JP2004525873A5 - - Google Patents
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- Publication number
- JP2004525873A5 JP2004525873A5 JP2002551496A JP2002551496A JP2004525873A5 JP 2004525873 A5 JP2004525873 A5 JP 2004525873A5 JP 2002551496 A JP2002551496 A JP 2002551496A JP 2002551496 A JP2002551496 A JP 2002551496A JP 2004525873 A5 JP2004525873 A5 JP 2004525873A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- mono
- alkoxy
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 Aryl imidazoles Chemical class 0.000 claims 1054
- 125000000217 alkyl group Chemical group 0.000 claims 381
- 229910052736 halogen Inorganic materials 0.000 claims 369
- 150000002367 halogens Chemical class 0.000 claims 369
- 125000001188 haloalkyl group Chemical group 0.000 claims 366
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 327
- 125000004093 cyano group Chemical group *C#N 0.000 claims 325
- 125000001424 substituent group Chemical group 0.000 claims 301
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 295
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 273
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 272
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 245
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 245
- 229910052739 hydrogen Inorganic materials 0.000 claims 187
- 239000001257 hydrogen Substances 0.000 claims 187
- 150000001875 compounds Chemical class 0.000 claims 185
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 181
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 179
- 125000003545 alkoxy group Chemical group 0.000 claims 162
- 125000000753 cycloalkyl group Chemical group 0.000 claims 141
- 150000002431 hydrogen Chemical class 0.000 claims 140
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 116
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 113
- 125000003342 alkenyl group Chemical group 0.000 claims 102
- 125000004076 pyridyl group Chemical group 0.000 claims 102
- 125000001544 thienyl group Chemical group 0.000 claims 96
- 125000000304 alkynyl group Chemical group 0.000 claims 91
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 85
- 125000003373 pyrazinyl group Chemical group 0.000 claims 84
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 83
- 125000004663 dialkyl amino group Chemical group 0.000 claims 81
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 78
- 125000001041 indolyl group Chemical group 0.000 claims 78
- 150000002148 esters Chemical class 0.000 claims 73
- 125000001624 naphthyl group Chemical group 0.000 claims 72
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 70
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 68
- 125000000928 benzodioxinyl group Chemical group O1C(=COC2=C1C=CC=C2)* 0.000 claims 67
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 66
- 125000002619 bicyclic group Chemical group 0.000 claims 66
- 229910052760 oxygen Inorganic materials 0.000 claims 66
- 239000001301 oxygen Substances 0.000 claims 66
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 65
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 64
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims 63
- 125000002883 imidazolyl group Chemical group 0.000 claims 54
- 125000003710 aryl alkyl group Chemical group 0.000 claims 48
- 125000001072 heteroaryl group Chemical group 0.000 claims 48
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 47
- 125000000168 pyrrolyl group Chemical group 0.000 claims 47
- 125000000623 heterocyclic group Chemical group 0.000 claims 46
- 125000005842 heteroatom Chemical group 0.000 claims 45
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 45
- 125000003226 pyrazolyl group Chemical group 0.000 claims 45
- 125000001425 triazolyl group Chemical group 0.000 claims 45
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 42
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 42
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 42
- 125000002971 oxazolyl group Chemical group 0.000 claims 42
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 42
