JP2004536617A - 核酸増幅方法 - Google Patents

核酸増幅方法 Download PDF

Info

Publication number
JP2004536617A
JP2004536617A JP2003517293A JP2003517293A JP2004536617A JP 2004536617 A JP2004536617 A JP 2004536617A JP 2003517293 A JP2003517293 A JP 2003517293A JP 2003517293 A JP2003517293 A JP 2003517293A JP 2004536617 A JP2004536617 A JP 2004536617A
Authority
JP
Japan
Prior art keywords
probe
amplification product
product
amplification
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003517293A
Other languages
English (en)
Japanese (ja)
Inventor
ランデグレン、ウルフ
グルベルグ、マティス
ニルソン、マティス
Original Assignee
バイオサイクリカ アクチボラゲット
ランデグレン ジーン テクノロジー アクチボラゲット
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオサイクリカ アクチボラゲット, ランデグレン ジーン テクノロジー アクチボラゲット filed Critical バイオサイクリカ アクチボラゲット
Publication of JP2004536617A publication Critical patent/JP2004536617A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6848Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2003517293A 2001-08-03 2002-07-12 核酸増幅方法 Pending JP2004536617A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0118959A GB2378245A (en) 2001-08-03 2001-08-03 Nucleic acid amplification method
PCT/SE2002/001378 WO2003012119A2 (en) 2001-08-03 2002-07-12 Nucleic acid amplification method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008316989A Division JP4559517B2 (ja) 2001-08-03 2008-12-12 核酸増幅方法

Publications (1)

Publication Number Publication Date
JP2004536617A true JP2004536617A (ja) 2004-12-09

Family

ID=9919749

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2003517293A Pending JP2004536617A (ja) 2001-08-03 2002-07-12 核酸増幅方法
JP2008316989A Expired - Lifetime JP4559517B2 (ja) 2001-08-03 2008-12-12 核酸増幅方法
JP2009230088A Expired - Lifetime JP4675424B2 (ja) 2001-08-03 2009-10-02 核酸増幅方法
JP2010125694A Expired - Lifetime JP5313204B2 (ja) 2001-08-03 2010-06-01 核酸増幅方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2008316989A Expired - Lifetime JP4559517B2 (ja) 2001-08-03 2008-12-12 核酸増幅方法
JP2009230088A Expired - Lifetime JP4675424B2 (ja) 2001-08-03 2009-10-02 核酸増幅方法
JP2010125694A Expired - Lifetime JP5313204B2 (ja) 2001-08-03 2010-06-01 核酸増幅方法

Country Status (7)

Country Link
US (3) US7320860B2 (cg-RX-API-DMAC7.html)
EP (4) EP1423532B1 (cg-RX-API-DMAC7.html)
JP (4) JP2004536617A (cg-RX-API-DMAC7.html)
AU (1) AU2002314693A1 (cg-RX-API-DMAC7.html)
CA (1) CA2455803A1 (cg-RX-API-DMAC7.html)
GB (1) GB2378245A (cg-RX-API-DMAC7.html)
WO (1) WO2003012119A2 (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008522628A (ja) * 2004-12-11 2008-07-03 サイトジェニックス, インコーポレイテッド 高品質核酸のセルフリー生合成及びその使用
JP2009077735A (ja) * 2001-08-03 2009-04-16 Biocyclica Ab 核酸増幅方法
JP2011505161A (ja) * 2007-12-04 2011-02-24 ピエール、ファーブル、メディカマン 抗体ライブラリーを作製およびスクリーニングするための新規な方法

