JP2004532223A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004532223A5 JP2004532223A5 JP2002582927A JP2002582927A JP2004532223A5 JP 2004532223 A5 JP2004532223 A5 JP 2004532223A5 JP 2002582927 A JP2002582927 A JP 2002582927A JP 2002582927 A JP2002582927 A JP 2002582927A JP 2004532223 A5 JP2004532223 A5 JP 2004532223A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- spiro
- piperidine
- group
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 58
- -1 -CH 2 OH Chemical group 0.000 claims 45
- 150000001875 compounds Chemical class 0.000 claims 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims 21
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 150000002431 hydrogen Chemical group 0.000 claims 10
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 8
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 7
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000002619 bicyclic group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000004043 oxo group Chemical group O=* 0.000 claims 5
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 4
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000002950 monocyclic group Chemical group 0.000 claims 4
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 2
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- PNULDNFMKQSJDK-UHFFFAOYSA-N 1'-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C12=CC=CC=C2CCC11CCN(C2CC3CCCCC3CC2)CC1 PNULDNFMKQSJDK-UHFFFAOYSA-N 0.000 claims 1
- RNXPWRGCFBJEBC-UHFFFAOYSA-N 1'-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)spiro[indene-1,4'-piperidine] Chemical compound C1=CC2=CC=CC=C2C1(CC1)CCN1C1CC2CCCCC2CC1 RNXPWRGCFBJEBC-UHFFFAOYSA-N 0.000 claims 1
- XQYSCVDRMWSQEL-UHFFFAOYSA-N 1'-(2,3-dihydro-1h-inden-2-yl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C12=CC=CC=C2CCC11CCN(C2CC3=CC=CC=C3C2)CC1 XQYSCVDRMWSQEL-UHFFFAOYSA-N 0.000 claims 1
- MPDHINFVEFHYFB-UHFFFAOYSA-N 1'-(2,3-dihydro-1h-inden-2-yl)spiro[indene-1,4'-piperidine] Chemical compound C1=CC2=CC=CC=C2C1(CC1)CCN1C1CC2=CC=CC=C2C1 MPDHINFVEFHYFB-UHFFFAOYSA-N 0.000 claims 1
- IZSOEQWAJSGUMC-UHFFFAOYSA-N 1'-(2-phenylethyl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1CC2(C3=CC=CC=C3CC2)CCN1CCC1=CC=CC=C1 IZSOEQWAJSGUMC-UHFFFAOYSA-N 0.000 claims 1
- LNMOBTPIDPUKDV-UHFFFAOYSA-N 1'-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-yl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound O1CC(C)(C)COC11CCC(N2CCC3(C4=CC=CC=C4CC3)CC2)CC1 LNMOBTPIDPUKDV-UHFFFAOYSA-N 0.000 claims 1
- YJGQGVFLPGUOQS-UHFFFAOYSA-N 1'-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-yl)spiro[indene-1,4'-piperidine] Chemical compound O1CC(C)(C)COC11CCC(N2CCC3(CC2)C2=CC=CC=C2C=C3)CC1 YJGQGVFLPGUOQS-UHFFFAOYSA-N 0.000 claims 1
- CKSLXVZSQPJDMO-UHFFFAOYSA-N 1'-(3,3-diphenylpropyl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1CC2(C3=CC=CC=C3CC2)CCN1CCC(C=1C=CC=CC=1)C1=CC=CC=C1 CKSLXVZSQPJDMO-UHFFFAOYSA-N 0.000 claims 1
