JP2004515463A5 - - Google Patents
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- Publication number
- JP2004515463A5 JP2004515463A5 JP2002512249A JP2002512249A JP2004515463A5 JP 2004515463 A5 JP2004515463 A5 JP 2004515463A5 JP 2002512249 A JP2002512249 A JP 2002512249A JP 2002512249 A JP2002512249 A JP 2002512249A JP 2004515463 A5 JP2004515463 A5 JP 2004515463A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- metronidazole
- aqueous solution
- niacinamide
- hpcd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 21
- 229960000282 metronidazole Drugs 0.000 claims 21
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 19
- 239000007864 aqueous solution Substances 0.000 claims 18
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 16
- 229960003966 nicotinamide Drugs 0.000 claims 16
- 235000005152 nicotinamide Nutrition 0.000 claims 16
- 239000011570 nicotinamide Substances 0.000 claims 16
- 238000000034 method Methods 0.000 claims 13
- 239000000243 solution Substances 0.000 claims 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000003349 gelling agent Substances 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 241001303601 Rosacea Species 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 239000008137 solubility enhancer Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/615,169 US6468989B1 (en) | 2000-07-13 | 2000-07-13 | Gel compositions containing metronidazole |
| PCT/US2001/019644 WO2002006349A1 (en) | 2000-07-13 | 2001-06-19 | Gel compositions containing metronidazole |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004515463A JP2004515463A (ja) | 2004-05-27 |
| JP2004515463A5 true JP2004515463A5 (enExample) | 2005-01-27 |
| JP4130358B2 JP4130358B2 (ja) | 2008-08-06 |
Family
ID=24464287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002512249A Expired - Lifetime JP4130358B2 (ja) | 2000-07-13 | 2001-06-19 | メトロニダゾール含有ゲル組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6468989B1 (enExample) |
| EP (1) | EP1303541B1 (enExample) |
| JP (1) | JP4130358B2 (enExample) |
| AR (1) | AR030245A1 (enExample) |
| AT (1) | ATE506950T1 (enExample) |
| AU (1) | AU2001269937A1 (enExample) |
| CA (1) | CA2405072C (enExample) |
| DE (1) | DE60144520D1 (enExample) |
| ES (1) | ES2365322T3 (enExample) |
| WO (1) | WO2002006349A1 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6605751B1 (en) | 1997-11-14 | 2003-08-12 | Acrymed | Silver-containing compositions, devices and methods for making |
| EP1244476B1 (en) | 1999-12-30 | 2006-05-31 | Acrymed | Methods and compositions for improved delivery devices |
| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| US6881726B2 (en) * | 2001-12-24 | 2005-04-19 | Dow Pharmaceutical Sciences | Aqueous compositions containing metronidazole |
| CN1678277B (zh) | 2002-07-29 | 2010-05-05 | 艾克里麦德公司 | 治疗皮肤病的方法和组合物 |
| US20060140984A1 (en) | 2002-10-25 | 2006-06-29 | Foamix Ltd. | Cosmetic and pharmaceutical foam |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US8119150B2 (en) * | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
| US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
| US8410102B2 (en) | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| US20050090564A1 (en) * | 2003-10-28 | 2005-04-28 | Wegener Paul T. | Compositions and treatments of bacterial vaginosis |
| ES2424644T3 (es) | 2004-05-25 | 2013-10-07 | Galderma Pharma S.A. | Compuestos, formulaciones y métodos para tratar o prevenir los trastornos inflamatorios de la piel |
| FR2887149B1 (fr) * | 2005-06-17 | 2007-08-03 | Galderma Sa | Procede de solubilisation du metronidazole |
| US8361553B2 (en) | 2004-07-30 | 2013-01-29 | Kimberly-Clark Worldwide, Inc. | Methods and compositions for metal nanoparticle treated surfaces |
| EP2789235B1 (en) | 2004-07-30 | 2015-12-23 | Avent, Inc. | Method of preparing silver nanoparticles |
| CN102783499A (zh) | 2004-07-30 | 2012-11-21 | 金伯利-克拉克环球有限公司 | 抗微生物的装置和组合物 |
| US9289378B2 (en) | 2004-09-20 | 2016-03-22 | Avent, Inc. | Antimicrobial amorphous compositions |
| US20060093675A1 (en) * | 2004-10-29 | 2006-05-04 | Mathew Ebmeier | Intravaginal treatment of vaginal infections with metronidazole compositions |
