JP2004528304A5 - - Google Patents
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- Publication number
- JP2004528304A5 JP2004528304A5 JP2002571049A JP2002571049A JP2004528304A5 JP 2004528304 A5 JP2004528304 A5 JP 2004528304A5 JP 2002571049 A JP2002571049 A JP 2002571049A JP 2002571049 A JP2002571049 A JP 2002571049A JP 2004528304 A5 JP2004528304 A5 JP 2004528304A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- group
- compound
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(CC(C1)(C2)C1C1)(C*21O)C(Nc1ccc(-c2nc(cc(cc3)C(Nc4ncccc4)=O)c3[n]2)c(F)c1)=O Chemical compound CC(CC(C1)(C2)C1C1)(C*21O)C(Nc1ccc(-c2nc(cc(cc3)C(Nc4ncccc4)=O)c3[n]2)c(F)c1)=O 0.000 description 6
- HZNGDHSYSASUQR-UHFFFAOYSA-N C=C1C(CC(C=C2)C(CC(CC3)=CC=C3F)=O)=C2NC1c(cc1)ccc1C(c(cc1)ccc1O)=O Chemical compound C=C1C(CC(C=C2)C(CC(CC3)=CC=C3F)=O)=C2NC1c(cc1)ccc1C(c(cc1)ccc1O)=O HZNGDHSYSASUQR-UHFFFAOYSA-N 0.000 description 1
- RXDOEJLOWQNIDV-UHFFFAOYSA-N CC(OC(CC(C1)C2)(CC1C1)CC21C(Nc(cc1)ccc1-c1nc(cc(cc2)C(Nc3ncccc3)=O)c2[nH]1)=O)=O Chemical compound CC(OC(CC(C1)C2)(CC1C1)CC21C(Nc(cc1)ccc1-c1nc(cc(cc2)C(Nc3ncccc3)=O)c2[nH]1)=O)=O RXDOEJLOWQNIDV-UHFFFAOYSA-N 0.000 description 1
- CHFMPFZRYQHSLK-UHFFFAOYSA-N CCC(C1)(CC(CC)=CC1(C)C(Nc(cc1)cc(F)c1-c1nc(cc(cc2)C(Nc3ncccc3)=O)c2[nH]1)=O)OC(C)=O Chemical compound CCC(C1)(CC(CC)=CC1(C)C(Nc(cc1)cc(F)c1-c1nc(cc(cc2)C(Nc3ncccc3)=O)c2[nH]1)=O)OC(C)=O CHFMPFZRYQHSLK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27526001P | 2001-03-12 | 2001-03-12 | |
| US10/090,044 US6759425B2 (en) | 1999-10-21 | 2002-02-27 | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| PCT/US2002/006801 WO2002072090A1 (en) | 2001-03-12 | 2002-02-28 | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004528304A JP2004528304A (ja) | 2004-09-16 |
| JP2004528304A5 true JP2004528304A5 (enExample) | 2006-01-05 |
Family
ID=34115140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002571049A Pending JP2004528304A (ja) | 2001-03-12 | 2002-02-28 | ＩｇＥを調節し、細胞増殖を阻害するためのベンゾイミダゾール化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7282518B2 (enExample) |
| EP (1) | EP1368028B1 (enExample) |
| JP (1) | JP2004528304A (enExample) |
| CN (1) | CN1496257A (enExample) |
| AR (1) | AR034023A1 (enExample) |
| AT (1) | ATE369853T1 (enExample) |
| BR (1) | BR0208010A (enExample) |
| CA (1) | CA2441177A1 (enExample) |
| CZ (1) | CZ20032691A3 (enExample) |
| DE (1) | DE60221804T2 (enExample) |
| DK (1) | DK1368028T3 (enExample) |
| ES (1) | ES2291455T3 (enExample) |
| HU (1) | HUP0303460A3 (enExample) |
| MX (1) | MXJL03000027A (enExample) |
| NZ (1) | NZ528835A (enExample) |
| PL (1) | PL364230A1 (enExample) |
| PT (1) | PT1368028E (enExample) |
| RU (1) | RU2003127367A (enExample) |
| WO (1) | WO2002072090A1 (enExample) |
| ZA (1) | ZA200307916B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| JP2004528304A (ja) * | 2001-03-12 | 2004-09-16 | アバニール・ファーマシューティカルズ | ＩｇＥを調節し、細胞増殖を阻害するためのベンゾイミダゾール化合物 |
| US8354397B2 (en) * | 2001-07-27 | 2013-01-15 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| EP1388535A1 (en) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated arylcycloalkylamines and their use as pharmaceuticals |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| AU2003270426A1 (en) * | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
| US20050239844A1 (en) * | 2002-11-02 | 2005-10-27 | Kyung-Lim Lee | Composition fo preventing secretion of immunoglobulin e-dependent histamine releasing factor |
