CY1108731T1 - Ενωσεις σπιροϊνδενιου και σπιροϊνδανιου - Google Patents
Ενωσεις σπιροϊνδενιου και σπιροϊνδανιουInfo
- Publication number
- CY1108731T1 CY1108731T1 CY20091100103T CY091100103T CY1108731T1 CY 1108731 T1 CY1108731 T1 CY 1108731T1 CY 20091100103 T CY20091100103 T CY 20091100103T CY 091100103 T CY091100103 T CY 091100103T CY 1108731 T1 CY1108731 T1 CY 1108731T1
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- Cyprus
- Prior art keywords
- spinline
- unions
- compound
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/32—Alcohol-abuse
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
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- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Μία ένωση του τύπου (I): (I) όπου τα Ζ, Α, Β, C, R1, R2, Χ1, Χ2, Q και n είναι όπως αποκαλύπτονται στην παρούσα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28467001P | 2001-04-18 | 2001-04-18 | |
EP02725733A EP1385514B9 (en) | 2001-04-18 | 2002-04-18 | Spiroindene and spiroindane compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108731T1 true CY1108731T1 (el) | 2014-04-09 |
Family
ID=23091075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100103T CY1108731T1 (el) | 2001-04-18 | 2009-01-27 | Ενωσεις σπιροϊνδενιου και σπιροϊνδανιου |
Country Status (13)
Country | Link |
---|---|
US (1) | US6828440B2 (el) |
EP (2) | EP2033644A1 (el) |
JP (1) | JP4489354B2 (el) |
AT (1) | ATE413175T1 (el) |
AU (1) | AU2002256282C1 (el) |
CA (1) | CA2443938C (el) |
CY (1) | CY1108731T1 (el) |
DE (1) | DE60229736D1 (el) |
DK (1) | DK1385514T5 (el) |
ES (1) | ES2316559T3 (el) |
PT (1) | PT1385514E (el) |
SI (1) | SI1385514T1 (el) |
WO (1) | WO2002085354A1 (el) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6374762B1 (en) * | 1997-10-27 | 2002-04-23 | Correct Craft, Inc. | Water sport towing apparatus |
MXPA04007242A (es) * | 2002-01-28 | 2004-10-29 | Pfizer | Compuestos de espiropiperidina n-sustituidos como ligandos para el receptor orl-1. |
ES2392340T3 (es) | 2002-03-29 | 2012-12-07 | Mitsubishi Tanabe Pharma Corporation | Remedio para los trastornos del sueño |
CA2520114A1 (en) | 2003-04-04 | 2004-10-21 | Merck & Co., Inc. | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists |
GB0328906D0 (en) * | 2003-12-12 | 2004-01-14 | Syngenta Participations Ag | Chemical compounds |
US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
JP2007530656A (ja) | 2004-03-29 | 2007-11-01 | ファイザー株式会社 | ORL1受容体拮抗薬としてのαアリールまたはヘテロアリールメチルβピペリジノプロパンアミド化合物 |
US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
JP5647759B2 (ja) | 2004-03-29 | 2015-01-07 | ユニヴァーシティ オブ サウス フロリダ | トリシリビン及び関連化合物による、腫瘍及び癌の有効な治療 |
US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
US20100009928A1 (en) * | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
EP1781288A2 (en) * | 2004-08-19 | 2007-05-09 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
US7786141B2 (en) * | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
NZ555444A (en) * | 2004-11-29 | 2011-01-28 | Vertex Pharma | Modulators of muscarinic receptors |
JP2009507800A (ja) * | 2005-09-09 | 2009-02-26 | ユーロ−セルティーク エス.エイ. | 縮合およびスピロ環化合物ならびにその使用 |
CN1870631B (zh) * | 2005-11-11 | 2010-04-14 | 华为技术有限公司 | 媒体网关的门控方法 |
RU2008130094A (ru) * | 2005-12-22 | 2010-01-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецепторов |
WO2007100670A1 (en) * | 2006-02-22 | 2007-09-07 | Vertex Pharmaceuticals Incorporated | Spiro condensed piperidnes as modulators of muscarinic receptors |
CN101426499A (zh) | 2006-02-22 | 2009-05-06 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
CA2656183A1 (en) * | 2006-06-29 | 2008-01-10 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
CN101553231A (zh) * | 2006-08-15 | 2009-10-07 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
CA2660974A1 (en) * | 2006-08-18 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
