UY28025A1 - Método de síntesis de un compuesto benzimidazol - Google Patents

Método de síntesis de un compuesto benzimidazol

Info

Publication number
UY28025A1
UY28025A1 UY28025A UY28025A UY28025A1 UY 28025 A1 UY28025 A1 UY 28025A1 UY 28025 A UY28025 A UY 28025A UY 28025 A UY28025 A UY 28025A UY 28025 A1 UY28025 A1 UY 28025A1
Authority
UY
Uruguay
Prior art keywords
synthesis method
carried out
water
reaction sequence
entire reaction
Prior art date
Application number
UY28025A
Other languages
English (en)
Inventor
Anders Gustavsson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20289310&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY28025(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY28025A1 publication Critical patent/UY28025A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Un proceso para la elaboración de omeprazol o esomeprazol a partir de alcohol pirmetílico vía cloruro de pirmetilo y pirmetazol, que se caracteriza por el hecho de que toda la secuencia de reacción se lleva a cabo sin la separación o purificación de los intermediarios. Más aun, la reacción se lleva a cabo en un sistema solvente común para toda la secuencia de reacción e inerte para los reactivos formados durante el proceso y utilizados en el proceso, e incluye un solvente orgánico inmiscible en agua y una cantidad específica de agua.
UY28025A 2002-10-18 2003-10-16 Método de síntesis de un compuesto benzimidazol UY28025A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0203092A SE0203092D0 (en) 2002-10-18 2002-10-18 Method for the synthesis of a benzimidazole compound

Publications (1)

Publication Number Publication Date
UY28025A1 true UY28025A1 (es) 2004-05-31

Family

ID=20289310

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28025A UY28025A1 (es) 2002-10-18 2003-10-16 Método de síntesis de un compuesto benzimidazol

Country Status (32)

Country Link
US (2) US7227024B2 (es)
EP (1) EP1556370B1 (es)
JP (1) JP4551221B2 (es)
KR (1) KR101065885B1 (es)
CN (2) CN100374436C (es)
AR (1) AR041639A1 (es)
AT (1) ATE398118T1 (es)
AU (1) AU2003269773B2 (es)
BR (1) BR0315254A (es)
CA (1) CA2501542C (es)
CY (1) CY1108255T1 (es)
DE (1) DE60321588D1 (es)
DK (1) DK1556370T3 (es)
ES (1) ES2306883T3 (es)
HK (1) HK1078852A1 (es)
IL (1) IL167795A (es)
IS (1) IS2590B (es)
MX (1) MXPA05003994A (es)
MY (1) MY133573A (es)
NO (1) NO330785B1 (es)
NZ (1) NZ539370A (es)
PL (1) PL376819A1 (es)
PT (1) PT1556370E (es)
RU (1) RU2324691C2 (es)
SA (1) SA03240344B1 (es)
SE (1) SE0203092D0 (es)
SI (1) SI1556370T1 (es)
TW (1) TWI310382B (es)
UA (1) UA79147C2 (es)
UY (1) UY28025A1 (es)
WO (1) WO2004035565A1 (es)
ZA (1) ZA200502577B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
CA2591405A1 (en) 2004-12-16 2006-06-22 Cipla Limited Process for the preparation of pantoprazole sodium
WO2010134099A1 (en) 2009-05-21 2010-11-25 Cadila Healthcare Limited One pot process for preparing omeprazole and related compounds
SG181535A1 (en) 2009-12-08 2012-07-30 Codexis Inc Synthesis of prazole compounds
US9267159B2 (en) 2010-12-08 2016-02-23 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
CN103570681A (zh) * 2012-07-24 2014-02-12 江苏柯菲平医药有限公司 一种埃索美拉唑关键中间体的制备方法
CN103232389A (zh) * 2013-05-08 2013-08-07 浙江新三和医药化工股份有限公司 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的制备方法
CN103524494A (zh) * 2013-11-07 2014-01-22 安徽国星生物化学有限公司 含甲基吡啶基团的巯基咪唑类衍生物及合成方法
CN108251466B (zh) * 2016-12-28 2021-07-02 浙江京新药业股份有限公司 一种酶法合成埃索美拉唑的方法
CN107400118B (zh) * 2017-08-29 2020-07-28 信泰制药（苏州）有限公司 埃索美拉唑中间体的制备方法
CN111943883A (zh) * 2020-08-21 2020-11-17 抚州三和医药化工有限公司 一种奥美氯化物的生产工艺
KR20220084718A (ko) 2020-12-14 2022-06-21 메디케어제약 주식회사 기능성 소화 불량을 동반한 위식도 역류 질환을 치료하는 약제학적 복합제제
KR20230090184A (ko) 2021-12-14 2023-06-21 메디케어제약 주식회사 에스오메프라졸 및 레바미피드를 포함하는 약제학적 복합제제

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4619997A (en) * 1984-09-06 1986-10-28 The Upjohn Company Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents
SE9002043D0 (sv) 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents
EP0870767B1 (en) * 1995-07-03 2000-02-16 Asahi Kasei Kogyo Kabushiki Kaisha 1-(5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrates
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
SE9704183D0 (sv) * 1997-11-14 1997-11-14 Astra Ab New process
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound

Also Published As

Publication number Publication date
PL376819A1 (pl) 2006-01-09
TWI310382B (en) 2009-06-01
US20080004447A1 (en) 2008-01-03
ES2306883T3 (es) 2008-11-16
CA2501542C (en) 2011-12-06
JP4551221B2 (ja) 2010-09-22
SE0203092D0 (en) 2002-10-18
KR101065885B1 (ko) 2011-09-19
WO2004035565A8 (en) 2005-05-19
WO2004035565A1 (en) 2004-04-29
AR041639A1 (es) 2005-05-26
IS7834A (is) 2005-05-03
EP1556370B1 (en) 2008-06-11
SA03240344B1 (ar) 2008-09-14
IL167795A (en) 2011-02-28
CN101230057A (zh) 2008-07-30
NZ539370A (en) 2006-11-30
DE60321588D1 (de) 2008-07-24
ATE398118T1 (de) 2008-07-15
US7683178B2 (en) 2010-03-23
MY133573A (en) 2007-11-30
IS2590B (is) 2010-02-15
RU2005109270A (ru) 2006-01-20
HK1078852A1 (en) 2006-03-24
PT1556370E (pt) 2008-08-06
CY1108255T1 (el) 2014-02-12
DK1556370T3 (da) 2008-09-01
NO330785B1 (no) 2011-07-18
UA79147C2 (en) 2007-05-25
NO20052158L (no) 2005-05-02
US7227024B2 (en) 2007-06-05
US20060084811A1 (en) 2006-04-20
EP1556370A1 (en) 2005-07-27
SI1556370T1 (sl) 2008-10-31
RU2324691C2 (ru) 2008-05-20
AU2003269773A1 (en) 2004-05-04
CA2501542A1 (en) 2004-04-29
JP2006505567A (ja) 2006-02-16
KR20050050145A (ko) 2005-05-27
AU2003269773B2 (en) 2007-02-01
CN100374436C (zh) 2008-03-12
BR0315254A (pt) 2005-08-23
CN1705656A (zh) 2005-12-07
CN101230057B (zh) 2011-09-14
MXPA05003994A (es) 2005-06-22
TW200500357A (en) 2005-01-01
ZA200502577B (en) 2005-10-12

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20150129