JP2004531501A5 - - Google Patents
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- Publication number
- JP2004531501A5 JP2004531501A5 JP2002576253A JP2002576253A JP2004531501A5 JP 2004531501 A5 JP2004531501 A5 JP 2004531501A5 JP 2002576253 A JP2002576253 A JP 2002576253A JP 2002576253 A JP2002576253 A JP 2002576253A JP 2004531501 A5 JP2004531501 A5 JP 2004531501A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- alkoxy
- optionally substituted
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000002252 acyl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 6
- -1 hydroxy-phenylene Chemical group 0.000 claims 5
- 150000003839 salts Chemical group 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- WTYGESWNSUGPKO-HSZRJFAPSA-N (2r)-2-amino-2-ethyl-4-[3-methoxy-4-(4-phenylbutoxy)phenyl]butan-1-ol Chemical compound COC1=CC(CC[C@@](N)(CO)CC)=CC=C1OCCCCC1=CC=CC=C1 WTYGESWNSUGPKO-HSZRJFAPSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- CETMIEJVKCOWKS-HXUWFJFHSA-N (2r)-2-amino-2-methyl-4-[4-(3-phenylpropoxy)phenyl]butan-1-ol Chemical compound C1=CC(CC[C@@](N)(CO)C)=CC=C1OCCCC1=CC=CC=C1 CETMIEJVKCOWKS-HXUWFJFHSA-N 0.000 claims 1
- TTWYWDKXOGKVDD-HXUWFJFHSA-N (2r)-2-amino-4-[4-(3-cyclohexylpropoxy)phenyl]-2-methylbutan-1-ol Chemical compound C1=CC(CC[C@@](N)(CO)C)=CC=C1OCCCC1CCCCC1 TTWYWDKXOGKVDD-HXUWFJFHSA-N 0.000 claims 1
- UIFQPECWUIOGLQ-UHFFFAOYSA-N 1-[4-[3-amino-4-hydroxy-3-(hydroxymethyl)butyl]phenyl]-5-cyclohexylpentan-1-one Chemical compound C1=CC(CCC(CO)(CO)N)=CC=C1C(=O)CCCCC1CCCCC1 UIFQPECWUIOGLQ-UHFFFAOYSA-N 0.000 claims 1
- FROOZUIUGSQXIX-JOCHJYFZSA-N [(2r)-2-amino-2-methyl-4-[4-(5-phenylpentoxy)phenyl]butyl] dihydrogen phosphate Chemical compound C1=CC(CC[C@](N)(C)COP(O)(O)=O)=CC=C1OCCCCCC1=CC=CC=C1 FROOZUIUGSQXIX-JOCHJYFZSA-N 0.000 claims 1
- XGJCXFMLNLXLFE-UHFFFAOYSA-N [2-amino-2-(hydroxymethyl)-4-[4-(5-phenylpentanoyl)phenyl]butyl] dihydrogen phosphate Chemical compound C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCC1=CC=CC=C1 XGJCXFMLNLXLFE-UHFFFAOYSA-N 0.000 claims 1
- HZRGEJWFLNYLGP-UHFFFAOYSA-N [2-amino-2-(hydroxymethyl)-4-[4-(7-phenylheptanoyl)phenyl]butyl] dihydrogen phosphate Chemical class C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCCCC1=CC=CC=C1 HZRGEJWFLNYLGP-UHFFFAOYSA-N 0.000 claims 1
- HNYWOJFTDKYXMR-UHFFFAOYSA-N [2-amino-4-[4-(5-cyclohexylpentanoyl)phenyl]-2-(hydroxymethyl)butyl] dihydrogen phosphate Chemical compound C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCC1CCCCC1 HNYWOJFTDKYXMR-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000004115 pentoxy group Chemical group [*]OC([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0107507A GB0107507D0 (en) | 2001-03-26 | 2001-03-26 | Organic compounds |
| GB0107506A GB0107506D0 (en) | 2001-03-26 | 2001-03-26 | Organic compounds |
| GB0108346A GB0108346D0 (en) | 2001-04-03 | 2001-04-03 | Organic compounds |
