JP2008516982A5 - - Google Patents
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- Publication number
- JP2008516982A5 JP2008516982A5 JP2007537010A JP2007537010A JP2008516982A5 JP 2008516982 A5 JP2008516982 A5 JP 2008516982A5 JP 2007537010 A JP2007537010 A JP 2007537010A JP 2007537010 A JP2007537010 A JP 2007537010A JP 2008516982 A5 JP2008516982 A5 JP 2008516982A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- aminopropyl
- difluorophenyl
- thiadiazol
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62004804P | 2004-10-19 | 2004-10-19 | |
| US60/620,048 | 2004-10-19 | ||
| US11/252,232 US7449486B2 (en) | 2004-10-19 | 2005-10-17 | Mitotic kinesin inhibitors and methods of use thereof |
| US11/252,232 | 2005-10-17 | ||
| PCT/US2005/037305 WO2006044825A2 (en) | 2004-10-19 | 2005-10-18 | Mitotic kinesin inhibitors and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012193218A Division JP5757666B2 (ja) | 2004-10-19 | 2012-09-03 | 有糸分裂キネシン阻害剤およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008516982A JP2008516982A (ja) | 2008-05-22 |
| JP2008516982A5 true JP2008516982A5 (enExample) | 2008-10-09 |
| JP5128283B2 JP5128283B2 (ja) | 2013-01-23 |
Family
ID=36203637
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007537010A Expired - Lifetime JP5128283B2 (ja) | 2004-10-19 | 2005-10-18 | 有糸分裂キネシン阻害剤およびその使用方法 |
| JP2012193218A Expired - Fee Related JP5757666B2 (ja) | 2004-10-19 | 2012-09-03 | 有糸分裂キネシン阻害剤およびその使用方法 |
| JP2014094479A Expired - Fee Related JP5911909B2 (ja) | 2004-10-19 | 2014-05-01 | 有糸分裂キネシン阻害剤およびその使用方法 |
| JP2015079762A Pending JP2015129191A (ja) | 2004-10-19 | 2015-04-09 | 有糸分裂キネシン阻害剤およびその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012193218A Expired - Fee Related JP5757666B2 (ja) | 2004-10-19 | 2012-09-03 | 有糸分裂キネシン阻害剤およびその使用方法 |
| JP2014094479A Expired - Fee Related JP5911909B2 (ja) | 2004-10-19 | 2014-05-01 | 有糸分裂キネシン阻害剤およびその使用方法 |
| JP2015079762A Pending JP2015129191A (ja) | 2004-10-19 | 2015-04-09 | 有糸分裂キネシン阻害剤およびその使用方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (8) | US7449486B2 (enExample) |
| EP (1) | EP1809280B1 (enExample) |
| JP (4) | JP5128283B2 (enExample) |
| KR (1) | KR101280755B1 (enExample) |
| CN (4) | CN103626720B (enExample) |
| AT (1) | ATE523196T1 (enExample) |
| AU (1) | AU2005295403B2 (enExample) |
| BR (1) | BRPI0518228B8 (enExample) |
| CA (4) | CA2584866C (enExample) |
| CY (1) | CY1112238T1 (enExample) |
| DK (1) | DK1809280T3 (enExample) |
| ES (1) | ES2370774T3 (enExample) |
| HR (1) | HRP20110764T1 (enExample) |
| IL (2) | IL182417A0 (enExample) |
| ME (1) | ME01950B (enExample) |
| MX (1) | MX2007004547A (enExample) |
| NO (1) | NO341725B1 (enExample) |
| NZ (1) | NZ554306A (enExample) |
| PL (1) | PL1809280T3 (enExample) |
| PT (1) | PT1809280E (enExample) |
| RS (1) | RS52037B (enExample) |
| RU (1) | RU2426729C2 (enExample) |
| SI (1) | SI1809280T1 (enExample) |
| TW (1) | TWI357900B (enExample) |
| WO (1) | WO2006044825A2 (enExample) |
