AU2002341155B2 - Antiviral compounds - Google Patents
Antiviral compounds Download PDFInfo
- Publication number
- AU2002341155B2 AU2002341155B2 AU2002341155A AU2002341155A AU2002341155B2 AU 2002341155 B2 AU2002341155 B2 AU 2002341155B2 AU 2002341155 A AU2002341155 A AU 2002341155A AU 2002341155 A AU2002341155 A AU 2002341155A AU 2002341155 B2 AU2002341155 B2 AU 2002341155B2
- Authority
- AU
- Australia
- Prior art keywords
- indolizinetetrol
- ester
- octahydro
- halogen
- castanospermine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title claims description 44
- 230000000840 anti-viral effect Effects 0.000 title description 16
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- 238000011282 treatment Methods 0.000 claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 19
- 229940124597 therapeutic agent Drugs 0.000 claims abstract 2
- -1 naphthalenecarbonyl Chemical group 0.000 claims description 77
- DWBDMLGCCJIACZ-ODXJTPSBSA-N [(1s,6s,7s,8r,8ar)-1,7,8-trihydroxy-1,2,3,5,6,7,8,8a-octahydroindolizin-6-yl] benzoate Chemical compound O([C@H]1CN2CC[C@@H]([C@@H]2[C@@H](O)[C@@H]1O)O)C(=O)C1=CC=CC=C1 DWBDMLGCCJIACZ-ODXJTPSBSA-N 0.000 claims description 34
- 229910052736 halogen Chemical group 0.000 claims description 29
- 150000002367 halogens Chemical group 0.000 claims description 29
- 239000001257 hydrogen Substances 0.000 claims description 29
- 229910052739 hydrogen Inorganic materials 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 26
- 230000000694 effects Effects 0.000 claims description 24
- 150000002431 hydrogen Chemical class 0.000 claims description 20
- 208000015181 infectious disease Diseases 0.000 claims description 20
- 125000001589 carboacyl group Chemical group 0.000 claims description 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 19
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- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 15
- 229940079322 interferon Drugs 0.000 claims description 13
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- 125000004414 alkyl thio group Chemical group 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
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- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB01108323.3 | 2001-05-03 | ||
| GBGB0110832.3A GB0110832D0 (en) | 2001-05-03 | 2001-05-03 | Antiviral compounds |
| PCT/EP2002/004944 WO2002089780A2 (en) | 2001-05-03 | 2002-05-02 | Antiviral compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002341155A1 AU2002341155A1 (en) | 2003-05-01 |
| AU2002341155B2 true AU2002341155B2 (en) | 2007-10-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002341155A Expired AU2002341155B2 (en) | 2001-05-03 | 2002-05-02 | Antiviral compounds |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7601735B2 (https=) |
| EP (1) | EP1387681B1 (https=) |
| JP (2) | JP2004527566A (https=) |
| KR (1) | KR100660241B1 (https=) |
| CN (1) | CN100428936C (https=) |
| AT (1) | ATE405261T1 (https=) |
| AU (1) | AU2002341155B2 (https=) |
| CA (1) | CA2445271A1 (https=) |
| CY (1) | CY1110437T1 (https=) |
| DE (1) | DE60228436D1 (https=) |
| DK (1) | DK1387681T3 (https=) |
| ES (1) | ES2312587T3 (https=) |
| GB (1) | GB0110832D0 (https=) |
| IL (2) | IL158558A0 (https=) |
| NO (1) | NO326292B1 (https=) |