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0304371D0 (en) * 2003-02-26 2003-04-02 Solexa Ltd DNA Sequence analysis
US7385043B1 (en) * 2003-04-30 2008-06-10 The Public Health Research Institute Of The City Of New York, Inc. Homogeneous multiplex screening assays and kits
SE0401270D0 (sv) 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel
WO2005113804A1 (en) * 2004-05-20 2005-12-01 Trillion Genomics Limited Use of mass labelled probes to detect target nucleic acids using mass spectrometry
EP1784754A4 (en) * 2004-08-13 2009-05-27 Harvard College OPTI-NANOPORE DNA READING PLATFORM WITH ULTRAHOLE THROUGHPUT
JP5103398B2 (ja) * 2005-06-06 2012-12-19 454 ライフ サイエンシーズ コーポレイション 両末端配列決定(pairedendsequencing)
EP1910537A1 (en) 2005-06-06 2008-04-16 454 Life Sciences Corporation Paired end sequencing
US20090264299A1 (en) 2006-02-24 2009-10-22 Complete Genomics, Inc. High throughput genome sequencing on DNA arrays
EP2620510B2 (en) 2005-06-15 2020-02-19 Complete Genomics Inc. Single molecule arrays for genetic and chemical analysis
US8137936B2 (en) * 2005-11-29 2012-03-20 Macevicz Stephen C Selected amplification of polynucleotides
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
WO2008070352A2 (en) 2006-10-27 2008-06-12 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
US20090075343A1 (en) 2006-11-09 2009-03-19 Complete Genomics, Inc. Selection of dna adaptor orientation by nicking
US7862999B2 (en) * 2007-01-17 2011-01-04 Affymetrix, Inc. Multiplex targeted amplification using flap nuclease
US20100047792A1 (en) * 2007-04-10 2010-02-25 Szendroe Istvan Label-free optical detection method
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
KR20100089060A (ko) * 2007-10-04 2010-08-11 할싸이언 몰레큘러 전자 현미경으로 핵산 중합체를 시퀀싱하는 방법
US8415099B2 (en) 2007-11-05 2013-04-09 Complete Genomics, Inc. Efficient base determination in sequencing reactions
WO2009073629A2 (en) 2007-11-29 2009-06-11 Complete Genomics, Inc. Efficient shotgun sequencing methods
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
US20090233809A1 (en) * 2008-03-04 2009-09-17 Affymetrix, Inc. Resequencing methods for identification of sequence variants
WO2010065568A2 (en) 2008-12-01 2010-06-10 Laboratory Corporation Of America Holdings METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95
BRPI1007321A2 (pt) 2009-01-15 2018-07-10 Laboratory Corp America Holdings métodos para medir e/ou quantificar a presença e/ou quantidade de her-3 ou her-3 em um complexo em uma amostra de um paciente, e para determinar se um indivíduo com um câncer é provável de responder ao tratamento com uma terapia alvejada, e, anticorpo.
SG172984A1 (en) * 2009-01-15 2011-08-29 Lab Corp America Holdings Methods of determining patient response by measurement of her-2 expression
WO2010126614A2 (en) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
WO2011027966A2 (en) * 2009-09-03 2011-03-10 Seegene, Inc. Td probe and its uses
EP2504448B1 (en) * 2009-11-25 2016-10-19 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
WO2011109379A1 (en) 2010-03-01 2011-09-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
EP2585593B1 (en) 2010-06-24 2017-03-01 Population Genetics Technologies Ltd. Methods for polynucleotide library production, immortalization and region of interest extraction
US10669569B2 (en) 2010-10-15 2020-06-02 Navinci Diagnostics Ab Dynamic range methods
CN101974638B (zh) * 2010-11-10 2012-10-03 华东医学生物技术研究所 连接反应偶联核酸侵入反应与切刻内切酶反应的核酸信号扩增检测方法
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
EP2673380B1 (en) 2011-02-09 2018-12-12 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
US9556473B2 (en) 2011-02-15 2017-01-31 Leica Biosystems Newcastle Ltd Methods for identifying nucleic acid sequences
EP2675916B1 (en) 2011-02-15 2016-08-24 Leica Biosystems Newcastle Limited METHOD FOR LOCALIZED IN SITU DETECTION OF mRNA
US8759036B2 (en) 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
US10597701B2 (en) 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US9228233B2 (en) 2011-10-17 2016-01-05 Good Start Genetics, Inc. Analysis methods
ES2741099T3 (es) 2012-02-28 2020-02-10 Agilent Technologies Inc Método de fijación de una secuencia de recuento para una muestra de ácido nucleico
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
KR101922124B1 (ko) 2012-08-27 2018-11-26 삼성전자주식회사 시료 중 rna로부터 dna를 증폭하는 방법
WO2014076214A1 (en) 2012-11-14 2014-05-22 Olink Ab Rca reporter probes and their use in detecting nucleic acid molecules
EP2920324B1 (en) 2012-11-14 2017-12-27 Olink Bioscience AB Localised rca-based amplification method
JP6112652B2 (ja) * 2012-11-29 2017-04-12 国立大学法人広島大学 標的dnaの特異的増幅方法
