JP2004532023A5 - - Google Patents
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- Publication number
- JP2004532023A5 JP2004532023A5 JP2002579516A JP2002579516A JP2004532023A5 JP 2004532023 A5 JP2004532023 A5 JP 2004532023A5 JP 2002579516 A JP2002579516 A JP 2002579516A JP 2002579516 A JP2002579516 A JP 2002579516A JP 2004532023 A5 JP2004532023 A5 JP 2004532023A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- antigen
- protein
- nucleic acid
- flavivirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 56
- 102000036639 antigens Human genes 0.000 claims 56
- 108091007433 antigens Proteins 0.000 claims 56
- 108020004707 nucleic acids Proteins 0.000 claims 38
- 102000039446 nucleic acids Human genes 0.000 claims 38
- 150000007523 nucleic acids Chemical class 0.000 claims 38
- 101710204837 Envelope small membrane protein Proteins 0.000 claims 24
- 241000710831 Flavivirus Species 0.000 claims 24
- 101710145006 Lysis protein Proteins 0.000 claims 24
- 241000700605 Viruses Species 0.000 claims 23
- 241000710842 Japanese encephalitis virus Species 0.000 claims 19
- 101710085938 Matrix protein Proteins 0.000 claims 17
- 101710127721 Membrane protein Proteins 0.000 claims 17
- 208000001490 Dengue Diseases 0.000 claims 16
- 206010012310 Dengue fever Diseases 0.000 claims 16
- 208000025729 dengue disease Diseases 0.000 claims 16
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 13
- 238000013518 transcription Methods 0.000 claims 13
- 230000035897 transcription Effects 0.000 claims 13
- 241000710888 St. Louis encephalitis virus Species 0.000 claims 8
- 241000710886 West Nile virus Species 0.000 claims 8
- 241000710772 Yellow fever virus Species 0.000 claims 8
- 229940051021 yellow-fever virus Drugs 0.000 claims 8
- 230000002163 immunogen Effects 0.000 claims 6
- 206010054261 Flavivirus infection Diseases 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 230000009918 complex formation Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 241000725619 Dengue virus Species 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108091035707 Consensus sequence Proteins 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 206010041896 St. Louis Encephalitis Diseases 0.000 claims 1
- 101710172711 Structural protein Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000014621 translational initiation Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/826,115 US7227011B2 (en) | 1998-06-04 | 2001-04-04 | Nucleic acid vaccines for prevention of flavivirus infection |
| PCT/US2002/010764 WO2002081754A1 (en) | 2001-04-04 | 2002-04-04 | Nucleic acid vaccines for prevention of flavivirus infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009192598A Division JP5236597B2 (ja) | 2001-04-04 | 2009-08-21 | フラビウイルス感染症の予防のための核酸ワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004532023A JP2004532023A (ja) | 2004-10-21 |
| JP2004532023A5 true JP2004532023A5 (https=) | 2008-01-10 |
| JP4448281B2 JP4448281B2 (ja) | 2010-04-07 |
Family
ID=25245753
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002579516A Expired - Lifetime JP4448281B2 (ja) | 2001-04-04 | 2002-04-04 | フラビウイルス感染症の予防のための核酸ワクチン |
| JP2009192598A Expired - Fee Related JP5236597B2 (ja) | 2001-04-04 | 2009-08-21 | フラビウイルス感染症の予防のための核酸ワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009192598A Expired - Fee Related JP5236597B2 (ja) | 2001-04-04 | 2009-08-21 | フラビウイルス感染症の予防のための核酸ワクチン |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US7227011B2 (https=) |