- 125000003831 tetrazolyl group Chemical group 0.000 claims 42
- 125000002541 furyl group Chemical group 0.000 claims 41
- 125000000842 isoxazolyl group Chemical group 0.000 claims 41
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 40
- 125000001786 isothiazolyl group Chemical group 0.000 claims 40
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 40
- 125000000335 thiazolyl group Chemical group 0.000 claims 40
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 37
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims 37
- 125000003884 phenylalkyl group Chemical group 0.000 claims 36
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 36
- 150000003839 salts Chemical class 0.000 claims 36
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 claims 34
- 239000000651 prodrug Substances 0.000 claims 34
- 229940002612 prodrug Drugs 0.000 claims 34
- 125000003418 alkyl amino alkoxy group Chemical group 0.000 claims 33
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 32
- 125000001977 isobenzofuranyl group Chemical group C=1(OC=C2C=CC=CC12)* 0.000 claims 30
- 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 claims 29
- 125000003282 alkyl amino group Chemical group 0.000 claims 28
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 27
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 24
- 229910052799 carbon Inorganic materials 0.000 claims 22
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 21
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 20
- 150000001721 carbon Chemical group 0.000 claims 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 16
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 15
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 14
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 14
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 12
- 239000005977 Ethylene Substances 0.000 claims 12
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 10
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 10
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 10
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 9
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 9
- 241000790917 Dioxys <bee> Species 0.000 claims 9
- 125000004422 alkyl sulphonamide group Chemical group 0.000 claims 9
- 238000003556 assay Methods 0.000 claims 8
- 230000035605 chemotaxis Effects 0.000 claims 8
- 230000001404 mediated effect Effects 0.000 claims 8
- 230000027425 release of sequestered calcium ion into cytosol Effects 0.000 claims 8
- 125000000547 substituted alkyl group Chemical group 0.000 claims 8
- 229940124530 sulfonamide Drugs 0.000 claims 8
- 150000003456 sulfonamides Chemical class 0.000 claims 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 7
- 150000001735 carboxylic acids Chemical class 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 125000003627 8 membered carbocyclic group Chemical group 0.000 claims 4
- 125000005330 8 membered heterocyclic group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000005945 imidazopyridyl group Chemical group 0.000 claims 4
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000005422 alkyl sulfonamido group Chemical group 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 108091006027 G proteins Proteins 0.000 claims 2
- 102000030782 GTP binding Human genes 0.000 claims 2
- 108091000058 GTP-Binding Proteins 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000005363 dialkylsulfonamide group Chemical group 0.000 claims 1
- 125000001288 lysyl group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- 150000003335 secondary amines Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- UWYZHKAOTLEWKK-UHFFFAOYSA-N tetrahydro-isoquinoline Natural products C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 claims 1
- 125000003039 tetrahydroisoquinolinyl group Chemical class C1(NCCC2=CC=CC=C12)* 0.000 claims 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2000/026816 WO2002049993A2 (en) | 2000-09-29 | 2000-09-29 | High affinity small molecule c5a receptor modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011092825A Division JP2011219476A (ja) | 2011-04-19 | 2011-04-19 | 高親和性低分子Ｃ５ａ受容体調節物質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004525873A JP2004525873A (ja) | 2004-08-26 |
