JP2004527566A5 - - Google Patents
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- JP2004527566A5 JP2004527566A5 JP2002586917A JP2002586917A JP2004527566A5 JP 2004527566 A5 JP2004527566 A5 JP 2004527566A5 JP 2002586917 A JP2002586917 A JP 2002586917A JP 2002586917 A JP2002586917 A JP 2002586917A JP 2004527566 A5 JP2004527566 A5 JP 2004527566A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- pharmaceutical composition
- composition according
- octahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 125000004432 carbon atom Chemical group C* 0.000 claims 76
- 239000008194 pharmaceutical composition Substances 0.000 claims 44
- -1 cyclohexanecarbonyl group Chemical group 0.000 claims 34
- JDVVGAQPNNXQDW-TVNFTVLESA-N Castinospermine Chemical compound C1[C@H](O)[C@@H](O)[C@H](O)[C@H]2[C@@H](O)CCN21 JDVVGAQPNNXQDW-TVNFTVLESA-N 0.000 claims 29
- 229910052736 halogen Inorganic materials 0.000 claims 24
- 150000002367 halogens Chemical group 0.000 claims 24
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 150000002431 hydrogen Chemical class 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 14
- 241000710831 Flavivirus Species 0.000 claims 12
- 102000004366 Glucosidases Human genes 0.000 claims 12
- 108010056771 Glucosidases Proteins 0.000 claims 12
- 125000002252 acyl group Chemical group 0.000 claims 12
- 239000003112 inhibitor Substances 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 241000700605 Viruses Species 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 230000029812 viral genome replication Effects 0.000 claims 5
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 4
- 241000711549 Hepacivirus C Species 0.000 claims 4
- 241000710842 Japanese encephalitis virus Species 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 241001474791 Proboscis Species 0.000 claims 4
- 206010037660 Pyrexia Diseases 0.000 claims 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 125000001589 carboacyl group Chemical group 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 230000009385 viral infection Effects 0.000 claims 4
- 230000036737 immune function Effects 0.000 claims 3
- ATCRIUVQKHMXSH-UHFFFAOYSA-M 2,4-dichlorobenzoate Chemical compound [O-]C(=O)C1=CC=C(Cl)C=C1Cl ATCRIUVQKHMXSH-UHFFFAOYSA-M 0.000 claims 2
- XXHDAWYDNSXJQM-UHFFFAOYSA-N 3-hexenoic acid Chemical compound CCC=CCC(O)=O XXHDAWYDNSXJQM-UHFFFAOYSA-N 0.000 claims 2
- TUXYZHVUPGXXQG-UHFFFAOYSA-M 4-bromobenzoate Chemical compound [O-]C(=O)C1=CC=C(Br)C=C1 TUXYZHVUPGXXQG-UHFFFAOYSA-M 0.000 claims 2
- 241001118702 Border disease virus Species 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 2
- JDVVGAQPNNXQDW-WCMLQCRESA-N Castanospermine Natural products O[C@H]1[C@@H](O)[C@H]2[C@@H](O)CCN2C[C@H]1O JDVVGAQPNNXQDW-WCMLQCRESA-N 0.000 claims 2
- 208000001726 Classical Swine Fever Diseases 0.000 claims 2
- 241000710777 Classical swine fever virus Species 0.000 claims 2
- 206010012735 Diarrhoea Diseases 0.000 claims 2
- 206010014596 Encephalitis Japanese B Diseases 0.000 claims 2
- 206010054261 Flavivirus infection Diseases 0.000 claims 2
- 208000005176 Hepatitis C Diseases 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 201000005807 Japanese encephalitis Diseases 0.000 claims 2
- 201000005805 Murray valley encephalitis Diseases 0.000 claims 2
- 208000011448 Omsk hemorrhagic fever Diseases 0.000 claims 2
- 241000710778 Pestivirus Species 0.000 claims 2
- 206010041896 St. Louis Encephalitis Diseases 0.000 claims 2
- 208000004006 Tick-borne encephalitis Diseases 0.000 claims 2
- 241000710771 Tick-borne encephalitis virus Species 0.000 claims 2
- 201000006449 West Nile encephalitis Diseases 0.000 claims 2
- 206010057293 West Nile viral infection Diseases 0.000 claims 2
- 208000003152 Yellow Fever Diseases 0.000 claims 2
- 241000710772 Yellow fever virus Species 0.000 claims 2
- 208000008921 border disease Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 229960002248 meradimate Drugs 0.000 claims 2
