CA2430953A1 - Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains - Google Patents

Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains Download PDF

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Publication number
CA2430953A1
CA2430953A1 CA002430953A CA2430953A CA2430953A1 CA 2430953 A1 CA2430953 A1 CA 2430953A1 CA 002430953 A CA002430953 A CA 002430953A CA 2430953 A CA2430953 A CA 2430953A CA 2430953 A1 CA2430953 A1 CA 2430953A1
Authority
CA
Canada
Prior art keywords
amino acid
ctld
beta
seq
tetranectin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002430953A
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English (en)
French (fr)
Inventor
Michael Etzerodt
Thor Las Holtet
Niels Jonas Heilskov Graversen
Hans Christian Thogersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bird Rock Bio Inc
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2430953A1 publication Critical patent/CA2430953A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002430953A 2000-12-13 2001-12-13 Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains Abandoned CA2430953A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200001872 2000-12-13
DKPA200001872 2000-12-13
US27209801P 2001-02-28 2001-02-28
US60/272,098 2001-02-28
PCT/DK2001/000825 WO2002048189A2 (en) 2000-12-13 2001-12-13 Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains

Publications (1)

Publication Number Publication Date
CA2430953A1 true CA2430953A1 (en) 2002-06-20

Family

ID=26068925

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002430953A Abandoned CA2430953A1 (en) 2000-12-13 2001-12-13 Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains

Country Status (14)

Country Link
US (2) US8017559B2 (https=)
EP (2) EP1341912B1 (https=)
JP (1) JP4493271B2 (https=)
KR (1) KR100865602B1 (https=)
CN (1) CN100580084C (https=)
AT (1) ATE431851T1 (https=)
AU (2) AU2002221568B2 (https=)
BR (1) BR0116138A (https=)
CA (1) CA2430953A1 (https=)
DE (1) DE60138764D1 (https=)
DK (1) DK1341912T3 (https=)
NO (1) NO20032663L (https=)
NZ (1) NZ526312A (https=)
WO (1) WO2002048189A2 (https=)

