JP2004517847A5 - - Google Patents
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- Publication number
- JP2004517847A5 JP2004517847A5 JP2002551530A JP2002551530A JP2004517847A5 JP 2004517847 A5 JP2004517847 A5 JP 2004517847A5 JP 2002551530 A JP2002551530 A JP 2002551530A JP 2002551530 A JP2002551530 A JP 2002551530A JP 2004517847 A5 JP2004517847 A5 JP 2004517847A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- compound
- phenyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- -1 2 -cyclopropyl Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- YRPJPJYKNGUMJQ-UHFFFAOYSA-N 2-[4-(4,9-diethoxy-3-oxo-1h-benzo[f]isoindol-2-yl)phenyl]-n-(4-fluorophenyl)sulfonylacetamide Chemical compound O=C1C2=C(OCC)C3=CC=CC=C3C(OCC)=C2CN1C(C=C1)=CC=C1CC(=O)NS(=O)(=O)C1=CC=C(F)C=C1 YRPJPJYKNGUMJQ-UHFFFAOYSA-N 0.000 claims 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 101150109738 Ptger4 gene Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- XREWXJVMYAXCJV-UHFFFAOYSA-N n-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1h-benzo[f]isoindol-2-yl)phenyl]acetamide Chemical compound O=C1C2=C(OCC)C3=CC=CC=C3C(OCC)=C2CN1C(C=C1)=CC=C1CC(=O)NS(=O)(=O)C1=CC=CC=C1 XREWXJVMYAXCJV-UHFFFAOYSA-N 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0031295.9A GB0031295D0 (en) | 2000-12-21 | 2000-12-21 | Naphthalene derivatives |
| PCT/GB2001/005706 WO2002050033A1 (en) | 2000-12-21 | 2001-12-20 | Benzo(f) isoindol derivatives and their use as ep4 receptor ligands |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004517847A JP2004517847A (ja) | 2004-06-17 |
| JP2004517847A5 true JP2004517847A5 (https=) | 2005-12-22 |
| JP4398150B2 JP4398150B2 (ja) | 2010-01-13 |
Family
ID=9905625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002551530A Expired - Fee Related JP4398150B2 (ja) | 2000-12-21 | 2001-12-20 | ベンゾ（ｆ）イソインドール誘導体およびそのＥＰ４受容体リガンドとしての使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7173047B2 (https=) |
| EP (1) | EP1343759A1 (https=) |
| JP (1) | JP4398150B2 (https=) |
| AU (1) | AU2002217287A1 (https=) |
| GB (1) | GB0031295D0 (https=) |
| WO (1) | WO2002050033A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN2001000224A (es) | 2000-10-19 | 2002-06-13 | Pfizer | Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos. |
| GB0103269D0 (en) * | 2001-02-09 | 2001-03-28 | Glaxo Group Ltd | Napthalene derivatives |
| EP1499305A2 (en) | 2002-04-12 | 2005-01-26 | Pfizer Japan Inc. | Use of ep4 receptor ligands in the treatment of il-6 involved diseases |
| WO2004073589A2 (en) * | 2003-02-24 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep4 (prostaglandin e2 ep4) |
| EP1740211A2 (en) * | 2004-04-20 | 2007-01-10 | Pfizer Products Incorporated | Combinations comprising alpha-2-delta ligands and ep4 receptor antagonists |
| US8013159B2 (en) | 2005-05-19 | 2011-09-06 | Merck Canada Inc. | Quinoline derivatives as EP4 antagonists |
| UY30121A1 (es) | 2006-02-03 | 2007-08-31 | Glaxo Group Ltd | Nuevos compuestos |
| US8207213B2 (en) * | 2006-02-03 | 2012-06-26 | Glaxo Group Limited | Benzoisoindole derivatives for the treatment of pain |
| GB0602900D0 (en) | 2006-02-13 | 2006-03-22 | Glaxo Group Ltd | Novel Compounds |
| GB0615111D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel compounds |
| GB0615105D0 (en) | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel compounds |
| GB0616498D0 (en) * | 2006-08-18 | 2006-09-27 | Glaxo Group Ltd | Novel compounds |
| US20080167377A1 (en) | 2006-12-15 | 2008-07-10 | Alessandra Gaiba | Novel compounds |
| GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
| JPWO2010087425A1 (ja) | 2009-01-30 | 2012-08-02 | 国立大学法人京都大学 | 前立腺癌の進行抑制剤および進行抑制方法 |
| WO2011047048A1 (en) | 2009-10-14 | 2011-04-21 | Gemmus Pharma, Inc. | Combination therapy treatment for viral infections |
| WO2014143591A1 (en) * | 2013-03-12 | 2014-09-18 | Allergan, Inc. | Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors |
| KR102456567B1 (ko) | 2013-08-09 | 2022-10-19 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| CN110621671A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物 |
| EP3625224B1 (en) | 2017-05-18 | 2021-08-04 | Idorsia Pharmaceuticals Ltd | N-substituted indole derivatives |
| PL3625228T3 (pl) | 2017-05-18 | 2021-12-20 | Idorsia Pharmaceuticals Ltd | Pochodne pirymidyny jako modulatory receptora pge2 |
| CN110621667A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 嘧啶衍生物 |
| EA201992676A1 (ru) | 2017-05-18 | 2020-05-06 | Идорсия Фармасьютиклз Лтд | Фенильные производные в качестве модуляторов pge2 рецепторов |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| US20230390303A1 (en) | 2020-11-13 | 2023-12-07 | Ono Pharmaceutical Co., Ltd. | Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3909864B2 (ja) * | 1995-07-26 | 2007-04-25 | 小野薬品工業株式会社 | ナフチルオキシ酢酸誘導体およびそれらを有効成分として含有する薬剤 |
| US6437146B1 (en) | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
| DE60012751T2 (de) * | 1999-08-10 | 2005-01-20 | Glaxo Group Ltd., Greenford | Verwendung von EP 4 Rezeptorliganden zur Behandlung von neuropathischem Schmerz |
| GB0031302D0 (en) * | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Napthalene derivatives |
-
2000
- 2000-12-21 GB GBGB0031295.9A patent/GB0031295D0/en not_active Ceased
-
2001
- 2001-12-20 WO PCT/GB2001/005706 patent/WO2002050033A1/en not_active Ceased
- 2001-12-20 AU AU2002217287A patent/AU2002217287A1/en not_active Abandoned
- 2001-12-20 JP JP2002551530A patent/JP4398150B2/ja not_active Expired - Fee Related
- 2001-12-20 US US10/450,639 patent/US7173047B2/en not_active Expired - Fee Related
- 2001-12-20 EP EP01271356A patent/EP1343759A1/en not_active Withdrawn
-
2006
- 2006-07-14 US US11/486,698 patent/US20060252799A1/en not_active Abandoned
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