DE60136840D1 - Verfahren zur quantifizierung der phosphokinaseaktivität auf proteinen - Google Patents

Verfahren zur quantifizierung der phosphokinaseaktivität auf proteinen

Info

Publication number
DE60136840D1
DE60136840D1 DE60136840T DE60136840T DE60136840D1 DE 60136840 D1 DE60136840 D1 DE 60136840D1 DE 60136840 T DE60136840 T DE 60136840T DE 60136840 T DE60136840 T DE 60136840T DE 60136840 D1 DE60136840 D1 DE 60136840D1
Authority
DE
Germany
Prior art keywords
phosphorylation
protein
proteins
quantitating
tau
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60136840T
Other languages
German (de)
English (en)
Inventor
Kevin J Reagan
Erik Schaeffer
Jimin Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies Corp
Original Assignee
Invitrogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invitrogen Corp filed Critical Invitrogen Corp
Application granted granted Critical
Publication of DE60136840D1 publication Critical patent/DE60136840D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60136840T 2000-09-27 2001-09-27 Verfahren zur quantifizierung der phosphokinaseaktivität auf proteinen Expired - Lifetime DE60136840D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23562000P 2000-09-27 2000-09-27
PCT/US2001/030186 WO2002027017A2 (en) 2000-09-27 2001-09-27 Method for quantifying phosphokinase activity on proteins

Publications (1)

Publication Number Publication Date
DE60136840D1 true DE60136840D1 (de) 2009-01-15

Family

ID=22886277

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60136840T Expired - Lifetime DE60136840D1 (de) 2000-09-27 2001-09-27 Verfahren zur quantifizierung der phosphokinaseaktivität auf proteinen

Country Status (7)

Country Link
US (4) US20030162230A1 (enExample)
EP (3) EP2298814A3 (enExample)
JP (2) JP2004516823A (enExample)
AT (1) ATE416385T1 (enExample)
CA (1) CA2423979C (enExample)
DE (1) DE60136840D1 (enExample)
WO (1) WO2002027017A2 (enExample)

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WO2005030981A2 (en) * 2003-09-25 2005-04-07 Invitrogen Corporation Homogeneous populations of molecules
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AR046639A1 (es) 2003-11-21 2005-12-14 Schering Corp Combinaciones terapeuticas de anticuerpo anti- igfr1
EP2283831A3 (en) 2004-12-03 2013-10-23 Merck Sharp & Dohme Corp. Biomakers for pre-selection of patients for anti-IGF1R therapy
US7807789B2 (en) * 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
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US20090203034A1 (en) * 2006-05-12 2009-08-13 Ailan Guo Reagents for the detection of tyrosine phosphorylation in brain ischemia signaling pathways
US20100160339A1 (en) * 2007-05-21 2010-06-24 Mayo Foundation For Medical Education And Research Treating pancreatitis
KR101612442B1 (ko) * 2008-05-13 2016-04-15 삼성전자주식회사 컨텐츠 시청 제한 정보의 제공 및 이용을 위한 방법 및장치
WO2011120082A1 (en) * 2010-03-29 2011-10-06 Medvet Science Pty. Ltd. A method of modulating protein 14-3-3 functionality by facilitating or inhibiting phosphorylation
US20170016900A1 (en) 2010-09-07 2017-01-19 Stephen G. Marx Kit for monitoring, detecting and staging gvhd
WO2012032511A2 (en) * 2010-09-07 2012-03-15 Stephen G Marx Kit for monitoring, detecting and staging gvhd
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
LT3083680T (lt) 2013-12-20 2020-04-10 F. Hoffmann-La Roche Ag Humanizuoti anti-tau(ps422) antikūnai ir jų naudojimo būdai
WO2015099094A1 (ja) * 2013-12-27 2015-07-02 国立大学法人東京医科歯科大学 アルツハイマー病及び前頭側頭葉変性症の診断方法、診断薬、治療薬、及びこれら薬剤のスクリーニング方法
CN106062560A (zh) * 2014-03-31 2016-10-26 默克专利股份公司 使用特异性抗体检测蛋白质修饰的方法
AR100978A1 (es) 2014-06-26 2016-11-16 Hoffmann La Roche LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
AR105089A1 (es) 2015-06-24 2017-09-06 Hoffmann La Roche ANTICUERPOS ANTI-TAU(pS422) HUMANIZADOS Y MÉTODOS DE UTILIZACIÓN
JO3711B1 (ar) 2015-07-13 2021-01-31 H Lundbeck As أجسام مضادة محددة لبروتين تاو وطرق استعمالها
JP7040774B2 (ja) * 2016-03-01 2022-03-23 マックォーリー・ユニバーシティ 神経学的症状の治療のためのリン酸化ｔａｕ及びｐ３８ガンマの使用
GEP20217222B (en) 2016-07-12 2021-02-10 Lundbeck A/S H Antibodies specific for hyperphosphorylated tau and methods of use thereof
ES2791962T3 (es) * 2016-11-21 2020-11-06 Univ Ruhr Bochum Ensayo combinado para el diagnóstico diferencial de la enfermedad de Alzheimer
WO2018127519A1 (en) 2017-01-04 2018-07-12 H. Lundbeck A/S Antibodies specific for hyperphosphorylated tau for the treatment of ocular diseases
US11504373B2 (en) * 2017-12-18 2022-11-22 Yale University Compounds and compositions for treating fibrosis
JP7362636B2 (ja) 2018-03-05 2023-10-17 ヤンセン ファーマシューティカ エヌ．ベー． 抗ｐｈｆ－タウ抗体及びその使用
KR20250042856A (ko) 2018-03-05 2025-03-27 얀센 파마슈티카 엔브이 신경퇴행을 검출하기 위한 분석
US11085935B2 (en) 2018-05-03 2021-08-10 Washington University Methods of treating based on site-specific tau phosphorylation
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
US12493043B2 (en) 2019-09-10 2025-12-09 Washington University Blood-based assay for diagnosing and treating based on site-specific tau phosphorylation

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Also Published As

Publication number Publication date
EP2298814A3 (en) 2012-05-30
ATE416385T1 (de) 2008-12-15
EP2040078A1 (en) 2009-03-25
US20120135426A1 (en) 2012-05-31
US20090104628A1 (en) 2009-04-23
JP2004516823A (ja) 2004-06-10
CA2423979A1 (en) 2002-04-04
JP2006225396A (ja) 2006-08-31
EP2298814A2 (en) 2011-03-23
CA2423979C (en) 2012-03-06
US7888050B2 (en) 2011-02-15
EP1328812B1 (en) 2008-12-03
US20110165588A1 (en) 2011-07-07
WO2002027017A3 (en) 2003-01-16
US8114617B2 (en) 2012-02-14
US20030162230A1 (en) 2003-08-28
EP1328812A2 (en) 2003-07-23
WO2002027017A2 (en) 2002-04-04

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