|
JP2003528076A
(ja)
*
|
2000-03-20 |
2003-09-24 |
メルク シャープ エンド ドーム リミテッド |
スルホンアミド置換架橋ビシクロアルキル誘導体
|
|
GB0209991D0
(en)
*
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0209995D0
(en)
*
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
ATE435219T1
(de)
*
|
2002-05-01 |
2009-07-15 |
Merck Sharp & Dohme |
Heteroaryl substituierte spirocyclische sulfamide zur hemmung von gamma sekretase
|
|
GB0209997D0
(en)
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0225475D0
(en)
*
|
2002-11-01 |
2002-12-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0225474D0
(en)
*
|
2002-11-01 |
2002-12-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US7521481B2
(en)
|
2003-02-27 |
2009-04-21 |
Mclaurin Joanne |
Methods of preventing, treating and diagnosing disorders of protein aggregation
|
|
MXPA05012323A
(es)
|
2003-05-16 |
2006-01-30 |
Merck Sharp & Dohme |
Sulfonamidas ciclicas para la inhibicion de gama-secretasa.
|
|
GB0318447D0
(en)
|
2003-08-05 |
2003-09-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CA2539042A1
(en)
*
|
2003-09-24 |
2005-04-07 |
Merck Sharp & Dohme Limited |
Gamma-secretase inhibitors
|
|
GB0326039D0
(en)
|
2003-11-07 |
2003-12-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
EP1740581B1
(en)
*
|
2004-04-20 |
2012-08-22 |
Merck Sharp & Dohme Corp. |
2, 4, 6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
WO2006123182A2
(en)
|
2005-05-17 |
2006-11-23 |
Merck Sharp & Dohme Limited |
Cyclohexyl sulphones for treatment of cancer
|
|
US8242103B2
(en)
|
2005-05-19 |
2012-08-14 |
Merck Sharp & Dohme Limited |
Sulphamides for treatment of cancer
|
|
EP1996182A4
(en)
*
|
2006-02-27 |
2009-08-12 |
Univ Johns Hopkins |
CANCER TREATMENT WITH GAMMA SECRETASE INHIBITORS
|
|
WO2008055945A1
(en)
|
2006-11-09 |
2008-05-15 |
Probiodrug Ag |
3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
|
|
JP2010509919A
(ja)
|
2006-11-15 |
2010-04-02 |
マサチューセッツ・アイ・アンド・イア・インファーマリー |
内耳細胞の生成
|
|
EP2091948B1
(en)
|
2006-11-30 |
2012-04-18 |
Probiodrug AG |
Novel inhibitors of glutaminyl cyclase
|
|
CA2676715A1
(en)
|
2007-02-12 |
2008-08-21 |
Merck & Co., Inc. |
Piperazine derivatives for treatment of ad and related conditions
|
|
CN101668525A
(zh)
|
2007-03-01 |
2010-03-10 |
前体生物药物股份公司 |
谷氨酰胺酰环化酶抑制剂的新用途
|
|
US8247403B2
(en)
|
2007-03-07 |
2012-08-21 |
Takeda Pharmaceutical Company Limited |
Benzoxazepine derivatives and use thereof
|
|
US9656991B2
(en)
|
2007-04-18 |
2017-05-23 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase
|
|
WO2009035522A1
(en)
*
|
2007-09-14 |
2009-03-19 |
Albert Einstein College Of Medicine Of Yeshiva University |
Use of gamma secretase inhibitors and notch pathway inhibitors for treatment and prevention of renal disease
|
|
ES2413504T3
(es)
|
2007-12-21 |
2013-07-16 |
Ligand Pharmaceuticals Inc. |
Moduladores selectivos del receptor de andrógeno (SARM) y usos de los mismos
|
|
EP2291181B9
(en)
|
2008-04-18 |
2013-09-11 |
University College Dublin National University Of Ireland, Dublin |
Captodiamine for the treatment of depression symptoms
|
|