ES2900102T3 (es) * 2013-02-20 2022-03-15 Univ Emory Composiciones para la secuenciación de ácidos nucleicos en mezclas
JP6408552B2 (ja) 2013-03-13 2018-10-17 メソ スケール テクノロジーズ エルエルシー 改善されたアッセイ方法
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
WO2014152421A1 (en) 2013-03-14 2014-09-25 Good Start Genetics, Inc. Methods for analyzing nucleic acids
WO2014143623A1 (en) 2013-03-15 2014-09-18 The Lubrizol Corporation Heavy metal free cpvc compositions
US8847799B1 (en) 2013-06-03 2014-09-30 Good Start Genetics, Inc. Methods and systems for storing sequence read data
WO2015013681A1 (en) 2013-07-25 2015-01-29 Bio-Rad Laboratories, Inc. Genetic assays
US9217167B2 (en) 2013-07-26 2015-12-22 General Electric Company Ligase-assisted nucleic acid circularization and amplification
US9644232B2 (en) 2013-07-26 2017-05-09 General Electric Company Method and device for collection and amplification of circulating nucleic acids
WO2015057565A1 (en) 2013-10-18 2015-04-23 Good Start Genetics, Inc. Methods for assessing a genomic region of a subject
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
GB201320145D0 (en) 2013-11-14 2014-01-01 Olink Ab Localised RCA-based amplification method using a padlock-probe
GB201321123D0 (en) 2013-11-29 2014-01-15 Linea Ab Q Amplification of circular molecules
GB2520765A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Multiplex detection of nucleic acids
US10112194B2 (en) 2014-04-14 2018-10-30 Q-Linea Ab Detection of microscopic objects
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
CN112239774B (zh) 2014-05-15 2024-12-03 中尺度技术有限责任公司 改进的测定方法
EP3074539B1 (en) 2014-06-13 2018-01-10 Q-Linea AB Method for detecting and characterising a microorganism
GB201413718D0 (en) 2014-08-01 2014-09-17 Olink Ab Method for selecting a target nucleic acid sequence
GB201413717D0 (en) 2014-08-01 2014-09-17 Olink Ab Method for selecting a target nucleic acid sequence
US20160048608A1 (en) 2014-08-15 2016-02-18 Good Start Genetics, Inc. Systems and methods for genetic analysis
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
US10429399B2 (en) 2014-09-24 2019-10-01 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
CA2965661C (en) 2014-10-23 2023-09-26 Ricardo Mancebo Reagents and methods for isothermal chain reaction
EP4095261B1 (en) 2015-01-06 2025-05-28 Molecular Loop Biosciences, Inc. Screening for structural variants
GB201507026D0 (en) 2015-04-24 2015-06-10 Linea Ab Q Medical sample transportation container
EP4219532A3 (en) 2015-06-05 2023-08-16 Dana-Farber Cancer Institute, Inc. Compositions and methods for transient gene therapy with enhanced stability
US10344336B2 (en) 2015-06-09 2019-07-09 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
GB201511129D0 (en) 2015-06-24 2015-08-05 Linea Ab Q Method of determining antimicrobial susceptibility of a microorganism
EP3608420B1 (en) 2015-07-29 2021-05-19 Progenity, Inc. Nucleic acids and methods for detecting chromosomal abnormalities
GB201518655D0 (en) 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
CN108779487A (zh) 2015-11-16 2018-11-09 普罗格尼迪公司 用于检测甲基化状态的核酸和方法
US10718017B2 (en) * 2016-03-31 2020-07-21 Arizona Board Of Regents On Behalf Of Arizona State University Probes and methods for measuring tandem repeats
GB2554767A (en) 2016-04-21 2018-04-11 Q Linea Ab Detecting and characterising a microorganism
US10655170B2 (en) 2016-07-06 2020-05-19 Takara Bio Usa, Inc. Coupling adaptors to a target nucleic acid
GB201614023D0 (en) 2016-08-16 2016-09-28 Olink Bioscience Ab Double-stranded circle probes
GB201621514D0 (en) 2016-12-16 2017-02-01 Q-Linea Ab Padlock probe detection method
US11661624B2 (en) 2017-03-30 2023-05-30 Pioneer Hi-Bred International, Inc. Methods of identifying and characterizing gene editing variations in nucleic acids
US11753434B2 (en) 2017-04-14 2023-09-12 Dana-Farber Cancer Institute, Inc. Compositions and methods for transient gene therapy with enhanced stability
US11459603B2 (en) * 2017-05-23 2022-10-04 Rutgers, The State University Of New Jersey Target mediated in situ signal amplification with dual interacting hairpin probes
CN111315895A (zh) 2017-09-14 2020-06-19 豪夫迈·罗氏有限公司 用于产生环状单链dna文库的新型方法
EP3682027B1 (en) 2017-09-15 2025-02-26 F. Hoffmann-La Roche AG Hybridization-extension-ligation strategy for generating circular single-stranded dna libraries
ES3029737T3 (en) 2017-10-06 2025-06-25 10X Genomics Inc Rna templated ligation
WO2019068797A1 (en) 2017-10-06 2019-04-11 F. Hoffmann-La Roche Ag CIRCULARIZATION METHODS FOR THE PREPARATION OF SAMPLE SAMPLES OF UNIQUE MOLECULES
WO2019086531A1 (en) 2017-11-03 2019-05-09 F. Hoffmann-La Roche Ag Linear consensus sequencing
