR041639A1 (enExample) |
| AT (1) | ATE398118T1 (enExample) |
| AU (1) | AU2003269773B2 (enExample) |
| BR (1) | BR0315254A (enExample) |
| CA (1) | CA2501542C (enExample) |
| CY (1) | CY1108255T1 (enExample) |
| DE (1) | DE60321588D1 (enExample) |
| DK (1) | DK1556370T3 (enExample) |
| ES (1) | ES2306883T3 (enExample) |
| IL (1) | IL167795A (enExample) |
| IS (1) | IS2590B (enExample) |
| MX (1) | MXPA05003994A (enExample) |
| MY (1) | MY133573A (enExample) |
| NO (1) | NO330785B1 (enExample) |
| NZ (1) | NZ539370A (enExample) |
| PL (1) | PL376819A1 (enExample) |
| PT (1) | PT1556370E (enExample) |
| RU (1) | RU2324691C2 (enExample) |
| SA (1) | SA03240344B1 (enExample) |
| SE (1) | SE0203092D0 (enExample) |
| SI (1) | SI1556370T1 (enExample) |
| TW (1) | TWI310382B (enExample) |
| UA (1) | UA79147C2 (enExample) |
| UY (1) | UY28025A1 (enExample) |
| WO (1) | WO2004035565A1 (enExample) |
| ZA (1) | ZA200502577B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0203092D0 (en) | 2002-10-18 | 2002-10-18 | Astrazeneca Ab | Method for the synthesis of a benzimidazole compound |
| JP5355893B2 (ja) * | 2004-12-16 | 2013-11-27 | シプラ・リミテッド | パントプラゾールナトリウムの製造方法 |
| WO2010134099A1 (en) | 2009-05-21 | 2010-11-25 | Cadila Healthcare Limited | One pot process for preparing omeprazole and related compounds |
| SG181535A1 (en) | 2009-12-08 | 2012-07-30 | Codexis Inc | Synthesis of prazole compounds |
| WO2012078800A2 (en) | 2010-12-08 | 2012-06-14 | Codexis, Inc. | Biocatalysts and methods for the synthesis of armodafinil |
| CN103570681A (zh) * | 2012-07-24 | 2014-02-12 | 江苏柯菲平医药有限公司 | 一种埃索美拉唑关键中间体的制备方法 |
| CN103232389A (zh) * | 2013-05-08 | 2013-08-07 | 浙江新三和医药化工股份有限公司 | 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的制备方法 |
| CN103524494A (zh) * | 2013-11-07 | 2014-01-22 | 安徽国星生物化学有限公司 | 含甲基吡啶基团的巯基咪唑类衍生物及合成方法 |
| CN108251466B (zh) * | 2016-12-28 | 2021-07-02 | 浙江京新药业股份有限公司 | 一种酶法合成埃索美拉唑的方法 |
| CN107400118B (zh) * | 2017-08-29 | 2020-07-28 | 信泰制药（苏州）有限公司 | 埃索美拉唑中间体的制备方法 |
| CN111943883A (zh) * | 2020-08-21 | 2020-11-17 | 抚州三和医药化工有限公司 | 一种奥美氯化物的生产工艺 |
| KR20220084718A (ko) | 2020-12-14 | 2022-06-21 | 메디케어제약 주식회사 | 기능성 소화 불량을 동반한 위식도 역류 질환을 치료하는 약제학적 복합제제 |
| KR20230090184A (ko) | 2021-12-14 | 2023-06-21 | 메디케어제약 주식회사 | 에스오메프라졸 및 레바미피드를 포함하는 약제학적 복합제제 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4619997A (en) * | 1984-09-06 | 1986-10-28 | The Upjohn Company | Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents |
| SE9002043D0 (sv) | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
| NZ244301A (en) * | 1991-09-20 | 1994-08-26 | Merck & Co Inc | Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds |
| WO1997002260A1 (en) * | 1995-07-03 | 1997-01-23 | Asahi Kasei Kogyo Kabushiki Kaisha | 1-(5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrates |
| SE521100C2 (sv) * | 1995-12-15 | 2003-09-30 | Astra Ab | Förfarande för framställning av en bensimidazolförening |
| SE9704183D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New process |
| SI20019A (sl) * | 1998-07-13 | 2000-02-29 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola |
| SE0203092D0 (en) * | 2002-10-18 | 2002-10-18 | Astrazeneca Ab | Method for the synthesis of a benzimidazole compound |
-
2002
- 2002-10-18 SE SE0203092A patent/SE0203092D0/xx unknown
-
2003
- 2003-10-09 TW TW092128112A patent/TWI310382B/zh not_active IP Right Cessation
- 2003-10-14 SA SA03240344A patent/SA03240344B1/ar unknown
- 2003-10-15 DE DE60321588T patent/DE60321588D1/de not_active Expired - Lifetime
- 2003-10-15 DK DK03751703T patent/DK1556370T3/da active
- 2003-10-15 CN CN2008100040145A patent/CN101230057B/zh not_active Expired - Lifetime
