JP2004515245A5 - - Google Patents
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- JP2004515245A5 JP2004515245A5 JP2002549720A JP2002549720A JP2004515245A5 JP 2004515245 A5 JP2004515245 A5 JP 2004515245A5 JP 2002549720 A JP2002549720 A JP 2002549720A JP 2002549720 A JP2002549720 A JP 2002549720A JP 2004515245 A5 JP2004515245 A5 JP 2004515245A5
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- JP
- Japan
- Prior art keywords
- seq
- tag
- loop
- dna
- coli
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 4
- 108091034117 Oligonucleotide Proteins 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001872 | 2000-12-13 | ||
| US27209801P | 2001-02-28 | 2001-02-28 | |
| PCT/DK2001/000825 WO2002048189A2 (en) | 2000-12-13 | 2001-12-13 | Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004515245A JP2004515245A (ja) | 2004-05-27 |
| JP2004515245A5 true JP2004515245A5 (https=) | 2010-04-08 |
| JP4493271B2 JP4493271B2 (ja) | 2010-06-30 |
Family
ID=26068925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002549720A Expired - Fee Related JP4493271B2 (ja) | 2000-12-13 | 2001-12-13 | Ｃ型レクチン様ドメインの骨格構造を有する蛋白質のコンビナトリアルライブラリ |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8017559B2 (https=) |
| EP (2) | EP1341912B1 (https=) |
| JP (1) | JP4493271B2 (https=) |
| KR (1) | KR100865602B1 (https=) |
| CN (1) | CN100580084C (https=) |
| AT (1) | ATE431851T1 (https=) |
| AU (2) | AU2156802A (https=) |
| BR (1) | BR0116138A (https=) |
| CA (1) | CA2430953A1 (https=) |
| DE (1) | DE60138764D1 (https=) |
| DK (1) | DK1341912T3 (https=) |
| NO (1) | NO20032663L (https=) |
| NZ (1) | NZ526312A (https=) |
| WO (1) | WO2002048189A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0116138A (pt) | 2000-12-13 | 2003-09-23 | Borean Pharma As | Bibliotecas combinatóriais de proteìnas tendo a estrutura de andaime de domìnios tipo lectina tipo c |
| WO2004005335A2 (en) * | 2002-07-05 | 2004-01-15 | Borean Pharma A/S | Multimerised growth hormone fusion proteins |
| CA2495336A1 (en) | 2002-08-20 | 2004-03-04 | Summit Glycoresearch Corporation | Use of lectin library for distinguishing glycoproteins or cells, diagnosing serum or cells, or fractionating glycoproteins or cells |
| US20070010658A1 (en) | 2002-10-29 | 2007-01-11 | Holtet Thor L | Trimeric binding proteins for trimeric cytokines |
| ATE482972T1 (de) * | 2003-11-06 | 2010-10-15 | Danisco Us Inc | Tgf-beta1-bindende und geträgerte peptide |
| US20100028995A1 (en) * | 2004-02-23 | 2010-02-04 | Anaphore, Inc. | Tetranectin Trimerizing Polypeptides |
| WO2006053568A1 (en) | 2004-11-22 | 2006-05-26 | Borean Pharma Aps | Tnf antagonists |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| MX2009005466A (es) | 2006-11-22 | 2009-08-17 | Adnexus A Bristol Myers Sqibb | Terapeuticos dirigidos a base de proteinas manipuladas para receptores de tirosina cinasas, incluyendo receptor de factor de crecimiento tipo insulina-i. |
| EP2195333A1 (en) * | 2007-09-12 | 2010-06-16 | Anaphore, Inc. | Hsp70-based treatment for autoimmune diseases |
| US20110027267A1 (en) * | 2007-11-09 | 2011-02-03 | Anaphore, Inc. | Fusion Proteins of Mannose Binding Lectins for Treatment of Disease |
| WO2009142773A2 (en) | 2008-05-22 | 2009-11-26 | Bristol-Myers Squibb Company | Multivalent fibronectin based scaffold domain proteins |
| US20130295106A1 (en) * | 2008-09-26 | 2013-11-07 | Oncomed Pharmaceuticals, Inc. | Frizzled-Binding Agents And Uses Thereof |
| SG190568A1 (en) | 2008-09-26 | 2013-06-28 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
| JP2012504969A (ja) | 2008-10-10 | 2012-03-01 | アナフォア インコーポレイテッド | Ｔｒａｉｌ−ｒ１及びｔｒａｉｌ−ｒ２に結合するポリペプチド |
| CN102686606A (zh) * | 2009-10-09 | 2012-09-19 | 阿纳福公司 | 结合il-23r的多肽 |
| CA2776954A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Combinatorial libraries based on c-type lectin domain |