JP7096893B2 (ja) 2018-02-05 2022-07-06 エフ.ホフマン-ラ ロシュ アーゲー 単一分子のための一本鎖環状dna鋳型の作製
CN111936635B (zh) 2018-03-02 2024-08-23 豪夫迈·罗氏有限公司 用于单分子测序的单链环状dna模板的产生
WO2019195346A1 (en) 2018-04-02 2019-10-10 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
CN109444102B (zh) * 2018-12-18 2021-03-23 济南大学 一种检测赭曲霉毒素a的荧光生物传感器及其制备方法和应用
KR20220010471A (ko) 2019-03-01 2022-01-25 메소 스케일 테크놀러지즈, 엘엘시 면역검정 방법에서 사용을 위한 전기화학발광성 표지화된 프로브, 이의 사용 방법 및 이를 포함하는 키트
WO2020206170A1 (en) 2019-04-02 2020-10-08 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
JP7727628B2 (ja) 2019-12-03 2025-08-21 アラマー バイオサイエンシーズ, インク. 核酸結合免疫サンドイッチアッセイ(nulisa)
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
US11492662B2 (en) 2020-08-06 2022-11-08 Singular Genomics Systems, Inc. Methods for in situ transcriptomics and proteomics
EP4121557A4 (en) 2020-08-06 2024-05-01 Singular Genomics Systems, Inc. Spatial sequencing
WO2022056078A1 (en) * 2020-09-11 2022-03-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rnase h-assisted detection assay for rna (radar)
AU2021345359A1 (en) 2020-09-21 2023-05-11 Enumera Molecular, Inc. Compositions and methods for isolation of cell-free dna
US12497651B2 (en) 2020-11-23 2025-12-16 Pleno, Inc. Encoded dual-probe endonuclease assays
WO2022235764A1 (en) 2021-05-05 2022-11-10 Singular Genomics Systems, Inc. Multiomic analysis device and methods of use thereof
GB202203185D0 (en) 2022-03-08 2022-04-20 Rarity Bioscience Ab Method for detecting nucleic acid amplification products
WO2024249961A1 (en) 2023-06-01 2024-12-05 Singular Genomics Systems, Inc. Methods and probes for detecting polynucleotide sequences in cells and tissues
GB202310278D0 (en) 2023-07-05 2023-08-16 Navinci Diagnostics Ab Stabilisation of phi29 polymerase
CN120249442B (zh) * 2025-06-04 2025-09-26 北京航空航天大学杭州创新研究院 一种基于邻近核酸扩增信号放大的超灵敏免疫检测方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
AU649066B2 (en) * 1990-07-25 1994-05-12 Syngene, Inc. Circular extension for generating multiple nucleic acid complements
JP3085409B2 (ja) 1991-03-29 2000-09-11 東洋紡績株式会社 標的核酸配列の検出方法およびそのための試薬キット
US6077668A (en) * 1993-04-15 2000-06-20 University Of Rochester Highly sensitive multimeric nucleic acid probes
US5714320A (en) 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
WO1995014106A2 (en) 1993-11-17 1995-05-26 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
DE69528670T2 (de) 1994-12-23 2004-03-11 Dade Behring Inc., Deerfield Nachweis von nukleinsäuren durch nuklease-katalysierte produktbildung
SE504798C2 (sv) 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
US6143495A (en) 1995-11-21 2000-11-07 Yale University Unimolecular segment amplification and sequencing
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
WO1997020948A1 (en) 1995-12-05 1997-06-12 Koch Joern Erland A cascade nucleic acid amplification reaction
US6124120A (en) 1997-10-08 2000-09-26 Yale University Multiple displacement amplification
EP1066414B1 (en) 1998-03-25 2009-06-10 Olink AB Rolling circle replication of padlock probes
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
US6150112A (en) 1998-09-18 2000-11-21 Yale University Methods for identifying DNA sequences for use in comparison of DNA samples by their lack of polymorphism using Y shape adaptors
US6235502B1 (en) * 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
US6830884B1 (en) * 1998-12-15 2004-12-14 Molecular Staging Inc. Method of amplification
AU781962B2 (en) 1998-12-15 2005-06-23 Qiagen Gmbh A method of amplification of a circularised nucleic acid probe
US6274320B1 (en) * 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
WO2001038580A2 (en) 1999-11-26 2001-05-31 Curagen Corporation Nucleic acid probe arrays
JP2003532380A (ja) 1999-12-02 2003-11-05 モレキュラー ステージング,インコーポレイテッド 線状自己アニーリングセグメントからの一本鎖環状dnaの産出
US6221603B1 (en) * 2000-02-04 2001-04-24 Molecular Dynamics, Inc. Rolling circle amplification assay for nucleic acid analysis
US6291187B1 (en) * 2000-05-12 2001-09-18 Molecular Staging, Inc. Poly-primed amplification of nucleic acid sequences
US6350580B1 (en) * 2000-10-11 2002-02-26 Stratagene Methods for detection of a target nucleic acid using a probe comprising secondary structure
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
GB2378245A (en) * 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
SE0401270D0 (sv) 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009077735A (ja) * 2001-08-03 2009-04-16 Biocyclica Ab 核酸増幅方法
JP2008522628A (ja) * 2004-12-11 2008-07-03 サイトジェニックス, インコーポレイテッド 高品質核酸のセルフリー生合成及びその使用
JP2011505161A (ja) * 2007-12-04 2011-02-24 ピエール、ファーブル、メディカマン 抗体ライブラリーを作製およびスクリーニングするための新規な方法

