CA2423979C - Method for quantifying phosphokinase activity on proteins - Google Patents
Method for quantifying phosphokinase activity on proteins Download PDFInfo
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- CA2423979C CA2423979C CA2423979A CA2423979A CA2423979C CA 2423979 C CA2423979 C CA 2423979C CA 2423979 A CA2423979 A CA 2423979A CA 2423979 A CA2423979 A CA 2423979A CA 2423979 C CA2423979 C CA 2423979C
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23562000P | 2000-09-27 | 2000-09-27 | |
| US60/235,620 | 2000-09-27 | ||
| PCT/US2001/030186 WO2002027017A2 (en) | 2000-09-27 | 2001-09-27 | Method for quantifying phosphokinase activity on proteins |
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| CA2423979A1 CA2423979A1 (en) | 2002-04-04 |
| CA2423979C true CA2423979C (en) | 2012-03-06 |
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|---|---|---|---|
| CA2423979A Expired - Lifetime CA2423979C (en) | 2000-09-27 | 2001-09-27 | Method for quantifying phosphokinase activity on proteins |
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|---|---|
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| JP (2) | JP2004516823A (enExample) |
| AT (1) | ATE416385T1 (enExample) |
| CA (1) | CA2423979C (enExample) |
| DE (1) | DE60136840D1 (enExample) |
| WO (1) | WO2002027017A2 (enExample) |
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| US20040014082A1 (en) * | 2000-08-11 | 2004-01-22 | Invitrogen Corporation | Highly homogeneous molecular markers for electrophoresis |
| US20030162230A1 (en) * | 2000-09-27 | 2003-08-28 | Reagan Kevin J. | Method for quantifying phosphokinase activity on proteins |
| GB0208104D0 (en) * | 2002-04-09 | 2002-05-22 | Univ Dundee | Method |
| NZ571508A (en) | 2002-05-24 | 2010-05-28 | Schering Corp | Neutralizing human anti-IGFR antibody |
| US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| EP1668146B1 (en) * | 2003-09-25 | 2014-11-12 | Life Technologies Corporation | Homogeneous populations of molecules |
| JP2007510434A (ja) | 2003-11-12 | 2007-04-26 | シェーリング コーポレイション | 多重遺伝子発現のためのプラスミドシステム |
| AR046639A1 (es) | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
| US7811562B2 (en) | 2004-12-03 | 2010-10-12 | Schering Corporation | Biomarkers for pre-selection of patients for anti-IGF1R therapy |
| US7807789B2 (en) * | 2004-12-21 | 2010-10-05 | Cell Signaling Technology, Inc. | Reagents for the detection of protein phosphorylation in EGFR-signaling pathways |
| EP1910828A4 (en) * | 2005-07-01 | 2012-03-14 | Univ St Louis | PHOSPHOSPECTIVE CHEMOKIN RECEPTOR ANTIBODIES |
| WO2007133688A2 (en) * | 2006-05-12 | 2007-11-22 | Cell Signaling Technology, Inc. | Reagents for the detection of tyrosine phosphorylation in brain ischemia signaling pathways |
| US20100160339A1 (en) * | 2007-05-21 | 2010-06-24 | Mayo Foundation For Medical Education And Research | Treating pancreatitis |
| KR101612442B1 (ko) | 2008-05-13 | 2016-04-15 | 삼성전자주식회사 | 컨텐츠 시청 제한 정보의 제공 및 이용을 위한 방법 및장치 |
| US20130231305A1 (en) * | 2010-03-29 | 2013-09-05 | Medvet Science Pty. Ltd. | Method of Modulating Protein 14-3-3 Functionality By Facilitating or Inhibiting Phosphorylation |
| US20170016900A1 (en) | 2010-09-07 | 2017-01-19 | Stephen G. Marx | Kit for monitoring, detecting and staging gvhd |