CA2743436C
(en)
|
2008-11-24 |
2017-10-31 |
Massachusetts Eye & Ear Infirmary |
Pathways to generate hair cells
|
|
WO2010114780A1
(en)
|
2009-04-01 |
2010-10-07 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
|
ES2548913T3
(es)
|
2009-09-11 |
2015-10-21 |
Probiodrug Ag |
Derivados heterocíclicos como inhibidores de glutaminil ciclasa
|
|
MY174452A
(en)
|
2009-10-14 |
2020-04-19 |
Schering Corp |
Substituted piperidines that increase p53 activity and the uses thereof
|
|
WO2011046774A1
(en)
*
|
2009-10-16 |
2011-04-21 |
Merck Sharp & Dohme Corp. |
Diaryl ether derivatives as notch sparing gamma secretase inhibitors
|
|
WO2011107530A2
(en)
|
2010-03-03 |
2011-09-09 |
Probiodrug Ag |
Novel inhibitors
|
|
CA2789440C
(en)
|
2010-03-10 |
2020-03-24 |
Probiodrug Ag |
Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
|
|
JP5945532B2
(ja)
|
2010-04-21 |
2016-07-05 |
プロビオドルグ エージー |
グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
|
|
US8999957B2
(en)
|
2010-06-24 |
2015-04-07 |
Merck Sharp & Dohme Corp. |
Heterocyclic compounds as ERK inhibitors
|
|
US8518907B2
(en)
|
2010-08-02 |
2013-08-27 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
|
|
EP3587574B1
(en)
|
2010-08-17 |
2022-03-16 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
|
|
US8946216B2
(en)
|
2010-09-01 |
2015-02-03 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as ERK inhibitors
|
|
US9242981B2
(en)
|
2010-09-16 |
2016-01-26 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel ERK inhibitors
|
|
US9260471B2
(en)
|
2010-10-29 |
2016-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
|
|
EP2654748B1
(en)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
|
US8530670B2
(en)
|
2011-03-16 |
2013-09-10 |
Probiodrug Ag |
Inhibitors
|
|
ES2389416B1
(es)
*
|
2011-03-30 |
2013-09-16 |
Fundación Instituto Mediterraneo Para El Avance De La Biotecnología Y La Investigación Sanitaria (Imabis) |
Uso de derivados de sulfamidas como neuroprotectores.
|
|
WO2013016411A1
(en)
*
|
2011-07-28 |
2013-01-31 |
Garry Robert Smith |
Novel fluorinated cyclic sulfamides exhibiting neuroprotective action and their method of use
|
|
US9023865B2
(en)
|
2011-10-27 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
|
EP3919620A1
(en)
|
2012-05-02 |
2021-12-08 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
|
JP6486272B2
(ja)
|
2012-09-07 |
2019-03-20 |
マサチューセッツ・アイ・アンド・イア・インファーマリー |
有毛細胞および／または支持細胞再生のための方法および組成物
|
|
EP3970725B1
(en)
|
2012-09-07 |
2025-08-20 |
Massachusetts Eye & Ear Infirmary |
A gamma secretase inhibitor for treating hearing loss
|
|
JP6280554B2
(ja)
|
2012-09-28 |
2018-02-14 |
メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． |
Ｅｒｋ阻害剤である新規化合物
|
|
DK2925888T3
(en)
|
2012-11-28 |
2017-12-18 |
Merck Sharp & Dohme |
COMPOSITIONS AND METHODS OF CANCER TREATMENT
|
|
AR094116A1
(es)
|
2012-12-20 |
2015-07-08 |
Merck Sharp & Dohme |
Imidazopiridinas sustituidas como inhibidores de hdm2
|
|
WO2014120748A1
(en)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
|
US8859286B2
(en)
|
2013-03-14 |
2014-10-14 |
