JP2004525183A - Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしてのキノリン−４−カルボキサミド誘導体 - Google Patents

Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしてのキノリン−４−カルボキサミド誘導体 Download PDF

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JP2004525183A
JP2004525183A JP2002581418A JP2002581418A JP2004525183A JP 2004525183 A JP2004525183 A JP 2004525183A JP 2002581418 A JP2002581418 A JP 2002581418A JP 2002581418 A JP2002581418 A JP 2002581418A JP 2004525183 A JP2004525183 A JP 2004525183A
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JP2004525183A5 (https=
Inventor
カルロ・ファリーナ
ステファニア・ガリアルディ
ジュゼッペ・アルナルド・マリア・ジャルディーナ
マリサ・マルティネッリ
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GlaxoSmithKline SpA
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Priority claimed from GB0205649A external-priority patent/GB0205649D0/en
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Publication of JP2004525183A publication Critical patent/JP2004525183A/ja
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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JP2002581418A 2001-04-11 2002-04-11 Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしてのキノリン−４−カルボキサミド誘導体 Pending JP2004525183A (ja)

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Application Number Priority Date Filing Date Title
GBGB0109123.0A GB0109123D0 (en) 2001-04-11 2001-04-11 Novel compounds
GB0205649A GB0205649D0 (en) 2002-03-11 2002-03-11 Novel compounds
PCT/EP2002/004066 WO2002083663A1 (en) 2001-04-11 2002-04-11 Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

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JP2004525183A true JP2004525183A (ja) 2004-08-19
JP2004525183A5 JP2004525183A5 (https=) 2005-12-22

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JP2002581419A Pending JP2004525184A (ja) 2001-04-11 2002-04-11 Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしての３−置換キノリン−４−カルボキサミド誘導体

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JP4361566B2 (ja) 2004-04-28 2009-11-11 武田薬品工業株式会社 縮合キノリン誘導体およびその使用
GB0417702D0 (en) * 2004-08-09 2004-09-08 Merck Sharp & Dohme New uses
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GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
CN101268052A (zh) * 2005-09-21 2008-09-17 阿斯利康(瑞典)有限公司 作为nk-3受体配体的n-氧代-杂环和n-氧代-烷基喹啉-4-甲酰胺
WO2008118454A2 (en) * 2007-03-23 2008-10-02 Amgen Inc. Derivatives of quinoline or benzopyrazine and their uses for the treatment of (inter alia) inflammatory diseases, autoimmune diseases or various kinds of cancer
WO2008153027A1 (ja) * 2007-06-11 2008-12-18 Takeda Pharmaceutical Company Limited ピロロキノリン誘導体およびその用途
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EP1659120A1 (en) 2006-05-24
DE60209362D1 (de) 2006-04-27
ES2259096T3 (es) 2006-09-16
ATE318266T1 (de) 2006-03-15
EP1385839B1 (en) 2006-02-22
US20070259882A1 (en) 2007-11-08
US20070161647A1 (en) 2007-07-12
EP1385839A1 (en) 2004-02-04
JP2004525184A (ja) 2004-08-19
ATE313539T1 (de) 2006-01-15
DE60208178T2 (de) 2006-08-24
EP1377567B1 (en) 2005-12-21
US20060229315A1 (en) 2006-10-12
WO2002083664A1 (en) 2002-10-24
WO2002083663A1 (en) 2002-10-24
EP1377567A1 (en) 2004-01-07
DE60208178D1 (de) 2006-01-26
ES2254688T3 (es) 2006-06-16
DE60209362T2 (de) 2006-10-26
US20050176762A1 (en) 2005-08-11
US20040152726A1 (en) 2004-08-05

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