JP2004529926A5 - - Google Patents
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- Publication number
- JP2004529926A5 JP2004529926A5 JP2002581427A JP2002581427A JP2004529926A5 JP 2004529926 A5 JP2004529926 A5 JP 2004529926A5 JP 2002581427 A JP2002581427 A JP 2002581427A JP 2002581427 A JP2002581427 A JP 2002581427A JP 2004529926 A5 JP2004529926 A5 JP 2004529926A5
- Authority
- JP
- Japan
- Prior art keywords
- het
- pyridin
- cyclopentylamino
- pyrazolo
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- FPZNHXIUFKJEHG-UHFFFAOYSA-N 3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)-n-(2-methoxyethyl)pyrazolo[1,5-a]pyridin-5-amine Chemical compound C=12C=C(NCCOC)C=CN2N=C(C=2C=CC(F)=CC=2)C=1C(N=1)=CC=NC=1NC1CCCC1 FPZNHXIUFKJEHG-UHFFFAOYSA-N 0.000 claims 1
- FDXDGPUMMWYVHH-UHFFFAOYSA-N 3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)-n-propan-2-ylpyrazolo[1,5-a]pyridin-5-amine Chemical compound C=12C=C(NC(C)C)C=CN2N=C(C=2C=CC(F)=CC=2)C=1C(N=1)=CC=NC=1NC1CCCC1 FDXDGPUMMWYVHH-UHFFFAOYSA-N 0.000 claims 1
- ZBASGXKVNVIJCM-UHFFFAOYSA-N 3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)-n-propan-2-ylpyrazolo[1,5-a]pyridin-6-amine Chemical compound N=1N2C=C(NC(C)C)C=CC2=C(C=2N=C(NC3CCCC3)N=CC=2)C=1C1=CC=C(F)C=C1 ZBASGXKVNVIJCM-UHFFFAOYSA-N 0.000 claims 1
- OUZIVEFGDDPQGR-UHFFFAOYSA-N 3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-5-amine Chemical compound C=12C=C(N)C=CN2N=C(C=2C=CC(F)=CC=2)C=1C(N=1)=CC=NC=1NC1CCCC1 OUZIVEFGDDPQGR-UHFFFAOYSA-N 0.000 claims 1
- FEIKULOVKMOBGQ-UHFFFAOYSA-N 3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-amine Chemical compound N=1N2C=C(N)C=CC2=C(C=2N=C(NC3CCCC3)N=CC=2)C=1C1=CC=C(F)C=C1 FEIKULOVKMOBGQ-UHFFFAOYSA-N 0.000 claims 1
- RMANLZQDOIEBGU-UHFFFAOYSA-N 3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-methoxyphenyl)-n-propan-2-ylpyrazolo[1,5-a]pyridin-5-amine Chemical compound C1=CC(OC)=CC=C1C1=NN(C=CC(NC(C)C)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 RMANLZQDOIEBGU-UHFFFAOYSA-N 0.000 claims 1
- NUKYEHFDVLNGFZ-UHFFFAOYSA-N 4-[5-(cyclopentylamino)-3-[2-(cyclopentylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-2-yl]phenol Chemical compound C1=CC(O)=CC=C1C1=NN(C=CC(NC2CCCC2)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 NUKYEHFDVLNGFZ-UHFFFAOYSA-N 0.000 claims 1
- HZRFMJKFCUASOU-UHFFFAOYSA-N 4-bromo-n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-5-amine Chemical compound C1=CC(F)=CC=C1C1=NN(C=CC(NC2CCCC2)=C2Br)C2=C1C1=CC=NC(NC2CCCC2)=N1 HZRFMJKFCUASOU-UHFFFAOYSA-N 0.000 claims 1
- KCKHDUBDEHXGJB-UHFFFAOYSA-N 4-bromo-n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-5-amine Chemical compound C1=CC(OC)=CC=C1C1=NN(C=CC(NC2CCCC2)=C2Br)C2=C1C1=CC=NC(NC2CCCC2)=N1 KCKHDUBDEHXGJB-UHFFFAOYSA-N 0.000 claims 1
- KOWHYEFJCNLWGI-UHFFFAOYSA-N 4-chloro-n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-5-amine Chemical compound C1=CC(F)=CC=C1C1=NN(C=CC(NC2CCCC2)=C2Cl)C2=C1C1=CC=NC(NC2CCCC2)=N1 KOWHYEFJCNLWGI-UHFFFAOYSA-N 0.000 claims 1
- WHOWUHRMZQLXRB-UHFFFAOYSA-N 4-chloro-n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-5-amine Chemical compound C1=CC(OC)=CC=C1C1=NN(C=CC(NC2CCCC2)=C2Cl)C2=C1C1=CC=NC(NC2CCCC2)=N1 WHOWUHRMZQLXRB-UHFFFAOYSA-N 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 208000029433 Herpesviridae infectious disease Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- SQOVLUIXVMRKMK-UHFFFAOYSA-N n-[3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-5-yl]methanesulfonamide Chemical compound C=12C=C(NS(=O)(=O)C)C=CN2N=C(C=2C=CC(F)=CC=2)C=1C(N=1)=CC=NC=1NC1CCCC1 SQOVLUIXVMRKMK-UHFFFAOYSA-N 0.000 claims 1
- LNVZHPGLGRXNAI-UHFFFAOYSA-N n-butyl-3-[2-(butylamino)pyridin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-4-amine Chemical compound C1=NC(NCCCC)=CC(C2=C3C(NCCCC)=CC=CN3N=C2C=2C=CC(F)=CC=2)=C1 LNVZHPGLGRXNAI-UHFFFAOYSA-N 0.000 claims 1