| ZA (1) | ZA200703168B (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE480527T1 (de) * | 2001-12-11 | 2010-09-15 | Kyowa Hakko Kirin Co Ltd | Thiadiazolinderivate zur krebsbehandlung |
| KR101096948B1 (ko) | 2003-04-18 | 2011-12-20 | 후지필름 홀딩스 가부시끼가이샤 | Ｍ기 키네신 저해제 |
| CA2528433A1 (en) * | 2003-06-10 | 2004-12-23 | Kyowa Hakko Kogyo Co., Ltd. | Thiadiazoline derivative |
| AU2005285422A1 (en) * | 2004-08-18 | 2006-03-23 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| US7449486B2 (en) | 2004-10-19 | 2008-11-11 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| CN101193878A (zh) * | 2005-03-22 | 2008-06-04 | 协和发酵工业株式会社 | 实体肿瘤治疗剂 |
| CN101193877A (zh) * | 2005-03-22 | 2008-06-04 | 协和发酵工业株式会社 | 造血系统肿瘤治疗剂 |
| UA95907C2 (en) | 2005-05-02 | 2011-09-26 | Эррей Биофарма Инк. | Mitotic kinesin inhibitors and methods of use thereof |
| WO2006137490A1 (ja) * | 2005-06-24 | 2006-12-28 | Kyowa Hakko Kogyo Co., Ltd. | 再狭窄治療剤 |
| US8324257B2 (en) * | 2006-10-03 | 2012-12-04 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| WO2008070739A1 (en) * | 2006-12-06 | 2008-06-12 | Cytokinetics, Inc. | Ksp activators |
| WO2009052288A1 (en) * | 2007-10-19 | 2009-04-23 | Schering Corporation | Spiro-condensed 1, 3, 4-thiadiazole derivatives for inhibiting ksp kinesin activity |
| CA2702990A1 (en) * | 2007-11-09 | 2009-05-14 | Schering Corporation | Compounds for inhibiting ksp kinesin activity |
| AU2009305588B2 (en) * | 2008-10-16 | 2015-08-13 | Array Biopharma Inc. | Inhibitors of mitosis for increasing apoptosis in therapy |
| US9561214B2 (en) * | 2008-10-16 | 2017-02-07 | Array Biopharma Inc. | Method of treatment using inhibitors of mitosis |
| US20120070370A1 (en) * | 2009-05-13 | 2012-03-22 | Siddiqui M Arshad | Spiro 1,3,4-thiadiazoline derivatives as ksp inhibitors |
| NZ601967A (en) | 2010-03-12 | 2015-03-27 | Omeros Corp | Pde10 inhibitors and related compositions and methods |
| FR2991199B1 (fr) * | 2012-05-30 | 2015-05-15 | IFP Energies Nouvelles | Procede de preparation d'un catalyseur mettant en oeuvre une etape de sechage rapide et son utilisation pour la synthese fischer-tropsch |
| IN2015KN00676A (enExample) | 2012-08-13 | 2015-07-17 | Array Biopharma Inc | |
| NZ631364A (en) | 2013-08-08 | 2017-09-29 | Array Biopharma Inc | Filanesib combined with pomalidomide displays enhanced anti-tumor activity |
| AU2014372833B2 (en) | 2013-12-23 | 2019-08-22 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (ADCs) with kinesin spindel protein (KSP) |
| NZ716462A (en) * | 2014-04-28 | 2017-11-24 | Omeros Corp | Optically active pde10 inhibitor |
| NZ630810A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
| JP6743015B2 (ja) | 2014-12-15 | 2020-08-19 | バイエル ファーマ アクチエンゲゼルシャフト | Ｋｓｐ阻害剤の脱グリコシル化抗ｔｗｅａｋｒ抗体との抗体薬物複合体（ａｄｃ類） |
| CA2980801A1 (en) | 2015-04-24 | 2016-10-27 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
| SG11201710639YA (en) | 2015-06-22 | 2018-01-30 | Bayer Pharma AG | Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups |
| WO2016207104A1 (de) | 2015-06-23 | 2016-12-29 | Bayer Pharma Aktiengesellschaft | Antikörper-wirkstoff-konjugate (adcs) von ksp-inhibitoren mit anti-b7h3-antikörpern |
| MX2017017138A (es) | 2015-06-23 | 2018-04-30 | Bayer Pharma AG | Conjugados homogeneos especificos de sitio con inhibidores de ksp. |
| CA2990394A1 (en) | 2015-06-23 | 2016-12-29 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates of kinesin spindel protein (ksp) inhibitors with anti-tweakr-antibodies |
| CA3003611C (en) | 2015-11-04 | 2022-11-01 | Omeros Corporation | Solid state forms of a pde10 inhibitor |
| WO2017216028A1 (en) | 2016-06-15 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| US11433140B2 (en) | 2016-12-21 | 2022-09-06 | Bayer Pharma Aktiengesellschaft | Specific antibody drug conjugates (ADCs) having KSP inhibitors |
| AU2017380871C1 (en) | 2016-12-21 | 2025-05-15 | Bayer Aktiengesellschaft | Antibody drug conjugates (ADCs) having enzymatically cleavable groups |
| CA3103327A1 (en) | 2018-06-18 | 2019-12-26 | Bayer Aktiengesellschaft | Binder/active agent conjugates directed against cxcr5, having enzymatically cleavable linkers and improved activity profile |
| KR20260019479A (ko) | 2023-05-04 | 2026-02-10 | 레볼루션 메디슨즈, 인크. | Ras 관련 질환 또는 장애를 위한 병용 요법 |
| CN121889155A (zh) | 2023-08-07 | 2026-04-17 | 锐新医药公司 | 用于治疗ras蛋白相关疾病或病症的rmc-6291 |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025096683A1 (en) * | 2023-10-30 | 2025-05-08 | University Of Health Sciences And Pharmacy In St. Louis | Err modulators |
| WO2025096684A1 (en) * | 2023-10-30 | 2025-05-08 | University Of Health Sciences And Pharmacy In St. Louis | Err modulators |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| WO2026090116A2 (en) | 2024-10-21 | 2026-04-30 | Revolution Medicines, Inc. | Ras inhibitors |
| US20260108528A1 (en) | 2024-10-22 | 2026-04-23 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2026090245A1 (en) | 2024-10-22 | 2026-04-30 | Revolution Medicines, Inc. | Use of ras inhibitors for treating cancer |
| WO2026106912A1 (en) | 2024-11-12 | 2026-05-21 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026112260A1 (en) | 2024-11-21 | 2026-05-28 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026122764A2 (en) | 2024-12-06 | 2026-06-11 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026128688A2 (en) | 2024-12-13 | 2026-06-18 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026161839A1 (en) | 2025-01-27 | 2026-07-30 | Revolution Medicines, Inc. | Ras inhibitors |
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|---|---|---|---|---|
| US2702803A (en) | 1954-04-12 | 1955-02-22 | Lilly Co Eli | Substituted heterodiazoles |
| SU1065410A1 (ru) * | 1982-05-07 | 1984-01-07 | Днепропетровский Ордена Трудового Красного Знамени Химико-Технологический Институт Им.Ф.Э.Дзержинского | Способ получени 2-амино-5-трет-алкил-1,3,4-тиадиазолов |
| ATE72431T1 (de) | 1985-08-31 | 1992-02-15 | Fisons Plc | 5-gliedrige heterocyclische angiotensinumwandlungsenzym-inhibitoren. |
