JP2004516823A - タンパク質に対するホスホキナーゼ活性の定量のための方法 - Google Patents
タンパク質に対するホスホキナーゼ活性の定量のための方法 Download PDFInfo
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| JP2018531580A (ja) * | 2015-07-13 | 2018-11-01 | ハー・ルンドベック・アクチエゼルスカベット | 過リン酸化タウに特異的な抗体およびその使用方法 |
| JP2019529336A (ja) * | 2016-07-12 | 2019-10-17 | ハー・ルンドベック・アクチエゼルスカベット | 過リン酸化タウに特異的な抗体およびその使用方法 |
| JP2019207260A (ja) * | 2013-12-27 | 2019-12-05 | 国立大学法人 東京医科歯科大学 | アルツハイマー病及び前頭側頭葉変性症の診断方法、診断薬、治療薬、及びこれら薬剤のスクリーニング方法 |
| JP2019537727A (ja) * | 2016-11-21 | 2019-12-26 | ルール−ウニベルシタット ボーフム | アルツハイマー病の鑑別診断のための複合アッセイ |
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| GB0208104D0 (en) * | 2002-04-09 | 2002-05-22 | Univ Dundee | Method |
| MXPA04011624A (es) | 2002-05-24 | 2005-03-07 | Schering Corp | Anticuerpo neutralizante humano anti-igfr. |
| US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
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| EP1668146B1 (en) * | 2003-09-25 | 2014-11-12 | Life Technologies Corporation | Homogeneous populations of molecules |
| CN1938428A (zh) | 2003-11-12 | 2007-03-28 | 先灵公司 | 多基因表达的质粒系统 |
| AR046639A1 (es) | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
| CA2589885A1 (en) | 2004-12-03 | 2006-06-08 | Schering Corporation | Biomarkers for pre-selection of patients for anti-igf1r therapy |
| US7807789B2 (en) * | 2004-12-21 | 2010-10-05 | Cell Signaling Technology, Inc. | Reagents for the detection of protein phosphorylation in EGFR-signaling pathways |
| EP1910828A4 (en) * | 2005-07-01 | 2012-03-14 | Univ St Louis | PHOSPHOSPECTIVE CHEMOKIN RECEPTOR ANTIBODIES |
| WO2007133688A2 (en) * | 2006-05-12 | 2007-11-22 | Cell Signaling Technology, Inc. | Reagents for the detection of tyrosine phosphorylation in brain ischemia signaling pathways |
| WO2008147687A1 (en) * | 2007-05-21 | 2008-12-04 | Mayo Foundation For Medical Education And Research | Treating pancreatitis |
| KR101612442B1 (ko) * | 2008-05-13 | 2016-04-15 | 삼성전자주식회사 | 컨텐츠 시청 제한 정보의 제공 및 이용을 위한 방법 및장치 |
| US20130231305A1 (en) * | 2010-03-29 | 2013-09-05 | Medvet Science Pty. Ltd. | Method of Modulating Protein 14-3-3 Functionality By Facilitating or Inhibiting Phosphorylation |
| US20170016900A1 (en) | 2010-09-07 | 2017-01-19 | Stephen G. Marx | Kit for monitoring, detecting and staging gvhd |
| ES2692833T3 (es) * | 2010-09-07 | 2018-12-05 | Stephen G. Marx | Kit para controlar, detectar y estadificar GVHD |
| US9200068B2 (en) | 2012-12-18 | 2015-12-01 | Regents Of The University Of Minnesota | Compositions and methods related to tauopathy |
| RS60031B1 (sr) | 2013-12-20 | 2020-04-30 | Hoffmann La Roche | Humanizovana anti-tau(ps422) antitela i načini upotrebe |
| EP3126843A1 (en) * | 2014-03-31 | 2017-02-08 | Merck Patent GmbH | Method for detecting protein modifications using specific antibodies |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
| PL3313877T3 (pl) | 2015-06-24 | 2020-11-02 | F. Hoffmann-La Roche Ag | Humanizowane przeciwciała przeciwko białku tau(pS422) i sposoby stosowania |
| US20190388519A1 (en) * | 2016-03-01 | 2019-12-26 | Macquarie University | Use of phosphorylated tau and p38gamma to treat a neurological condition |
| US10995137B2 (en) | 2017-01-04 | 2021-05-04 | H. Lundbeck A/S | Antibodies specific for hyperphosphorlated tau for the treatment of ocular diseases |
| MX2020006398A (es) * | 2017-12-18 | 2020-09-07 | Univ Yale | Compuestos y composiciones para tratar la fibrosis. |
| EP3762414A4 (en) | 2018-03-05 | 2022-01-05 | Janssen Pharmaceutica NV | TESTS TO DETECT NEURODEGENERATION |
| KR20200130350A (ko) | 2018-03-05 | 2020-11-18 | 얀센 파마슈티카 엔.브이. | 항-phf-타우 항체 및 이의 용도 |
| US11085935B2 (en) * | 2018-05-03 | 2021-08-10 | Washington University | Methods of treating based on site-specific tau phosphorylation |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| AU2020344577A1 (en) | 2019-09-10 | 2022-03-31 | Washington University | Blood-based assay for diagnosing and treating based on site-specific tau phosphorylation |
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| DE2354288C2 (de) | 1973-10-30 | 1976-01-02 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von Aminophenylalkyläthern |