EP2433935A1 (en) * | 2007-08-31 | 2012-03-28 | Purdue Pharma LP | Substituted-quinoxaline-type-piperidine compounds and the uses thereof |
AU2008307440A1 (en) * | 2007-10-03 | 2009-04-09 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
US8383629B2 (en) * | 2008-02-27 | 2013-02-26 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 |
EP2537844A1 (en) | 2008-07-21 | 2012-12-26 | Purdue Pharma L.P. | Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof |
US8431700B2 (en) * | 2009-03-03 | 2013-04-30 | Vanderbilt University | Alkylsulfonyl-2,3-dihydrospiro[indene-1,4′-piperidine] analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders |
AR078522A1 (es) * | 2009-10-15 | 2011-11-16 | Lilly Co Eli | Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis |
WO2014102589A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Quinazolin-4(3h)-one-type piperidine compounds and uses thereof |
WO2014102588A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
US10118927B2 (en) | 2012-12-27 | 2018-11-06 | Purdue Pharma L.P. | Substituted piperidin-4-amino-type compounds and uses thereof |
WO2014102594A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
UA124972C2 (uk) | 2016-07-29 | 2021-12-22 | Янссен Фармацевтика Нв | Способи лікування раку передміхурової залози |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1335831A (fr) | 1962-10-09 | 1963-08-23 | Res Lab Dr C Janssen Nv | Procédé de préparation de nu-(3, 3-diphényl-3-alcanoyl)-propylspiro |
US3161645A (en) | 1962-12-18 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds |
US3318900A (en) | 1964-05-06 | 1967-05-09 | Janssen Pharmaceutica Nv | Derivatives of benzimidazolinyl piperidine |
US3325499A (en) | 1964-11-02 | 1967-06-13 | Mcneilab Inc | 1-(1-hydrocarbyl-4-piperdyl)-2-indolinone |
US3666764A (en) * | 1970-08-26 | 1972-05-30 | Mead Johnson & Co | Spiroindenylpiperidines |
DE2609645A1 (de) | 1976-03-09 | 1977-09-15 | Boehringer Sohn Ingelheim | Aminoalkylheterocyclen |
US4329353A (en) | 1980-10-22 | 1982-05-11 | Janssen Pharmaceutica, N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof |
US4410528A (en) | 1980-05-16 | 1983-10-18 | Kyowa Hakko Kogyo Co., Ltd. | Hypotensive piperidine derivatives |
JPS58180481A (ja) | 1982-04-15 | 1983-10-21 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
JPS60120872A (ja) | 1983-12-01 | 1985-06-28 | Kyowa Hakko Kogyo Co Ltd | 新規なヘテロ環状化合物及び強心剤 |
EP0445974A3 (en) * | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
DK78692D0 (da) * | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
US5536716A (en) | 1992-12-11 | 1996-07-16 | Merck & Co., Inc. | Spiro piperidines and homologs which promote release of growth hormone |
DK0681571T3 (da) * | 1993-01-28 | 1998-11-23 | Merck & Co Inc | Spiro-substituerede azacykliske forbindelser som tachykininreceptorantagonister |
US5457207A (en) * | 1993-10-05 | 1995-10-10 | Regents Of The University Of Minnesota | Spirovesamicols |
US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
WO1995028397A1 (en) | 1994-04-14 | 1995-10-26 | Merck & Co., Inc. | Alpha1c adrenergic receptor antagonists |
FR2722190B1 (fr) | 1994-07-05 | 1996-10-04 | Sanofi Sa | Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant |
US5767118A (en) | 1994-10-26 | 1998-06-16 | Merck & Co., Inc. | 4-Heterocyclic peperidines promote release of growth hormone |
US5574044A (en) | 1994-10-27 | 1996-11-12 | Merck & Co., Inc. | Muscarine antagonists |
JPH11507670A (ja) | 1995-06-12 | 1999-07-06 | ジー.ディー.サール アンド カンパニー | シクロオキシゲナーゼ−2インヒビターと5−リポキシゲナーゼインヒビターの組合せによる炎症と炎症関連疾患の治療 |
US6150355A (en) | 1995-09-13 | 2000-11-21 | Kyowa Hakko Kogyo Co., Ltd. | Phenylpiperidine derivative |
DE69736776T2 (de) | 1996-04-19 | 2007-01-18 | Neurosearch A/S | 1-(4-piperidyl)-benzimidazole mit neurotropher aktivität |
AU5604998A (en) | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
