JP2004524340A5 - - Google Patents
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- JP2004524340A5 JP2004524340A5 JP2002573793A JP2002573793A JP2004524340A5 JP 2004524340 A5 JP2004524340 A5 JP 2004524340A5 JP 2002573793 A JP2002573793 A JP 2002573793A JP 2002573793 A JP2002573793 A JP 2002573793A JP 2004524340 A5 JP2004524340 A5 JP 2004524340A5
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- Japan
- Prior art keywords
- group
- carbon atoms
- alkyl group
- branched
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims description 82
- 125000004432 carbon atom Chemical group C* 0.000 claims description 63
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 239000001257 hydrogen Substances 0.000 claims description 25
- 125000003118 aryl group Chemical group 0.000 claims description 23
- 125000000304 alkynyl group Chemical group 0.000 claims description 15
- 125000000623 heterocyclic group Chemical group 0.000 claims description 15
- 125000003342 alkenyl group Chemical group 0.000 claims description 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 14
- 150000002431 hydrogen Chemical group 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 125000006575 electron-withdrawing group Chemical group 0.000 claims description 9
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 101100149686 Caenorhabditis elegans snr-4 gene Proteins 0.000 claims description 2
- 101100478234 Caenorhabditis elegans spr-4 gene Proteins 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 7
- 208000004296 neuralgia Diseases 0.000 claims 6
- 208000021722 neuropathic pain Diseases 0.000 claims 6
- 230000002093 peripheral effect Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 208000004454 Hyperalgesia Diseases 0.000 claims 4
- 206010065390 Inflammatory pain Diseases 0.000 claims 4
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 4
- VPPJLAIAVCUEMN-GFCCVEGCSA-N lacosamide Chemical compound COC[C@@H](NC(C)=O)C(=O)NCC1=CC=CC=C1 VPPJLAIAVCUEMN-GFCCVEGCSA-N 0.000 claims 4
- 208000000094 Chronic Pain Diseases 0.000 claims 3
- 208000005298 acute pain Diseases 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 3
- 230000002757 inflammatory effect Effects 0.000 claims 3
- 230000002981 neuropathic effect Effects 0.000 claims 3
- 201000008482 osteoarthritis Diseases 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- XCVDGQBGMARFRY-GFCCVEGCSA-N (2r)-2-acetamido-n-[(3-fluorophenyl)methyl]-3-methoxypropanamide Chemical compound COC[C@@H](NC(C)=O)C(=O)NCC1=CC=CC(F)=C1 XCVDGQBGMARFRY-GFCCVEGCSA-N 0.000 claims 1
- PVNGTPGYSFGJIH-GFCCVEGCSA-N (2r)-2-acetamido-n-[(4-fluorophenyl)methyl]-3-methoxypropanamide Chemical compound COC[C@@H](NC(C)=O)C(=O)NCC1=CC=C(F)C=C1 PVNGTPGYSFGJIH-GFCCVEGCSA-N 0.000 claims 1
- SGBCQENKTXKIRD-MRXNPFEDSA-N (2r)-2-acetamido-n-benzyl-2-phenylacetamide Chemical compound O=C([C@H](NC(=O)C)C=1C=CC=CC=1)NCC1=CC=CC=C1 SGBCQENKTXKIRD-MRXNPFEDSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- JPYQFYIEOUVJDU-UHFFFAOYSA-N beclamide Chemical compound ClCCC(=O)NCC1=CC=CC=C1 JPYQFYIEOUVJDU-UHFFFAOYSA-N 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01106891.3 | 2001-03-20 | ||
| EP01106891A EP1243262B1 (en) | 2001-03-20 | 2001-03-20 | Novel use of a peptide class of compound for treating non-neuropathic inflammatory pain |
| PCT/EP2002/003034 WO2002074784A2 (en) | 2001-03-20 | 2002-03-19 | Novel use of a peptide class of compound for treating non neuropathic inflammatory pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004524340A JP2004524340A (ja) | 2004-08-12 |
| JP2004524340A5 true JP2004524340A5 (https=) | 2008-09-04 |
| JP4955906B2 JP4955906B2 (ja) | 2012-06-20 |
Family
ID=8176844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573793A Expired - Fee Related JP4955906B2 (ja) | 2001-03-20 | 2002-03-19 | 非ニューロパシー炎症性疼痛を治療するための化合物のペプチドクラスの新規の使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US6803481B2 (https=) |
| EP (2) | EP1243262B1 (https=) |
| JP (1) | JP4955906B2 (https=) |
| KR (1) | KR100773100B1 (https=) |
| CN (2) | CN100415225C (https=) |
| AT (2) | ATE327744T1 (https=) |
| AU (1) | AU2002257681C1 (https=) |
| BR (1) | BR0205823A (https=) |
| CA (1) | CA2419397C (https=) |
| CY (3) | CY1105533T1 (https=) |
