JP2004520021A5 - - Google Patents
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- Publication number
- JP2004520021A5 JP2004520021A5 JP2002546744A JP2002546744A JP2004520021A5 JP 2004520021 A5 JP2004520021 A5 JP 2004520021A5 JP 2002546744 A JP2002546744 A JP 2002546744A JP 2002546744 A JP2002546744 A JP 2002546744A JP 2004520021 A5 JP2004520021 A5 JP 2004520021A5
- Authority
- JP
- Japan
- Prior art keywords
- molecule
- carrier
- photosensitizer
- molecules
- transport
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003504 photosensitizing agent Substances 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 15
- 230000032258 transport Effects 0.000 description 13
- 230000003834 intracellular effect Effects 0.000 description 7
- 230000008685 targeting Effects 0.000 description 7
- 239000002245 particle Substances 0.000 description 6
- 241000701161 unidentified adenovirus Species 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000004700 cellular uptake Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 2
- 108010039918 Polylysine Proteins 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 229920000656 polylysine Polymers 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- -1 cationic lipid Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000012202 endocytosis Effects 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 210000001163 endosome Anatomy 0.000 description 1
- 210000002288 golgi apparatus Anatomy 0.000 description 1
- 210000004020 intracellular membrane Anatomy 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0029134A GB0029134D0 (en) | 2000-11-29 | 2000-11-29 | Method |
| GB0029404A GB0029404D0 (en) | 2000-12-01 | 2000-12-01 | Method |
| GB0114695A GB0114695D0 (en) | 2001-06-15 | 2001-06-15 | Method |
| PCT/GB2001/005299 WO2002044396A1 (en) | 2000-11-29 | 2001-11-29 | Photochemical internalization for delivery of molecules into the cytosol |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004520021A JP2004520021A (ja) | 2004-07-08 |
| JP2004520021A5 true JP2004520021A5 (https=) | 2009-12-24 |
| JP4578770B2 JP4578770B2 (ja) | 2010-11-10 |
Family
ID=27255991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002546744A Expired - Fee Related JP4578770B2 (ja) | 2000-11-29 | 2001-11-29 | 細胞質中への分子送達のための光化学的内在化 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7223600B2 (https=) |
| EP (1) | EP1346059B1 (https=) |
| JP (1) | JP4578770B2 (https=) |
| KR (2) | KR20080080685A (https=) |
| CN (1) | CN100558903C (https=) |
| AU (2) | AU2002220853B2 (https=) |
| BR (1) | BR0115795A (https=) |
| CA (1) | CA2430087C (https=) |
| CZ (1) | CZ301427B6 (https=) |
| ES (1) | ES2383516T3 (https=) |
| HU (1) | HU229805B1 (https=) |
| PL (1) | PL213560B1 (https=) |
| PT (1) | PT1346059E (https=) |
| WO (1) | WO2002044396A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9905911D0 (en) | 1999-03-15 | 1999-05-05 | Photocure As | Method |
| PT1346059E (pt) * | 2000-11-29 | 2012-06-01 | Pci Biotech As | Internalização fotoquímica para distribuição de moléculas no citosol |
| GB0415263D0 (en) * | 2004-07-07 | 2004-08-11 | Norwegian Radium Hospital Res | Method |
| GB0613753D0 (en) * | 2006-07-11 | 2006-08-23 | Norwegian Radium Hospital Res | Method |
| WO2008073856A2 (en) * | 2006-12-08 | 2008-06-19 | Massachusetts Institute Of Technology | Delivery of nanoparticles and/or agents to cells |
| RU2339414C1 (ru) * | 2007-03-27 | 2008-11-27 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Способ подавления роста опухолей |
| US8411669B2 (en) * | 2008-04-18 | 2013-04-02 | Cisco Technology, Inc. | Distributed transcoding on IP phones with idle DSP channels |