| NZ (1) | NZ529448A (https=) |
| PT (1) | PT1387681E (https=) |
| WO (1) | WO2002089780A2 (https=) |
| ZA (1) | ZA200308483B (https=) |
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| GB0116643D0 (en) * | 2001-07-09 | 2001-08-29 | Virogen Ltd | Antiviral compounds |
| GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| WO2006085141A2 (en) * | 2004-08-13 | 2006-08-17 | Migenix Inc. | Compositions and methods for treating or preventing hepadnaviridae infection |
| MX2007003853A (es) * | 2004-10-06 | 2007-11-21 | Migenix Inc | Composiciones antivirales en combinacion que comprenden castanospermina y metodos de uso. |
| JP2008530124A (ja) * | 2005-02-09 | 2008-08-07 | ミジェニックス インコーポレイテッド | フラビウイルス感染症を処置または予防するための組成物および方法 |
| JP2007297289A (ja) * | 2006-04-27 | 2007-11-15 | Kitasato Gakuen | 抗ウイルス剤 |
| US20080131398A1 (en) * | 2006-08-21 | 2008-06-05 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| KR101314166B1 (ko) * | 2011-06-16 | 2013-10-04 | 건국대학교 산학협력단 | 석이버섯 가수분해 효소 추출물 또는 이로로부터 분리된 화합물을 유효성분으로 함유하는 항산화 조성물 |
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| CN102343083A (zh) * | 2011-10-17 | 2012-02-08 | 中国科学院成都生物研究所 | 一种抗病毒的组合药物 |
| MY170991A (en) | 2013-03-15 | 2019-09-23 | 60? Pharmaceuticals Llc | Dosing regimens of celgosivir for the treatment of dengue |
| MD4794B1 (ro) | 2013-09-27 | 2022-02-28 | Merck Sharp & Dohme Corp | Derivaţi de chinolizină substituiţi utili ca inhibitori de integrază HIV |
| US10046005B2 (en) * | 2014-02-07 | 2018-08-14 | Shaker A. Mousa | Composition and method of use for combinations of anti-viral protease, polymerase inhibitors and natural bioactive compounds in the treatment of hepatitis C infection |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| SG10201912141YA (en) * | 2015-12-11 | 2020-02-27 | 60 Pharmaceuticals Llc | Novel dosing regimens of celgosivir for the prevention of dengue |
| MX2018011788A (es) | 2016-03-31 | 2019-05-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| HRP20210847T1 (hr) | 2016-03-31 | 2021-07-23 | Janssen Pharmaceuticals, Inc. | Supstituirani derivati indola kao inhibitori replikacije denga virusa |
| KR102359766B1 (ko) | 2016-04-01 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EA201992782A1 (ru) | 2017-05-22 | 2020-03-24 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| CN110753682B (zh) | 2017-05-22 | 2023-06-30 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
| JP7497790B2 (ja) * | 2019-12-27 | 2024-06-11 | 国立大学法人北海道大学 | 豚コレラの治療及び／又は予防剤 |
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| CA1315276C (en) | 1987-07-02 | 1993-03-30 | Paul S. Liu | Castanospermine esters and glycosides |
| US5004746A (en) | 1987-09-29 | 1991-04-02 | Merrell Dow Pharmaceuticals Inc. | Anti-retroviral castanospermine esters |
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| US5017563A (en) * | 1988-06-23 | 1991-05-21 | Merrell Dow Pharmaceuticals Inc. | Castanospermine esters and glycosides |
| US4970317A (en) | 1989-08-08 | 1990-11-13 | Merrell Dow Pharmaceuticals Inc. | Process for the preparation of castanospermine esters |
| US5093501A (en) | 1990-03-12 | 1992-03-03 | Merrell Dow Pharmaceuticals Inc. | Intermediates in a process for the preparation of castanospermine |