- SQQVANPMGGBYDX-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-5-amine Chemical compound C1=CC(F)=CC=C1C1=NN(C=CC(NC2CCCC2)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 SQQVANPMGGBYDX-UHFFFAOYSA-N 0.000 claims 1
- XDGMTTPBMWQFBC-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-amine Chemical compound C1=CC(F)=CC=C1C1=NN(C=C(NC2CCCC2)C=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 XDGMTTPBMWQFBC-UHFFFAOYSA-N 0.000 claims 1
- URUUOQUMOPTRRE-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-5-amine Chemical compound C1=CC(OC)=CC=C1C1=NN(C=CC(NC2CCCC2)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 URUUOQUMOPTRRE-UHFFFAOYSA-N 0.000 claims 1
- NLKACQGBKCKERK-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-[4-(2-methylpropoxy)phenyl]pyrazolo[1,5-a]pyridin-5-amine Chemical compound C1=CC(OCC(C)C)=CC=C1C1=NN(C=CC(NC2CCCC2)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 NLKACQGBKCKERK-UHFFFAOYSA-N 0.000 claims 1
- GBVRWXQLLMGEQJ-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-[4-(cyclopropylmethoxy)phenyl]pyrazolo[1,5-a]pyridin-5-amine Chemical compound C1CC1COC(C=C1)=CC=C1C(C(=C1C=2)C=3N=C(NC4CCCC4)N=CC=3)=NN1C=CC=2NC1CCCC1 GBVRWXQLLMGEQJ-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28274901P | 2001-04-10 | 2001-04-10 | |
| PCT/US2002/008793 WO2002083672A1 (en) | 2001-04-10 | 2002-03-21 | Antiviral pyrazolopyridine compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004529926A JP2004529926A (ja) | 2004-09-30 |
| JP2004529926A5 true JP2004529926A5 (https=) | 2005-07-28 |
| JP4219171B2 JP4219171B2 (ja) | 2009-02-04 |
Family
ID=23082954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002581427A Expired - Fee Related JP4219171B2 (ja) | 2001-04-10 | 2002-03-21 | 抗ウイルス性ピラゾロピリジン化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7141569B2 (https=) |
| EP (1) | EP1377575B1 (https=) |
| JP (1) | JP4219171B2 (https=) |
| AT (1) | ATE332301T1 (https=) |
| DE (1) | DE60212949T2 (https=) |
| ES (1) | ES2266487T3 (https=) |
| WO (1) | WO2002083672A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60220525T2 (de) * | 2001-09-07 | 2008-02-07 | Smithkline Beecham Corp. | Pyrazolo-pyridine für die behandlung von herpes-ansteckungen |
| AU2003217712A1 (en) | 2002-03-07 | 2003-09-22 | Smithkline Beecham Corporation | Pyrazolopyrimidine and pyrazolotriazine derivatives and pharmaceutical compositions containing them |
| US7153863B2 (en) * | 2002-10-03 | 2006-12-26 | Smithkline Beecham Corporation | Therapeutic compounds based on pyrazolopyridline derivatives |
| US7812022B2 (en) * | 2004-12-21 | 2010-10-12 | Glaxosmithkline Llc | 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors |
| CN101326182B (zh) * | 2005-12-05 | 2011-09-28 | 史密丝克莱恩比彻姆公司 | 2-嘧啶基吡唑并吡啶ErbB激酶抑制剂 |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| EP2402335A1 (en) | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
| EP2402336A1 (en) | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
| KR102431436B1 (ko) | 2014-08-29 | 2022-08-10 | 테스 파마 에스.알.엘. | α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제 |
| WO2017041005A1 (en) | 2015-09-03 | 2017-03-09 | Abbott Molecular Inc. | Hybridization buffers comprising an alkyl diester |
| EP3365340B1 (en) | 2015-10-19 | 2022-08-10 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20170145025A1 (en) | 2015-11-19 | 2017-05-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2916874T3 (es) | 2015-12-17 | 2022-07-06 | Incyte Corp | Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1 |
| AU2016379372A1 (en) | 2015-12-22 | 2018-08-02 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| CN108779490A (zh) * | 2016-01-08 | 2018-11-09 | 雅培分子公司 | 包含硫氰酸胍的杂交缓冲液 |
| ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| ES2905980T3 (es) | 2016-05-26 | 2022-04-12 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| BR112018076534A2 (pt) | 2016-06-20 | 2019-04-02 | Incyte Corporation | compostos heterocíclicos como imunomoduladores |
| MA45669A (fr) | 2016-07-14 | 2019-05-22 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| ES2941716T3 (es) | 2016-08-29 | 2023-05-25 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| ES2899402T3 (es) | 2016-12-22 | 2022-03-11 | Incyte Corp | Derivados de piridina como inmunomoduladores |
| WO2018119286A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
| ES2874756T3 (es) | 2016-12-22 | 2021-11-05 | Incyte Corp | Derivados de triazolo[1,5-A]piridina como inmunomoduladores |
| EP3558990B1 (en) | 2016-12-22 | 2022-08-10 | Incyte Corporation | Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers |
| AU2017382870B2 (en) | 2016-12-22 | 2022-03-24 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
| CR20200520A (es) | 2018-03-30 | 2021-03-09 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| WO2019217821A1 (en) | 2018-05-11 | 2019-11-14 | Incyte Corporation | Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators |
| EP4010342A1 (en) | 2019-08-09 | 2022-06-15 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
| WO2021067217A1 (en) | 2019-09-30 | 2021-04-08 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
| BR112022009031A2 (pt) | 2019-11-11 | 2022-10-11 | Incyte Corp | Sais e formas cristalinas de um inibidor de pd-1/pd-l1 |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| WO2022099075A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Crystalline form of a pd-1/pd-l1 inhibitor |
| US11866434B2 (en) | 2020-11-06 | 2024-01-09 | Incyte Corporation | Process for making a PD-1/PD-L1 inhibitor and salts and crystalline forms thereof |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5200478A (en) * | 1983-04-04 | 1993-04-06 | Solvay S.A. | Method for activating supported chromium oxide catalysts and olefin polymerization process carried out therewith |
| EP0151962A3 (en) | 1984-01-25 | 1985-10-02 | Beecham Group Plc | Pyrazolopyridine derivatives |
| GB8404586D0 (en) | 1984-02-22 | 1984-03-28 | Beecham Group Plc | Compounds |
| GB8404584D0 (en) | 1984-02-22 | 1984-03-28 | Beecham Group Plc | Compounds |
| US5002941A (en) | 1985-12-12 | 1991-03-26 | Smithkline Beecham Corporation | Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors |
| US4925849A (en) * | 1987-06-15 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutically useful pyrazolopyridines |
| US5541188A (en) * | 1987-09-15 | 1996-07-30 | The Rowett Research Institute | Therapeutic applications of beta-adrenergic agonists |
| US5155114A (en) * | 1989-01-23 | 1992-10-13 | Fujisawa Pharmaceutical Company, Ltd. | Method of treatment using pyrazolopyridine compound |
| GB8901423D0 (en) * | 1989-01-23 | 1989-03-15 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| KR920702621A (ko) | 1989-06-13 | 1992-10-06 | 스튜어트 알. 슈터 | 단핵세포 및/또는 마크로파지에 의한 인터루킨-1 또는 종양회사인자 생성의 억제 |
| AU622330B2 (en) | 1989-06-23 | 1992-04-02 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides |
| KR930700104A (ko) | 1990-06-12 | 1993-03-13 | 원본미기재 | 5-리프옥시게나제 및 사이클로옥시게나제 경로 개재된 질병의 억제 |
| GB9015764D0 (en) | 1990-07-18 | 1990-09-05 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| DE69232323T2 (de) | 1991-01-29 | 2002-08-08 | Fujisawa Pharmaceutical Co., Ltd. | Verwendung von Adenosinantagonisten zur Vorbeugung und Behandlung von Pankreatitis und Ulcera |
| GB9107513D0 (en) | 1991-04-10 | 1991-05-29 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| US5300478A (en) * | 1993-01-28 | 1994-04-05 | Zeneca Limited | Substituted fused pyrazolo compounds |
| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| AU694157B2 (en) * | 1993-12-29 | 1998-07-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine adenosine antagonists |