Also Published As

Publication number Publication date
EP1423532A2 (en) 2004-06-02
US7790388B2 (en) 2010-09-07
JP2009077735A (ja) 2009-04-16
EP2236622B1 (en) 2017-09-06
US20050287526A1 (en) 2005-12-29
GB0118959D0 (en) 2001-09-26
WO2003012119A2 (en) 2003-02-13
JP5313204B2 (ja) 2013-10-09
EP2224016A1 (en) 2010-09-01
CA2455803A1 (en) 2003-02-13
GB2378245A (en) 2003-02-05
EP1423532B1 (en) 2013-05-22
WO2003012119A3 (en) 2003-11-13
EP2236622A3 (en) 2010-11-03
USRE44265E1 (en) 2013-06-04
JP4675424B2 (ja) 2011-04-20
US7320860B2 (en) 2008-01-22
JP2009297045A (ja) 2009-12-24
AU2002314693A1 (en) 2003-02-17
JP2010183916A (ja) 2010-08-26
EP2251439B1 (en) 2013-09-11
EP2236622A2 (en) 2010-10-06
JP4559517B2 (ja) 2010-10-06
US20080131899A1 (en) 2008-06-05
EP2251439A1 (en) 2010-11-17

Similar Documents

Publication Publication Date Title
JP4559517B2 (ja) 核酸増幅方法
US20250263779A1 (en) Methods of detecting an analyte
JP6571895B1 (ja) 核酸プローブ及びゲノム断片検出方法
AU2010290277B2 (en) TD probe and its uses
EP2516679B1 (en) Tsg primer target detection
CA2979858C (en) Detection of target nucleic acid sequences by pto cleavage and extension assay in a liquid phase
CA2790153C (en) Thd primer target detection
JPH02268683A (ja) 単一プライマーを用いる核酸の増幅
JP3909010B2 (ja) 高度ダイナミックレンジを有する定量的多重pcr
KR102672338B1 (ko) 분할된 t7 프로모터를 이용한 중증 급성 호흡기 증후군 코로나바이러스 2 검출 및/또는 이의 돌연변이 검출용 등온 단일 반응 프로브 세트 및 이의 용도
HK1245352A1 (en) Method for the simultaneous detection of multiple nucleic acid sequences in a sample

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050530

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080613

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080912

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080922

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081014

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081021

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081112

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081119

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081128

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20081128

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090106

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090403

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090410

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090424

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090522