MXPA03002788A - Moduladores de receptor c5a de molecula pequena de alta afinidad. - Google Patents

Moduladores de receptor c5a de molecula pequena de alta afinidad.

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Publication number
MXPA03002788A
MXPA03002788A MXPA03002788A MXPA03002788A MXPA03002788A MX PA03002788 A MXPA03002788 A MX PA03002788A MX PA03002788 A MXPA03002788 A MX PA03002788A MX PA03002788 A MXPA03002788 A MX PA03002788A MX PA03002788 A MXPA03002788 A MX PA03002788A
Authority
MX
Mexico
Prior art keywords
alkyl
amino
mono
alkoxy
optionally substituted
Prior art date
Application number
MXPA03002788A
Other languages
English (en)
Spanish (es)
Inventor
Xiaoyan Zhang
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of MXPA03002788A publication Critical patent/MXPA03002788A/es

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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MXPA03002788A 2000-09-29 2000-09-29 Moduladores de receptor c5a de molecula pequena de alta afinidad. MXPA03002788A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/026816 WO2002049993A2 (en) 2000-09-29 2000-09-29 High affinity small molecule c5a receptor modulators

Publications (1)

Publication Number Publication Date
MXPA03002788A true MXPA03002788A (es) 2004-12-13

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MXPA03002788A MXPA03002788A (es) 2000-09-29 2000-09-29 Moduladores de receptor c5a de molecula pequena de alta afinidad.