- LJLKBUNRUSZMSI-UHFFFAOYSA-N 1'-(3,3-diphenylpropyl)spiro[indene-1,4'-piperidine] Chemical compound C1CC2(C3=CC=CC=C3C=C2)CCN1CCC(C=1C=CC=CC=1)C1=CC=CC=C1 LJLKBUNRUSZMSI-UHFFFAOYSA-N 0.000 claims 1
- JUYHQLDPNTVZBQ-UHFFFAOYSA-N 1'-(3-bicyclo[2.2.1]heptanyl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1CC2=CC=CC=C2C1(CC1)CCN1C1CC2CC1CC2 JUYHQLDPNTVZBQ-UHFFFAOYSA-N 0.000 claims 1
- OSUBZFYIAFSCFG-UHFFFAOYSA-N 1'-(3-bicyclo[2.2.1]heptanyl)spiro[indene-1,4'-piperidine] Chemical compound C1=CC2=CC=CC=C2C1(CC1)CCN1C1CC2CC1CC2 OSUBZFYIAFSCFG-UHFFFAOYSA-N 0.000 claims 1
- YMFHWBXASJRUMY-UHFFFAOYSA-N 1'-(4-propan-2-ylcyclohexyl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1CC(C(C)C)CCC1N1CCC2(C3=CC=CC=C3CC2)CC1 YMFHWBXASJRUMY-UHFFFAOYSA-N 0.000 claims 1
- VWFGAZKJOPTKMR-UHFFFAOYSA-N 1'-(4-propan-2-ylcyclohexyl)spiro[indene-1,4'-piperidine] Chemical compound C1CC(C(C)C)CCC1N1CCC2(C3=CC=CC=C3C=C2)CC1 VWFGAZKJOPTKMR-UHFFFAOYSA-N 0.000 claims 1
- KRPSXNNVCBQCEC-UHFFFAOYSA-N 1'-(4-propylcyclohexyl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1CC(CCC)CCC1N1CCC2(C3=CC=CC=C3CC2)CC1 KRPSXNNVCBQCEC-UHFFFAOYSA-N 0.000 claims 1
- DEQOCEXKPGKZSN-UHFFFAOYSA-N 1'-(5-methylhexan-2-yl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1CN(C(C)CCC(C)C)CCC11C2=CC=CC=C2CC1 DEQOCEXKPGKZSN-UHFFFAOYSA-N 0.000 claims 1
- LNOMOXRJKOWWGC-UHFFFAOYSA-N 1'-(5-methylhexan-2-yl)spiro[indene-1,4'-piperidine] Chemical compound C1CN(C(C)CCC(C)C)CCC21C1=CC=CC=C1C=C2 LNOMOXRJKOWWGC-UHFFFAOYSA-N 0.000 claims 1
- QOWJAEKTRKLYBG-UHFFFAOYSA-N 1'-(6,11-dihydro-5h-dibenzo[1,2-a:1',2'-e][7]annulen-11-yl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C12=CC=CC=C2CCC2=CC=CC=C2C1N(CC1)CCC11CCC2=CC=CC=C21 QOWJAEKTRKLYBG-UHFFFAOYSA-N 0.000 claims 1
- HVSPQHTVYBVQHM-UHFFFAOYSA-N 1'-(6,11-dihydro-5h-dibenzo[1,2-a:1',2'-e][7]annulen-11-yl)spiro[indene-1,4'-piperidine] Chemical compound C12=CC=CC=C2CCC2=CC=CC=C2C1N1CCC2(C3=CC=CC=C3C=C2)CC1 HVSPQHTVYBVQHM-UHFFFAOYSA-N 0.000 claims 1
- XINKQWBLHGCLOJ-UHFFFAOYSA-N 1'-(7-bicyclo[2.2.1]heptanyl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1CC2=CC=CC=C2C1(CC1)CCN1C1C2CCC1CC2 XINKQWBLHGCLOJ-UHFFFAOYSA-N 0.000 claims 1
- BAJSEEKSPUDVGQ-UHFFFAOYSA-N 1'-(cyclooctylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1CC2(C3=CC=CC=C3CC2)CCN1CC1CCCCCCC1 BAJSEEKSPUDVGQ-UHFFFAOYSA-N 0.000 claims 1
- PIAHAZASHUUYOH-UHFFFAOYSA-N 1'-(cyclooctylmethyl)spiro[indene-1,4'-piperidine] Chemical compound C1CC2(C3=CC=CC=C3C=C2)CCN1CC1CCCCCCC1 PIAHAZASHUUYOH-UHFFFAOYSA-N 0.000 claims 1
- ZPDQZCRLHXPZRI-UHFFFAOYSA-N 1'-(naphthalen-1-ylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1=CC=C2C(CN3CCC4(C5=CC=CC=C5CC4)CC3)=CC=CC2=C1 ZPDQZCRLHXPZRI-UHFFFAOYSA-N 0.000 claims 1
- VAYBSXTUUZARGP-UHFFFAOYSA-N 1'-(naphthalen-1-ylmethyl)spiro[indene-1,4'-piperidine] Chemical compound C1=CC=C2C(CN3CCC4(CC3)C3=CC=CC=C3C=C4)=CC=CC2=C1 VAYBSXTUUZARGP-UHFFFAOYSA-N 0.000 claims 1