Viacyte, Inc. |
In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
|
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
|
EP3613418A1
(en)
|
2014-01-17 |
2020-02-26 |
Ligand Pharmaceuticals, Inc. |
Methods and compositions for modulating hormone levels
|
|
KR20170029490A
(ko)
|
2014-07-11 |
2017-03-15 |
제넨테크, 인크. |
노치 경로 억제
|
|
WO2016022776A2
(en)
|
2014-08-06 |
2016-02-11 |
Massachusetts Eye And Ear Infirmary |
Increasing atoh1 life to drive sensorineural hair cell differentiantion
|
|
AU2016206808A1
(en)
|
2015-01-14 |
2017-08-31 |
Bristol-Myers Squibb Company |
Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
|
|
US20180214553A1
(en)
|
2015-07-24 |
2018-08-02 |
Oncotracker, Inc. |
Gamma secretase modulators for the treatment of immune system dysfunction
|
|
WO2017096233A1
(en)
|
2015-12-04 |
2017-06-08 |
Massachusetts Eye And Ear Infirmary |
Treatment of hearing loss by inhibition of casein kinase 1
|
|
AU2017212655B2
(en)
|
2016-01-29 |
2024-01-18 |
Decibel Therapeutics, Inc. |
Expansion and differentiation of inner ear supporting cells and methods of use thereof
|
|
EP3458076A4
(en)
|
2016-05-16 |
2020-01-22 |
The General Hospital Corporation |
HUMAN RESPIRATORY STEM CELLS IN BREEDING LUNG EPITHEL
|
|
EP3525785B1
(en)
|
2016-10-12 |
2025-08-27 |
Merck Sharp & Dohme LLC |
Kdm5 inhibitors
|
|
JP6904612B2
(ja)
|
2016-12-16 |
2021-07-21 |
パイプライン セラピューティクス， インコーポレイテッド |
蝸牛シナプス障害を処置する方法
|
|
SG11201907580SA
(en)
|
2017-02-17 |
2019-09-27 |
Hutchinson Fred Cancer Res |
Combination therapies for treatment of bcma-related cancers and autoimmune disorders
|
|
EP3461819B1
(en)
|
2017-09-29 |
2020-05-27 |
Probiodrug AG |
Inhibitors of glutaminyl cyclase
|
|
US10947234B2
(en)
|
2017-11-08 |
2021-03-16 |
Merck Sharp & Dohme Corp. |
PRMT5 inhibitors
|
|
EP3706747B1
(en)
|
2017-11-08 |
2025-09-03 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
|
US11993602B2
(en)
|
2018-08-07 |
2024-05-28 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
|
EP3833355A4
(en)
|
2018-08-07 |
2022-05-11 |
Merck Sharp & Dohme Corp. |
PRMT5 INHIBITORS
|
|
WO2020033284A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
|
BR112021020864A2
(pt)
|
2019-04-19 |
2021-12-14 |
Ligand Pharm Inc |
Formas cristalinas e métodos de produção de formas cristalinas de um composto
|
|
WO2021126729A1
(en)
|
2019-12-17 |
2021-06-24 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
|
AU2020408148B2
(en)
|
2019-12-17 |
2025-04-24 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
|
US20230108114A1
(en)
|
2019-12-17 |
2023-04-06 |
Merck Sharp & Dohme Llc |
Prmt5 inhibitors
|
|
IL296723A
(en)
|
2020-03-26 |
2022-11-01 |
Seagen Inc |
Methods of treating multiple myeloma
|
|
CN120225528A
(zh)
|
2022-09-02 |
2025-06-27 |
默沙东有限责任公司 |
依喜替康衍生的拓扑异构酶-1抑制剂药物组合物及其用途
|
|
CR20250146A
(es)
|
2022-10-25 |
2025-05-26 |
Merck Sharp & Dohme Llc |
Enlazadores-cargas útiles de adc derivados de exatecán, composiciones farmacéuticas, y usos de los mismos
|
|
CN120359051A
(zh)
|
2022-12-14 |
2025-07-22 |
默沙东有限责任公司 |
奥瑞他汀接头-载荷、药物组合物及其用途
|