| US5066807A (en) | 1990-03-12 | 1991-11-19 | Merrell Dow Pharmaceuticals Inc. | Process for the preparation of castanospermine |
| GB9027433D0 (en) | 1990-12-18 | 1991-02-06 | Merrell Dow Pharma | Anti-herpes castanospermine esters |
| US5959111A (en) | 1997-05-22 | 1999-09-28 | Hoechst Marion Roussel, Inc. | Process for preparing 6-0-monoesters of castanospermine |
| BR9813508A (pt) * | 1997-12-11 | 2000-10-03 | Univ Oxford | Inibição de replicação viral associada com membrana |
| AU2001234596A1 (en) * | 2000-01-28 | 2001-08-07 | Timothy M Block | Use of castanospermine and substituted-castanospermine compounds for treating hepatitis virus infections |
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2002
- 2002-05-02 WO PCT/EP2002/004944 patent/WO2002089780A2/en not_active Ceased
- 2002-05-02 KR KR1020037014319A patent/KR100660241B1/ko not_active Expired - Fee Related
- 2002-05-02 AU AU2002341155A patent/AU2002341155B2/en not_active Expired
- 2002-05-02 IL IL15855802A patent/IL158558A0/xx active IP Right Grant
- 2002-05-02 DE DE60228436T patent/DE60228436D1/de not_active Expired - Lifetime
- 2002-05-02 CN CNB028099044A patent/CN100428936C/zh not_active Expired - Lifetime
- 2002-05-02 DK DK02742947T patent/DK1387681T3/da active
- 2002-05-02 EP EP02742947A patent/EP1387681B1/en not_active Expired - Lifetime
- 2002-05-02 CA CA002445271A patent/CA2445271A1/en not_active Abandoned
- 2002-05-02 PT PT02742947T patent/PT1387681E/pt unknown
- 2002-05-02 JP JP2002586917A patent/JP2004527566A/ja not_active Ceased
- 2002-05-02 US US10/475,830 patent/US7601735B2/en not_active Expired - Lifetime
- 2002-05-02 NZ NZ529448A patent/NZ529448A/en not_active IP Right Cessation
- 2002-05-02 ES ES02742947T patent/ES2312587T3/es not_active Expired - Lifetime
- 2002-05-02 AT AT02742947T patent/ATE405261T1/de active
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- 2003-10-30 ZA ZA200308483A patent/ZA200308483B/en unknown
- 2003-10-31 NO NO20034878A patent/NO326292B1/no not_active IP Right Cessation
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2005
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| US5939430A (en) * | 1993-02-22 | 1999-08-17 | Merrell Pharmaceuticals Inc. | Combinations of retroviral inhibitors |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2004527566A (ja) | 2004-09-09 |
| IL158558A (en) | 2011-09-27 |
| HK1068538A1 (zh) | 2005-04-29 |
| EP1387681A2 (en) | 2004-02-11 |
| IL158558A0 (en) | 2004-05-12 |
| US7601735B2 (en) | 2009-10-13 |
| WO2002089780A2 (en) | 2002-11-14 |
| CN100428936C (zh) | 2008-10-29 |
| NO20034878L (no) | 2003-12-22 |
| CA2445271A1 (en) | 2002-11-14 |
| DE60228436D1 (de) | 2008-10-02 |
| JP2005290015A (ja) | 2005-10-20 |
| CN1516582A (zh) | 2004-07-28 |
| KR100660241B1 (ko) | 2006-12-20 |
| ES2312587T3 (es) | 2009-03-01 |
| DK1387681T3 (da) | 2009-01-05 |
| ZA200308483B (en) | 2005-10-26 |
| CY1110437T1 (el) | 2015-04-29 |
| US20040147549A1 (en) | 2004-07-29 |
| PT1387681E (pt) | 2008-12-02 |
| ATE405261T1 (de) | 2008-09-15 |
| NZ529448A (en) | 2005-11-25 |
| WO2002089780A3 (en) | 2003-03-06 |
| NO20034878D0 (no) | 2003-10-31 |
| GB0110832D0 (en) | 2001-06-27 |
| JP4406383B2 (ja) | 2010-01-27 |
| EP1387681B1 (en) | 2008-08-20 |
| NO326292B1 (no) | 2008-11-03 |
| KR20040007527A (ko) | 2004-01-24 |
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