- KXMWVKLODWPLHK-UHFFFAOYSA-N 1'-(naphthalen-2-ylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1=CC=CC2=CC(CN3CCC4(C5=CC=CC=C5CC4)CC3)=CC=C21 KXMWVKLODWPLHK-UHFFFAOYSA-N 0.000 claims 1
- WTAUIAKKKYILAA-UHFFFAOYSA-N 1'-(naphthalen-2-ylmethyl)spiro[indene-1,4'-piperidine] Chemical compound C1=CC=CC2=CC(CN3CCC4(CC3)C3=CC=CC=C3C=C4)=CC=C21 WTAUIAKKKYILAA-UHFFFAOYSA-N 0.000 claims 1
- GSXJSGMDWKPVBY-UHFFFAOYSA-N 1'-(phenylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1CC2(C3=CC=CC=C3CC2)CCN1CC1=CC=CC=C1 GSXJSGMDWKPVBY-UHFFFAOYSA-N 0.000 claims 1
- AANJKKDEXNNEKD-UHFFFAOYSA-N 1'-[(4-phenylmethoxyphenyl)methyl]spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C=1C=C(CN2CCC3(C4=CC=CC=C4CC3)CC2)C=CC=1OCC1=CC=CC=C1 AANJKKDEXNNEKD-UHFFFAOYSA-N 0.000 claims 1
- MWRSALXQUKNUKD-UHFFFAOYSA-N 1'-[(4-phenylmethoxyphenyl)methyl]spiro[indene-1,4'-piperidine] Chemical compound C=1C=C(CN2CCC3(CC2)C2=CC=CC=C2C=C3)C=CC=1OCC1=CC=CC=C1 MWRSALXQUKNUKD-UHFFFAOYSA-N 0.000 claims 1
- WOHHMRWQNDCZPA-UHFFFAOYSA-N 1'-[(4-phenylphenyl)methyl]spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1CC2(C3=CC=CC=C3CC2)CCN1CC(C=C1)=CC=C1C1=CC=CC=C1 WOHHMRWQNDCZPA-UHFFFAOYSA-N 0.000 claims 1
- LVPJERPQXNELLP-UHFFFAOYSA-N 1'-[(4-phenylphenyl)methyl]spiro[indene-1,4'-piperidine] Chemical compound C1CC2(C3=CC=CC=C3C=C2)CCN1CC(C=C1)=CC=C1C1=CC=CC=C1 LVPJERPQXNELLP-UHFFFAOYSA-N 0.000 claims 1
- YVXWZLBBLSRVOP-UHFFFAOYSA-N 1'-[4,4-bis(4-fluorophenyl)butyl]spiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCCN1CCC2(C3=CC=CC=C3CC2)CC1 YVXWZLBBLSRVOP-UHFFFAOYSA-N 0.000 claims 1
- JVQBWBKDYBNJLP-UHFFFAOYSA-N 1'-[4,4-bis(4-fluorophenyl)butyl]spiro[indene-1,4'-piperidine] Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCCN1CCC2(C3=CC=CC=C3C=C2)CC1 JVQBWBKDYBNJLP-UHFFFAOYSA-N 0.000 claims 1
- OQPGVLZDVOZJLJ-UHFFFAOYSA-N 1'-cyclodecylspiro[indene-1,4'-piperidine] Chemical compound C1CC2(C3=CC=CC=C3C=C2)CCN1C1CCCCCCCCC1 OQPGVLZDVOZJLJ-UHFFFAOYSA-N 0.000 claims 1
- UTNYZWUCOISVME-UHFFFAOYSA-N 1'-cyclooctylspiro[1,2-dihydroindene-3,4'-piperidine] Chemical compound C12=CC=CC=C2CCC1(CC1)CCN1C1CCCCCCC1 UTNYZWUCOISVME-UHFFFAOYSA-N 0.000 claims 1
- URGFMBOYZAXORX-UHFFFAOYSA-N 1'-cyclooctylspiro[indene-1,4'-piperidine] Chemical compound C1CC2(C3=CC=CC=C3C=C2)CCN1C1CCCCCCC1 URGFMBOYZAXORX-UHFFFAOYSA-N 0.000 claims 1
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 1
- YCDROFISSLEFEV-UHFFFAOYSA-N 4-(spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)benzonitrile Chemical compound C1=CC(C#N)=CC=C1CN1CCC2(C3=CC=CC=C3CC2)CC1 YCDROFISSLEFEV-UHFFFAOYSA-N 0.000 claims 1
- 125000005330 8 membered heterocyclic group Chemical group 0.000 claims 1
- 241000790917 Dioxys <bee> Species 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000004945 acylaminoalkyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000006547 cyclononyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28467001P | 2001-04-18 | 2001-04-18 | |