| ATE363905T1 (de) * | 2003-04-17 | 2007-06-15 | Janssen Pharmaceutica Nv | 2-phenyl-benzimidazol und 2-phenyl-imidazo-4,5)- pyridin-derivate als checkpoint-kinase-cds1 (chk2)-hemmer zur behandlung von krebs |
| AU2004263190A1 (en) * | 2003-08-08 | 2005-02-17 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
| US7485658B2 (en) * | 2003-08-21 | 2009-02-03 | Osi Pharmaceuticals, Inc. | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors |
| BRPI0413785A (pt) | 2003-08-21 | 2006-11-07 | Osi Pharm Inc | composto, composição, e, método de tratamento de distúrbio hiperproliferativo |
| DE602005027739D1 (de) | 2004-06-30 | 2011-06-09 | Janssen Pharmaceutica Nv | Arylsubstituiertes benzimidazol- und imidazopyridinether als wirkstoffe gegen krebs |
| CN101300251B (zh) * | 2005-09-06 | 2011-08-03 | 史密丝克莱恩比彻姆公司 | 作为plk抑制剂的苯并咪唑噻吩化合物 |
| JP2009001495A (ja) * | 2005-10-13 | 2009-01-08 | Taisho Pharmaceutical Co Ltd | ２−アリール−ベンゾイミダゾール−５−カルボキサミド誘導体 |
| ATE533485T1 (de) | 2005-10-31 | 2011-12-15 | Merck Sharp & Dohme | Cetp-inhibitoren |
| AU2006311914C1 (en) * | 2005-11-03 | 2013-10-24 | Chembridge Corporation | Heterocyclic compounds as tyrosine kinase modulators |
| GB0606774D0 (en) * | 2006-04-03 | 2006-05-10 | Novartis Ag | Organic compounds |
| AR063311A1 (es) | 2006-10-18 | 2009-01-21 | Novartis Ag | Compuestos organicos |
| WO2008128968A1 (en) * | 2007-04-19 | 2008-10-30 | Novartis Ag | Nicotinic acid derivatives as modulators of metabotropic glutamate receptor-5 |
| WO2009043784A1 (en) | 2007-10-04 | 2009-04-09 | F. Hoffmann-La Roche Ag | Cyclopropyl aryl amide derivatives and uses thereof |
| WO2009112445A1 (en) * | 2008-03-10 | 2009-09-17 | Novartis Ag | Method of increasing cellular phosphatidyl choline by dgat1 inhibition |
| CN103288803B (zh) * | 2013-05-17 | 2017-10-31 | 郎恒元 | 苯并咪唑酰胺类化合物及其制备方法和应用 |
| CN104208701A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 含有抗真菌药物的复方吸入制剂 |
| CN110234640B (zh) * | 2016-09-20 | 2023-04-07 | 利昂贝拉尔中心 | 作为抗癌剂的苯并咪唑衍生物 |
| EP3810117A4 (en) * | 2018-06-01 | 2022-03-02 | Merck Sharp & Dohme Corp. | NEW [3.3.1] BICYCLO COMPOUNDS AS INDOLAMINE-2,3-DIOXYGENASE INHIBITORS |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3224512A1 (de) | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| US4510158A (en) | 1984-03-05 | 1985-04-09 | Sterling Drug Inc. | 2-Phenylindole derivatives, their use as complement inhibitors |
| WO1986006739A1 (en) | 1985-05-03 | 1986-11-20 | The Foxboro Company | Distillation cut point control |
| US4939133A (en) | 1985-10-01 | 1990-07-03 | Warner-Lambert Company | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade |
| LU86258A1 (fr) | 1986-01-21 | 1987-09-03 | Rech Dermatologiques C I R D S | Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
| US5206257A (en) | 1987-03-05 | 1993-04-27 | May & Baker Limited | Pesticidal method using 2-phenylimidazole derivatives |
| JP2630432B2 (ja) | 1987-08-24 | 1997-07-16 | コニカ株式会社 | 新規なシアンカプラーを含有するハロゲン化銀カラー写真感光材料 |
| ES2058490T3 (es) | 1988-02-02 | 1994-11-01 | Schering Biotech Corp | Metodo de reducir respuestas de inmunoglobulina e. |
| JP2700475B2 (ja) | 1988-07-30 | 1998-01-21 | コニカ株式会社 | 非線形光学材料および非線形光学素子 |
| IT1232252B (it) | 1989-02-22 | 1992-01-28 | Rotta Research Lab | Derivati della n fenil benzamide ad attivita' antiulcera ed antiallerica e procedimento per la loro preparazione |
| FR2643903A1 (fr) | 1989-03-03 | 1990-09-07 | Union Pharma Scient Appl | Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux |
| EP0415886A3 (en) | 1989-08-30 | 1991-10-23 | Ciba-Geigy Ag | Aza compounds |