| WO2012032511A2 (en) * | 2010-09-07 | 2012-03-15 | Stephen G Marx | Kit for monitoring, detecting and staging gvhd |
| US9200068B2 (en) | 2012-12-18 | 2015-12-01 | Regents Of The University Of Minnesota | Compositions and methods related to tauopathy |
| ES2778498T3 (es) | 2013-12-20 | 2020-08-10 | Hoffmann La Roche | Anticuerpos anti-tau(pS422) humanizados y procedimientos de uso |
| JP6584322B2 (ja) * | 2013-12-27 | 2019-10-02 | 国立大学法人 東京医科歯科大学 | アルツハイマー病及び前頭側頭葉変性症の診断方法、診断薬、治療薬、及びこれら薬剤のスクリーニング方法 |
| JP6840541B2 (ja) * | 2014-03-31 | 2021-03-10 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 修飾特異的バインダーを使用することによる分析物を分析するための方法 |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
| EP3744732B1 (en) | 2015-06-24 | 2025-09-10 | F. Hoffmann-La Roche AG | Humanized anti-tau(ps422) antibodies and methods of use |
| JO3711B1 (ar) * | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
| EP3423080B1 (en) * | 2016-03-01 | 2024-01-24 | Macquarie University | Phosphorylated tau and p38gamma for treating a neurological condition |
| MA56165A (fr) | 2016-07-12 | 2022-04-20 | H Lundbeck As | Anticorps spécifiques de la protéine tau hyperphosphorylée et leurs procédés d'utilisation |
| ES2791962T3 (es) * | 2016-11-21 | 2020-11-06 | Univ Ruhr Bochum | Ensayo combinado para el diagnóstico diferencial de la enfermedad de Alzheimer |
| CN110267985B (zh) | 2017-01-04 | 2023-05-23 | H.隆德贝克有限公司 | 用于治疗眼科疾病的特异性针对过度磷酸化τ蛋白的抗体 |
| CN111670188B (zh) * | 2017-12-18 | 2023-06-23 | 耶鲁大学 | 用于治疗纤维化的化合物和组合物 |
| CN112105640B (zh) | 2018-03-05 | 2025-03-04 | 詹森药业有限公司 | 检测神经退行性变的测定 |
| EA202092088A1 (ru) | 2018-03-05 | 2020-11-13 | Янссен Фармацевтика Нв | Антитела анти-phf-тау и их применение |
| US11085935B2 (en) | 2018-05-03 | 2021-08-10 | Washington University | Methods of treating based on site-specific tau phosphorylation |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| BR112022004326A2 (pt) | 2019-09-10 | 2022-08-23 | Univ Washington | Ensaio de base sanguínea para diagnóstico e tratamento com base em fosforilação de tau específica do sítio |
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| DE2354288C2 (de) | 1973-10-30 | 1976-01-02 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von Aminophenylalkyläthern |
| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| US5733734A (en) * | 1991-08-14 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments |
| JPH05126833A (ja) | 1991-10-31 | 1993-05-21 | Tosoh Corp | チロシンキナ−ゼ活性の免疫化学的測定法及びそのキツト |
| DE69233767D1 (de) * | 1991-12-06 | 2009-09-17 | Max Planck Gesellschaft | Verwendung von Protein-Kinasen zur Diagnose und Behandlung der Alzheimer-Krankheit |
| EP0544942A1 (en) * | 1991-12-06 | 1993-06-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Novel tools for the diagnosis and treatment of Alzheimer disease |
| ES2268684T3 (es) | 1992-04-10 | 2007-03-16 | Dana-Farber Cancer Institute, Inc. | Inmunodeteccion de fosfoproteina especifica al estado de activacion. |
| DE69318420T2 (de) * | 1992-12-14 | 1999-01-28 | Naamloze Vennootschap Innogenetics S.A., Gent | Monoklonale antikörper gegen das mikrotubulusassoziierte tauprotein,hybridomen, die diese antikörper sezernieren, antigenerkennung durch diese monoklonalen antikörper und deren verwendung |
