KR100865602B1 - 스캐폴드 구조의 ｃ-타입 렉틴 유사 도메인을 가지는단백질의 조합 라이브러리 - Google Patents

스캐폴드 구조의 ｃ-타입 렉틴 유사 도메인을 가지는단백질의 조합 라이브러리 Download PDF

Info

Publication number
KR100865602B1
KR100865602B1 KR1020037007858A KR20037007858A KR100865602B1 KR 100865602 B1 KR100865602 B1 KR 100865602B1 KR 1020037007858 A KR1020037007858 A KR 1020037007858A KR 20037007858 A KR20037007858 A KR 20037007858A KR 100865602 B1 KR100865602 B1 KR 100865602B1
Authority
KR
South Korea
Prior art keywords
nucleic acid
ensemble
ala
amino acid
glu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020037007858A
Other languages
English (en)
Korean (ko)
Other versions
KR20040018316A (ko
Inventor
마이클 에트제로드트
토르 라스 홀테트
닐스 조나스 헤일스코브 그라베르센
한스 크리티안 토게르젠
Original Assignee
아나포르, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아나포르, 인코포레이티드 filed Critical 아나포르, 인코포레이티드
Publication of KR20040018316A publication Critical patent/KR20040018316A/ko
Application granted granted Critical
Publication of KR100865602B1 publication Critical patent/KR100865602B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020037007858A 2000-12-13 2001-12-13 스캐폴드 구조의 ｃ-타입 렉틴 유사 도메인을 가지는단백질의 조합 라이브러리 Expired - Fee Related KR100865602B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200001872 2000-12-13
DKPA200001872 2000-12-13
US27209801P 2001-02-28 2001-02-28
US60/272,098 2001-02-28
PCT/DK2001/000825 WO2002048189A2 (en) 2000-12-13 2001-12-13 Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains

Publications (2)

Publication Number Publication Date
KR20040018316A KR20040018316A (ko) 2004-03-03
KR100865602B1 true KR100865602B1 (ko) 2008-10-27

Family

ID=26068925

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037007858A Expired - Fee Related KR100865602B1 (ko) 2000-12-13 2001-12-13 스캐폴드 구조의 ｃ-타입 렉틴 유사 도메인을 가지는단백질의 조합 라이브러리

Country Status (14)

