JP2004512321A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004512321A5 JP2004512321A5 JP2002537703A JP2002537703A JP2004512321A5 JP 2004512321 A5 JP2004512321 A5 JP 2004512321A5 JP 2002537703 A JP2002537703 A JP 2002537703A JP 2002537703 A JP2002537703 A JP 2002537703A JP 2004512321 A5 JP2004512321 A5 JP 2004512321A5
- Authority
- JP
- Japan
- Prior art keywords
- gabapentin
- ion exchange
- resin
- ammonia solution
- exchange resin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 6
- 229960002870 gabapentin Drugs 0.000 description 5
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 4
- 235000011114 ammonium hydroxide Nutrition 0.000 description 4
- 239000003456 ion exchange resin Substances 0.000 description 4
- 229920003303 ion-exchange polymer Polymers 0.000 description 4
- XBUDZAQEMFGLEU-UHFFFAOYSA-N 2-[1-(aminomethyl)cyclohexyl]acetic acid;hydron;chloride Chemical compound Cl.OC(=O)CC1(CN)CCCCC1 XBUDZAQEMFGLEU-UHFFFAOYSA-N 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 229910017053 inorganic salt Inorganic materials 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 241000287462 Phalacrocorax carbo Species 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical group 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2000A002285 | 2000-10-23 | ||
| IT2000MI002285A IT1319234B1 (it) | 2000-10-23 | 2000-10-23 | Processo di preparazione di gabapentina. |
| PCT/EP2001/011867 WO2002034709A1 (en) | 2000-10-23 | 2001-10-15 | Process for the preparation of gabapentin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004512321A JP2004512321A (ja) | 2004-04-22 |
| JP2004512321A5 true JP2004512321A5 (enExample) | 2008-06-26 |
| JP4723794B2 JP4723794B2 (ja) | 2011-07-13 |
Family
ID=11446013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002537703A Expired - Fee Related JP4723794B2 (ja) | 2000-10-23 | 2001-10-15 | ガバペンチンの製法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7199266B2 (enExample) |
| EP (2) | EP1475366A1 (enExample) |
| JP (1) | JP4723794B2 (enExample) |
| AT (1) | ATE312809T1 (enExample) |
| CA (1) | CA2425615C (enExample) |
| CY (1) | CY1106481T1 (enExample) |
| DE (1) | DE60115954T2 (enExample) |
| DK (1) | DK1341749T3 (enExample) |
| ES (2) | ES2254528T3 (enExample) |
| GB (1) | GB2383041B (enExample) |
| HU (1) | HUP0302602A2 (enExample) |
| IL (2) | IL154789A0 (enExample) |
| IT (1) | IT1319234B1 (enExample) |
| WO (1) | WO2002034709A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1319234B1 (it) | 2000-10-23 | 2003-09-26 | Zambon Spa | Processo di preparazione di gabapentina. |
| US20040034248A1 (en) * | 2002-04-16 | 2004-02-19 | Taro Pharmaceutical Industries, Ltd. | Process for preparing gabapentin |
| PT1603863E (pt) * | 2002-11-20 | 2010-02-05 | Hikal Ltd | Processo para a preparação de ácidos amino-metil-cicloalcano-acéticos |
| WO2004093780A2 (en) * | 2003-04-21 | 2004-11-04 | Matrix Laboratories Ltd | Process for the preparation of gabapentin form-ii |
| WO2004093779A2 (en) * | 2003-04-21 | 2004-11-04 | Matrix Laboratories Ltd | Process for the preparation of gabapentin form-ii |
| US20070043236A1 (en) * | 2003-05-19 | 2007-02-22 | Chandiran Thakashina M | Process for preparation of gabapentin |
| ITMI20031247A1 (it) * | 2003-06-20 | 2004-12-21 | Zambon Spa | Processo per la purificazione di gabapentina |
| ITMI20032165A1 (it) * | 2003-11-11 | 2005-05-12 | Zambon Spa | Processo di preparazione di gabapentina |
| ITMI20032456A1 (it) * | 2003-12-16 | 2005-06-17 | Zambon Spa | Processo per la purificazione di gabapentina |
| ITMI20040579A1 (it) * | 2004-03-25 | 2004-06-25 | Zambon Spa | Processo di preparazione di gabapentina |
| ITMI20041271A1 (it) * | 2004-06-24 | 2004-09-24 | Zambon Spa | Processo di preparazione di gabapentina |
| GB0416228D0 (en) * | 2004-07-20 | 2004-08-25 | Sandoz Ind Products S A | Process for the preparation of gabapentin |
| ITMI20042418A1 (it) * | 2004-12-17 | 2005-03-17 | Zambon Spa | Processo per la purificazione della gabapentina |
| US7442834B2 (en) * | 2006-06-12 | 2008-10-28 | Zhejiang Chiral Medicine Chemicals Co., Ltd. | Process suitable for industrial scale production of gabapentin |
| WO2008106217A1 (en) * | 2007-02-28 | 2008-09-04 | Teva Pharmaceutical Industries Ltd. | Preparation of gabapentin by liquid-liquid extraction |