| JP2004525873A5 true JP2004525873A5 (enExample) | 2007-11-22 |
| JP5260818B2 JP5260818B2 (ja) | 2013-08-14 |
Family
ID=21741822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002551496A Expired - Fee Related JP5260818B2 (ja) | 2000-09-29 | 2000-09-29 | 高親和性低分子Ｃ５ａ受容体調節物質 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1322309B1 (enExample) |
| JP (1) | JP5260818B2 (enExample) |
| KR (1) | KR20030060887A (enExample) |
| CN (1) | CN1454086A (enExample) |
| AT (1) | ATE404553T1 (enExample) |
| AU (1) | AU7622500A (enExample) |
| BR (1) | BR0017338A (enExample) |
| DE (1) | DE60039921D1 (enExample) |
| IL (1) | IL154993A0 (enExample) |
| MX (1) | MXPA03002788A (enExample) |
| NO (1) | NO20031370L (enExample) |
| WO (1) | WO2002049993A2 (enExample) |
| YU (1) | YU23503A (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| AU2003225971A1 (en) * | 2002-03-28 | 2003-10-13 | Yang Gao | Substituted biaryl amides as c5a receptor modulators |
| EP1487798A4 (en) | 2002-03-28 | 2005-07-13 | Neurogen Corp | Substituted tetrahydroisoquinolines as C5A receptor modulators |
| US6858637B2 (en) | 2002-03-28 | 2005-02-22 | Neurogen Corporation | Substituted biaryl amides as C5a receptor modulators |
| WO2003082829A1 (en) * | 2002-03-29 | 2003-10-09 | Neurogen Corporation | New aryl imidazoles and related compounds as c5a receptor modulators |
| GB0214139D0 (en) * | 2002-06-19 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
| WO2004018460A1 (en) * | 2002-08-21 | 2004-03-04 | Neurogen Corporation | Amino methyl imidazoles as c5a receptor modulators |
| JP3714948B2 (ja) * | 2002-09-11 | 2005-11-09 | 呉羽化学工業株式会社 | アミン化合物及びその用途 |
| AU2003291403A1 (en) | 2002-11-08 | 2004-06-03 | Neurogen Corporation | 3-substituted-6-aryl pyridined as ligands of c5a receptors |
| MXPA05011886A (es) | 2003-05-15 | 2006-02-17 | Tanox Inc | Metodos y composiciones para la prevencion y tratamiento de septicemia. |
| CA2558600C (en) | 2004-03-10 | 2013-07-09 | Kureha Corporation | A substituted-trialkyl amine compound with anti-viral activity based on antagonism against a chemokine receptor cxcr4 |
| EP1814576A2 (en) * | 2004-07-20 | 2007-08-08 | Critical Therapeutics, Inc. | Combination therapies of hmgb and complement inhibitors against inflammation |
| JP2007284352A (ja) * | 2004-08-05 | 2007-11-01 | Dai Ichi Seiyaku Co Ltd | ピラゾール誘導体 |
| US7825256B2 (en) | 2004-12-01 | 2010-11-02 | Kalypsys, Inc. | Inducible nitric oxide synthase dimerization inhibitors |
| EP1856126A2 (en) | 2005-02-17 | 2007-11-21 | Wyeth a Corporation of the State of Delaware | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
| EP1739078A1 (de) | 2005-05-30 | 2007-01-03 | Jerini AG | C5a-Rezeptor-Antagonisten |
| LT3508477T (lt) | 2008-12-22 | 2022-02-10 | Chemocentryx, Inc. | C5ar antagonistai |
| SI2585064T1 (sl) | 2010-06-24 | 2017-08-31 | Chemocentryx, Inc. | Antagonisti C5AR |
| CN105307651A (zh) * | 2013-04-22 | 2016-02-03 | 艾伯维公司 | 噻唑类化合物及其用途 |
| ES2926828T3 (es) | 2014-09-29 | 2022-10-28 | Chemocentryx Inc | Procesos e intermedios en la preparación de antagonistas de C5aR |
| EP3072891A1 (en) * | 2015-03-24 | 2016-09-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | New Toll-Like Receptor 9 Antagonists |
| JP7339733B2 (ja) | 2016-01-14 | 2023-09-06 | ケモセントリックス，インコーポレイティド | Ｃ３腎症を処置する方法 |
| WO2017176620A2 (en) | 2016-04-04 | 2017-10-12 | Chemocentryx, Inc. | SOLUBLE C5aR ANTAGONISTS |
| WO2018222601A1 (en) | 2017-05-31 | 2018-12-06 | Chemocentryx, Inc. | 5-5 FUSED RINGS AS C5a INHIBITORS |
| EP3630775B1 (en) | 2017-05-31 | 2022-12-14 | ChemoCentryx, Inc. | 6-5 FUSED RINGS AS C5a INHIBITORS |
| CN111741754A (zh) | 2017-10-30 | 2020-10-02 | 凯莫森特里克斯股份有限公司 | 作为免疫调节剂的氘代化合物 |
| US10759807B2 (en) | 2017-12-22 | 2020-09-01 | Chemocentryx, Inc. | Diaryl substituted 5,5-fused ring compounds as C5aR inhibitors |