- 2003-10-15 EP EP03751703A patent/EP1556370B1/en not_active Expired - Lifetime
- 2003-10-15 BR BR0315254-5A patent/BR0315254A/pt not_active IP Right Cessation
- 2003-10-15 PL PL376819A patent/PL376819A1/pl unknown
- 2003-10-15 KR KR1020057006554A patent/KR101065885B1/ko not_active Expired - Fee Related
- 2003-10-15 CA CA2501542A patent/CA2501542C/en not_active Expired - Fee Related
- 2003-10-15 US US10/531,412 patent/US7227024B2/en not_active Expired - Lifetime
- 2003-10-15 CN CNB2003801014302A patent/CN100374436C/zh not_active Expired - Lifetime
- 2003-10-15 WO PCT/SE2003/001602 patent/WO2004035565A1/en not_active Ceased
- 2003-10-15 ES ES03751703T patent/ES2306883T3/es not_active Expired - Lifetime
- 2003-10-15 JP JP2004545137A patent/JP4551221B2/ja not_active Expired - Fee Related
- 2003-10-15 SI SI200331301T patent/SI1556370T1/sl unknown
- 2003-10-15 MX MXPA05003994A patent/MXPA05003994A/es active IP Right Grant
- 2003-10-15 NZ NZ539370A patent/NZ539370A/en not_active IP Right Cessation
- 2003-10-15 UA UAA200502927A patent/UA79147C2/uk unknown
- 2003-10-15 RU RU2005109270/04A patent/RU2324691C2/ru active
- 2003-10-15 AT AT03751703T patent/ATE398118T1/de active
- 2003-10-15 AU AU2003269773A patent/AU2003269773B2/en not_active Expired
- 2003-10-15 PT PT03751703T patent/PT1556370E/pt unknown
- 2003-10-16 MY MYPI20033949A patent/MY133573A/en unknown
- 2003-10-16 UY UY28025A patent/UY28025A1/es not_active Application Discontinuation
- 2003-10-16 AR ARP030103769A patent/AR041639A1/es not_active Application Discontinuation
-
2005
- 2005-03-30 ZA ZA200502577A patent/ZA200502577B/en unknown
- 2005-03-31 IL IL167795A patent/IL167795A/en not_active IP Right Cessation
- 2005-05-02 NO NO20052158A patent/NO330785B1/no not_active IP Right Cessation
- 2005-05-03 IS IS7834A patent/IS2590B/is unknown
-
2007
- 2007-05-16 US US11/749,282 patent/US7683178B2/en not_active Expired - Lifetime
-
2008
- 2008-08-12 CY CY20081100852T patent/CY1108255T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006505567A5 (enExample) | ||
| EP1515963B1 (en) | A process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof | |
| EP0946546B1 (fr) | Derives de la pyridin-2-yl-methylamine, leur procede de preparation et leur application comme medicaments | |
| CN1113879C (zh) | 苯并咪唑化合物的合成方法 | |
| RU98110659A (ru) | Способ синтеза соединений бензимидазола | |
| US8563733B2 (en) | Process for the preparation of esomeprazole and salts thereof | |
| JP2550455B2 (ja) | ４ーアルキルイミダゾール誘導体 | |
| NO20070865L (no) | Fremgangsmate for fremstilling av 2'-deoksy-2',2'-difluorcytidin. | |
| CA2501542A1 (en) | Method for the synthesis of a benzimidazole compound | |
| CN105130955A (zh) | 富马酸沃诺拉赞的制备方法 | |
| WO2001085167A1 (en) | Pharmaceutical compositions comprising proton pump inhibitors and gastrin/cholecystokinin receptor ligands | |
| CN101031562A (zh) | 咪唑－5－羧酸类衍生物、制备方法及其应用 | |
| JP2005502636A5 (enExample) | ||
| RU2001103900A (ru) | Усовершенствованный способ синтеза 5-метокси-2-[(4-метокси-3,5-диметил-2-пиридил)метил]сульфинил-1н-бензимидазола | |
| CA2474246A1 (en) | Alkylammonium salts of omeprazole and esomeprazole | |
| JP2007506664A5 (enExample) | ||
| US20100210848A1 (en) | Process for optically active sulfoxide compounds | |
| CN117203200A (zh) | 黄嘌呤氧化酶抑制剂的制备方法 | |
| JP2014169302A (ja) | （ｓ）−オメプラゾールのマグネシウム塩の固形形態とその製造方法 | |
| CN1726214A (zh) | 泰妥拉唑的(－)对映异构体及其在治疗中的应用 | |
| JP2004536810A5 (enExample) | ||
| JP2005526073A5 (enExample) | ||
| WO2010146428A1 (en) | An improved process for the preparation of rabeprazole | |
| JP2007504223A5 (enExample) | ||
| JP2010043053A (ja) | 高純度のレバミピドの製造方法 |