| PCT/EP2002/003389 WO2002076995A2 (en) | 2001-03-26 | 2002-03-26 | 2-amino-propanol derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004531501A JP2004531501A (ja) | 2004-10-14 |
| JP2004531501A5 true JP2004531501A5 (OSRAM) | 2005-06-02 |
| JP4012823B2 JP4012823B2 (ja) | 2007-11-21 |
Family
ID=27256123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576253A Expired - Fee Related JP4012823B2 (ja) | 2001-03-26 | 2002-03-26 | ２−アミノ−誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7326801B2 (OSRAM) |
| EP (1) | EP1377593B1 (OSRAM) |
| JP (1) | JP4012823B2 (OSRAM) |
| KR (1) | KR20030093279A (OSRAM) |
| CN (1) | CN1620461A (OSRAM) |
| AT (1) | ATE314383T1 (OSRAM) |
| BR (1) | BR0208365A (OSRAM) |
| CA (1) | CA2442178A1 (OSRAM) |
| CZ (1) | CZ20032560A3 (OSRAM) |
| DE (1) | DE60208355T2 (OSRAM) |
| DK (1) | DK1377593T3 (OSRAM) |
| ES (1) | ES2254675T3 (OSRAM) |
| IL (1) | IL157773A0 (OSRAM) |
| MX (1) | MXPA03008755A (OSRAM) |
| NO (1) | NO20034291L (OSRAM) |
| PL (1) | PL367348A1 (OSRAM) |
| SK (1) | SK11942003A3 (OSRAM) |
| WO (1) | WO2002076995A2 (OSRAM) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE435202T1 (de) | 2002-01-11 | 2009-07-15 | Daiichi Sankyo Co Ltd | Aminoalkoholderivat oder phosphonsäurederivat und diese enthaltende medizinische zusammensetzung |
| BR0311173A (pt) | 2002-05-16 | 2005-03-15 | Novartis Ag | Uso de agentes de ligação do receptor de edg em câncer |
| RU2358717C2 (ru) * | 2002-05-16 | 2009-06-20 | Новартис Аг | Применение средств, связывающих edg-рецептор, в лечении ракового заболевания |
| GB0217152D0 (en) * | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| EP1546110A4 (en) | 2002-07-30 | 2008-03-26 | Univ Virginia | COMPOUNDS WITH EFFECT ON SIGNAL TRANSMISSION BY SPHINGOSINE-1-PHOSPHATE |
| AU2003273865A1 (en) | 2002-09-13 | 2004-04-30 | Novartis Ag | Amino-propanol derivatives |
| JP4571497B2 (ja) | 2002-09-19 | 2010-10-27 | 杏林製薬株式会社 | アミノアルコール誘導体とその付加塩及び免疫抑制剤 |
| RU2391094C2 (ru) | 2002-09-24 | 2010-06-10 | Новартис Аг | Применение агониста рецептора s1p и способ лечения, облегчения или задержки прогрессирования неврита зрительного нерва или демиелинизационных заболеваний |
| EP1594508B1 (en) * | 2003-02-11 | 2012-08-08 | Irm Llc | Novel bicyclic compounds and compositions |
| AU2004213297B2 (en) | 2003-02-18 | 2009-03-19 | Kyorin Pharmaceutical Co., Ltd. | Aminophosphonic acid derivatives, addition salts thereof and S1P receptor modulators |
| GB2400318B (en) | 2003-04-08 | 2005-08-10 | Novartis Ag | Pharmaceutical composition comprising an S1P receptor agonist |
| ES2383298T3 (es) * | 2003-04-30 | 2012-06-20 | Novartis Ag | Derivados del amino-propanol como moduladores del receptor esfingosina-1-fosfato |
| BRPI0409977A (pt) * | 2003-04-30 | 2006-05-09 | Novartis Ag | derivados de aminopropanol como moduladores de receptores esfingosina-1-fosfato |
| GB0313612D0 (en) * | 2003-06-12 | 2003-07-16 | Novartis Ag | Organic compounds |
