JP2004520021A5 - - Google Patents
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- Publication number
- JP2004520021A5 JP2004520021A5 JP2002546744A JP2002546744A JP2004520021A5 JP 2004520021 A5 JP2004520021 A5 JP 2004520021A5 JP 2002546744 A JP2002546744 A JP 2002546744A JP 2002546744 A JP2002546744 A JP 2002546744A JP 2004520021 A5 JP2004520021 A5 JP 2004520021A5
- Authority
- JP
- Japan
- Prior art keywords
- molecule
- carrier
- photosensitizer
- molecules
- transport
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003504 photosensitizing agent Substances 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 15
- 230000032258 transport Effects 0.000 description 13
- 230000003834 intracellular effect Effects 0.000 description 7
- 230000008685 targeting Effects 0.000 description 7
- 239000002245 particle Substances 0.000 description 6
- 241000701161 unidentified adenovirus Species 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000004700 cellular uptake Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 2
- 108010039918 Polylysine Proteins 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 229920000656 polylysine Polymers 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- -1 cationic lipid Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000012202 endocytosis Effects 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 210000001163 endosome Anatomy 0.000 description 1
- 210000002288 golgi apparatus Anatomy 0.000 description 1
- 210000004020 intracellular membrane Anatomy 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0029134A GB0029134D0 (en) | 2000-11-29 | 2000-11-29 | Method |
| GB0029404A GB0029404D0 (en) | 2000-12-01 | 2000-12-01 | Method |
| GB0114695A GB0114695D0 (en) | 2001-06-15 | 2001-06-15 | Method |
| PCT/GB2001/005299 WO2002044396A1 (en) | 2000-11-29 | 2001-11-29 | Photochemical internalization for delivery of molecules into the cytosol |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004520021A JP2004520021A (ja) | 2004-07-08 |
| JP2004520021A5 true JP2004520021A5 (https=) | 2009-12-24 |
| JP4578770B2 JP4578770B2 (ja) | 2010-11-10 |
Family
ID=27255991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002546744A Expired - Fee Related JP4578770B2 (ja) | 2000-11-29 | 2001-11-29 | 細胞質中への分子送達のための光化学的内在化 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7223600B2 (https=) |
| EP (1) | EP1346059B1 (https=) |
| JP (1) | JP4578770B2 (https=) |
| KR (2) | KR100980153B1 (https=) |
| CN (1) | CN100558903C (https=) |
| AU (2) | AU2085302A (https=) |
| BR (1) | BR0115795A (https=) |
| CA (1) | CA2430087C (https=) |
| CZ (1) | CZ301427B6 (https=) |
| ES (1) | ES2383516T3 (https=) |
| HU (1) | HU229805B1 (https=) |
| PL (1) | PL213560B1 (https=) |
| PT (1) | PT1346059E (https=) |
| WO (1) | WO2002044396A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9905911D0 (en) | 1999-03-15 | 1999-05-05 | Photocure As | Method |
| KR100980153B1 (ko) * | 2000-11-29 | 2010-09-03 | 피씨아이 바이오테크 에이에스 | 사이토졸 내로의 분자 전달을 위한 광화학적 내부이행 |
| GB0415263D0 (en) * | 2004-07-07 | 2004-08-11 | Norwegian Radium Hospital Res | Method |
| GB0613753D0 (en) | 2006-07-11 | 2006-08-23 | Norwegian Radium Hospital Res | Method |
| EP2099496A2 (en) * | 2006-12-08 | 2009-09-16 | Massachusetts Institute of Technology | Delivery of nanoparticles and/or agents to cells |
| RU2339414C1 (ru) * | 2007-03-27 | 2008-11-27 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Способ подавления роста опухолей |
| US8411669B2 (en) * | 2008-04-18 | 2013-04-02 | Cisco Technology, Inc. | Distributed transcoding on IP phones with idle DSP channels |