| PCT/US2002/012357 WO2002085354A1 (en) | 2001-04-18 | 2002-04-18 | Spiroindene and spiroindane compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004532223A JP2004532223A (ja) | 2004-10-21 |
| JP2004532223A5 true JP2004532223A5 (https=) | 2005-12-22 |
| JP4489354B2 JP4489354B2 (ja) | 2010-06-23 |
Family
ID=23091075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002582927A Expired - Fee Related JP4489354B2 (ja) | 2001-04-18 | 2002-04-18 | スピロインデンおよびスピロインダン化合物類 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6828440B2 (https=) |
| EP (2) | EP1385514B9 (https=) |
| JP (1) | JP4489354B2 (https=) |
| AT (1) | ATE413175T1 (https=) |
| AU (1) | AU2002256282C1 (https=) |
| CA (1) | CA2443938C (https=) |
| CY (1) | CY1108731T1 (https=) |
| DE (1) | DE60229736D1 (https=) |
| DK (1) | DK1385514T5 (https=) |
| ES (1) | ES2316559T3 (https=) |
| PT (1) | PT1385514E (https=) |
| SI (1) | SI1385514T1 (https=) |
| WO (1) | WO2002085354A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6374762B1 (en) * | 1997-10-27 | 2002-04-23 | Correct Craft, Inc. | Water sport towing apparatus |
| WO2003064425A1 (en) * | 2002-01-28 | 2003-08-07 | Pfizer Japan Inc. | N-substituted spiropiperidine compounds as ligands for orl-1 receptor |
| JP4056977B2 (ja) * | 2002-03-29 | 2008-03-05 | 田辺三菱製薬株式会社 | 睡眠障害治療薬 |
| JP3856815B2 (ja) | 2003-04-04 | 2006-12-13 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン−４受容体アゴニストとしてのアシル化スピロピペリジン誘導体 |
| GB0328906D0 (en) * | 2003-12-12 | 2004-01-14 | Syngenta Participations Ag | Chemical compounds |
| US20100028339A1 (en) * | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
| AU2005228410A1 (en) | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| CA2563164A1 (en) | 2004-03-29 | 2005-10-06 | Pfizer Inc. | Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists |
| TW200621244A (en) * | 2004-08-19 | 2006-07-01 | Vertex Pharma | Modulators of muscarinic receptors |
| US7786141B2 (en) * | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
| JP2008521825A (ja) * | 2004-11-29 | 2008-06-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
| WO2007028638A1 (en) * | 2005-09-09 | 2007-03-15 | Euro-Celtique S.A. | Fused and spirocycle compounds and the use thereof |
| CN1870631B (zh) * | 2005-11-11 | 2010-04-14 | 华为技术有限公司 | 媒体网关的门控方法 |
| US7858635B2 (en) * | 2005-12-22 | 2010-12-28 | Vertex Pharmaceuticals Incorporated | Spiro compounds as modulators of muscarinic receptors |
| CN101426499A (zh) | 2006-02-22 | 2009-05-06 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
| NZ570497A (en) * | 2006-02-22 | 2011-09-30 | Vertex Pharma | Spiro condensed 4,4'-quinilino-piperidines derivatives as modulators of muscarinic receptors |
| CN101500565A (zh) * | 2006-06-29 | 2009-08-05 | 弗特克斯药品有限公司 | 毒蕈碱性受体的调节剂 |
| EP2051712A2 (en) * | 2006-08-15 | 2009-04-29 | Vertex Pharmceuticals Incorporated | Modulators of muscarinic receptors |