| EP (3) | EP2332572B1 (https=) |
| JP (2) | JP4448281B2 (https=) |
| KR (1) | KR100913984B1 (https=) |
| CN (2) | CN101002936A (https=) |
| BR (1) | BRPI0208301B8 (https=) |
| CA (1) | CA2443323C (https=) |
| MX (1) | MXPA03008838A (https=) |
| NZ (1) | NZ529106A (https=) |
| WO (1) | WO2002081754A1 (https=) |
| ZA (1) | ZA200307580B (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7227011B2 (en) * | 1998-06-04 | 2007-06-05 | United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Nucleic acid vaccines for prevention of flavivirus infection |
| US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| AU2001227889A1 (en) | 2000-01-14 | 2001-07-24 | The United States of America, represented by The Secretary, Department of Health & Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| US20050031641A1 (en) * | 2001-04-06 | 2005-02-10 | Loosmore Sheena May | Recombinant vaccine against West Nile Virus |
| FR2823222B1 (fr) * | 2001-04-06 | 2004-02-06 | Merial Sas | Vaccin contre le virus de la fievre du nil |
| US7740863B2 (en) * | 2001-04-06 | 2010-06-22 | Merial | Recombinant vaccine against West Nile Virus |
| US20040037848A1 (en) * | 2001-04-06 | 2004-02-26 | Audonnet Jean-Christophe Francis | Recombinant vaccine against West Nile Virus |
| US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
| HU228690B1 (en) * | 2001-07-27 | 2013-05-28 | Wyeth Corp | West nile vaccine |
| WO2003020884A2 (en) * | 2001-08-14 | 2003-03-13 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Method for rapid generation of mature dendritic cells |
| US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
| WO2003054161A2 (en) | 2001-12-20 | 2003-07-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS |
| AU2003263853A1 (en) * | 2002-08-16 | 2004-03-03 | Board Of Regents The University Of Texas System | Compositions and methods related to flavivirus envelope protein domain iii antigens |
| US8263091B2 (en) * | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
| EP1601947A2 (en) * | 2002-10-31 | 2005-12-07 | Health Research, Incorporated | Diagnostic test for west nile virus |
| JP5250179B2 (ja) | 2002-11-08 | 2013-07-31 | ザ アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド | フラビウイルス融合インヒビター |
| CA2432738A1 (en) * | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
| US8475808B2 (en) | 2003-05-23 | 2013-07-02 | Novartis Vaccines And Diagnostics, Inc. | Immunogenic reagents from west nile virus |
| US7060280B2 (en) * | 2003-06-11 | 2006-06-13 | Academia Sinica | Immunization against flavivirus |
| US7585621B2 (en) | 2003-09-09 | 2009-09-08 | Idexx Laboratories, Inc. | Detection of West Nile virus infection and vaccination |
| US7074555B2 (en) | 2004-04-28 | 2006-07-11 | Idexx Laboratories, Inc. | Detection of West Nile Virus |
| EP1742963A2 (en) * | 2004-05-04 | 2007-01-17 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Synthesis and purification of west nile virus virus-like particles |
| CN103088038B (zh) * | 2004-07-12 | 2015-06-24 | 美国天甲生物医药有限公司 | 黄病毒疫苗 |
| CA2576798C (en) | 2004-07-27 | 2014-09-09 | Gwong-Jen J. Chang | Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes and methods for their use |
| WO2006029300A2 (en) * | 2004-09-09 | 2006-03-16 | Research Development Foundation | Flavivirus variants having phenotypic variation and immunogenic compositions thereof |
| SG156666A1 (en) * | 2004-10-20 | 2009-11-26 | Acambis Inc | Vaccines against japanese encephalitis virus and west nile virus |