- 229940095102 methyl benzoate Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- CHXZRHMQQRUVHF-UHFFFAOYSA-N thiophene A Natural products CC#CC1=CC=C(C#CC#CC=C)S1 CHXZRHMQQRUVHF-UHFFFAOYSA-N 0.000 claims 2
- 229940051021 yellow-fever virus Drugs 0.000 claims 2
- 229940124186 Dehydrogenase inhibitor Drugs 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 1
- 229930010555 Inosine Natural products 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- 101800001530 Thymosin alpha Proteins 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229960003786 inosine Drugs 0.000 claims 1
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims 1
- 229960000951 mycophenolic acid Drugs 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0110832.3A GB0110832D0 (en) | 2001-05-03 | 2001-05-03 | Antiviral compounds |
| PCT/EP2002/004944 WO2002089780A2 (en) | 2001-05-03 | 2002-05-02 | Antiviral compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005161641A Division JP4406383B2 (ja) | 2001-05-03 | 2005-06-01 | 抗ウイルス化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527566A JP2004527566A (ja) | 2004-09-09 |
| JP2004527566A5 true JP2004527566A5 (https=) | 2005-12-22 |
Family
ID=9913938
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002586917A Ceased JP2004527566A (ja) | 2001-05-03 | 2002-05-02 | 抗ウイルス化合物 |
| JP2005161641A Expired - Lifetime JP4406383B2 (ja) | 2001-05-03 | 2005-06-01 | 抗ウイルス化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005161641A Expired - Lifetime JP4406383B2 (ja) | 2001-05-03 | 2005-06-01 | 抗ウイルス化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7601735B2 (https=) |
| EP (1) | EP1387681B1 (https=) |
| JP (2) | JP2004527566A (https=) |
| KR (1) | KR100660241B1 (https=) |
| CN (1) | CN100428936C (https=) |
| AT (1) | ATE405261T1 (https=) |
| AU (1) | AU2002341155B2 (https=) |
| CA (1) | CA2445271A1 (https=) |
| CY (1) | CY1110437T1 (https=) |
| DE (1) | DE60228436D1 (https=) |
| DK (1) | DK1387681T3 (https=) |
| ES (1) | ES2312587T3 (https=) |
| GB (1) | GB0110832D0 (https=) |
| IL (2) | IL158558A0 (https=) |
| NO (1) | NO326292B1 (https=) |
| NZ (1) | NZ529448A (https=) |
| PT (1) | PT1387681E (https=) |
| WO (1) | WO2002089780A2 (https=) |
| ZA (1) | ZA200308483B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0116643D0 (en) * | 2001-07-09 | 2001-08-29 | Virogen Ltd | Antiviral compounds |
| GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| WO2006085141A2 (en) * | 2004-08-13 | 2006-08-17 | Migenix Inc. | Compositions and methods for treating or preventing hepadnaviridae infection |
| MX2007003853A (es) * | 2004-10-06 | 2007-11-21 | Migenix Inc | Composiciones antivirales en combinacion que comprenden castanospermina y metodos de uso. |
| JP2008530124A (ja) * | 2005-02-09 | 2008-08-07 | ミジェニックス インコーポレイテッド | フラビウイルス感染症を処置または予防するための組成物および方法 |
| JP2007297289A (ja) * | 2006-04-27 | 2007-11-15 | Kitasato Gakuen | 抗ウイルス剤 |
| US20080131398A1 (en) * | 2006-08-21 | 2008-06-05 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| KR101314166B1 (ko) * | 2011-06-16 | 2013-10-04 | 건국대학교 산학협력단 | 석이버섯 가수분해 효소 추출물 또는 이로로부터 분리된 화합물을 유효성분으로 함유하는 항산화 조성물 |
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| CN102343083A (zh) * | 2011-10-17 | 2012-02-08 | 中国科学院成都生物研究所 | 一种抗病毒的组合药物 |
| MY170991A (en) | 2013-03-15 | 2019-09-23 | 60? Pharmaceuticals Llc | Dosing regimens of celgosivir for the treatment of dengue |
| MD4794B1 (ro) | 2013-09-27 | 2022-02-28 | Merck Sharp & Dohme Corp | Derivaţi de chinolizină substituiţi utili ca inhibitori de integrază HIV |
| US10046005B2 (en) * | 2014-02-07 | 2018-08-14 | Shaker A. Mousa | Composition and method of use for combinations of anti-viral protease, polymerase inhibitors and natural bioactive compounds in the treatment of hepatitis C infection |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| SG10201912141YA (en) * | 2015-12-11 | 2020-02-27 | 60 Pharmaceuticals Llc | Novel dosing regimens of celgosivir for the prevention of dengue |
