JP2004517947A5 - - Google Patents
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- Publication number
- JP2004517947A5 JP2004517947A5 JP2002562330A JP2002562330A JP2004517947A5 JP 2004517947 A5 JP2004517947 A5 JP 2004517947A5 JP 2002562330 A JP2002562330 A JP 2002562330A JP 2002562330 A JP2002562330 A JP 2002562330A JP 2004517947 A5 JP2004517947 A5 JP 2004517947A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- hydroxy
- carboxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 24
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 9
- -1 cyano, ethynyl Chemical group 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 claims 6
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 230000001823 pruritic effect Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- KYJSGWVPWUBKGL-UHFFFAOYSA-N 2-methyl-6-(2-pyridin-3-ylethynyl)pyridine Chemical group CC1=CC=CC(C#CC=2C=NC=CC=2)=N1 KYJSGWVPWUBKGL-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000006518 morpholino carbonyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])N(C(*)=O)C1([H])[H] 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0103045.1A GB0103045D0 (en) | 2001-02-07 | 2001-02-07 | Organic Compounds |
| PCT/EP2002/001250 WO2002062323A2 (en) | 2001-02-07 | 2002-02-06 | Use of mglur5 antagonists for the treatment of pruritic conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012084772A Division JP2012131829A (ja) | 2001-02-07 | 2012-04-03 | そう痒状態の処置のためのｍｇｌｕｒ５アンタゴニストの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004517947A JP2004517947A (ja) | 2004-06-17 |
| JP2004517947A5 true JP2004517947A5 (enExample) | 2005-12-22 |
Family
ID=9908300
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002562330A Withdrawn JP2004517947A (ja) | 2001-02-07 | 2002-02-06 | そう痒状態の処置のためのｍｇｌｕｒ５アンタゴニストの使用 |
| JP2012084772A Pending JP2012131829A (ja) | 2001-02-07 | 2012-04-03 | そう痒状態の処置のためのｍｇｌｕｒ５アンタゴニストの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012084772A Pending JP2012131829A (ja) | 2001-02-07 | 2012-04-03 | そう痒状態の処置のためのｍｇｌｕｒ５アンタゴニストの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20040106582A1 (enExample) |
| EP (1) | EP1359905B1 (enExample) |
| JP (2) | JP2004517947A (enExample) |
| CN (1) | CN1253151C (enExample) |
| AT (1) | ATE333869T1 (enExample) |
| AU (1) | AU2002231777A1 (enExample) |
| BR (1) | BR0206917A (enExample) |
| CA (1) | CA2433409C (enExample) |
| DE (1) | DE60213365T2 (enExample) |
| ES (1) | ES2271229T3 (enExample) |
| GB (1) | GB0103045D0 (enExample) |
| PT (1) | PT1359905E (enExample) |
| WO (1) | WO2002062323A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0128996D0 (en) * | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| GB0322612D0 (en) * | 2003-09-26 | 2003-10-29 | Novartis Ag | Organic compounds |
| CN1871001A (zh) * | 2003-10-31 | 2006-11-29 | 阿斯利康(瑞典)有限公司 | 炔烃ⅲ |
| JP2007509935A (ja) * | 2003-10-31 | 2007-04-19 | アストラゼネカ アクチボラグ | アルキンズｉｉ |
| EP1677789A1 (en) * | 2003-10-31 | 2006-07-12 | AstraZeneca AB | Alkynes i |
| GB0503646D0 (en) * | 2005-02-22 | 2005-03-30 | Novartis Ag | Organic compounds |
| GB0508319D0 (en) | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| RU2015111206A (ru) | 2012-08-30 | 2016-10-20 | Ниппон Синяку Ко., Лтд. | Пиридиновое производное и лекарственное средство |
| CR20170536A (es) | 2015-06-03 | 2018-02-01 | Hoffmann La Roche | Derivados de etinilo |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013744B1 (en) * | 1989-12-29 | 1994-09-20 | Allegran Inc | Acetylenes disubstituted with a pyridinyl group and a substituted phenyl group having retinoid like activity |
| FR2719044B1 (fr) * | 1994-04-26 | 1996-05-31 | Cird Galderma | Nouveaux composés bi-aromatiques acétylénés à groupement adamantyle, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
| US5534641A (en) * | 1994-12-29 | 1996-07-09 | Allergan | Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
| US5498795A (en) * | 1994-12-29 | 1996-03-12 | Allergan, Inc. | Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| US6774138B2 (en) * | 1999-08-31 | 2004-08-10 | Merck & Co., Inc. | Thiazolyl(pyridyl)ethyne compounds |
-
2001
- 2001-02-07 GB GBGB0103045.1A patent/GB0103045D0/en not_active Ceased
-
2002
- 2002-02-06 ES ES02711840T patent/ES2271229T3/es not_active Expired - Lifetime
- 2002-02-06 JP JP2002562330A patent/JP2004517947A/ja not_active Withdrawn
- 2002-02-06 DE DE60213365T patent/DE60213365T2/de not_active Expired - Lifetime
- 2002-02-06 US US10/466,183 patent/US20040106582A1/en not_active Abandoned
- 2002-02-06 AT AT02711840T patent/ATE333869T1/de active
- 2002-02-06 CN CNB028046307A patent/CN1253151C/zh not_active Expired - Fee Related
- 2002-02-06 EP EP02711840A patent/EP1359905B1/en not_active Expired - Lifetime
- 2002-02-06 BR BR0206917-2A patent/BR0206917A/pt not_active Application Discontinuation
- 2002-02-06 PT PT02711840T patent/PT1359905E/pt unknown
- 2002-02-06 WO PCT/EP2002/001250 patent/WO2002062323A2/en not_active Ceased
- 2002-02-06 AU AU2002231777A patent/AU2002231777A1/en not_active Abandoned
- 2002-02-06 CA CA2433409A patent/CA2433409C/en not_active Expired - Fee Related
-
2007
- 2007-06-26 US US11/823,310 patent/US20070265279A1/en not_active Abandoned
-
2012
- 2012-04-03 JP JP2012084772A patent/JP2012131829A/ja active Pending
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