JP2004513108A5 - - Google Patents

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Publication number
JP2004513108A5
JP2004513108A5 JP2002539315A JP2002539315A JP2004513108A5 JP 2004513108 A5 JP2004513108 A5 JP 2004513108A5 JP 2002539315 A JP2002539315 A JP 2002539315A JP 2002539315 A JP2002539315 A JP 2002539315A JP 2004513108 A5 JP2004513108 A5 JP 2004513108A5
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JP
Japan
Prior art keywords
ring
oxadiazol
compound according
alkyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002539315A
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English (en)
Japanese (ja)
Other versions
JP3880051B2 (ja
JP2004513108A (ja
Filing date
Publication date
Priority claimed from GB0026827A external-priority patent/GB0026827D0/en
Priority claimed from GB0122685A external-priority patent/GB0122685D0/en
Application filed filed Critical
Priority claimed from PCT/GB2001/004817 external-priority patent/WO2002036555A1/en
Publication of JP2004513108A publication Critical patent/JP2004513108A/ja
Publication of JP2004513108A5 publication Critical patent/JP2004513108A5/ja
Application granted granted Critical
Publication of JP3880051B2 publication Critical patent/JP3880051B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2002539315A 2000-11-02 2001-10-29 γ−セクレターゼ阻害剤としてのスルファミド Expired - Fee Related JP3880051B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0026827A GB0026827D0 (en) 2000-11-02 2000-11-02 Therapeutic agents
GB0122685A GB0122685D0 (en) 2001-09-20 2001-09-20 Therapeutic agents
PCT/GB2001/004817 WO2002036555A1 (en) 2000-11-02 2001-10-29 Sulfamides as gamma-secretase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006078136A Division JP4495686B2 (ja) 2000-11-02 2006-03-22 γ−セクレターゼ阻害剤としてのスルファミド

Publications (3)

Publication Number Publication Date
JP2004513108A JP2004513108A (ja) 2004-04-30
JP2004513108A5 true JP2004513108A5 (enExample) 2006-05-18
JP3880051B2 JP3880051B2 (ja) 2007-02-14

Family

ID=26245228

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002539315A Expired - Fee Related JP3880051B2 (ja) 2000-11-02 2001-10-29 γ−セクレターゼ阻害剤としてのスルファミド
JP2006078136A Expired - Fee Related JP4495686B2 (ja) 2000-11-02 2006-03-22 γ−セクレターゼ阻害剤としてのスルファミド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006078136A Expired - Fee Related JP4495686B2 (ja) 2000-11-02 2006-03-22 γ−セクレターゼ阻害剤としてのスルファミド

Country Status (9)

Country Link
US (1) US7138400B2 (enExample)
EP (1) EP1334085B1 (enExample)
JP (2) JP3880051B2 (enExample)
AT (1) ATE302753T1 (enExample)
AU (2) AU2002210747B2 (enExample)
CA (1) CA2427206C (enExample)
DE (1) DE60112957T2 (enExample)
ES (1) ES2248397T3 (enExample)
WO (1) WO2002036555A1 (enExample)

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GB0225474D0 (en) 2002-11-01 2002-12-11 Merck Sharp & Dohme Therapeutic agents
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ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
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US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
EP2584903B1 (en) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
CN103068980B (zh) 2010-08-02 2017-04-05 瑟纳治疗公司 使用短干扰核酸(siNA)的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1(CTNNB1)基因表达的抑制
RU2745848C2 (ru) 2010-08-17 2021-04-01 Сирна Терапьютикс, Инк. ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
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EP2892506B1 (en) 2012-09-07 2021-11-03 Massachusetts Eye & Ear Infirmary Treating hearing loss with the gamma-secretase inhibitor ly411575
CA2884309A1 (en) 2012-09-07 2014-03-13 Massachusetts Eye And Ear Infirmary Methods and compositions for regenerating hair cells and/or supporting cells from differentiated cochlear cells or differentiated utricular cells by modulation of notch and cmyc activity
CA2882950A1 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
SMT201700595T1 (it) 2012-11-28 2018-03-08 Merck Sharp & Dohme Composizioni e metodi per trattare il cancro
WO2014100065A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
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GB0209995D0 (en) * 2002-05-01 2002-06-12 Merck Sharp & Dohme Therapeutic agents
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