| WO2008021545A2 (en) * | 2006-08-18 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| TW201322983A (zh) * | 2007-08-31 | 2013-06-16 | Purdue Pharma Lp | 經取代之喹□啉型哌啶化合物及其用途 |
| MX2010003373A (es) * | 2007-10-03 | 2010-04-30 | Vertex Pharma | Moduladores de receptores muscarinicos. |
| JP5451646B2 (ja) * | 2008-02-27 | 2014-03-26 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 |
| CN102105465B (zh) | 2008-07-21 | 2015-03-11 | 普渡制药公司 | 取代的喹喔啉型桥连哌啶化合物及其用途 |
| US8431700B2 (en) * | 2009-03-03 | 2013-04-30 | Vanderbilt University | Alkylsulfonyl-2,3-dihydrospiro[indene-1,4′-piperidine] analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders |
| AR078522A1 (es) * | 2009-10-15 | 2011-11-16 | Lilly Co Eli | Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis |
| US10118927B2 (en) | 2012-12-27 | 2018-11-06 | Purdue Pharma L.P. | Substituted piperidin-4-amino-type compounds and uses thereof |
| US9951038B2 (en) | 2012-12-27 | 2018-04-24 | Purdue Pharma L.P. | Quinazolin-4(3H)-one-type piperidine compounds and uses thereof |
| US9090618B2 (en) | 2012-12-27 | 2015-07-28 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
| WO2014102588A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
| BR112019001398A2 (pt) | 2016-07-29 | 2019-05-07 | Janssen Pharmaceutica Nv | métodos para tratamento de câncer de próstata |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1335831A (fr) | 1962-10-09 | 1963-08-23 | Res Lab Dr C Janssen Nv | Procédé de préparation de nu-(3, 3-diphényl-3-alcanoyl)-propylspiro |
| US3161645A (en) | 1962-12-18 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds |
| US3318900A (en) | 1964-05-06 | 1967-05-09 | Janssen Pharmaceutica Nv | Derivatives of benzimidazolinyl piperidine |
| US3325499A (en) | 1964-11-02 | 1967-06-13 | Mcneilab Inc | 1-(1-hydrocarbyl-4-piperdyl)-2-indolinone |
| US3666764A (en) * | 1970-08-26 | 1972-05-30 | Mead Johnson & Co | Spiroindenylpiperidines |
| DE2609645A1 (de) | 1976-03-09 | 1977-09-15 | Boehringer Sohn Ingelheim | Aminoalkylheterocyclen |
| US4329353A (en) | 1980-10-22 | 1982-05-11 | Janssen Pharmaceutica, N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof |
| US4410528A (en) | 1980-05-16 | 1983-10-18 | Kyowa Hakko Kogyo Co., Ltd. | Hypotensive piperidine derivatives |
| JPS58180481A (ja) | 1982-04-15 | 1983-10-21 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
| JPS60120872A (ja) | 1983-12-01 | 1985-06-28 | Kyowa Hakko Kogyo Co Ltd | 新規なヘテロ環状化合物及び強心剤 |
| EP0445974A3 (en) * | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
| DK78692D0 (da) | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
| US5536716A (en) | 1992-12-11 | 1996-07-16 | Merck & Co., Inc. | Spiro piperidines and homologs which promote release of growth hormone |
| DE69412067T2 (de) | 1993-01-28 | 1999-03-25 | Merck & Co., Inc., Rahway, N.J. | Substituierte spiro-azaringen als tachykinine rezeptor antagonisten |
| US5457207A (en) * | 1993-10-05 | 1995-10-10 | Regents Of The University Of Minnesota | Spirovesamicols |