| GB0811955D0 (en) | 2008-06-30 | 2008-07-30 | Pci Biotech As | Method |
| US8808733B2 (en) | 2009-03-31 | 2014-08-19 | The Board Of Trustees Of The University Of Arkansas | Method of controlled drug release from a liposome carrier |
| GB0914287D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
| GB0914286D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Method |
| US9872833B2 (en) * | 2011-10-07 | 2018-01-23 | National University Corporation Tottori University | Liposome composite body |
| US9849087B2 (en) | 2011-11-08 | 2017-12-26 | The Board Of Trustees Of The University Of Arkansas | Methods and compositions for X-ray induced release from pH sensitive liposomes |
| DK2911650T3 (da) * | 2012-10-29 | 2019-11-18 | Agency Science Tech & Res | Hidtil ukendt reagens til gen-lægemiddel-terapeutika |
| US20160040128A1 (en) * | 2013-03-15 | 2016-02-11 | Pci Biotech As | Method |
| EP3035969B1 (en) | 2013-08-19 | 2022-08-03 | S.M. Discovery Holdings Inc. | Peptidic nanodelivery composition targeting two receptors |
| AU2014314149B2 (en) * | 2013-08-28 | 2019-12-19 | Pci Biotech As | Compound and method for vaccination and immunisation |
| WO2015028575A1 (en) * | 2013-08-28 | 2015-03-05 | Pci Biotech As | Immunisation method by photochemical internalisation |
| US10973896B2 (en) | 2014-04-11 | 2021-04-13 | Pci Biotech As | Treatment or prevention of melanoma using photochemical internalization of a melanoma antigen |
| WO2016030529A1 (en) | 2014-08-28 | 2016-03-03 | Pci Biotech As | Compound and method |
| GB201415250D0 (en) * | 2014-08-28 | 2014-10-15 | Pci Biotech As | Compound and method |
| GB201503776D0 (en) | 2015-03-05 | 2015-04-22 | Pci Biotech As | Compound and method |
| WO2018017954A1 (en) * | 2016-07-21 | 2018-01-25 | Rutgers, The State University Of New Jersey | Antimicrobial cationic systems and methods of use |
| ES2841941T3 (es) | 2016-10-14 | 2021-07-12 | Pci Biotech As | Tratamiento del colangiocarcinoma a través de la internalización fotoquímica de gemcitabina inducida por TPCS2a |
| KR101911725B1 (ko) * | 2017-01-16 | 2018-12-28 | 주식회사 코어파마 | 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법 |
| CN107029236B (zh) * | 2017-04-18 | 2020-04-10 | 中国医学科学院生物医学工程研究所 | 一种吲哚菁绿自组装纳米疫苗及制备方法 |
| GB201718631D0 (en) | 2017-11-10 | 2017-12-27 | Pci Biotech As | Method |
| GB201801169D0 (en) | 2018-01-24 | 2018-03-07 | Pci Biotech As | Method |
| WO2020017962A1 (en) | 2018-07-16 | 2020-01-23 | Dcprime B.V. | A combination product for use in tumor vaccination. |
| CA3109804A1 (en) | 2018-08-16 | 2020-02-20 | The Regents Of The University Of California | Chemically and photochemically initiated cell membrane blebbing to induce cell vesicle production, modifications thereof, and uses thereof |
| CA3133410A1 (en) | 2019-04-25 | 2020-10-29 | Dcprime B.V. | Methods of tumor vaccination |
| CN115916963A (zh) | 2020-03-27 | 2023-04-04 | 门德斯有限公司 | 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途 |
| US20210322471A1 (en) | 2020-03-27 | 2021-10-21 | Dcprime B.V. | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| EP4171617A1 (en) | 2020-06-30 | 2023-05-03 | Mendus B.V. | Use of leukemia-derived cells in ovarian cancer vaccines |
| CA3196677A1 (en) | 2020-11-05 | 2022-05-12 | Erik Hans MANTING | Use of tumor-independent antigens in immunotherapies |
| JP2024506249A (ja) | 2021-01-22 | 2024-02-13 | メンドゥス・ベスローテン・フェンノートシャップ | 腫瘍ワクチン接種の方法 |
| CA3212351A1 (en) | 2021-03-12 | 2022-09-15 | Mendus B.V. | Methods of vaccination and use of cd47 blockade |
| GB202115451D0 (en) | 2021-10-27 | 2021-12-08 | Pci Biotech As | Method |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4649151A (en) | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