| US4762072A (en) * | 1986-10-07 | 1988-08-09 | Westinghouse Electric Corp. | Desk and space dividing wall panel assembly |
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| EP1492487B1 (en) | 2002-03-08 | 2009-11-11 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| WO2004002029A1 (de) | 2002-06-25 | 2003-12-31 | Andreas Gall | Anordnung zur erfassung der nutzung von rds-rundfunkempfängern |
| US7294643B2 (en) * | 2002-11-22 | 2007-11-13 | Board Of Regents, The University Of Texas System | UK-1 analogues: methods of preparation and use |
| US20050004186A1 (en) | 2002-12-20 | 2005-01-06 | Pfizer Inc | MEK inhibiting compounds |
| US20040167188A1 (en) | 2003-02-14 | 2004-08-26 | Zhili Xin | Protein-tyrosine phosphatase inhibitors and uses thereof |
| KR101096948B1 (ko) | 2003-04-18 | 2011-12-20 | 후지필름 홀딩스 가부시끼가이샤 | Ｍ기 키네신 저해제 |
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| US20050009877A1 (en) | 2003-05-15 | 2005-01-13 | Henry Lu | Methods of identifying HCV NS5B polymerase inhibitors and their uses |
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| CA2528433A1 (en) | 2003-06-10 | 2004-12-23 | Kyowa Hakko Kogyo Co., Ltd. | Thiadiazoline derivative |
| JPWO2004111023A1 (ja) | 2003-06-10 | 2006-07-27 | 協和醗酵工業株式会社 | チアジアゾリン−１−オキシド誘導体 |
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| AU2005285422A1 (en) | 2004-08-18 | 2006-03-23 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| US7449486B2 (en) | 2004-10-19 | 2008-11-11 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| FR2876586B1 (fr) | 2004-10-20 | 2007-10-12 | Persee Medica | Composition pour prevenir ou traiter le stress, notamment les bouffees de stress chronique et permanent |
| JP2008137893A (ja) * | 2005-03-22 | 2008-06-19 | Kyowa Hakko Kogyo Co Ltd | 関節炎治療剤 |
| CN101193878A (zh) * | 2005-03-22 | 2008-06-04 | 协和发酵工业株式会社 | 实体肿瘤治疗剂 |
| JP2006265107A (ja) * | 2005-03-22 | 2006-10-05 | Kyowa Hakko Kogyo Co Ltd | 緑内障治療剤 |
| JP2008150291A (ja) * | 2005-03-22 | 2008-07-03 | Kyowa Hakko Kogyo Co Ltd | 乾癬治療剤 |
| CN101193877A (zh) * | 2005-03-22 | 2008-06-04 | 协和发酵工业株式会社 | 造血系统肿瘤治疗剂 |
| UA95907C2 (en) | 2005-05-02 | 2011-09-26 | Эррей Биофарма Инк. | Mitotic kinesin inhibitors and methods of use thereof |
| WO2006137490A1 (ja) * | 2005-06-24 | 2006-12-28 | Kyowa Hakko Kogyo Co., Ltd. | 再狭窄治療剤 |
| US8324257B2 (en) | 2006-10-03 | 2012-12-04 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| TWI411395B (zh) | 2007-12-24 | 2013-10-11 | Syngenta Participations Ag | 殺蟲化合物 |
| US9561214B2 (en) | 2008-10-16 | 2017-02-07 | Array Biopharma Inc. | Method of treatment using inhibitors of mitosis |
| IN2015KN00676A (enExample) | 2012-08-13 | 2015-07-17 | Array Biopharma Inc | |
| NZ631364A (en) | 2013-08-08 | 2017-09-29 | Array Biopharma Inc | Filanesib combined with pomalidomide displays enhanced anti-tumor activity |
-
2005
- 2005-10-17 US US11/252,232 patent/US7449486B2/en not_active Expired - Lifetime
- 2005-10-18 CN CN201310526809.3A patent/CN103626720B/zh not_active Expired - Lifetime
- 2005-10-18 ME MEP-2011-460A patent/ME01950B/me unknown