| US5521213A (en) | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
| US5552422A (en) * | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
| EA199700209A1 (ru) | 1995-04-04 | 1998-04-30 | Глаксо Груп Лимитед | ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-a]ПИРИДИНА |
| WO1996041645A1 (en) | 1995-06-12 | 1996-12-27 | G.D. Searle & Co. | Combination of a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist for the treatment of inflammations |
| DE69635048T2 (de) | 1995-06-12 | 2006-02-16 | G.D. Searle & Co. | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
| US5700816A (en) * | 1995-06-12 | 1997-12-23 | Isakson; Peter C. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor |
| FR2757059B1 (fr) | 1996-12-12 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouvelle application therapeutique des derives du pyrrole |
| FR2757166B1 (fr) | 1996-12-12 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| CA2294057A1 (en) | 1997-06-13 | 1998-12-17 | Smithkline Beecham Corporation | Novel pyrazole and pyrazoline substituted compounds |
| ES2256817T3 (es) | 1997-09-05 | 2006-07-16 | Glaxo Group Limited | Composiciones farmaceuticas que comprenden derivados de 2,3-diaril-pirazolo(1,5-b)piridazina. |
| WO1999058523A1 (en) | 1998-05-14 | 1999-11-18 | G.D. Searle & Co. | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
| US6245789B1 (en) | 1998-05-19 | 2001-06-12 | The Procter & Gamble Company | HIV and viral treatment |
| FR2779724B1 (fr) | 1998-06-10 | 2001-04-20 | Rhone Poulenc Rorer Sa | Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| HUP0104204A3 (en) | 1998-11-03 | 2002-06-28 | Glaxo Group Ltd | Pyrazolopyridine derivatives as cox-2 inhibitors, process for their preparation and pharmaceutical compositions thereof |
| US6498166B1 (en) | 1999-02-27 | 2002-12-24 | Smithkline Beecham Corporation | Pyrazolopyridines |
| EE04592B1 (et) | 1999-06-28 | 2006-02-15 | Janssen Pharmaceutica N.V. | Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt |
| GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| AUPQ969800A0 (en) * | 2000-08-28 | 2000-09-21 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine compound and pharmaceutical use thereof |
| EP1341788B1 (en) | 2000-12-15 | 2005-08-10 | Glaxo Group Limited | Pyrazolopyridines |
| DE60112330T2 (de) | 2000-12-15 | 2006-04-13 | Glaxo Group Ltd., Greenford | Pyrazolopyridinderivate |
| GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| WO2002078701A1 (en) * | 2001-03-30 | 2002-10-10 | Smithkline Beecham Corporation | Use of pyrazolopyridines as therapeutic compounds |
| US7034030B2 (en) * | 2001-03-30 | 2006-04-25 | Smithkline Beecham Corporation | Pyralopyridines, process for their preparation and use as therapeutic compounds |
| ATE296826T1 (de) * | 2001-04-27 | 2005-06-15 | Smithkline Beecham Corp | Pyrazolo(1,5)pyridinderivate |
| CA2450555A1 (en) | 2001-06-25 | 2003-01-03 | Merck & Co., Inc. | (pyrimidyl)(phenyl)substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds |
-
2002
- 2002-03-21 JP JP2002581427A patent/JP4219171B2/ja not_active Expired - Fee Related
- 2002-03-21 EP EP02723554A patent/EP1377575B1/en not_active Expired - Lifetime
- 2002-03-21 DE DE60212949T patent/DE60212949T2/de not_active Expired - Fee Related
- 2002-03-21 ES ES02723554T patent/ES2266487T3/es not_active Expired - Lifetime
- 2002-03-21 WO PCT/US2002/008793 patent/WO2002083672A1/en not_active Ceased
- 2002-03-21 AT AT02723554T patent/ATE332301T1/de not_active IP Right Cessation
- 2002-03-21 US US10/473,491 patent/US7141569B2/en not_active Expired - Fee Related
-
2006
- 2006-06-06 US US11/422,357 patent/US20060235043A1/en not_active Abandoned
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