| WO2006107655A2 (en) * | 2005-04-01 | 2006-10-12 | Wyeth | Use of wnv dna vaccine in combination with a conventional vaccine to overcome immunogen interference |
| EP3311836A1 (en) | 2005-04-08 | 2018-04-25 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| CA2612047C (en) * | 2005-06-24 | 2015-05-12 | Intervet International B.V. | Inactivated chimeric vaccines and related methods of use |
| US7455842B2 (en) * | 2005-12-05 | 2008-11-25 | University Of Kansas | Chimeric West Nile viruses and uses thereof |
| US20070190617A1 (en) * | 2006-02-13 | 2007-08-16 | Chang-Jer Wu | DNA vaccine for Japanese encephalitis virus |
| US20080044808A1 (en) * | 2006-08-15 | 2008-02-21 | Qian-Li Song | West nile virus antigen and assay |
| ES2517615T3 (es) * | 2006-11-09 | 2014-11-03 | The United States Of America As Represented By The Secretary Of The Navy | Inducción de una respuesta inmunitaria frente al virus del dengue usando un enfoque de sensibilización-refuerzo |
| PL2308514T3 (pl) | 2007-03-23 | 2013-11-29 | To Bbb Holding B V | Koniugaty do ukierunkowanego dostarczania leku poprzez barierę krew-mózg |
| JP2008263964A (ja) * | 2007-03-29 | 2008-11-06 | Yamaguchi Univ | コウモリ由来細胞株 |
| EP2003144A1 (en) * | 2007-06-15 | 2008-12-17 | Institut Pasteur | Method for the diagnosis or the screening of an arbovirus infection, reagents useful in said method and their applications |
| WO2009024534A2 (en) * | 2007-08-17 | 2009-02-26 | Intercell Ag | Japanese encephalitis virus (jev) and tick-borne encephalitis virus (tbev) peptides stimulating human t cell responses |
| US8138318B2 (en) * | 2007-09-13 | 2012-03-20 | Abbott Laboratories | Hepatitis B pre-S2 nucleic acid |
| KR101686942B1 (ko) * | 2008-01-11 | 2016-12-28 | 이노비오 파마수티컬즈, 인크. | 뎅기 바이러스 다중 서브타입에 대항하는 신규한 백신 |
| WO2009098277A1 (en) * | 2008-02-08 | 2009-08-13 | Intercell Ag | Flaviviridae mutants comprising a deletion in the capsid protein for use as vaccines |
| US20110262472A1 (en) * | 2008-04-22 | 2011-10-27 | Cytos Biotechnology Ag | Vaccine compositions for the treatment of dengue fever and uses thereof |
| CN101333246B (zh) * | 2008-07-30 | 2011-04-13 | 中国农业科学院哈尔滨兽医研究所 | 乙型脑炎病毒e蛋白中和性b细胞抗原表位多肽及其应用 |
| AU2009287449B2 (en) | 2008-08-29 | 2015-04-30 | Boehringer Ingelheim Animal Health USA Inc. | West nile virus vaccine |
| CN101607983B (zh) * | 2009-07-29 | 2012-06-13 | 中国农业科学院哈尔滨兽医研究所 | 乙型脑炎病毒PrM/M蛋白B细胞抗原表位多肽及应用 |
| CA3150411C (en) | 2009-07-31 | 2023-09-12 | Pnuvax Inc. | High yield yellow fever virus strain with increased propagation in cells |
| US20110182976A1 (en) * | 2010-01-28 | 2011-07-28 | National Taiwan Ocean University | Lipoplex-patch based dna vaccine |
| WO2011146933A2 (en) | 2010-05-21 | 2011-11-24 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Universal dengue virus sequences and methods of use |
| AR079970A1 (es) * | 2010-07-23 | 2012-02-29 | Xcellerex Inc | Cepas de alto rendimiento del virus de la fiebre amarilla con una propagacion incrementada en las celulas |
| WO2012065105A2 (en) * | 2010-11-12 | 2012-05-18 | Thomas Monath | Chimeric flavivirus vaccines |
| BR112013023354B1 (pt) | 2011-03-14 | 2022-02-15 | Boehringer Ingelheim Animal Health Usa Inc | Composição imunogênica compreendendo cepas de vírus da rinite equina a (erav) e seu método de produção |