- 2005-10-18 PT PT05819172T patent/PT1809280E/pt unknown
- 2005-10-18 DK DK05819172.7T patent/DK1809280T3/da active
- 2005-10-18 RU RU2007118632/04A patent/RU2426729C2/ru active
- 2005-10-18 CN CNA2005800436289A patent/CN101083988A/zh active Pending
- 2005-10-18 CA CA2584866A patent/CA2584866C/en not_active Expired - Lifetime
- 2005-10-18 HR HR20110764T patent/HRP20110764T1/hr unknown
- 2005-10-18 WO PCT/US2005/037305 patent/WO2006044825A2/en not_active Ceased
- 2005-10-18 BR BRPI0518228A patent/BRPI0518228B8/pt active IP Right Grant
- 2005-10-18 CN CN2011103759246A patent/CN102532051A/zh active Pending
- 2005-10-18 KR KR1020077011307A patent/KR101280755B1/ko not_active Expired - Fee Related
- 2005-10-18 RS RS20110460A patent/RS52037B/sr unknown
- 2005-10-18 AU AU2005295403A patent/AU2005295403B2/en not_active Expired
- 2005-10-18 AT AT05819172T patent/ATE523196T1/de active
- 2005-10-18 CA CA2952920A patent/CA2952920A1/en not_active Abandoned
- 2005-10-18 ES ES05819172T patent/ES2370774T3/es not_active Expired - Lifetime
- 2005-10-18 EP EP05819172A patent/EP1809280B1/en not_active Expired - Lifetime
- 2005-10-18 NZ NZ554306A patent/NZ554306A/en not_active IP Right Cessation
- 2005-10-18 CN CN201310585349.1A patent/CN103951633B/zh not_active Expired - Lifetime
- 2005-10-18 MX MX2007004547A patent/MX2007004547A/es active IP Right Grant
- 2005-10-18 SI SI200531391T patent/SI1809280T1/sl unknown
- 2005-10-18 CA CA2868912A patent/CA2868912C/en not_active Expired - Lifetime
- 2005-10-18 PL PL05819172T patent/PL1809280T3/pl unknown
- 2005-10-18 JP JP2007537010A patent/JP5128283B2/ja not_active Expired - Lifetime
- 2005-10-18 CA CA2852516A patent/CA2852516C/en not_active Expired - Lifetime
- 2005-10-19 TW TW094136480A patent/TWI357900B/zh not_active IP Right Cessation
-
2007
- 2007-04-10 IL IL182417A patent/IL182417A0/en active IP Right Grant
- 2007-04-17 ZA ZA200703168A patent/ZA200703168B/en unknown
- 2007-05-18 NO NO20072558A patent/NO341725B1/no unknown
-
2008
- 2008-03-06 US US12/043,456 patent/US7956073B2/en active Active
-
2011
- 2011-04-25 US US13/093,729 patent/US8236825B2/en not_active Expired - Lifetime
- 2011-10-21 CY CY20111101002T patent/CY1112238T1/el unknown
-
2012
- 2012-05-17 IL IL219857A patent/IL219857A0/en unknown
- 2012-06-29 US US13/538,698 patent/US8623895B2/en not_active Expired - Fee Related
- 2012-09-03 JP JP2012193218A patent/JP5757666B2/ja not_active Expired - Fee Related
-
2013
- 2013-12-06 US US14/099,276 patent/US9102639B2/en not_active Expired - Lifetime
-
2014
- 2014-05-01 JP JP2014094479A patent/JP5911909B2/ja not_active Expired - Fee Related
-
2015
- 2015-04-06 US US14/679,866 patent/US9499503B2/en not_active Expired - Lifetime
- 2015-04-09 JP JP2015079762A patent/JP2015129191A/ja active Pending
-
2016
- 2016-11-21 US US15/357,613 patent/US10017482B2/en not_active Expired - Fee Related
-
2018
- 2018-06-14 US US16/009,030 patent/US20180334441A1/en not_active Abandoned
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