JP2004536633A5 - - Google Patents
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- JP2004536633A5 JP2004536633A5 JP2002591047A JP2002591047A JP2004536633A5 JP 2004536633 A5 JP2004536633 A5 JP 2004536633A5 JP 2002591047 A JP2002591047 A JP 2002591047A JP 2002591047 A JP2002591047 A JP 2002591047A JP 2004536633 A5 JP2004536633 A5 JP 2004536633A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkylene
- alkyl
- formula
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 hydroxy, sulfo Chemical group 0.000 claims 27
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 239000013590 bulk material Substances 0.000 claims 6
- RWRIWBAIICGTTQ-UHFFFAOYSA-N difluoromethane Chemical compound FCF RWRIWBAIICGTTQ-UHFFFAOYSA-N 0.000 claims 6
- 229920001477 hydrophilic polymer Polymers 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000006850 spacer group Chemical group 0.000 claims 5
- 125000004406 C3-C8 cycloalkylene group Chemical group 0.000 claims 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 239000003505 polymerization initiator Substances 0.000 claims 4
- 238000006116 polymerization reaction Methods 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 239000002131 composite material Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 210000004087 cornea Anatomy 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- 150000001450 anions Chemical class 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000003999 initiator Substances 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 150000002482 oligosaccharides Polymers 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 229960002591 hydroxyproline Drugs 0.000 claims 1
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 125000001261 isocyanato group Chemical group *N=C=O 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 125000001810 isothiocyanato group Chemical group *N=C=S 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 239000007870 radical polymerization initiator Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000005717 substituted cycloalkylene group Chemical group 0.000 claims 1
- 125000004964 sulfoalkyl group Chemical group 0.000 claims 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01810503 | 2001-05-21 | ||
| PCT/EP2002/005495 WO2002094331A1 (en) | 2001-05-21 | 2002-05-17 | Bottle-brush type coatings with entangled hydrophilic polymer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004536633A JP2004536633A (ja) | 2004-12-09 |
| JP2004536633A5 true JP2004536633A5 (enExample) | 2005-12-22 |
Family
ID=8183924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002591047A Pending JP2004536633A (ja) | 2001-05-21 | 2002-05-17 | 絡み合った親水性ポリマーを有するボトル−ブラシ型コーティング |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6835410B2 (enExample) |
| EP (1) | EP1395302B1 (enExample) |
| JP (1) | JP2004536633A (enExample) |
| AT (1) | ATE288289T1 (enExample) |
| DE (1) | DE60202866T2 (enExample) |
| WO (1) | WO2002094331A1 (enExample) |
Families Citing this family (68)
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| JP2003063932A (ja) * | 2001-08-24 | 2003-03-05 | Catalysts & Chem Ind Co Ltd | 化粧料用改質無機微粒子およびそれを配合した化粧料 |
| TW200407367A (en) * | 2001-11-13 | 2004-05-16 | Novartis Ag | Method for modifying the surface of biomedical articles |
| US8172395B2 (en) | 2002-12-03 | 2012-05-08 | Novartis Ag | Medical devices having antimicrobial coatings thereon |
| US7727581B2 (en) * | 2004-03-17 | 2010-06-01 | Essilor International Compagnie Generale D' Optique | Process for applying a coating on an optical lens face and implementation system |
| DE102004057155B4 (de) * | 2004-11-26 | 2007-02-01 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur chemischen Funktionalisierung von Oberflächen durch Plasmapolymerisation |
| CA2641021C (en) | 2006-02-01 | 2015-07-07 | Hollister Incorporated | Methods of applying a hydrophilic coating to a substrate, and substrates having a hydrophilic coating |
| US8795782B2 (en) | 2006-08-18 | 2014-08-05 | Commonwealth Scientific And Industrial Research Organisation | Polymeric coatings and methods for forming them |
| JP5567337B2 (ja) | 2006-08-18 | 2014-08-06 | コモンウェルス サイエンティフィック アンドインダストリアル リサーチ オーガナイゼーション | ポリマー被膜及びそれらを形成させる方法 |
| JP5374852B2 (ja) * | 2007-10-17 | 2013-12-25 | 日油株式会社 | 結晶性熱可塑性樹脂組成物 |
| US8575268B2 (en) * | 2007-08-27 | 2013-11-05 | Nof Corporation | Thermoplastic resin composition |
| JP5272353B2 (ja) * | 2007-08-27 | 2013-08-28 | 日油株式会社 | 熱可塑性樹脂組成物 |
| US20090111942A1 (en) * | 2007-10-25 | 2009-04-30 | Bausch & Lomb Incorporated | Method for Making Surface Modified Biomedical Devices |
| JP5253851B2 (ja) * | 2008-03-18 | 2013-07-31 | 株式会社シード | 眼用レンズ及び眼用レンズの製造方法 |
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| JP3926847B2 (ja) * | 1995-12-08 | 2007-06-06 | ノバルティス アクチエンゲゼルシャフト | プラズマに誘導されたポリマー被覆 |
| AR009439A1 (es) * | 1996-12-23 | 2000-04-12 | Novartis Ag | Un articulo que comprende un sustrato con un recubrimiento polimerico primario que porta grupos reactivos predominantemente en su superficie, unmetodo para preparar dicho articulo, un articulo que posee un recubrimiento de tipo hibrido y una lente de contacto |
| TW473488B (en) | 1998-04-30 | 2002-01-21 | Novartis Ag | Composite materials, biomedical articles formed thereof and process for their manufacture |
| US6087415A (en) * | 1998-06-11 | 2000-07-11 | Johnson & Johnson Vision Care, Inc. | Biomedical devices with hydrophilic coatings |
| US20010036556A1 (en) * | 1998-10-20 | 2001-11-01 | James S. Jen | Coatings for biomedical devices |
| US6440571B1 (en) * | 1999-05-20 | 2002-08-27 | Bausch & Lomb Incorporated | Surface treatment of silicone medical devices with reactive hydrophilic polymers |
| EP1095966B1 (en) | 1999-10-27 | 2006-01-11 | Novartis AG | Process for the modification of a material surface |
-
2002
- 2002-05-09 US US10/142,300 patent/US6835410B2/en not_active Expired - Lifetime
- 2002-05-17 WO PCT/EP2002/005495 patent/WO2002094331A1/en not_active Ceased
- 2002-05-17 EP EP02727603A patent/EP1395302B1/en not_active Expired - Lifetime
- 2002-05-17 DE DE60202866T patent/DE60202866T2/de not_active Expired - Lifetime
- 2002-05-17 JP JP2002591047A patent/JP2004536633A/ja active Pending
- 2002-05-17 AT AT02727603T patent/ATE288289T1/de not_active IP Right Cessation
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