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| JPH05126833A (ja) | 1991-10-31 | 1993-05-21 | Tosoh Corp | チロシンキナ−ゼ活性の免疫化学的測定法及びそのキツト |
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| CA2195672A1 (en) * | 1994-07-29 | 1996-02-15 | Eugeen Vanmechelen | Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications |
| US6001580A (en) * | 1995-03-28 | 1999-12-14 | Takeda Chemical Industries, Inc. | Method for assaying ERK2 map kinase |
| JP5031140B2 (ja) * | 1997-11-07 | 2012-09-19 | バイオサイテックス | リン酸化ｖａｓｐ（血管拡張剤−刺激リン蛋白質）に対する抗体、その調製用のハイブリドーマ細胞およびその使用 |
| WO1999029894A1 (en) * | 1997-12-05 | 1999-06-17 | Pharmacia & Upjohn Company | Fluorescence-based high throughput screening assays for protein kinases and phosphatases |
| GB9803399D0 (en) * | 1998-02-19 | 1998-04-15 | Imp Cancer Res Tech | Protein kinase c |
| JP2000034300A (ja) * | 1998-07-17 | 2000-02-02 | Mitsubishi Chemicals Corp | 抗リン酸化タウ蛋白質抗体及びそれを用いるアルツハイマー病の検出方法 |
| US6309863B1 (en) | 1999-01-25 | 2001-10-30 | Brookhaven Science Associates | Methods for generating phosphorylation site-specific immunological reagents |
| DE60045586D1 (de) * | 1999-06-09 | 2011-03-10 | Molecular Devices Inc | Testverfahren zur messung der phosphorylierung |
| WO2001011367A1 (fr) | 1999-08-04 | 2001-02-15 | Medical & Biological Laboratories Co., Ltd. | Methode d'analyse de l'activite enzymatique de phosphorylation du complexe cycline/cdk |
| HK1048513B (en) * | 2000-01-24 | 2007-12-07 | Fujirebio Europe N.V. | Diagnosis of tauopathies determining tau/phospho-tau ratio |
| US20030166016A1 (en) | 2000-04-28 | 2003-09-04 | Foster Barbara A. | Assay methods for cyclin dependent kinases |
| US20030162230A1 (en) | 2000-09-27 | 2003-08-28 | Reagan Kevin J. | Method for quantifying phosphokinase activity on proteins |
-
2001
- 2001-09-07 US US09/948,972 patent/US20030162230A1/en not_active Abandoned
- 2001-09-27 WO PCT/US2001/030186 patent/WO2002027017A2/en not_active Ceased
- 2001-09-27 JP JP2002530779A patent/JP2004516823A/ja not_active Withdrawn
- 2001-09-27 AT AT01973567T patent/ATE416385T1/de not_active IP Right Cessation
- 2001-09-27 CA CA2423979A patent/CA2423979C/en not_active Expired - Lifetime
- 2001-09-27 EP EP10179876A patent/EP2298814A3/en not_active Withdrawn
- 2001-09-27 DE DE60136840T patent/DE60136840D1/de not_active Expired - Lifetime
- 2001-09-27 EP EP01973567A patent/EP1328812B1/en not_active Expired - Lifetime
- 2001-09-27 EP EP08169121A patent/EP2040078A1/en not_active Withdrawn
-
2006
- 2006-03-22 JP JP2006079226A patent/JP2006225396A/ja active Pending
-
2008
- 2008-07-24 US US12/179,526 patent/US7888050B2/en not_active Expired - Fee Related
-
2010
- 2010-12-16 US US12/970,250 patent/US8114617B2/en not_active Expired - Fee Related
-
2011
- 2011-09-26 US US13/245,045 patent/US20120135426A1/en not_active Abandoned
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019207260A (ja) * | 2013-12-27 | 2019-12-05 | 国立大学法人 東京医科歯科大学 | アルツハイマー病及び前頭側頭葉変性症の診断方法、診断薬、治療薬、及びこれら薬剤のスクリーニング方法 |
| JP2018531580A (ja) * | 2015-07-13 | 2018-11-01 | ハー・ルンドベック・アクチエゼルスカベット | 過リン酸化タウに特異的な抗体およびその使用方法 |
| JP2019529336A (ja) * | 2016-07-12 | 2019-10-17 | ハー・ルンドベック・アクチエゼルスカベット | 過リン酸化タウに特異的な抗体およびその使用方法 |
| JP7029415B2 (ja) | 2016-07-12 | 2022-03-03 | ハー・ルンドベック・アクチエゼルスカベット | 過リン酸化タウに特異的な抗体およびその使用方法 |
| JP2019537727A (ja) * | 2016-11-21 | 2019-12-26 | ルール−ウニベルシタット ボーフム | アルツハイマー病の鑑別診断のための複合アッセイ |
| JP7117476B2 (ja) | 2016-11-21 | 2022-08-15 | ベータセンス ゲーエムベーハー | アルツハイマー病の鑑別診断のための複合アッセイ |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1328812B1 (en) | 2008-12-03 |
| US8114617B2 (en) | 2012-02-14 |
| CA2423979A1 (en) | 2002-04-04 |
| US20090104628A1 (en) | 2009-04-23 |
| US20110165588A1 (en) | 2011-07-07 |
| DE60136840D1 (de) | 2009-01-15 |
| ATE416385T1 (de) | 2008-12-15 |
| EP2040078A1 (en) | 2009-03-25 |
| US7888050B2 (en) | 2011-02-15 |
| EP1328812A2 (en) | 2003-07-23 |
| EP2298814A3 (en) | 2012-05-30 |
| US20120135426A1 (en) | 2012-05-31 |
| CA2423979C (en) | 2012-03-06 |
| JP2006225396A (ja) | 2006-08-31 |
| EP2298814A2 (en) | 2011-03-23 |
| WO2002027017A2 (en) | 2002-04-04 |
| US20030162230A1 (en) | 2003-08-28 |
| WO2002027017A3 (en) | 2003-01-16 |
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