| EP3269728B1 (en) | 2011-10-20 | 2020-12-16 | The Government of The United States of America as represented by The Secretary, Department of Health and Human Services | Dengue virus e-glycoprotein polypeptides containing mutations that eliminate immunodominant cross-reactive epitopes |
| US8920804B2 (en) | 2011-12-22 | 2014-12-30 | Inbios International, Inc. | Methods and materials for the detection of dengue virus infection |
| AU2013295016A1 (en) * | 2012-07-24 | 2015-01-29 | Sanofi Pasteur | Vaccine compositions for prevention against dengue virus infection |
| TWI852899B (zh) | 2014-09-02 | 2024-08-21 | 法商賽諾菲巴斯德公司 | 疫苗組合物 |
| EP3031923A1 (en) * | 2014-12-11 | 2016-06-15 | Institut Pasteur | Lentiviral vector-based japanese encephalitis immunogenic composition |
| CN104630160B (zh) * | 2015-01-23 | 2018-04-27 | 中国农业科学院哈尔滨兽医研究所 | 表达西尼罗热病毒PrM/E蛋白的重组新城疫LaSota疫苗株 |
| EP3316905A1 (en) | 2015-07-03 | 2018-05-09 | Sanofi Pasteur | Concomitant dengue and yellow fever vaccination |
| MA42502A (fr) * | 2015-07-21 | 2018-05-30 | Modernatx Inc | Vaccins contre une maladie infectieuse |
| US10947277B2 (en) | 2016-06-13 | 2021-03-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nucleic acids encoding zika virus-like particles and their use in zika virus vaccines and diagnostic assays |
| US20180028643A1 (en) * | 2016-06-21 | 2018-02-01 | Brock Adam Kingstad-Bakke | Zika virus vaccines using virus-like particles |
| US10898566B2 (en) | 2016-09-19 | 2021-01-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Zika virus vaccines |
| WO2018091540A1 (en) * | 2016-11-17 | 2018-05-24 | Glaxosmithkline Biologicals Sa | Zika viral antigen constructs |
| WO2018152526A1 (en) | 2017-02-20 | 2018-08-23 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Zika virus vaccines |
| WO2019069130A1 (en) | 2017-10-05 | 2019-04-11 | Sanofi Pasteur | COMPOSITIONS FOR RECALL VACCINATION AGAINST DENGUE |
| EP3530668A1 (en) * | 2018-02-22 | 2019-08-28 | Euroimmun Medizinische Labordiagnostika AG | A novel assay for the diagnosis of viral infections |
| WO2019162454A1 (en) * | 2018-02-22 | 2019-08-29 | Euroimmun Medizinische Labordiagnostika Ag | Assay for the diagnosis of viral infections |
| CN113429479B (zh) * | 2018-04-04 | 2023-03-10 | 中国科学院微生物研究所 | 一种高灵敏度的黄热病毒人源单克隆抗体及其应用 |
| CN108904793B (zh) * | 2018-07-29 | 2021-03-30 | 首都医科大学附属北京友谊医院 | 预防流行性乙型脑炎的dna疫苗及其构建方法 |
| US12576144B2 (en) * | 2018-12-20 | 2026-03-17 | The Wistar Institute Of Anatomy And Biology | Vaccines against Powassan virus, and methods of using same |
| KR20220149907A (ko) * | 2019-12-18 | 2022-11-09 | 진원생명과학 주식회사 | 환자의 예방접종 및 치료를 위한 포와산(powassan) 바이러스 항원 및 관련 조성물, 및 그의 용도 |
| KR102216078B1 (ko) * | 2020-04-22 | 2021-02-16 | 국방과학연구소 | 유전자 백신으로 사용하기 위한 항원 유전자 전달용 발현 벡터 및 이를 포함하는 유전자 백신 |
| WO2021262659A1 (en) * | 2020-06-22 | 2021-12-30 | University Of Connecticut | Flavivirus signal peptides, vaccine constructs, and methods therefor |
| EP4612495A1 (en) * | 2022-11-02 | 2025-09-10 | Takeda Vaccines, Inc. | A method for determining the infectivity of a virus |
Family Cites Families (33)
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|---|---|---|---|---|
| FR1601438A (https=) | 1968-10-17 | 1970-08-24 | ||
| JPS53133627A (en) | 1977-04-25 | 1978-11-21 | Nippon Seibutsu Kagaku Kenkiyu | High purity deactivated vaccine for japanese encephalitis |
| JPH0768267B2 (ja) * | 1986-06-05 | 1995-07-26 | 財団法人阪大微生物病研究会 | フラビウイルス抗原 |
| JPS634895A (ja) | 1986-06-24 | 1988-01-09 | Mitsubishi Electric Corp | オゾン精製水供給装置 |
| JPS63105682A (ja) | 1986-10-23 | 1988-05-10 | Mitsubishi Kasei Corp | デングウイルス３型由来のｃＤＮＡ |