| US20110086806A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Polypeptides that Bind IL-23R |
| WO2011074941A1 (en) * | 2009-12-15 | 2011-06-23 | Universiti Malaya | A method of high throughput screening of inhibitors that inhibit interaction of an attachment protein to cell receptors using recombinant phage display |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| KR101294982B1 (ko) * | 2011-12-09 | 2013-08-08 | 경북대학교 산학협력단 | 단백질 골격모듈을 포함하는 융합 폴리펩타이드 및 이를 이용한 목적 단백질에 특이적인 펩타이드 라이브러리 스크리닝 방법 |
| JP6126075B2 (ja) * | 2012-03-02 | 2017-05-10 | 国立研究開発法人科学技術振興機構 | 機能性核酸分子の構築法、および当該方法に用いる核酸組合せ物 |
| AU2013334790A1 (en) | 2012-10-23 | 2015-04-30 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using Wnt pathway-binding agents |
| AU2014212081A1 (en) | 2013-02-04 | 2015-08-13 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| US20160039877A1 (en) | 2013-03-15 | 2016-02-11 | Shenzhen Hightide Biopharmaceutical, Ltd. | Compositions and methods of using islet neogenesis peptides and analogs thereof |
| GB201311031D0 (en) | 2013-06-20 | 2013-08-07 | Queen Mary & Westfield College | Method |
| RU2715905C2 (ru) | 2014-10-01 | 2020-03-04 | МЕДИММЬЮН, ЭлЭлСи | Способ конъюгации полипептида |
| AR111963A1 (es) | 2017-05-26 | 2019-09-04 | Univ California | Método y moléculas |
| CN113372428B (zh) * | 2021-05-21 | 2022-07-08 | 广东食品药品职业学院 | 文昌鱼C型凝集素BjCTL4基因及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07506253A (ja) | 1992-04-30 | 1995-07-13 | ジェネンテク，インコーポレイテッド | セレクチン変異体 |
| US5679548A (en) * | 1993-02-02 | 1997-10-21 | The Scripps Research Institute | Methods for producing polypeptide metal binding sites and compositions thereof |
| AU674568B2 (en) | 1993-02-04 | 1997-01-02 | Anaphore, Inc. | Improved method for the refolding of proteins |
| US6025485A (en) * | 1997-02-14 | 2000-02-15 | Arcaris, Inc. | Methods and compositions for peptide libraries displayed on light-emitting scaffolds |
| WO1998056906A1 (en) | 1997-06-11 | 1998-12-17 | Thoegersen Hans Christian | Trimerising module |
| EP0947582A1 (en) * | 1998-03-31 | 1999-10-06 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
| US6180343B1 (en) * | 1998-10-08 | 2001-01-30 | Rigel Pharmaceuticals, Inc. | Green fluorescent protein fusions with random peptides |
| BR0116138A (pt) | 2000-12-13 | 2003-09-23 | Borean Pharma As | Bibliotecas combinatóriais de proteìnas tendo a estrutura de andaime de domìnios tipo lectina tipo c |
-
2001
- 2001-12-13 BR BR0116138-5A patent/BR0116138A/pt not_active IP Right Cessation
- 2001-12-13 CA CA002430953A patent/CA2430953A1/en not_active Abandoned
- 2001-12-13 WO PCT/DK2001/000825 patent/WO2002048189A2/en not_active Ceased
- 2001-12-13 EP EP01270552A patent/EP1341912B1/en not_active Expired - Lifetime
- 2001-12-13 KR KR1020037007858A patent/KR100865602B1/ko not_active Expired - Fee Related
- 2001-12-13 AU AU2156802A patent/AU2156802A/xx active Pending
- 2001-12-13 EP EP09160663A patent/EP2105503B1/en not_active Expired - Lifetime
- 2001-12-13 NZ NZ526312A patent/NZ526312A/en not_active IP Right Cessation
- 2001-12-13 DE DE60138764T patent/DE60138764D1/de not_active Expired - Lifetime
- 2001-12-13 DK DK01270552T patent/DK1341912T3/da active
- 2001-12-13 AU AU2002221568A patent/AU2002221568B2/en not_active Ceased
- 2001-12-13 AT AT01270552T patent/ATE431851T1/de not_active IP Right Cessation
- 2001-12-13 JP JP2002549720A patent/JP4493271B2/ja not_active Expired - Fee Related
- 2001-12-13 CN CN01821632A patent/CN100580084C/zh not_active Expired - Fee Related
-
2003
- 2003-06-12 NO NO20032663A patent/NO20032663L/no not_active Application Discontinuation
-
2006
- 2006-12-04 US US11/633,040 patent/US8017559B2/en not_active Expired - Fee Related
-
2011
- 2011-06-08 US US13/156,138 patent/US20120094873A1/en not_active Abandoned
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