| US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| WO1995028397A1 (en) | 1994-04-14 | 1995-10-26 | Merck & Co., Inc. | Alpha1c adrenergic receptor antagonists |
| FR2722190B1 (fr) | 1994-07-05 | 1996-10-04 | Sanofi Sa | Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant |
| US5767118A (en) | 1994-10-26 | 1998-06-16 | Merck & Co., Inc. | 4-Heterocyclic peperidines promote release of growth hormone |
| US5574044A (en) | 1994-10-27 | 1996-11-12 | Merck & Co., Inc. | Muscarine antagonists |
| DE69635048T2 (de) | 1995-06-12 | 2006-02-16 | G.D. Searle & Co. | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
| US6150355A (en) | 1995-09-13 | 2000-11-21 | Kyowa Hakko Kogyo Co., Ltd. | Phenylpiperidine derivative |
| WO1997040035A1 (en) | 1996-04-19 | 1997-10-30 | Neurosearch A/S | 1-(4-piperidyl)-benzimidazoles having neurotrophic activity |
| AU5604998A (en) * | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
| US6063796A (en) | 1997-04-04 | 2000-05-16 | Merck & Co., Inc. | Somatostatin agonists |
| WO1998054168A1 (en) | 1997-05-30 | 1998-12-03 | Banyu Pharmaceutical Co., Ltd. | 2-oxoimidazole derivatives |
| JPH10330377A (ja) | 1997-06-02 | 1998-12-15 | Kyowa Hakko Kogyo Co Ltd | ピペリジン誘導体 |
| US6166037A (en) | 1997-08-28 | 2000-12-26 | Merck & Co., Inc. | Pyrrolidine and piperidine modulators of chemokine receptor activity |
| GB9718833D0 (en) | 1997-09-04 | 1997-11-12 | Merck Sharp & Dohme | Therapeutic agents |
| EP0921125B1 (en) | 1997-12-05 | 2002-01-30 | F. Hoffmann-La Roche Ag | 1,3,8-Triazaspiro[4,5]decan-4-on derivatives |
| US6166209A (en) * | 1997-12-11 | 2000-12-26 | Hoffmann-La Roche Inc. | Piperidine derivatives |
| US6013644A (en) * | 1997-12-12 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
| EA200000683A1 (ru) | 1998-01-19 | 2000-12-25 | Пфайзер Инк. | Производные ряда 4-(2-кето-1-бензимидазолинил)пиперидина в качестве агонистов orl1-рецептора |
| EP1072263A4 (en) | 1998-03-26 | 2004-03-31 | Japan Tobacco Inc | AMID DERIVATIVES AND NOCICEPTINANT AGONISTS |
| WO1999059997A1 (en) | 1998-05-18 | 1999-11-25 | Novo Nordisk A/S | Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes |
| EP1087770A4 (en) | 1998-06-15 | 2001-11-14 | Merck & Co Inc | PRENYL PROTEIN TRANSFERASE INHIBITORS |
| US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| ID29137A (id) | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
| MA26659A1 (fr) | 1998-08-06 | 2004-12-20 | Pfizer | Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. |
| JP2001011050A (ja) * | 1999-04-30 | 2001-01-16 | Sankyo Co Ltd | 含窒素飽和複素環化合物 |
| WO2001022919A2 (en) | 1999-09-30 | 2001-04-05 | Merck & Co., Inc. | Spiro[bicyclic -azacycloalkyl and -cycloalkyl] derivatives and uses thereof |
| SE9904652D0 (sv) | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
| ATE413878T1 (de) | 2000-09-06 | 2008-11-15 | Ortho Mcneil Pharm Inc | Methode zum bekämpfen der allergien durch verwendung von substituierten pyrazolen |