| DK168690B1 (da) | 1985-04-30 | 1994-05-24 | Nippon Petrochemicals Co Ltd | Farmaceutiske præparater til detektion og/eller behandling af pattedyrtumorer |
| NO891491D0 (no) | 1987-08-12 | 1989-04-11 | Peter Nemeth | Prosedyre for befrielse av celleblandinger og vev for uoenskede populasjoner. |
| GB8721108D0 (en) | 1987-09-08 | 1987-10-14 | Salford University Of | Liposomes |
| NO176947C (no) | 1988-07-06 | 1995-06-28 | Long Island Jewish Medical Ct | Fremgangsmåte for fremstilling av et topisk preparat for fotodynamisk terapi |
| US5059619A (en) | 1989-06-14 | 1991-10-22 | Quadra Logic Technologies, Inc. | Stable freeze-dried polyhematoporphyrin ether/ester |
| NO179410C (no) | 1989-07-17 | 1996-10-02 | Univ British Columbia | Analogifremgangsmåte for fremstilling av terapeutisk aktive monobenzofyriner og anvendelse av disse |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5179120A (en) | 1991-06-28 | 1993-01-12 | Cytopharm, Inc. | Porphycene compounds for photodynamic therapy |
| PL165249B1 (pl) | 1991-10-29 | 1994-11-30 | Wojskowa Akad Tech | Sposób otrzymywania soli kompleksowych hematoporfiryny i jej pochodnych PL PL PL PL PL PL PL |
| US5258453A (en) | 1992-01-21 | 1993-11-02 | University Of Utah | Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light |
| GB9318841D0 (en) | 1993-09-10 | 1993-10-27 | Res Foundation Of The Norwegia | Composition |
| NO180167C (no) * | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
| HU225148B1 (en) | 1995-03-10 | 2006-07-28 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy or diagnosis, products and kits comprising thereof and method of in vitro diagnosis by their using |
| GB9700396D0 (en) | 1997-01-10 | 1997-02-26 | Photocure As | Photochemotherapeutic compositions |
| CZ294715B6 (cs) * | 1997-05-07 | 2005-02-16 | Qlt Inc. | Ethylenglykol estery monohydrobenzoporfyrinových derivátů jako fotoaktivní činidla |
| DE60040274D1 (de) | 1999-03-10 | 2008-10-30 | Phogen Ltd | Verabreichung von nukleinsäuren und proteinen an zellen |
| GB9905911D0 (en) * | 1999-03-15 | 1999-05-05 | Photocure As | Method |
| GB0018527D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Composition |
| PT1346059E (pt) * | 2000-11-29 | 2012-06-01 | Pci Biotech As | Internalização fotoquímica para distribuição de moléculas no citosol |
-
2001
- 2001-11-29 PT PT01998646T patent/PT1346059E/pt unknown
- 2001-11-29 ES ES01998646T patent/ES2383516T3/es not_active Expired - Lifetime
- 2001-11-29 EP EP01998646A patent/EP1346059B1/en not_active Expired - Lifetime
- 2001-11-29 CN CNB018223575A patent/CN100558903C/zh not_active Expired - Fee Related
- 2001-11-29 AU AU2002220853A patent/AU2002220853B2/en not_active Ceased
- 2001-11-29 JP JP2002546744A patent/JP4578770B2/ja not_active Expired - Fee Related
- 2001-11-29 KR KR1020087020801A patent/KR20080080685A/ko not_active Ceased
- 2001-11-29 AU AU2085302A patent/AU2085302A/xx active Pending
- 2001-11-29 KR KR1020037007253A patent/KR100980153B1/ko not_active Expired - Fee Related
- 2001-11-29 PL PL365006A patent/PL213560B1/pl unknown
- 2001-11-29 US US10/433,136 patent/US7223600B2/en not_active Expired - Fee Related
- 2001-11-29 WO PCT/GB2001/005299 patent/WO2002044396A1/en not_active Ceased
- 2001-11-29 CA CA2430087A patent/CA2430087C/en not_active Expired - Fee Related
- 2001-11-29 HU HU0402260A patent/HU229805B1/hu not_active IP Right Cessation
- 2001-11-29 BR BR0115795-7A patent/BR0115795A/pt not_active IP Right Cessation
- 2001-11-29 CZ CZ20031791A patent/CZ301427B6/cs not_active IP Right Cessation
-
2007
- 2007-05-09 US US11/746,394 patent/US8008077B2/en not_active Expired - Fee Related
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