| GB0811955D0 (en) | 2008-06-30 | 2008-07-30 | Pci Biotech As | Method |
| US8808733B2 (en) | 2009-03-31 | 2014-08-19 | The Board Of Trustees Of The University Of Arkansas | Method of controlled drug release from a liposome carrier |
| GB0914287D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
| GB0914286D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Method |
| JP5979385B2 (ja) * | 2011-10-07 | 2016-08-24 | 国立大学法人鳥取大学 | リポソーム複合体 |
| WO2013070872A1 (en) | 2011-11-08 | 2013-05-16 | The Board Of Trustees Of The University Of Arkansas | Methods and compositions for x-ray induced release from ph sensitive liposomes |
| CN105101951B (zh) * | 2012-10-29 | 2021-08-03 | 新加坡科技研究局 | 一种用于基因-药物治疗的新型试剂 |
| CA2906279A1 (en) * | 2013-03-15 | 2014-09-18 | Pci Biotech As | A method of generating antigen presenting cells using photochemical internalisation |
| WO2015024931A1 (en) | 2013-08-19 | 2015-02-26 | Moghimi Seyed Moien | Peptidic nanodelivery composition targeting two receptors |
| JP6684215B2 (ja) * | 2013-08-28 | 2020-04-22 | ピーシーアイ バイオテック エイエス | 予防接種用化合物および免疫化用化合物、ならびに予防接種方法および免疫化方法 |
| WO2015028575A1 (en) * | 2013-08-28 | 2015-03-05 | Pci Biotech As | Immunisation method by photochemical internalisation |
| AU2014390262B2 (en) | 2014-04-11 | 2020-11-26 | Pci Biotech As | Method of treating melanoma |
| GB201415250D0 (en) * | 2014-08-28 | 2014-10-15 | Pci Biotech As | Compound and method |
| EP3185901B1 (en) | 2014-08-28 | 2023-10-04 | PCI Biotech AS | Compound and method |
| GB201503776D0 (en) | 2015-03-05 | 2015-04-22 | Pci Biotech As | Compound and method |
| WO2018017954A1 (en) * | 2016-07-21 | 2018-01-25 | Rutgers, The State University Of New Jersey | Antimicrobial cationic systems and methods of use |
| AU2017342086A1 (en) | 2016-10-14 | 2019-05-09 | Pci Biotech As | Treatment of cholangiocarcinoma with TPCS-2a induced photochemical internalisation of gemcitabine |
| KR101911725B1 (ko) * | 2017-01-16 | 2018-12-28 | 주식회사 코어파마 | 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법 |
| CN107029236B (zh) * | 2017-04-18 | 2020-04-10 | 中国医学科学院生物医学工程研究所 | 一种吲哚菁绿自组装纳米疫苗及制备方法 |
| GB201718631D0 (en) * | 2017-11-10 | 2017-12-27 | Pci Biotech As | Method |
| GB201801169D0 (en) | 2018-01-24 | 2018-03-07 | Pci Biotech As | Method |
| EP3823668A1 (en) | 2018-07-16 | 2021-05-26 | DCPrime B.V. | A combination product for use in tumor vaccination |
| CA3109804A1 (en) | 2018-08-16 | 2020-02-20 | The Regents Of The University Of California | Chemically and photochemically initiated cell membrane blebbing to induce cell vesicle production, modifications thereof, and uses thereof |
| AU2020264083A1 (en) | 2019-04-25 | 2021-12-02 | Mendus B.V. | Methods of tumor vaccination |
| US20210322471A1 (en) | 2020-03-27 | 2021-10-21 | Dcprime B.V. | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| US12091681B2 (en) | 2020-03-27 | 2024-09-17 | Mendus B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| CN116133679A (zh) | 2020-06-30 | 2023-05-16 | 门德斯有限公司 | 白血病衍生细胞在卵巢癌疫苗中的用途 |
| WO2022097068A1 (en) | 2020-11-05 | 2022-05-12 | Dcprime B.V. | Use of tumor-independent antigens in immunotherapies |
| AU2022211682A1 (en) | 2021-01-22 | 2023-08-03 | Mendus B.V. | Methods of tumor vaccination |
| KR20230157388A (ko) | 2021-03-12 | 2023-11-16 | 멘두스 비.브이. | 백신접종의 방법 및 cd47 차단의 용도 |
| GB202115451D0 (en) | 2021-10-27 | 2021-12-08 | Pci Biotech As | Method |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4649151A (en) | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