| US6924361B1 (en) | 1993-11-02 | 2005-08-02 | Phosphoproteomics Llc | Phosphopeptide-specific antibodies that are activity specific; methods of production and antibody uses |
| AU697142B2 (en) * | 1993-11-23 | 1998-10-01 | Genentech Inc. | Protein tyrosine kinases named Rse |
| ATE335007T1 (de) * | 1993-12-21 | 2006-08-15 | Innogenetics Nv | Monoklonale antikörper gegen phf-tau, hybridomen die diese ausscheiden, antigenerkennung durch diesen antikörper und deren verwendungen |
| US6348310B1 (en) * | 1994-03-04 | 2002-02-19 | Promega Corporation | Quantitation of individual protein kinase activity |
| US5763198A (en) * | 1994-07-22 | 1998-06-09 | Sugen, Inc. | Screening assays for compounds |
| AU710952B2 (en) * | 1994-07-29 | 1999-09-30 | Innogenetics N.V. | Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications |
| US6001580A (en) * | 1995-03-28 | 1999-12-14 | Takeda Chemical Industries, Inc. | Method for assaying ERK2 map kinase |
| JP5031140B2 (ja) * | 1997-11-07 | 2012-09-19 | バイオサイテックス | リン酸化ｖａｓｐ（血管拡張剤−刺激リン蛋白質）に対する抗体、その調製用のハイブリドーマ細胞およびその使用 |
| CA2306686A1 (en) * | 1997-12-05 | 1999-06-17 | Pharmacia & Upjohn Company | Fluorescence-based high throughput screening assays for protein kinases and phosphatases |
| GB9803399D0 (en) * | 1998-02-19 | 1998-04-15 | Imp Cancer Res Tech | Protein kinase c |
| JP2000034300A (ja) * | 1998-07-17 | 2000-02-02 | Mitsubishi Chemicals Corp | 抗リン酸化タウ蛋白質抗体及びそれを用いるアルツハイマー病の検出方法 |
| US6309863B1 (en) | 1999-01-25 | 2001-10-30 | Brookhaven Science Associates | Methods for generating phosphorylation site-specific immunological reagents |
| AU5604900A (en) * | 1999-06-09 | 2000-12-28 | Ljl Biosystems, Inc. | Phosphorylation assays |
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| US20030166016A1 (en) | 2000-04-28 | 2003-09-04 | Foster Barbara A. | Assay methods for cyclin dependent kinases |
| US20030162230A1 (en) | 2000-09-27 | 2003-08-28 | Reagan Kevin J. | Method for quantifying phosphokinase activity on proteins |
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- 2001-09-27 DE DE60136840T patent/DE60136840D1/de not_active Expired - Lifetime
- 2001-09-27 WO PCT/US2001/030186 patent/WO2002027017A2/en not_active Ceased
- 2001-09-27 CA CA2423979A patent/CA2423979C/en not_active Expired - Lifetime
-
2006
- 2006-03-22 JP JP2006079226A patent/JP2006225396A/ja active Pending
-
2008
- 2008-07-24 US US12/179,526 patent/US7888050B2/en not_active Expired - Fee Related
-
2010
- 2010-12-16 US US12/970,250 patent/US8114617B2/en not_active Expired - Fee Related
-
2011
- 2011-09-26 US US13/245,045 patent/US20120135426A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002027017A3 (en) | 2003-01-16 |
| US20030162230A1 (en) | 2003-08-28 |
| US7888050B2 (en) | 2011-02-15 |
| EP1328812A2 (en) | 2003-07-23 |
| US8114617B2 (en) | 2012-02-14 |
| JP2006225396A (ja) | 2006-08-31 |
| DE60136840D1 (de) | 2009-01-15 |
| US20120135426A1 (en) | 2012-05-31 |
| EP1328812B1 (en) | 2008-12-03 |
| ATE416385T1 (de) | 2008-12-15 |
| EP2298814A2 (en) | 2011-03-23 |
| EP2298814A3 (en) | 2012-05-30 |
| JP2004516823A (ja) | 2004-06-10 |
| US20110165588A1 (en) | 2011-07-07 |
| WO2002027017A2 (en) | 2002-04-04 |
| EP2040078A1 (en) | 2009-03-25 |
| CA2423979A1 (en) | 2002-04-04 |
| US20090104628A1 (en) | 2009-04-23 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20210927 |