| FR2614219B1 (fr) | 1987-04-23 | 1993-07-09 | Materiels Annexes Dialyse | Procede de fabrication de granules destines a la preparation de solutions de dialyse et installation pour sa mise en oeuvre. |
| JPH084508B2 (ja) * | 1987-09-16 | 1996-01-24 | 国立予防衛生研究所長 | 組み換えワクチニアウイルス |
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| JP2511494B2 (ja) * | 1988-05-12 | 1996-06-26 | 善治 松浦 | 日本脳炎ウイルス表面抗原蛋白質の製造法 |
| IL91304A0 (en) | 1988-08-20 | 1990-03-19 | Us Health | Recombinant vaccinia virus for prevention of disease caused by flavivirus |
| JPH0425408A (ja) | 1990-05-21 | 1992-01-29 | Hitachi Ltd | ペレタイジングシステムの自動連続運転制御方法 |
| FR2665710A1 (fr) | 1990-08-10 | 1992-02-14 | Pasteur Institut | Baculovirus recombinant exprimant les proteines e et ns1 de virus appartenant aux flaviviridae ou de virus apparentes aux flaviviridae, applications diagnostiques et therapeutiques. |
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| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
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| JPH07265093A (ja) | 1994-03-30 | 1995-10-17 | Chemo Sero Therapeut Res Inst | 哺乳動物細胞を用いる日本脳炎ウイルス表面抗原蛋白質の製法 |
| DE69624815T2 (de) | 1995-05-24 | 2003-07-10 | Hawaii Biotech Group | Untereinheitsimpfstoff gegen flavivirus infektion |
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| ATE316796T1 (de) | 1997-11-20 | 2006-02-15 | Us Army Medical Res And Materi | Dna impfstoffe gegen zecken-flavivieren |
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| AU2002305028A1 (en) | 2001-02-28 | 2002-10-28 | Brown University Research Foundation | West nile virus epitopes and uses thereof |
| WO2002072036A2 (en) | 2001-03-12 | 2002-09-19 | Yale University | Compositions and methods comprising west nile virus polypeptides |
-
2001
- 2001-04-04 US US09/826,115 patent/US7227011B2/en not_active Expired - Lifetime
-
2002
- 2002-04-04 BR BR0208301-9 patent/BRPI0208301B8/pt not_active IP Right Cessation
- 2002-04-04 EP EP10177282.0A patent/EP2332572B1/en not_active Expired - Lifetime
- 2002-04-04 MX MXPA03008838A patent/MXPA03008838A/es active IP Right Grant
- 2002-04-04 JP JP2002579516A patent/JP4448281B2/ja not_active Expired - Lifetime
- 2002-04-04 EP EP02763960A patent/EP1383931A4/en not_active Withdrawn
- 2002-04-04 NZ NZ529106A patent/NZ529106A/en not_active IP Right Cessation
- 2002-04-04 CN CNA2007100020999A patent/CN101002936A/zh active Pending
- 2002-04-04 WO PCT/US2002/010764 patent/WO2002081754A1/en not_active Ceased
- 2002-04-04 EP EP08004141A patent/EP1935991B1/en not_active Expired - Lifetime
- 2002-04-04 KR KR1020037013021A patent/KR100913984B1/ko not_active Expired - Lifetime
- 2002-04-04 CA CA2443323A patent/CA2443323C/en not_active Expired - Lifetime
- 2002-04-04 US US10/500,796 patent/US7662394B2/en not_active Expired - Lifetime
- 2002-04-04 CN CNB02807758XA patent/CN1304575C/zh not_active Expired - Lifetime
-
2003
- 2003-09-29 ZA ZA2003/07580A patent/ZA200307580B/en unknown
-
2006
- 2006-06-14 US US11/424,138 patent/US7632510B2/en not_active Expired - Lifetime
- 2006-06-14 US US11/424,127 patent/US7521177B2/en not_active Expired - Fee Related
-
2009
- 2009-07-24 US US12/508,946 patent/US8232379B2/en not_active Expired - Fee Related
- 2009-08-21 JP JP2009192598A patent/JP5236597B2/ja not_active Expired - Fee Related
- 2009-10-15 US US12/580,080 patent/US8221768B2/en not_active Expired - Fee Related
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