US6063796A (en) | 1997-04-04 | 2000-05-16 | Merck & Co., Inc. | Somatostatin agonists |
ATE276242T1 (de) | 1997-05-30 | 2004-10-15 | Banyu Pharma Co Ltd | 2-oxoimidazol-derivate |
JPH10330377A (ja) | 1997-06-02 | 1998-12-15 | Kyowa Hakko Kogyo Co Ltd | ピペリジン誘導体 |
US6166037A (en) | 1997-08-28 | 2000-12-26 | Merck & Co., Inc. | Pyrrolidine and piperidine modulators of chemokine receptor activity |
GB9718833D0 (en) * | 1997-09-04 | 1997-11-12 | Merck Sharp & Dohme | Therapeutic agents |
EP0921125B1 (en) | 1997-12-05 | 2002-01-30 | F. Hoffmann-La Roche Ag | 1,3,8-Triazaspiro[4,5]decan-4-on derivatives |
US6166209A (en) * | 1997-12-11 | 2000-12-26 | Hoffmann-La Roche Inc. | Piperidine derivatives |
US6013644A (en) * | 1997-12-12 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
JP3342478B2 (ja) | 1998-01-19 | 2002-11-11 | ファイザー製薬株式会社 | Orl1−レセプターアゴニストとしての4−(2−ケト−1−ベンズイミダゾリニル)ピペリジン化合物 |
AU754716B2 (en) | 1998-03-26 | 2002-11-21 | Japan Tobacco Inc. | Amide derivatives and nociceptin antagonists |
JP2002515503A (ja) | 1998-05-18 | 2002-05-28 | ノボ ノルディスク アクティーゼルスカブ | オピオイド受容体のサブタイプへの高い親和性を有する新規1,3,8−トリアザスピロ〔4,5〕デカノン |
EP1087770A4 (en) | 1998-06-15 | 2001-11-14 | Merck & Co Inc | INHIBITORS OF PRENYL PROTEIN TRANSFERASE |
US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
ID29137A (id) | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
MA26659A1 (fr) | 1998-08-06 | 2004-12-20 | Pfizer | Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. |
JP2001011050A (ja) * | 1999-04-30 | 2001-01-16 | Sankyo Co Ltd | 含窒素飽和複素環化合物 |
AU7716600A (en) * | 1999-09-30 | 2001-04-30 | Merck & Co., Inc. | Spiro[bicyclic -azacycloalkyl and -cycloalkyl] derivatives and uses thereof |
SE9904652D0 (sv) | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
HUP0302475A2 (hu) | 2000-09-06 | 2003-11-28 | Ortho-Mcneil Pharmaceutical, Inc. | Eljárás allergia kezelésére szubsztituált pirazolok alkalmazásával |
AU2001288110A1 (en) * | 2000-09-27 | 2002-04-08 | Takeda Chemical Industries Ltd. | Spiro compounds |
-
2002
- 2002-04-18 CA CA2443938A patent/CA2443938C/en not_active Expired - Fee Related
- 2002-04-18 AT AT02725733T patent/ATE413175T1/de active
- 2002-04-18 PT PT02725733T patent/PT1385514E/pt unknown
- 2002-04-18 DE DE60229736T patent/DE60229736D1/de not_active Expired - Lifetime
- 2002-04-18 SI SI200230789T patent/SI1385514T1/sl unknown
- 2002-04-18 ES ES02725733T patent/ES2316559T3/es not_active Expired - Lifetime
- 2002-04-18 EP EP08168203A patent/EP2033644A1/en not_active Withdrawn
- 2002-04-18 AU AU2002256282A patent/AU2002256282C1/en not_active Ceased
- 2002-04-18 JP JP2002582927A patent/JP4489354B2/ja not_active Expired - Fee Related
- 2002-04-18 EP EP02725733A patent/EP1385514B9/en not_active Expired - Lifetime
- 2002-04-18 US US10/126,472 patent/US6828440B2/en not_active Expired - Lifetime
- 2002-04-18 DK DK02725733T patent/DK1385514T5/da active
- 2002-04-18 WO PCT/US2002/012357 patent/WO2002085354A1/en active IP Right Grant
-
2009
- 2009-01-27 CY CY20091100103T patent/CY1108731T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20030018041A1 (en) | 2003-01-23 |
EP2033644A1 (en) | 2009-03-11 |
PT1385514E (pt) | 2009-02-04 |
EP1385514A4 (en) | 2005-04-13 |
SI1385514T1 (sl) | 2009-04-30 |
EP1385514B1 (en) | 2008-11-05 |
US6828440B2 (en) | 2004-12-07 |
ES2316559T3 (es) | 2009-04-16 |
JP4489354B2 (ja) | 2010-06-23 |
AU2002256282B2 (en) | 2005-08-11 |
JP2004532223A (ja) | 2004-10-21 |
CA2443938C (en) | 2010-06-22 |
CA2443938A1 (en) | 2002-10-31 |
DK1385514T5 (da) | 2009-03-09 |
EP1385514B9 (en) | 2009-08-12 |
DK1385514T3 (da) | 2009-01-19 |
DE60229736D1 (de) | 2008-12-18 |
ATE413175T1 (de) | 2008-11-15 |
WO2002085354A1 (en) | 2002-10-31 |
AU2002256282C1 (en) | 2006-08-17 |
EP1385514A1 (en) | 2004-02-04 |
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