| EP3728203B1 (en) | 2017-12-22 | 2024-03-13 | ChemoCentryx, Inc. | DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS |
| ES2993034T3 (en) | 2018-04-02 | 2024-12-20 | Chemocentryx Inc | Prodrugs of fused-bicyclic c5ar antagonists |
| CN114957165A (zh) * | 2021-02-26 | 2022-08-30 | 清华大学 | 一种抗病毒化合物及其制备方法和应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6157590A (ja) * | 1984-08-29 | 1986-03-24 | Asahi Shiyueebell Kk | シラン化合物およびその製造法 |
| US5159083A (en) * | 1990-12-28 | 1992-10-27 | Neurogen Corporation | Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands |
| US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
| MX9308025A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus dela inmunodeficiencia humana, procedimiento para supreparacion y formulacion farmaceutica que los contiene. |
| US5652237A (en) * | 1994-09-09 | 1997-07-29 | Warner-Lambert Company | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes |
| AU4368996A (en) * | 1994-11-23 | 1996-06-17 | Neurogen Corporation | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands |
| GB9426103D0 (en) * | 1994-12-23 | 1995-02-22 | Merck Sharp & Dohme | Therapeutic agents |
| EP0912559B1 (en) * | 1996-07-13 | 2002-11-06 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| AU726585B2 (en) * | 1997-05-29 | 2000-11-09 | Merck & Co., Inc. | Biarylalkanoic acids as cell adhesion inhibitors |
| MY153569A (en) * | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| ATE317691T1 (de) * | 1998-03-20 | 2006-03-15 | Daiichi Asubio Pharma Co Ltd | Benzochinonderivate enthaltende hemmer von nf-kb |
| NZ508790A (en) * | 1998-05-22 | 2003-10-31 | Scios Inc | Heterocyclic compounds and methods to treat cardiac failure and other disorders |
| BR9912013A (pt) * | 1998-07-10 | 2001-04-10 | Astrazeneca Ab | Composto, composição farmacêutica, método de tratar uma condição de doença, e, processo para preparar um composto |
| US6423519B1 (en) * | 1998-07-15 | 2002-07-23 | Gpc Biotech Inc. | Compositions and methods for inhibiting fungal growth |
| ID27787A (id) * | 1998-08-21 | 2001-04-26 | Viro Pharma Inc | Senyawa, komposisi dan metode untuk pengobatan atau pencegahan infeksi yang disebabkan oleh virus dan penyakit-penyakit yang berkaitan |
| US6437146B1 (en) * | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
| CA2348234A1 (en) * | 1998-10-29 | 2000-05-11 | Chunjian Liu | Compounds derived from an amine nucleus that are inhibitors of impdh enzyme |
| US6503905B1 (en) * | 1998-12-29 | 2003-01-07 | Pfizer Inc | 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives |
| PL350998A1 (en) * | 1999-03-24 | 2003-02-24 | Anormed Inc | Chemokine recpetor binding heterocyclic compounds |
| US6369226B1 (en) * | 1999-06-21 | 2002-04-09 | Agouron Pharmaceuticals, Inc. | Substituted benzamide inhibitors of rhinovirus 3C protease |
| WO2001021598A1 (en) * | 1999-09-23 | 2001-03-29 | Astrazeneca Ab | Therapeutic quinazoline compounds |
| BR0113932A (pt) * | 2000-09-15 | 2003-06-24 | Anormed Inc | Compostos heterocìclicos que se ligam ao receptor da quimiocina |
-
2000
- 2000-09-29 EP EP00965522A patent/EP1322309B1/en not_active Expired - Lifetime
- 2000-09-29 DE DE60039921T patent/DE60039921D1/de not_active Expired - Lifetime
- 2000-09-29 BR BR0017338-0A patent/BR0017338A/pt not_active IP Right Cessation
- 2000-09-29 YU YU23503A patent/YU23503A/sh unknown
- 2000-09-29 AU AU7622500A patent/AU7622500A/xx active Pending
- 2000-09-29 MX MXPA03002788A patent/MXPA03002788A/es unknown
- 2000-09-29 WO PCT/US2000/026816 patent/WO2002049993A2/en not_active Ceased
- 2000-09-29 IL IL15499300A patent/IL154993A0/xx unknown
- 2000-09-29 JP JP2002551496A patent/JP5260818B2/ja not_active Expired - Fee Related
- 2000-09-29 KR KR10-2003-7003410A patent/KR20030060887A/ko not_active Ceased
- 2000-09-29 CN CN00819935A patent/CN1454086A/zh active Pending
- 2000-09-29 AT AT00965522T patent/ATE404553T1/de not_active IP Right Cessation
-
2003
- 2003-03-26 NO NO20031370A patent/NO20031370L/no unknown
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