Country Link
US (2) US8017559B2 (https=)
EP (2) EP1341912B1 (https=)
JP (1) JP4493271B2 (https=)
KR (1) KR100865602B1 (https=)
CN (1) CN100580084C (https=)
AT (1) ATE431851T1 (https=)
AU (2) AU2002221568B2 (https=)
BR (1) BR0116138A (https=)
CA (1) CA2430953A1 (https=)
DE (1) DE60138764D1 (https=)
DK (1) DK1341912T3 (https=)
NO (1) NO20032663L (https=)
NZ (1) NZ526312A (https=)
WO (1) WO2002048189A2 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE431851T1 (de) 2000-12-13 2009-06-15 Anaphore Inc Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c- typ lectin-ähnlichen domäne als gerüststruktur
AU2003239777A1 (en) * 2002-07-05 2004-01-23 Borean Pharma A/S Multimerised growth hormone fusion proteins
JPWO2004018513A1 (ja) 2002-08-20 2005-12-08 サミット・グライコリサーチ株式会社 糖タンパク質若しくは細胞の識別、血清若しくは細胞診断、或いは糖タンパク質若しくは細胞分画のためのレクチンライブラリの使用
EP2311867A1 (en) 2002-10-29 2011-04-20 Anaphore, Inc. Trimeric binding proteins for trimeric cytokines
DE602004029393D1 (de) * 2003-11-06 2010-11-11 Danisco Us Inc Tgf-beta1-bindende und geträgerte peptide
US20100028995A1 (en) * 2004-02-23 2010-02-04 Anaphore, Inc. Tetranectin Trimerizing Polypeptides
AU2005306168A1 (en) * 2004-11-22 2006-05-26 Anaphore, Inc. TNF antagonists
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
CA2670471A1 (en) 2006-11-22 2008-06-05 Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
JP2010538655A (ja) * 2007-09-12 2010-12-16 アナフォア インコーポレイテッド 自己免疫疾患についてのｈｓｐ７０に基づく治療
CN101918439A (zh) * 2007-11-09 2010-12-15 阿纳福公司 用于治疗疾病的甘露糖结合凝集素融合蛋白
PE20091931A1 (es) 2008-05-22 2009-12-31 Bristol Myers Squibb Co Proteinas de dominio de armazon basadas en fibronectina multivalentes
US20130295106A1 (en) * 2008-09-26 2013-11-07 Oncomed Pharmaceuticals, Inc. Frizzled-Binding Agents And Uses Thereof
CN103002911B (zh) 2008-09-26 2015-08-26 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
CA2739663A1 (en) 2008-10-10 2010-05-15 Anaphore, Inc. Polypeptides that bind trail-r1 and trail-r2
WO2011043835A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that bind il-23r
US20110086806A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that Bind IL-23R
JP2013507123A (ja) * 2009-10-09 2013-03-04 アナフォア インコーポレイテッド Ｃ型レクチンドメインをベースとするコンビナトリアルライブラリー
WO2011074941A1 (en) * 2009-12-15 2011-06-23 Universiti Malaya A method of high throughput screening of inhibitors that inhibit interaction of an attachment protein to cell receptors using recombinant phage display
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
CA2794674A1 (en) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
KR101294982B1 (ko) * 2011-12-09 2013-08-08 경북대학교 산학협력단 단백질 골격모듈을 포함하는 융합 폴리펩타이드 및 이를 이용한 목적 단백질에 특이적인 펩타이드 라이브러리 스크리닝 방법
WO2013129663A1 (ja) * 2012-03-02 2013-09-06 独立行政法人理化学研究所 機能性核酸分子の構築法、および当該方法に用いる核酸組合せ物
WO2014066328A1 (en) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
WO2014139182A1 (en) 2013-03-15 2014-09-18 Shenzhen Hightide Biopharmaceutical, Ltd. Compositions and methods of using islet neogenesis peptides and analogs thereof
GB201311031D0 (en) 2013-06-20 2013-08-07 Queen Mary & Westfield College Method
JP6863888B2 (ja) 2014-10-01 2021-04-21 メディミューン，エルエルシー ポリペプチドをコンジュゲートさせる方法
AR111963A1 (es) 2017-05-26 2019-09-04 Univ California Método y moléculas
CN113372428B (zh) * 2021-05-21 2022-07-08 广东食品药品职业学院 文昌鱼C型凝集素BjCTL4基因及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0639224T3 (da) 1992-04-30 2000-10-30 Genentech Inc Varianter i lectindomænet af selectin
US5679548A (en) * 1993-02-02 1997-10-21 The Scripps Research Institute Methods for producing polypeptide metal binding sites and compositions thereof
CA2155335C (en) * 1993-02-04 2001-06-05 HANS CHRISTIAN THõGERSEN Improved method for the refolding of proteins
US6025485A (en) * 1997-02-14 2000-02-15 Arcaris, Inc. Methods and compositions for peptide libraries displayed on light-emitting scaffolds
AU736707B2 (en) 1997-06-11 2001-08-02 Anaphore, Inc. Trimerising module
EP0947582A1 (en) * 1998-03-31 1999-10-06 Innogenetics N.V. A polypeptide structure for use as a scaffold
US6180343B1 (en) * 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
ATE431851T1 (de) 2000-12-13 2009-06-15 Anaphore Inc Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c- typ lectin-ähnlichen domäne als gerüststruktur

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Biological Chemistry, Vol.275(48), 01 December 2000, pages 37390-37396