| FR2658511B1 (fr) | 1990-02-16 | 1992-06-19 | Union Pharma Scient Appl | Nouveaux derives de benzimidazole et d'azabenzimidazole, antagonistes des recepteurs au thromboxane; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| AU8225991A (en) | 1990-07-31 | 1992-03-02 | Teikoku Hormone Mfg. Co., Ltd. | 2-phenylindole derivative |
| DK0469477T3 (da) | 1990-08-02 | 1995-12-27 | Hoffmann La Roche | Antiallergisk kombination |
| US5656762A (en) | 1990-12-28 | 1997-08-12 | Neurogen Corporation | 4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives, dopamine receptor subtype specific ligands |
| JPH06263993A (ja) | 1991-01-21 | 1994-09-20 | Konica Corp | アゾメチン系染料、インドアニリン系染料及びインドフェノール系染料の製造法 |
| IE71647B1 (en) | 1991-01-28 | 1997-02-26 | Rhone Poulenc Rorer Ltd | Benzamide derivatives |
| EP0607373B1 (en) | 1992-06-15 | 1997-03-19 | Celltech Therapeutics Limited | Trisubstituted phenyl derivatives as selective phosphodiesterase iv inhibitors |
| US5322847A (en) | 1992-11-05 | 1994-06-21 | Pfizer Inc. | Azabenzimidazoles in the treatment of asthma, arthritis and related diseases |
| IL113472A0 (en) | 1994-04-29 | 1995-07-31 | Lilly Co Eli | Non-peptidyl tachykinin receptor antogonists |
| US5643893A (en) | 1994-06-22 | 1997-07-01 | Macronex, Inc. | N-substituted-(Dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives, useful as inhibitors of inflammatory cytokines |
| DE4426625A1 (de) | 1994-07-27 | 1996-03-14 | Schering Ag | 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| US5496826A (en) | 1994-09-02 | 1996-03-05 | Bristol-Myers Squibb Company | Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides |
| US5821258A (en) * | 1994-12-27 | 1998-10-13 | Mitsui Chemicals, Inc. | Phenylbenzimidazole derivatives |
| DE19503160A1 (de) | 1995-02-01 | 1996-08-08 | Bayer Ag | Verwendung von Phenylcyclohexylcarbonsäureamiden |
| IL123147A (en) | 1995-08-02 | 2004-02-19 | Univ Newcastle Ventures Ltd | Benzamide imidazole - 4 carboxamide and their use |
| US6387938B1 (en) | 1996-07-05 | 2002-05-14 | Mochida Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| TW467902B (en) | 1996-07-31 | 2001-12-11 | Bristol Myers Squibb Co | Diphenyl heterocycles as potassium channel modulators |
| US6153631A (en) | 1996-10-23 | 2000-11-28 | Zymogenetics, Inc. | Compositions and methods for treating bone deficit conditions |
| JP2001510450A (ja) | 1996-10-23 | 2001-07-31 | ザイモジェネティクス，インコーポレイテッド | 骨欠損状態を処置するための組成物および方法 |
| CA2232467A1 (en) | 1997-03-20 | 1998-09-20 | Richard A. Glennon | Imidazoles with serotonin receptor binding activity |
| US6034256A (en) | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
| CN1265665A (zh) | 1997-06-10 | 2000-09-06 | 葛兰素集团有限公司 | 苯并咪唑衍生物 |
| GB9718833D0 (en) | 1997-09-04 | 1997-11-12 | Merck Sharp & Dohme | Therapeutic agents |
| ATE281834T1 (de) | 1997-09-26 | 2004-11-15 | Zentaris Gmbh | Azabenzimidazol-verbindungen zur modulation der serin/threonin protein-kinase funktion |
| US6100282A (en) | 1998-01-02 | 2000-08-08 | Hoffman-La Roche Inc. | Thiazole derivatives |
| US6303645B1 (en) | 1998-05-22 | 2001-10-16 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| US6911462B2 (en) | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| US6271390B1 (en) | 1998-05-22 | 2001-08-07 | Avanir Pharmaceuticals | Suppression of the IgE-dependent allergic response by benzimidazole analogs |
| US6919366B2 (en) | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| US6369091B1 (en) | 1998-05-22 | 2002-04-09 | Avanir Pharmaceuticals | Benzimidazole analogs as down-regulators of IgE |
| JP2000095767A (ja) * | 1998-09-28 | 2000-04-04 | Takeda Chem Ind Ltd | 性腺刺激ホルモン放出ホルモン拮抗剤 |