| JPH0764728B2 (ja) | 1985-04-30 | 1995-07-12 | 日本石油化学株式会社 | 新規なテトラピロ−ル医薬用組成物 |
| NO891491L (no) | 1987-08-12 | 1989-04-11 | Peter Nemeth | Prosedyre for befrielse av celleblandinger og vev for uoenskede populasjoner. |
| GB8721108D0 (en) | 1987-09-08 | 1987-10-14 | Salford University Of | Liposomes |
| NO176947C (no) | 1988-07-06 | 1995-06-28 | Long Island Jewish Medical Ct | Fremgangsmåte for fremstilling av et topisk preparat for fotodynamisk terapi |
| US5059619A (en) | 1989-06-14 | 1991-10-22 | Quadra Logic Technologies, Inc. | Stable freeze-dried polyhematoporphyrin ether/ester |
| NO179410C (no) | 1989-07-17 | 1996-10-02 | Univ British Columbia | Analogifremgangsmåte for fremstilling av terapeutisk aktive monobenzofyriner og anvendelse av disse |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5179120A (en) | 1991-06-28 | 1993-01-12 | Cytopharm, Inc. | Porphycene compounds for photodynamic therapy |
| PL165249B1 (pl) | 1991-10-29 | 1994-11-30 | Wojskowa Akad Tech | Sposób otrzymywania soli kompleksowych hematoporfiryny i jej pochodnych PL PL PL PL PL PL PL |
| US5258453A (en) | 1992-01-21 | 1993-11-02 | University Of Utah | Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light |
| GB9318841D0 (en) | 1993-09-10 | 1993-10-27 | Res Foundation Of The Norwegia | Composition |
| NO180167C (no) | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
| ATE202076T1 (de) | 1995-03-10 | 2001-06-15 | Photocure Asa | Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie |
| GB9700396D0 (en) | 1997-01-10 | 1997-02-26 | Photocure As | Photochemotherapeutic compositions |
| DK0983273T3 (da) * | 1997-05-07 | 2002-04-22 | Univ British Columbia | Ethylenglycolestere af monohydrobenzoporphyrinderivater som fotoaktive midler |
| DE60040274D1 (de) | 1999-03-10 | 2008-10-30 | Phogen Ltd | Verabreichung von nukleinsäuren und proteinen an zellen |
| GB9905911D0 (en) | 1999-03-15 | 1999-05-05 | Photocure As | Method |
| GB0018527D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Composition |
| KR100980153B1 (ko) * | 2000-11-29 | 2010-09-03 | 피씨아이 바이오테크 에이에스 | 사이토졸 내로의 분자 전달을 위한 광화학적 내부이행 |
-
2001
- 2001-11-29 KR KR1020037007253A patent/KR100980153B1/ko not_active Expired - Fee Related
- 2001-11-29 PL PL365006A patent/PL213560B1/pl unknown
- 2001-11-29 CN CNB018223575A patent/CN100558903C/zh not_active Expired - Fee Related
- 2001-11-29 AU AU2085302A patent/AU2085302A/xx active Pending
- 2001-11-29 CZ CZ20031791A patent/CZ301427B6/cs not_active IP Right Cessation
- 2001-11-29 JP JP2002546744A patent/JP4578770B2/ja not_active Expired - Fee Related
- 2001-11-29 CA CA2430087A patent/CA2430087C/en not_active Expired - Fee Related
- 2001-11-29 ES ES01998646T patent/ES2383516T3/es not_active Expired - Lifetime
- 2001-11-29 EP EP01998646A patent/EP1346059B1/en not_active Expired - Lifetime
- 2001-11-29 US US10/433,136 patent/US7223600B2/en not_active Expired - Fee Related
- 2001-11-29 BR BR0115795-7A patent/BR0115795A/pt not_active IP Right Cessation
- 2001-11-29 AU AU2002220853A patent/AU2002220853B2/en not_active Ceased
- 2001-11-29 HU HU0402260A patent/HU229805B1/hu not_active IP Right Cessation
- 2001-11-29 WO PCT/GB2001/005299 patent/WO2002044396A1/en not_active Ceased
- 2001-11-29 PT PT01998646T patent/PT1346059E/pt unknown
- 2001-11-29 KR KR1020087020801A patent/KR20080080685A/ko not_active Ceased
-
2007
- 2007-05-09 US US11/746,394 patent/US8008077B2/en not_active Expired - Fee Related
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