| BRPI0612448A2 (pt) | 2005-05-09 | 2010-11-23 | Foamix Ltd | composição espumosa de sacarìdeo |
| FR2890559B1 (fr) * | 2005-09-13 | 2011-06-24 | Galderma Sa | Mousses dermatologiques a base de metronidazole et emulsions pour la preparation |
| FR2890560B1 (fr) * | 2005-09-13 | 2011-06-24 | Galderma Sa | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation |
| WO2007127236A2 (en) | 2006-04-28 | 2007-11-08 | Acrymed, Inc. | Antimicrobial site dressings |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
| WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
| WO2010041141A2 (en) | 2008-10-07 | 2010-04-15 | Foamix Ltd. | Oil-based foamable carriers and formulations |
| CA2709199A1 (en) | 2007-12-21 | 2009-07-02 | Galderma Laboratories, Inc. | Pre-surgical treatment |
| AU2009205314A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| US7893097B2 (en) | 2008-02-02 | 2011-02-22 | Dow Pharmaceutical Sciences, Inc. | Methods and compositions for increasing solubility of azole drug compounds that are poorly soluble in water |
| US20100105750A1 (en) * | 2008-10-23 | 2010-04-29 | Nycomed Us Inc. | Stable metronidazole gel formulations |
| US20120087872A1 (en) | 2009-04-28 | 2012-04-12 | Foamix Ltd. | Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof |
| WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| AU2010302350B2 (en) | 2009-10-02 | 2015-06-18 | Journey Medical Corporation | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| EP2329849B1 (en) | 2009-11-18 | 2015-04-29 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
| US8394800B2 (en) * | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| CN103298472A (zh) | 2010-03-26 | 2013-09-11 | 盖尔德马研究及发展公司 | 安全和有效治疗红斑的改进的方法和组合物 |
| WO2011117378A2 (en) | 2010-03-26 | 2011-09-29 | Galderma Research & Development | Improved methods and compositions for safe and effective treatment of telangiectasia |
| US12661407B2 (en) | 2010-04-08 | 2026-06-23 | Journey Medical Corporation | Compositions, gels and foams with rheology modulators and uses thereof |
| RU2587041C2 (ru) | 2010-06-30 | 2016-06-10 | Галдерма Ресерч Энд Девелопмент | Способ предотвращения или лечения опухоли кожи |
| AU2011273509A1 (en) | 2010-06-30 | 2013-06-13 | Galderma Research & Development | Use of alpha-adrenergic receptor agonist for preventing or treating skin tumor |
| US8053427B1 (en) | 2010-10-21 | 2011-11-08 | Galderma R&D SNC | Brimonidine gel composition |
| ES2498217T5 (es) | 2010-10-21 | 2018-03-19 | Galderma S.A. | Composición en forma de gel basada en brimonidina |
| AU2012275292B2 (en) | 2011-06-28 | 2015-11-12 | Chemo Research, S.L. | High dosage mucoadhesive metronidazole aqueous-based gel formulations their use to treat bacterial vaginosis |
| WO2013016072A1 (en) | 2011-07-22 | 2013-01-31 | Allergan, Inc. | Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating skin diseases |
| WO2013057579A2 (en) | 2011-10-19 | 2013-04-25 | Galderma Pharma S.A. | Method of reducing facial flushing associated with systemic use of phosphodiesterase type 5 inhibitors |
| PH12014500785A1 (en) | 2011-10-19 | 2014-05-12 | Galderma Sa | Method for treating capillary hemangiomas |
| US9283217B2 (en) | 2011-11-10 | 2016-03-15 | Allergan, Inc. | Pharmaceutical compositions comprising 7-(1 H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions |
| UA109359C2 (xx) | 2011-11-10 | 2015-08-10 | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
| WO2014113493A1 (en) | 2013-01-16 | 2014-07-24 | Emory University | Cas9-nucleic acid complexes and uses related thereto |
| CN105209049B (zh) | 2013-05-02 | 2019-05-14 | 医学科技研究公司 | 抗微生物组合物及其制造方法 |
| KR102221499B1 (ko) | 2013-09-26 | 2021-03-02 | 갈데르마 소시에떼아노님 | 위축성 피부 흉터를 치료하기 위한 프로스타글라딘 F2α 및 그 유사체 |
| US10117911B2 (en) | 2015-05-29 | 2018-11-06 | Agenovir Corporation | Compositions and methods to treat herpes simplex virus infections |
| AU2017241767B2 (en) | 2016-03-28 | 2021-07-22 | Allergan, Inc. | Phenyl urea derivatives as N-formyl peptide receptor modulators |
| MX2020012139A (es) | 2016-09-08 | 2021-01-29 | Vyne Pharmaceuticals Inc | Composiciones y metodos para tratar rosacea y acne. |
