AU2002217287A1 - Benzo(f) isoindol derivatives and their use as ep4 receptor ligands - Google Patents

Benzo(f) isoindol derivatives and their use as ep4 receptor ligands

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Publication number
AU2002217287A1
AU2002217287A1 AU2002217287A AU1728702A AU2002217287A1 AU 2002217287 A1 AU2002217287 A1 AU 2002217287A1 AU 2002217287 A AU2002217287 A AU 2002217287A AU 1728702 A AU1728702 A AU 1728702A AU 2002217287 A1 AU2002217287 A1 AU 2002217287A1
Authority
AU
Australia
Prior art keywords
benzo
receptor ligands
isoindol
derivatives
isoindol derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002217287A
Other languages
English (en)
Inventor
Stephen Vernon Frye
Gerard Martin Paul Giblin
Susan Roomans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU2002217287A1 publication Critical patent/AU2002217287A1/en
Abandoned legal-status Critical Current

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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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AU2002217287A 2000-12-21 2001-12-20 Benzo(f) isoindol derivatives and their use as ep4 receptor ligands Abandoned AU2002217287A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0031295 2000-12-21
GBGB0031295.9A GB0031295D0 (en) 2000-12-21 2000-12-21 Naphthalene derivatives
PCT/GB2001/005706 WO2002050033A1 (en) 2000-12-21 2001-12-20 Benzo(f) isoindol derivatives and their use as ep4 receptor ligands

Publications (1)

Publication Number Publication Date
AU2002217287A1 true AU2002217287A1 (en) 2002-07-01

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AU2002217287A Abandoned AU2002217287A1 (en) 2000-12-21 2001-12-20 Benzo(f) isoindol derivatives and their use as ep4 receptor ligands

Country Status (6)

Country Link
US (2) US7173047B2 (https=)
EP (1) EP1343759A1 (https=)
JP (1) JP4398150B2 (https=)
AU (1) AU2002217287A1 (https=)
GB (1) GB0031295D0 (https=)
WO (1) WO2002050033A1 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN2001000224A (es) 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
GB0103269D0 (en) * 2001-02-09 2001-03-28 Glaxo Group Ltd Napthalene derivatives
EP1499305A2 (en) 2002-04-12 2005-01-26 Pfizer Japan Inc. Use of ep4 receptor ligands in the treatment of il-6 involved diseases
WO2004073589A2 (en) * 2003-02-24 2004-09-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep4 (prostaglandin e2 ep4)
EP1740211A2 (en) * 2004-04-20 2007-01-10 Pfizer Products Incorporated Combinations comprising alpha-2-delta ligands and ep4 receptor antagonists
US8013159B2 (en) 2005-05-19 2011-09-06 Merck Canada Inc. Quinoline derivatives as EP4 antagonists
UY30121A1 (es) 2006-02-03 2007-08-31 Glaxo Group Ltd Nuevos compuestos
US8207213B2 (en) * 2006-02-03 2012-06-26 Glaxo Group Limited Benzoisoindole derivatives for the treatment of pain
GB0602900D0 (en) 2006-02-13 2006-03-22 Glaxo Group Ltd Novel Compounds
GB0615111D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel compounds
GB0615105D0 (en) 2006-07-28 2006-09-06 Glaxo Group Ltd Novel compounds
GB0616498D0 (en) * 2006-08-18 2006-09-27 Glaxo Group Ltd Novel compounds
US20080167377A1 (en) 2006-12-15 2008-07-10 Alessandra Gaiba Novel compounds
GB0721611D0 (en) 2007-11-02 2007-12-12 Glaxo Group Ltd Novel compounds
JPWO2010087425A1 (ja) 2009-01-30 2012-08-02 国立大学法人京都大学 前立腺癌の進行抑制剤および進行抑制方法
WO2011047048A1 (en) 2009-10-14 2011-04-21 Gemmus Pharma, Inc. Combination therapy treatment for viral infections
WO2014143591A1 (en) * 2013-03-12 2014-09-18 Allergan, Inc. Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
CN110621671A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物
EP3625224B1 (en) 2017-05-18 2021-08-04 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
PL3625228T3 (pl) 2017-05-18 2021-12-20 Idorsia Pharmaceuticals Ltd Pochodne pirymidyny jako modulatory receptora pge2
CN110621667A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 嘧啶衍生物
EA201992676A1 (ru) 2017-05-18 2020-05-06 Идорсия Фармасьютиклз Лтд Фенильные производные в качестве модуляторов pge2 рецепторов
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3909864B2 (ja) * 1995-07-26 2007-04-25 小野薬品工業株式会社 ナフチルオキシ酢酸誘導体およびそれらを有効成分として含有する薬剤
US6437146B1 (en) 1998-09-25 2002-08-20 Fujisawa Pharmaceutical Co., Ltd. Oxazole compounds as prostaglandin e2 agonists or antagonists
DE60012751T2 (de) * 1999-08-10 2005-01-20 Glaxo Group Ltd., Greenford Verwendung von EP 4 Rezeptorliganden zur Behandlung von neuropathischem Schmerz
GB0031302D0 (en) * 2000-12-21 2001-01-31 Glaxo Group Ltd Napthalene derivatives

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