| AU2001288110A1 (en) * | 2000-09-27 | 2002-04-08 | Takeda Chemical Industries Ltd. | Spiro compounds |
-
2002
- 2002-04-18 PT PT02725733T patent/PT1385514E/pt unknown
- 2002-04-18 WO PCT/US2002/012357 patent/WO2002085354A1/en not_active Ceased
- 2002-04-18 DE DE60229736T patent/DE60229736D1/de not_active Expired - Lifetime
- 2002-04-18 AU AU2002256282A patent/AU2002256282C1/en not_active Ceased
- 2002-04-18 DK DK02725733T patent/DK1385514T5/da active
- 2002-04-18 AT AT02725733T patent/ATE413175T1/de active
- 2002-04-18 EP EP02725733A patent/EP1385514B9/en not_active Expired - Lifetime
- 2002-04-18 JP JP2002582927A patent/JP4489354B2/ja not_active Expired - Fee Related
- 2002-04-18 CA CA2443938A patent/CA2443938C/en not_active Expired - Fee Related
- 2002-04-18 SI SI200230789T patent/SI1385514T1/sl unknown
- 2002-04-18 EP EP08168203A patent/EP2033644A1/en not_active Withdrawn
- 2002-04-18 ES ES02725733T patent/ES2316559T3/es not_active Expired - Lifetime
- 2002-04-18 US US10/126,472 patent/US6828440B2/en not_active Expired - Lifetime
-
2009
- 2009-01-27 CY CY20091100103T patent/CY1108731T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004532223A5 (https=) | ||
| JP2004531531A5 (https=) | ||
| JP2004531532A5 (https=) | ||
| JP2005518330A5 (https=) | ||
| CA2443938A1 (en) | Spiroindene and spiroindane compounds as opioid ligands useful for treating pain | |
| SU1138032A3 (ru) | Способ получени производных бициклического пиримидин-5-она или их солей с фармацевтически приемлемыми кислотами,или их цис- или транс-изомеров | |
| RU2667907C2 (ru) | ИНГИБИРУЮЩЕЕ Trk СОЕДИНЕНИЕ | |
| PE20211703A1 (es) | Compuesto derivado heterotriciclico novedoso y uso del mismo | |
| KR910019615A (ko) | 위산분비 억제 방법 | |
| RU2014123434A (ru) | Фармацевтические соединения | |
| RU2444362C2 (ru) | Лекарственное средство | |
| CO5580770A2 (es) | Compuestos de quinolina terapeuticos con propiedades antagonistas de 5-ht | |
| CY1110382T1 (el) | Πυραζινο υποκατεστημενες αρυλοβενζοδιαζεπινες | |
| RU2004126612A (ru) | Хиназолиновые соединения | |
| CA2444108A1 (en) | Nociceptin analogs | |
| AR028683A1 (es) | Derivados de 1,3,8-triaza-espiro[4.5]decan-4-ona | |
| JP2004002414A5 (https=) | ||
| DK110395A (da) | 1-Substituerede 4-(4-(lavere alkyl)sulfonylaminobenzoyl)-piperidiner, farmakologisk acceptable salte deraf samt farmaceutiske præparater med indhold af sådanne | |
| JP2005538062A5 (https=) | ||
| RU2010111729A (ru) | Ингибиторы активности протеинтирозинкиназы | |
| RU2014115290A (ru) | Производные 1-фенил 2-пиридинилалкиловых спиртов в качестве ингибиторов | |
| JPWO2002010135A1 (ja) | ３，４−ジヒドロイソキノリン誘導体化合物及びその化合物を有効成分とする薬剤 | |
| EP2313100B1 (en) | Inhibitors of the plasmodial surface anion channel as antimalarials | |
| JP2011506501A5 (https=) | ||
| RU2009119421A (ru) | Производные 2-фенил-6-аминокарбонилпиримидина и их применение в качестве антагонистов тромбоцитарного рецептора адф (p2y12 рецептора) |