Also Published As

Publication number Publication date
AU2156802A (en) 2002-06-24
US20120094873A1 (en) 2012-04-19
EP2105503A2 (en) 2009-09-30
BR0116138A (pt) 2003-09-23
ATE431851T1 (de) 2009-06-15
CN1484698A (zh) 2004-03-24
WO2002048189A2 (en) 2002-06-20
DK1341912T3 (da) 2009-09-21
JP4493271B2 (ja) 2010-06-30
AU2002221568B2 (en) 2005-06-02
JP2004515245A (ja) 2004-05-27
CA2430953A1 (en) 2002-06-20
KR20040018316A (ko) 2004-03-03
NO20032663D0 (no) 2003-06-12
US8017559B2 (en) 2011-09-13
WO2002048189A3 (en) 2003-01-09
DE60138764D1 (de) 2009-07-02
US20070275393A1 (en) 2007-11-29
EP1341912B1 (en) 2009-05-20
EP2105503A3 (en) 2011-03-02
EP2105503B1 (en) 2012-09-19
NO20032663L (no) 2003-07-17
CN100580084C (zh) 2010-01-13
NZ526312A (en) 2004-11-26
EP1341912A2 (en) 2003-09-10

Similar Documents

Publication Publication Date Title
KR100865602B1 (ko) 스캐폴드 구조의 ｃ-타입 렉틴 유사 도메인을 가지는단백질의 조합 라이브러리
US20040132094A1 (en) Combinatorial libraries of proteins having the scaffold structure of c-type lectinlike domains
JP5291279B2 (ja) 反復モジュールを含む反復タンパク質の集合体
EP1266025B1 (en) Protein scaffolds for antibody mimics and other binding proteins
AU2002221568A1 (en) Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains
US20110086770A1 (en) Combinatorial Libraries Based on C-type Lectin-like Domain
US20170334958A1 (en) Protein scaffolds for antibody mimics and other binding proteins
US20110028403A1 (en) HSP70-Based Treatment for Autoimmune Diseases and Cancer
WO2002032925A9 (en) Protein scaffolds for antibody mimics and other binding proteins
WO2011043834A1 (en) Combinatorial libraries based on c-type lectin domain
CA2297109A1 (en) 5' ests for secreted proteins expressed in muscle and other mesodermal tissues
JPWO1995001432A1 (ja) 新規ポリペプチド及びそれをコードするｄｎａ
CN117858982A (zh) 人纤连蛋白iii型蛋白支架
HK1154044A (en) Method for the identification and isolation of binding polypeptides from combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains
Class et al. Patent application title: COMBINATORIAL LIBRARIES OF PROTEINS HAVING THE SCAFFOLD STRUCTURE OF C-TYPE LECTIN-LIKE DOMAINS Inventors: Michael Etzerodt (Hinnerup, DK) Thor Las Holtet (Ronde, DK) Thor Las Holtet (Ronde, DK) Niels Jonas Heilskov Graversen (Abyhoj, DK) Hans Christian Thøgersen (Mundelstrup, DK) Assignees: ANAPHORE, INC.
JP2839837B2 (ja) 顆粒球コロニー刺激因子受容体のリガンド結合領域蛋白質をコードしているｄｎａ
AU2002301051B2 (en) Extended cDNAs for secreted proteins
AU2010303879A1 (en) Combinatorial libraries based on C-type lectin domain
JP2000007699A (ja) ウズラのｈ１ヒストン及びその遺伝子
JPH0995497A (ja) 新規蛋白質およびそれをコードするｄｎａ並びに該蛋白質の産生方法

Legal Events

Date Code Title Description
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R15-X000 Change to inventor requested

St.27 status event code: A-3-3-R10-R15-oth-X000

R16-X000 Change to inventor recorded

St.27 status event code: A-3-3-R10-R16-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20111010

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20121022

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20121022