| MX2018011788A (es) | 2016-03-31 | 2019-05-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| HRP20210847T1 (hr) | 2016-03-31 | 2021-07-23 | Janssen Pharmaceuticals, Inc. | Supstituirani derivati indola kao inhibitori replikacije denga virusa |
| KR102359766B1 (ko) | 2016-04-01 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EA201992782A1 (ru) | 2017-05-22 | 2020-03-24 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| CN110753682B (zh) | 2017-05-22 | 2023-06-30 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
| JP7497790B2 (ja) * | 2019-12-27 | 2024-06-11 | 国立大学法人北海道大学 | 豚コレラの治療及び／又は予防剤 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1315276C (en) | 1987-07-02 | 1993-03-30 | Paul S. Liu | Castanospermine esters and glycosides |
| US5004746A (en) | 1987-09-29 | 1991-04-02 | Merrell Dow Pharmaceuticals Inc. | Anti-retroviral castanospermine esters |
| US4849430A (en) | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
| US5017563A (en) * | 1988-06-23 | 1991-05-21 | Merrell Dow Pharmaceuticals Inc. | Castanospermine esters and glycosides |
| US4970317A (en) | 1989-08-08 | 1990-11-13 | Merrell Dow Pharmaceuticals Inc. | Process for the preparation of castanospermine esters |
| US5093501A (en) | 1990-03-12 | 1992-03-03 | Merrell Dow Pharmaceuticals Inc. | Intermediates in a process for the preparation of castanospermine |
| US5066807A (en) | 1990-03-12 | 1991-11-19 | Merrell Dow Pharmaceuticals Inc. | Process for the preparation of castanospermine |
| GB9027433D0 (en) | 1990-12-18 | 1991-02-06 | Merrell Dow Pharma | Anti-herpes castanospermine esters |
| US5939430A (en) * | 1993-02-22 | 1999-08-17 | Merrell Pharmaceuticals Inc. | Combinations of retroviral inhibitors |
| GB9719189D0 (en) * | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | New therapeutic method |
| US5959111A (en) | 1997-05-22 | 1999-09-28 | Hoechst Marion Roussel, Inc. | Process for preparing 6-0-monoesters of castanospermine |
| BR9813508A (pt) * | 1997-12-11 | 2000-10-03 | Univ Oxford | Inibição de replicação viral associada com membrana |
| AU2001234596A1 (en) * | 2000-01-28 | 2001-08-07 | Timothy M Block | Use of castanospermine and substituted-castanospermine compounds for treating hepatitis virus infections |
-
2001
- 2001-05-03 GB GBGB0110832.3A patent/GB0110832D0/en not_active Ceased
-
2002
- 2002-05-02 WO PCT/EP2002/004944 patent/WO2002089780A2/en not_active Ceased
- 2002-05-02 KR KR1020037014319A patent/KR100660241B1/ko not_active Expired - Fee Related
- 2002-05-02 AU AU2002341155A patent/AU2002341155B2/en not_active Expired
- 2002-05-02 IL IL15855802A patent/IL158558A0/xx active IP Right Grant
- 2002-05-02 DE DE60228436T patent/DE60228436D1/de not_active Expired - Lifetime
- 2002-05-02 CN CNB028099044A patent/CN100428936C/zh not_active Expired - Lifetime
- 2002-05-02 DK DK02742947T patent/DK1387681T3/da active
- 2002-05-02 EP EP02742947A patent/EP1387681B1/en not_active Expired - Lifetime
- 2002-05-02 CA CA002445271A patent/CA2445271A1/en not_active Abandoned
- 2002-05-02 PT PT02742947T patent/PT1387681E/pt unknown
- 2002-05-02 JP JP2002586917A patent/JP2004527566A/ja not_active Ceased
- 2002-05-02 US US10/475,830 patent/US7601735B2/en not_active Expired - Lifetime
- 2002-05-02 NZ NZ529448A patent/NZ529448A/en not_active IP Right Cessation
- 2002-05-02 ES ES02742947T patent/ES2312587T3/es not_active Expired - Lifetime
- 2002-05-02 AT AT02742947T patent/ATE405261T1/de active
-
2003
- 2003-10-23 IL IL158558A patent/IL158558A/en unknown
- 2003-10-30 ZA ZA200308483A patent/ZA200308483B/en unknown
- 2003-10-31 NO NO20034878A patent/NO326292B1/no not_active IP Right Cessation
-
2005
- 2005-06-01 JP JP2005161641A patent/JP4406383B2/ja not_active Expired - Lifetime
-
2008
- 2008-11-19 CY CY20081101328T patent/CY1110437T1/el unknown
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