| CZ (1) | CZ20032763A3 (https=) |
| DE (3) | DE60120104T2 (https=) |
| DK (2) | DK1243262T3 (https=) |
| EA (1) | EA007532B1 (https=) |
| ES (2) | ES2262567T3 (https=) |
| FR (1) | FR09C0041I2 (https=) |
| HU (1) | HUP0303600A3 (https=) |
| IL (2) | IL154087A0 (https=) |
| LU (1) | LU91590I2 (https=) |
| MX (1) | MXPA03008467A (https=) |
| NL (1) | NL300399I1 (https=) |
| NO (1) | NO20033629D0 (https=) |
| NZ (1) | NZ523865A (https=) |
| PL (1) | PL216213B1 (https=) |
| PT (2) | PT1243262E (https=) |
| SI (2) | SI1373300T1 (https=) |
| SK (1) | SK287539B6 (https=) |
| UA (1) | UA82645C2 (https=) |
| WO (1) | WO2002074784A2 (https=) |
| ZA (1) | ZA200300858B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60131032T2 (de) * | 2000-08-25 | 2008-08-14 | Research Corp. Technologies, Inc., Tucson | Verwendung von antikonvulsiven Aminosäure zur Behandlung von Migräne |
| DE60120104T2 (de) * | 2001-03-20 | 2006-09-21 | Schwarz Pharma Ag | Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz |
| DK1243263T3 (da) * | 2001-03-21 | 2003-03-17 | Sanol Arznei Schwarz Gmbh | Hidtil ukendt anvendelse af en klasse af peptidforbindelser til behandling af allodyni eller andre forskellige typer af kronisk- eller fantomsmerte |
| JP4664924B2 (ja) * | 2003-12-02 | 2011-04-06 | ウーツェーベー ファルマ ゲーエムベーハー | 中枢神経因性疼痛の治療のためのペプチド化合物の新規使用 |
| EP1579858A1 (en) * | 2004-03-26 | 2005-09-28 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in painful diabetic neuropathy |
| US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
| US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
| AU2005232395B2 (en) * | 2004-04-16 | 2010-09-09 | Schwarz Pharma Ag | Use of peptidic compounds for the prophylaxis and treatment of chronic headache |
| EP1604654A1 (en) | 2004-05-18 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating dyskinesia |
| EP1604655A1 (en) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
| EP1604656A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
| US7427601B2 (en) * | 2004-06-24 | 2008-09-23 | Schwarz Pharma Ag | Method for treating tremor |
| EA014055B1 (ru) * | 2004-08-27 | 2010-08-30 | Шварц Фарма Аг | Применение пептидных соединений для лечения боли при раке кости, а также боли, вызванной химиотерапией и нуклеозидами |
| EP1642889A1 (en) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| US20060252749A1 (en) * | 2005-01-28 | 2006-11-09 | Srz Properties, Inc. | Lacosamide for add-on therapy of psychosis |
| AR057643A1 (es) | 2005-01-28 | 2007-12-12 | Sanol Arznei Schwarz Gmbh | Lacosamida para terapia adjunta |
| EP1754476A1 (en) | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| GB0523550D0 (en) | 2005-11-18 | 2005-12-28 | Hunter Fleming Ltd | Therapeutic uses of steroidal compounds |
| ATE530175T1 (de) * | 2006-06-08 | 2011-11-15 | Ucb Pharma Gmbh | Therapeutische kombination für schmerzhafte medizinische zustände |
| EP1873527A1 (en) * | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
| EA019757B1 (ru) | 2006-06-15 | 2014-06-30 | ЮСиБи ФАРМА ГМБХ | Фармацевтическая композиция с синергетическим противосудорожным эффектом |
| CN101466390B (zh) | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
| EP1920780A1 (en) * | 2006-10-12 | 2008-05-14 | Schwarz Pharma Ag | Peptide compounds for the treatment of hyperexcitability disorders |
| US8829033B2 (en) | 2009-09-23 | 2014-09-09 | The University Of North Carolina At Chapel Hill | N-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents |
| EP2468261A1 (en) | 2010-12-02 | 2012-06-27 | UCB Pharma GmbH | Formulation of lacosamide |
| BR112013013525A2 (pt) | 2010-12-02 | 2016-10-18 | Ucb Pharma Gmbh | formulação de liberação controlada sólida de lacosamida para administração oral, composição farmacêutica sólida, e, método para a prevenção, alívio e/ou tratamento de uma doença do sistema nervoso central |
| GB2524689B (en) | 2011-05-20 | 2016-01-27 | Gw Pharma Ltd | Cannabinoids for use in the treatment of neuropathic pain |
| DK2858496T3 (da) * | 2012-05-10 | 2023-07-24 | Solutex Na Llc | Olier med anti-inflammatorisk aktivitet, som indeholder naturlige specialiserede pro-afhjælpningsmediatorer og deres forløbere |
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