| EP2368872A1 (en) | 2010-03-25 | 2011-09-28 | Serichim S.r.l. | Process for the preparation of Gabapentin |
| ITMI20131757A1 (it) | 2013-10-22 | 2015-04-23 | Zach System Spa | Processo di preparazione di gabapentina |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1145512A (en) * | 1965-09-21 | 1969-03-19 | Kyowa Hakko Kogyo Company Ltd | Method for isolating tryptophan |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| DE2460891C2 (de) | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| JPS6261592A (ja) | 1985-09-13 | 1987-03-18 | Ajinomoto Co Inc | 塩基性アミノ酸の分離方法 |
| DE3928183A1 (de) | 1989-08-25 | 1991-02-28 | Goedecke Ag | Lactamfreie cyclische aminosaeuren |
| JPH04134054A (ja) * | 1990-09-25 | 1992-05-07 | Ajinomoto Co Inc | イオン交換樹脂を用いるアミノ酸の精製方法 |
| HU217844B (hu) | 1994-11-18 | 2000-04-28 | Aeci Limited | Eljárás aminosav kinyerésére |
| JPH08183768A (ja) * | 1994-12-28 | 1996-07-16 | Mitsui Toatsu Chem Inc | Ｌ−プロリンの単離法 |
| ES2164527B1 (es) | 1999-04-26 | 2003-04-01 | Medichen S A | Procedimiento de obtencion de gabapentina de calidad farmaceutica. |
| IT1319234B1 (it) | 2000-10-23 | 2003-09-26 | Zambon Spa | Processo di preparazione di gabapentina. |
| US20040034248A1 (en) | 2002-04-16 | 2004-02-19 | Taro Pharmaceutical Industries, Ltd. | Process for preparing gabapentin |
-
2000
- 2000-10-23 IT IT2000MI002285A patent/IT1319234B1/it active
-
2001
- 2001-10-15 EP EP04016428A patent/EP1475366A1/en not_active Ceased
- 2001-10-15 IL IL15478901A patent/IL154789A0/xx unknown
- 2001-10-15 US US10/399,409 patent/US7199266B2/en not_active Expired - Lifetime
- 2001-10-15 HU HU0302602A patent/HUP0302602A2/hu unknown
- 2001-10-15 DE DE60115954T patent/DE60115954T2/de not_active Expired - Lifetime
- 2001-10-15 ES ES01988708T patent/ES2254528T3/es not_active Expired - Lifetime
- 2001-10-15 DK DK01988708T patent/DK1341749T3/da active
- 2001-10-15 GB GB0306346A patent/GB2383041B/en not_active Expired - Fee Related
- 2001-10-15 EP EP01988708A patent/EP1341749B1/en not_active Expired - Lifetime
- 2001-10-15 JP JP2002537703A patent/JP4723794B2/ja not_active Expired - Fee Related
- 2001-10-15 CA CA2425615A patent/CA2425615C/en not_active Expired - Lifetime
- 2001-10-15 WO PCT/EP2001/011867 patent/WO2002034709A1/en not_active Ceased
- 2001-10-15 AT AT01988708T patent/ATE312809T1/de active
-
2003
- 2003-03-06 IL IL154789A patent/IL154789A/en not_active IP Right Cessation
- 2003-03-28 ES ES200350018A patent/ES2206078B1/es not_active Expired - Fee Related
-
2006
- 2006-03-09 CY CY20061100328T patent/CY1106481T1/el unknown
- 2006-03-28 US US11/390,451 patent/US7365227B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004512321A5 (enExample) | ||
| EP2070583A3 (en) | Production of purified water and high value chemicals from salt water | |
| CA2425615A1 (en) | Process for the purification of gabapentin using a strong cation exchange resin | |
| TW200635858A (en) | Process to prepare salt | |
| IL45955A (en) | Metal particularly gold recovery | |
| CA2133702A1 (fr) | Procede d'elimination d'ions sulfates contenus dans les solutions salines | |
| JPH0220575B2 (enExample) | ||
| RU94025664A (ru) | Способ получения полимерного органоминерального сорбента | |
| CH416478A (fr) | Procédé pour préparer de l'eau douce | |
| JP2003315496A5 (enExample) | ||
| CN116121557A (zh) | 一种采用铝系吸附剂从硫酸钠型或碳酸钠型盐湖提锂方法 | |
| CA2397674A1 (en) | Coating an aluminum alloy substrate | |
| Jain et al. | Ground water pollution-endemic of fluorosis | |
| CN206428090U (zh) | 一种海水淡化一体式复合滤芯 | |
| RU2002128716A (ru) | Индикаторный состав для определения меди (ii) в водных растворах | |
| RU2007110162A (ru) | Способ получения монокристаллов благородного металла или его соли нано-и/или микроразмеров | |
| CA2553733A1 (en) | Process for producing lactoperoxidase | |
| RU2000116192A (ru) | Способ комплексной переработки попутных вод нефтяных месторождений | |
| JP3955162B2 (ja) | 酸溶液から酸を除去する方法およびその装置 | |
| BR9803921A (pt) | Remoção de sais de soluções aquosas de sulfonamidas. | |
| RU2002128715A (ru) | Индикаторный состав для определения палладия (ii) в водных растворах | |
| RU2003112129A (ru) | Способ переработки азотно-кислых альфасодержащих растворов с высоким содержанием трёхвалентного железа | |
| RU2002130412A (ru) | Способ выделения платиновых металлов | |
| KR920009698A (ko) | 천연산출염의 염 분리방법 | |
| TH68654A (th) | วิธีการทำให้เกลือบริสุทธิ์ |