| NZ510760A (en) | 1998-10-23 | 2003-08-29 | F | Bicyclic nitrogen heterocycles |
| CN1331682A (zh) * | 1998-11-03 | 2002-01-16 | 巴斯福股份公司 | 取代的2－苯基苯并咪唑类,其制备和用途 |
| HRP20010451A2 (en) | 1998-11-17 | 2003-04-30 | Basf Ag | 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof |
| IL143303A0 (en) | 1998-11-27 | 2002-04-21 | Basf Ag | Substituted benzimidazoles and their use as parp inhibitors |
| DE19918211A1 (de) | 1999-04-22 | 2000-10-26 | Basf Ag | Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung |
| DE19920936A1 (de) | 1999-05-07 | 2000-11-09 | Basf Ag | Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung |
| US6423734B1 (en) | 1999-08-13 | 2002-07-23 | The Procter & Gamble Company | Method of preventing cancer |
| DE19939463A1 (de) | 1999-08-20 | 2001-02-22 | Boehringer Ingelheim Pharma | Aminocarbonyl-substituierte Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US6759425B2 (en) | 1999-10-21 | 2004-07-06 | Avanir Pharmaceuticals | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| US6242461B1 (en) | 2000-01-25 | 2001-06-05 | Pfizer Inc. | Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases |
| GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
| US6537994B2 (en) | 2000-07-17 | 2003-03-25 | Wyeth | Heterocyclic β3 adrenergic receptor agonists |
| JP2004528304A (ja) * | 2001-03-12 | 2004-09-16 | アバニール・ファーマシューティカルズ | ＩｇＥを調節し、細胞増殖を阻害するためのベンゾイミダゾール化合物 |
| MXPA03008205A (es) | 2001-03-12 | 2004-01-29 | Janssen Pharmaceutica Nv | Procedimiento para la preparacion de compuestos de imidazol. |
| US6777442B2 (en) | 2001-03-12 | 2004-08-17 | Bayer Aktiengesellschaft | Diphenyl derivatives |
| TW200304820A (en) | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
| RU2005134670A (ru) | 2003-04-10 | 2006-06-10 | Аванир Фармасьютикалс (Us) | Производные имидазола для лечения аллергических и гиперпролиферативных нарушений |
| AU2004263190A1 (en) | 2003-08-08 | 2005-02-17 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
-
2002
- 2002-02-28 JP JP2002571049A patent/JP2004528304A/ja active Pending
- 2002-02-28 NZ NZ528835A patent/NZ528835A/en unknown
- 2002-02-28 PT PT02715052T patent/PT1368028E/pt unknown
- 2002-02-28 RU RU2003127367/15A patent/RU2003127367A/ru not_active Application Discontinuation
- 2002-02-28 PL PL02364230A patent/PL364230A1/xx unknown
- 2002-02-28 CA CA002441177A patent/CA2441177A1/en not_active Abandoned
- 2002-02-28 BR BR0208010-9A patent/BR0208010A/pt not_active IP Right Cessation
- 2002-02-28 CZ CZ20032691A patent/CZ20032691A3/cs unknown
- 2002-02-28 DE DE60221804T patent/DE60221804T2/de not_active Expired - Fee Related
- 2002-02-28 HU HU0303460A patent/HUP0303460A3/hu unknown
- 2002-02-28 CN CNA028064860A patent/CN1496257A/zh active Pending
- 2002-02-28 EP EP02715052A patent/EP1368028B1/en not_active Expired - Lifetime
- 2002-02-28 DK DK02715052T patent/DK1368028T3/da active
- 2002-02-28 ES ES02715052T patent/ES2291455T3/es not_active Expired - Lifetime
- 2002-02-28 AT AT02715052T patent/ATE369853T1/de not_active IP Right Cessation
- 2002-02-28 WO PCT/US2002/006801 patent/WO2002072090A1/en not_active Ceased
- 2002-02-28 MX MXJL03000027A patent/MXJL03000027A/es not_active Application Discontinuation
- 2002-03-11 AR ARP020100869A patent/AR034023A1/es unknown
-
2003
- 2003-10-10 ZA ZA200307916A patent/ZA200307916B/en unknown
-
2004
- 2004-03-05 US US10/795,006 patent/US7282518B2/en not_active Expired - Fee Related
-
2007
- 2007-04-27 US US11/741,702 patent/US20070202133A1/en not_active Abandoned
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