| CN110314133A (zh) * | 2019-06-28 | 2019-10-11 | 石家庄四药有限公司 | 一种甲硝唑氯化钠注射液及其制备方法 |
| EP4192431A1 (en) | 2020-08-04 | 2023-06-14 | Venthera, Inc. | Formulations of phosphoinositide 3-kinase inhibitors |
| CA3255435A1 (en) | 2022-05-20 | 2023-11-23 | Dermbiont, Inc. | Compositions and formulations allowing the use of a PK inhibitor for the prevention, treatment, and improvement of skin diseases, conditions, and disorders |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4032645A (en) | 1975-06-19 | 1977-06-28 | G. D. Searle & Co. | Injectable metronidazole composition |
| DE3346123A1 (de) | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| US4596795A (en) | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
| US4727064A (en) | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US4837378A (en) * | 1986-01-15 | 1989-06-06 | Curatek Pharmaceuticals, Inc. | Topical metronidazole formulations and therapeutic uses thereof |
| DE3773383D1 (de) * | 1987-03-20 | 1991-10-31 | Curatek Pharmaceuticals | Neue topische metronidazol-formulierungen. |
| US5536743A (en) | 1988-01-15 | 1996-07-16 | Curatek Pharmaceuticals Limited Partnership | Intravaginal treatment of vaginal infections with buffered metronidazole compositions |
| EP0335545B2 (en) | 1988-03-29 | 1998-09-23 | University Of Florida | Pharmaceutical formulations for parenteral use |
| US5997856A (en) | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| TW200402B (enExample) | 1990-08-13 | 1993-02-21 | Senju Pharma Co | |
| DE69232535T4 (de) * | 1991-06-24 | 2003-09-11 | Hcell Technology, Inc. | In langzeitkultur gehaltene hormon-absondernde pankreatische zellen |
| US5747341A (en) * | 1991-06-24 | 1998-05-05 | Pacific Biomedical Research, Inc. | Culture media having low osmolarity for establishing and maintaining hormone-secreting cells in long-term culture |
| US5602112A (en) * | 1992-06-19 | 1997-02-11 | Supergen, Inc. | Pharmaceutical formulation |
| US5472954A (en) | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| US5324718A (en) * | 1992-07-14 | 1994-06-28 | Thorsteinn Loftsson | Cyclodextrin/drug complexation |
| US5298410A (en) * | 1993-02-25 | 1994-03-29 | Sterling Winthrop Inc. | Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life |
| JPH07157440A (ja) * | 1993-10-15 | 1995-06-20 | Takeda Chem Ind Ltd | 医薬用組成物 |
| FR2722098B1 (fr) | 1994-07-06 | 1996-08-23 | Cird Galderma | Nouveaux medicaments a base de metro-nidazole ou d'un melange synergetique de metronidazole et de clindamycine |
| KR20010023256A (ko) * | 1997-08-27 | 2001-03-26 | 헥살 아게 | 용해도와 생체 이용성이 개선된 신규의 멜록시캄 의약조성물 |
| US5989523A (en) * | 1998-03-20 | 1999-11-23 | Fitzjarrell; Edwin A. | Topical spray for treating acne containing niacinamide and NaPCA |
| WO2000015224A1 (en) * | 1998-09-17 | 2000-03-23 | Eli Lilly And Company | Protein formulations |
| US6183766B1 (en) * | 1999-02-12 | 2001-02-06 | The Procter & Gamble Company | Skin sanitizing compositions |
| EP1383445A4 (en) * | 2001-03-20 | 2005-04-13 | Cydex Inc | FORMULATIONS WITH PROPOFOL AND A SULFOALKYL ETHER CYCLODEXTRIN |
| US6881726B2 (en) * | 2001-12-24 | 2005-04-19 | Dow Pharmaceutical Sciences | Aqueous compositions containing metronidazole |
-
2000
- 2000-07-13 US US09/615,169 patent/US6468989B1/en not_active Expired - Lifetime
-
2001
- 2001-06-19 WO PCT/US2001/019644 patent/WO2002006349A1/en not_active Ceased
- 2001-06-19 EP EP01948497A patent/EP1303541B1/en not_active Expired - Lifetime
- 2001-06-19 AT AT01948497T patent/ATE506950T1/de not_active IP Right Cessation
- 2001-06-19 ES ES01948497T patent/ES2365322T3/es not_active Expired - Lifetime
- 2001-06-19 DE DE60144520T patent/DE60144520D1/de not_active Expired - Lifetime
- 2001-06-19 JP JP2002512249A patent/JP4130358B2/ja not_active Expired - Lifetime
- 2001-06-19 CA CA002405072A patent/CA2405072C/en not_active Expired - Fee Related
- 2001-06-19 AU AU2001269937A patent/AU2001269937A1/en not_active Abandoned
- 2001-07-12 AR ARP010103309A patent/AR030245A1/es active IP Right Grant
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