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EP (1) EP1322309B1 (enExample)
JP (1) JP5260818B2 (enExample)
KR (1) KR20030060887A (enExample)
CN (1) CN1454086A (enExample)
AT (1) ATE404553T1 (enExample)
AU (1) AU7622500A (enExample)
BR (1) BR0017338A (enExample)
DE (1) DE60039921D1 (enExample)
IL (1) IL154993A0 (enExample)
MX (1) MXPA03002788A (enExample)
NO (1) NO20031370L (enExample)
WO (1) WO2002049993A2 (enExample)
YU (1) YU23503A (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
CA2479928A1 (en) * 2002-03-28 2003-10-09 Neurogen Corporation Substituted biaryl amides as c5a receptor modulators
WO2003082828A1 (en) 2002-03-28 2003-10-09 Neurogen Corporation Substituted tetrahydroisoquinolines as c5a receptor modulators
US6858637B2 (en) 2002-03-28 2005-02-22 Neurogen Corporation Substituted biaryl amides as C5a receptor modulators
JP2005528368A (ja) * 2002-03-29 2005-09-22 ニューロジェン・コーポレーション Ｃ５ａ受容体モジュレータである新規なアリールイミダゾール及び関連化合物。
GB0214139D0 (en) * 2002-06-19 2002-07-31 Glaxo Group Ltd Chemical compounds
US7169775B2 (en) 2002-08-21 2007-01-30 Neurogen Corporation Amino methyl imidazoles as C5a receptor modulators
JP3714948B2 (ja) 2002-09-11 2005-11-09 呉羽化学工業株式会社 アミン化合物及びその用途
ATE552253T1 (de) 2002-11-08 2012-04-15 Novartis Int Pharm Ltd 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren
US8329169B2 (en) 2003-05-15 2012-12-11 Genentech, Inc. Methods and compositions for the prevention and treatment of sepsis
CA2558600C (en) 2004-03-10 2013-07-09 Kureha Corporation A substituted-trialkyl amine compound with anti-viral activity based on antagonism against a chemokine receptor cxcr4
EP1814576A2 (en) * 2004-07-20 2007-08-08 Critical Therapeutics, Inc. Combination therapies of hmgb and complement inhibitors against inflammation
JP2007284352A (ja) * 2004-08-05 2007-11-01 Dai Ichi Seiyaku Co Ltd ピラゾール誘導体
EP1817030A2 (en) 2004-12-01 2007-08-15 Kalypsys, Inc. Inducible nitric oxide synthase dimerization inhibitors
AR052674A1 (es) 2005-02-17 2007-03-28 Wyeth Corp Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilcondensados
EP1739078A1 (de) 2005-05-30 2007-01-03 Jerini AG C5a-Rezeptor-Antagonisten
RS54998B1 (sr) 2008-12-22 2016-11-30 Chemocentryx Inc Antagonisti c5ar
HRP20171176T1 (hr) 2010-06-24 2017-10-06 Chemocentryx, Inc. C5ar antagonisti
BR112015026847A2 (pt) * 2013-04-22 2017-07-25 Abbvie Inc tiazóis e usos dos mesmos
CN106999481B (zh) 2014-09-29 2021-04-16 凯莫森特里克斯股份有限公司 制备C5aR拮抗剂的方法和中间体
EP3072891A1 (en) * 2015-03-24 2016-09-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. New Toll-Like Receptor 9 Antagonists
TWI791423B (zh) 2016-01-14 2023-02-11 美商卡默森屈有限公司 C3腎絲球病變之治療方法
MA44629A (fr) 2016-04-04 2021-03-24 Chemocentryx Inc Antagonistes de c5ar solubles
MA48803A (fr) 2017-05-31 2020-04-08 Chemocentryx Inc Cycles 6-5 fusionnés utilisés en tant qu'inhibiteurs de c5a
MA48800A (fr) 2017-05-31 2020-04-08 Chemocentryx Inc Cycles 5-5 fusionnés utilisés en tant qu'inhibiteurs de c5a
EP3703687A4 (en) 2017-10-30 2021-04-07 ChemoCentryx, Inc. DEUTERATED COMPOUNDS USED AS IMMUNOMODULATORS
CN111788185B (zh) 2017-12-22 2024-12-13 凯莫森特里克斯股份有限公司 作为C5a抑制剂的二芳基取代的6,5稠合环化合物
MA51327A (fr) 2017-12-22 2021-05-26 Chemocentryx Inc Composés cycliques fusionnés en 5,5 à substitution diaryle, utilisés en tant qu'inhibiteurs du c5ar
MA52245A (fr) 2018-04-02 2021-04-28 Chemocentryx Inc Promédicaments d'antagonistes de c5ar bicycliques fusionnés
CN114957165A (zh) * 2021-02-26 2022-08-30 清华大学 一种抗病毒化合物及其制备方法和应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6157590A (ja) * 1984-08-29 1986-03-24 Asahi Shiyueebell Kk シラン化合物およびその製造法
US5159083A (en) * 1990-12-28 1992-10-27 Neurogen Corporation Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
MX9308025A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus dela inmunodeficiencia humana, procedimiento para supreparacion y formulacion farmaceutica que los contiene.
US5652237A (en) * 1994-09-09 1997-07-29 Warner-Lambert Company 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
BR9509760A (pt) * 1994-11-23 1998-06-30 Neurogen Corp Composto
GB9426103D0 (en) * 1994-12-23 1995-02-22 Merck Sharp & Dohme Therapeutic agents
WO1998002434A1 (en) * 1996-07-13 1998-01-22 Glaxo Group Limited Fused heterocyclic compounds as protein tyrosine kinase inhibitors
EP1017382B1 (en) * 1997-05-29 2006-03-01 Merck & Co., Inc. (a New Jersey corp.) Biarylalkanoic acids as cell adhesion inhibitors
MY153569A (en) * 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
CN1181817C (zh) * 1998-03-20 2004-12-29 第一三得利制药株式会社 以苯基甲苯醌为有效成分的NF-kB抑制剂
ES2258331T3 (es) * 1998-05-22 2006-08-16 Scios Inc. Compuestos heterociclicos y procedimientos de tratamiento de insuficiencia cardiaca y otros trastornos.
EP1097137A1 (en) * 1998-07-10 2001-05-09 AstraZeneca AB N-substituted naphthalene carboxamides as neurokinin-receptor antagonists
US6423519B1 (en) * 1998-07-15 2002-07-23 Gpc Biotech Inc. Compositions and methods for inhibiting fungal growth
AU743411B2 (en) * 1998-08-21 2002-01-24 Viropharma Incorporated Compounds, compositions and methods for treating or preventing viral infections and associated diseases
US6437146B1 (en) * 1998-09-25 2002-08-20 Fujisawa Pharmaceutical Co., Ltd. Oxazole compounds as prostaglandin e2 agonists or antagonists
EP1126843A4 (en) * 1998-10-29 2005-06-15 Bristol Myers Squibb Co AMINO-CELL DERIVATIVE COMPOUNDS INHIBITORS OF ENZYME IMPDH
US6503905B1 (en) * 1998-12-29 2003-01-07 Pfizer Inc 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
PL350998A1 (en) * 1999-03-24 2003-02-24 Anormed Inc Chemokine recpetor binding heterocyclic compounds
US6369226B1 (en) * 1999-06-21 2002-04-09 Agouron Pharmaceuticals, Inc. Substituted benzamide inhibitors of rhinovirus 3C protease
ATE339406T1 (de) * 1999-09-23 2006-10-15 Astrazeneca Ab Chinazoline verbindungen als heilmittel
DE60143457D1 (de) * 2000-09-15 2010-12-23 Anormed Inc Chemokin Rezeptor bindende heterozyklische Verbindungen

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