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ATE431851T1 (de) 2000-12-13 2009-06-15 Anaphore Inc Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c- typ lectin-ähnlichen domäne als gerüststruktur
AU2003239777A1 (en) * 2002-07-05 2004-01-23 Borean Pharma A/S Multimerised growth hormone fusion proteins
JPWO2004018513A1 (ja) 2002-08-20 2005-12-08 サミット・グライコリサーチ株式会社 糖タンパク質若しくは細胞の識別、血清若しくは細胞診断、或いは糖タンパク質若しくは細胞分画のためのレクチンライブラリの使用
EP2311867A1 (en) 2002-10-29 2011-04-20 Anaphore, Inc. Trimeric binding proteins for trimeric cytokines
DE602004029393D1 (de) * 2003-11-06 2010-11-11 Danisco Us Inc Tgf-beta1-bindende und geträgerte peptide
US20100028995A1 (en) * 2004-02-23 2010-02-04 Anaphore, Inc. Tetranectin Trimerizing Polypeptides
AU2005306168A1 (en) * 2004-11-22 2006-05-26 Anaphore, Inc. TNF antagonists
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
CA2670471A1 (en) 2006-11-22 2008-06-05 Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
JP2010538655A (ja) * 2007-09-12 2010-12-16 アナフォア インコーポレイテッド 自己免疫疾患についてのｈｓｐ７０に基づく治療
CN101918439A (zh) * 2007-11-09 2010-12-15 阿纳福公司 用于治疗疾病的甘露糖结合凝集素融合蛋白
PE20091931A1 (es) 2008-05-22 2009-12-31 Bristol Myers Squibb Co Proteinas de dominio de armazon basadas en fibronectina multivalentes
US20130295106A1 (en) * 2008-09-26 2013-11-07 Oncomed Pharmaceuticals, Inc. Frizzled-Binding Agents And Uses Thereof
CN103002911B (zh) 2008-09-26 2015-08-26 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
CA2739663A1 (en) 2008-10-10 2010-05-15 Anaphore, Inc. Polypeptides that bind trail-r1 and trail-r2
WO2011043835A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that bind il-23r
US20110086806A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that Bind IL-23R
JP2013507123A (ja) * 2009-10-09 2013-03-04 アナフォア インコーポレイテッド Ｃ型レクチンドメインをベースとするコンビナトリアルライブラリー
WO2011074941A1 (en) * 2009-12-15 2011-06-23 Universiti Malaya A method of high throughput screening of inhibitors that inhibit interaction of an attachment protein to cell receptors using recombinant phage display
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
CA2794674A1 (en) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
KR101294982B1 (ko) * 2011-12-09 2013-08-08 경북대학교 산학협력단 단백질 골격모듈을 포함하는 융합 폴리펩타이드 및 이를 이용한 목적 단백질에 특이적인 펩타이드 라이브러리 스크리닝 방법
WO2013129663A1 (ja) * 2012-03-02 2013-09-06 独立行政法人理化学研究所 機能性核酸分子の構築法、および当該方法に用いる核酸組合せ物
WO2014066328A1 (en) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
WO2014139182A1 (en) 2013-03-15 2014-09-18 Shenzhen Hightide Biopharmaceutical, Ltd. Compositions and methods of using islet neogenesis peptides and analogs thereof
GB201311031D0 (en) 2013-06-20 2013-08-07 Queen Mary & Westfield College Method
JP6863888B2 (ja) 2014-10-01 2021-04-21 メディミューン，エルエルシー ポリペプチドをコンジュゲートさせる方法
AR111963A1 (es) 2017-05-26 2019-09-04 Univ California Método y moléculas
CN113372428B (zh) * 2021-05-21 2022-07-08 广东食品药品职业学院 文昌鱼C型凝集素BjCTL4基因及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0639224T3 (da) 1992-04-30 2000-10-30 Genentech Inc Varianter i lectindomænet af selectin
US5679548A (en) * 1993-02-02 1997-10-21 The Scripps Research Institute Methods for producing polypeptide metal binding sites and compositions thereof
CA2155335C (en) * 1993-02-04 2001-06-05 HANS CHRISTIAN THõGERSEN Improved method for the refolding of proteins
US6025485A (en) * 1997-02-14 2000-02-15 Arcaris, Inc. Methods and compositions for peptide libraries displayed on light-emitting scaffolds
AU736707B2 (en) 1997-06-11 2001-08-02 Anaphore, Inc. Trimerising module
EP0947582A1 (en) * 1998-03-31 1999-10-06 Innogenetics N.V. A polypeptide structure for use as a scaffold
US6180343B1 (en) * 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
ATE431851T1 (de) 2000-12-13 2009-06-15 Anaphore Inc Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c- typ lectin-ähnlichen domäne als gerüststruktur

Also Published As

Publication number Publication date
AU2156802A (en) 2002-06-24
US20120094873A1 (en) 2012-04-19
KR100865602B1 (ko) 2008-10-27
EP2105503A2 (en) 2009-09-30
BR0116138A (pt) 2003-09-23
ATE431851T1 (de) 2009-06-15
CN1484698A (zh) 2004-03-24
WO2002048189A2 (en) 2002-06-20
DK1341912T3 (da) 2009-09-21
JP4493271B2 (ja) 2010-06-30
AU2002221568B2 (en) 2005-06-02
JP2004515245A (ja) 2004-05-27
KR20040018316A (ko) 2004-03-03
NO20032663D0 (no) 2003-06-12
US8017559B2 (en) 2011-09-13
WO2002048189A3 (en) 2003-01-09
DE60138764D1 (de) 2009-07-02
US20070275393A1 (en) 2007-11-29
EP1341912B1 (en) 2009-05-20
EP2105503A3 (en) 2011-03-02
EP2105503B1 (en) 2012-09-19
NO20032663L (no) 2003-07-17
CN100580084C (zh) 2010-01-13
NZ526312A (en) 2004-11-26
EP1341912A2 (en) 2003-09-10

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20131213