| EP1660449B1 (en) * | 2003-08-28 | 2009-11-18 | Novartis AG | Aminopropanol derivatives |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| WO2005041899A2 (en) | 2003-11-03 | 2005-05-12 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
| WO2005044780A1 (ja) * | 2003-11-10 | 2005-05-19 | Kyorin Pharmaceutical Co., Ltd. | アミノカルボン酸誘導体とその付加塩及びｓ１ｐ受容体調節剤 |
| GB0329498D0 (en) * | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
| GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| CN1921847B (zh) | 2004-02-24 | 2010-06-16 | 三共株式会社 | 氨基醇化合物 |
| GB0405289D0 (en) | 2004-03-09 | 2004-04-21 | Novartis Ag | Organic compounds |
| BRPI0510627A (pt) * | 2004-05-03 | 2007-10-30 | Novartis Ag | combinações que compreendem um agonista do receptor s1p e um inibidor da jak3 quinase |
| GB0411929D0 (en) | 2004-05-27 | 2004-06-30 | Novartis Ag | Organic compounds |
| SI1772145T1 (sl) * | 2004-07-16 | 2011-06-30 | Kyorin Seiyaku Kk | Postopek za učinkovito uporabo zdravila in postopek za preprečevanje stranskih učinkov |
| PT1773307E (pt) | 2004-07-30 | 2015-01-14 | Novartis Ag | Formulações de compostos à base de 2-amino-1,3- propanodiol |
| JP2008509931A (ja) | 2004-08-13 | 2008-04-03 | プレーシス ファーマスーティカルズ インコーポレイテッド | スフィンゴシン−１−ホスフェート（ｓ１ｐ）レセプター活性を調節するための方法および組成物 |
| PT2511262T (pt) * | 2004-10-12 | 2017-03-30 | Kyorin Seiyaku Kk | Processo para a produção de cloridrato de 2-amino-2-[2-[4-(3- benziloxi-feniltio)-2-clorofenil[etil]-1,3-propanodiol |
| KR20130041385A (ko) | 2004-11-29 | 2013-04-24 | 노파르티스 아게 | Ｓ１ｐ 수용체 효능제의 투여 용법 |
| BRPI0607435A2 (pt) | 2005-02-14 | 2010-04-06 | Univ Virginia | composto ou um sal ou éster farmaceuticamente aceitável do mesmo, e, uso de um composto |
| GB0504544D0 (en) * | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| EA013816B1 (ru) | 2005-09-01 | 2010-08-30 | Арес Трейдинг С.А. | Лечение неврита зрительного нерва |
| WO2007043433A1 (ja) * | 2005-10-07 | 2007-04-19 | Kyorin Pharmaceutical Co., Ltd. | ２－アミノ－１，３－プロパンジオール誘導体を有効成分とする肝臓疾患治療剤および肝臓疾患治療方法 |
| ES2369520T3 (es) * | 2005-12-15 | 2011-12-01 | Mitsubishi Tanabe Pharma Corporation | Compuesto amínico y su uso para propósitos médicos. |
| EP1986623A2 (en) | 2006-01-27 | 2008-11-05 | University Of Virginia Patent Foundation | Method for treatment of neuropathic pain |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| JP2009526073A (ja) | 2006-02-09 | 2009-07-16 | ユニバーシティ オブ バージニア パテント ファンデーション | 二環式スフィンゴシン−１−リン酸受容体アナログ |
| KR101059593B1 (ko) | 2006-04-11 | 2011-08-25 | 노파르티스 아게 | Ｈｃｖ/ｈｉｖ 억제제 및 이들의 용도 |
| SG174029A1 (en) * | 2006-08-08 | 2011-09-29 | Kyorin Seiyaku Kk | Aminoalcohol derivative and immunosuppressant containing the same as active ingredient |
| SG174028A1 (en) * | 2006-08-08 | 2011-09-29 | Kyorin Seiyaku Kk | Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient |
| EP2097371A2 (en) | 2006-11-21 | 2009-09-09 | University Of Virginia Patent Foundation | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity |
| JP2010510250A (ja) | 2006-11-21 | 2010-04-02 | ユニバーシティ オブ バージニア パテント ファンデーション | スフィンゴシン＝１−燐酸受容体アゴニスト活性を有するヒドリンダンアナログ |
| NZ576893A (en) | 2006-11-21 | 2012-01-12 | Univ Virginia Patent Found | Tetralin analogs having sphingosine 1-phosphate agonist activity |
| WO2008153159A1 (ja) | 2007-06-14 | 2008-12-18 | Mitsubishi Tanabe Pharma Corporation | アミン化合物及びその医薬用途 |
| JP5452237B2 (ja) * | 2008-02-07 | 2014-03-26 | 杏林製薬株式会社 | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
| EA201390532A1 (ru) | 2010-10-08 | 2013-09-30 | Новартис Аг | Композиции сульфамидых ингибиторов ns3, содержащие витамин е |
| GB201715786D0 (en) | 2017-09-29 | 2017-11-15 | Univ College Cardiff Consultants Ltd | Compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0627406T3 (da) | 1992-10-21 | 1999-07-12 | Taito Co | 2-Amino-1,3-propandiolforbindelser og immunundertrykkende midler |
| ES2065855B1 (es) * | 1993-05-31 | 1995-09-01 | Menarini Lab | Procedimiento para la preparacion de nuevos derivados desoxiazafosfolipidicos con accion inhibidora de la fosfolipasa a2, nuevos derivados desoxiazafosfolipidicos obtenidos y utilizacion de los mismos. |
| ATE211726T1 (de) * | 1994-08-22 | 2002-01-15 | Welfide Corp | Benzolderivate und deren medizinische verwendung |
| DK1319651T3 (da) * | 1997-04-04 | 2005-08-01 | Mitsubishi Pharma Corp | 2-aminopropan-1,3-diolforbindelser, medicinsk anvendelse deraf og mellemprodukter til syntese af disse |
| SK152003A3 (en) | 2000-07-13 | 2004-07-07 | Sankyo Co | Amino alcohol derivatives |
| JP2004507552A (ja) | 2000-08-31 | 2004-03-11 | メルク エンド カムパニー インコーポレーテッド | 免疫調節剤としてのリン酸誘導体 |
-
2002
- 2002-03-26 PL PL02367348A patent/PL367348A1/xx not_active Application Discontinuation
- 2002-03-26 BR BR0208365-5A patent/BR0208365A/pt not_active Application Discontinuation
- 2002-03-26 EP EP02727484A patent/EP1377593B1/en not_active Expired - Lifetime
- 2002-03-26 JP JP2002576253A patent/JP4012823B2/ja not_active Expired - Fee Related
- 2002-03-26 WO PCT/EP2002/003389 patent/WO2002076995A2/en not_active Ceased
- 2002-03-26 AT AT02727484T patent/ATE314383T1/de active
- 2002-03-26 ES ES02727484T patent/ES2254675T3/es not_active Expired - Lifetime
- 2002-03-26 DE DE60208355T patent/DE60208355T2/de not_active Expired - Lifetime
- 2002-03-26 SK SK1194-2003A patent/SK11942003A3/sk unknown
- 2002-03-26 MX MXPA03008755A patent/MXPA03008755A/es unknown
- 2002-03-26 CA CA002442178A patent/CA2442178A1/en not_active Abandoned
- 2002-03-26 IL IL15777302A patent/IL157773A0/xx unknown
- 2002-03-26 CZ CZ20032560A patent/CZ20032560A3/cs unknown
- 2002-03-26 US US10/472,127 patent/US7326801B2/en not_active Expired - Fee Related
- 2002-03-26 KR KR10-2003-7012474A patent/KR20030093279A/ko not_active Ceased
- 2002-03-26 CN CNA028068378A patent/CN1620461A/zh active Pending
- 2002-03-26 DK DK02727484T patent/DK1377593T3/da active
-
2003
- 2003-09-25 NO NO20034291A patent/NO20034291L/no not_active Application Discontinuation
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